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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16310

FusionGeneSummary for HK2_ONECUT3

check button Fusion gene summary
Fusion gene informationFusion gene name: HK2_ONECUT3
Fusion gene ID: 16310
HgeneTgene
Gene symbol

HK2

ONECUT3

Gene ID

29911

390874

Gene namehook microtubule tethering protein 2one cut homeobox 3
SynonymsHK2OC3
Cytomap

19p13.13

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein Hook homolog 2h-hook2hHK2hook homolog 2one cut domain family member 3OC-3transcription factor ONECUT-3
Modification date2018052320180523
UniProtAcc

P52789

O60422

Ensembl transtripts involved in fusion geneENST00000290573, ENST00000409174, 
ENST00000382349, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 2 X 2=12
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HK2 [Title/Abstract] AND ONECUT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-09-1662-01AHK2chr2

75101576

+ONECUT3chr19

1775152

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000290573ENST00000382349HK2chr2

75101576

+ONECUT3chr19

1775152

+
Frame-shitENST00000409174ENST00000382349HK2chr2

75101576

+ONECUT3chr19

1775152

+

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FusionProtFeatures for HK2_ONECUT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HK2

P52789

ONECUT3

O60422

Transcriptional activator. Binds the consensus DNAsequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters suchas those of HNF3B and TTR (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HK2_ONECUT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HK2_ONECUT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HK2UBQLN1, PRKCE, ELAVL1, SLC2A4, UBQLN4, NUDCD3, ITGA4, PARK2, FBXO6, ARIH2, FNTA, H2AFV, HEXB, IPO5, NUBP1, PDLIM1, WDR61, PYGL, EGFR, MAGEA12, CNBP, BUB3, HYOU1, PPME1, SRM, TBCB, TPP2, MARS, SEPT10, SEPT6, NTRK1, HSP90AA1, RAD18, IRF3, FOXB1, FOXH1, FOXI2, FOXL1, FOXL2, COQ9, NDUFA4, C15orf48, HK1, HK3, TESONECUT3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HK2_ONECUT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HK2_ONECUT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHK2C0028754Obesity1CTD_human
HgeneHK2C0151744Myocardial Ischemia1CTD_human