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Fusion gene ID: 16310 |
FusionGeneSummary for HK2_ONECUT3 |
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Fusion gene information | Fusion gene name: HK2_ONECUT3 | Fusion gene ID: 16310 | Hgene | Tgene | Gene symbol | HK2 | ONECUT3 | Gene ID | 29911 | 390874 |
Gene name | hook microtubule tethering protein 2 | one cut homeobox 3 | |
Synonyms | HK2 | OC3 | |
Cytomap | 19p13.13 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Hook homolog 2h-hook2hHK2hook homolog 2 | one cut domain family member 3OC-3transcription factor ONECUT-3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P52789 | O60422 | |
Ensembl transtripts involved in fusion gene | ENST00000290573, ENST00000409174, | ENST00000382349, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 2 X 2=12 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: HK2 [Title/Abstract] AND ONECUT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-09-1662-01A | HK2 | chr2 | 75101576 | + | ONECUT3 | chr19 | 1775152 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000290573 | ENST00000382349 | HK2 | chr2 | 75101576 | + | ONECUT3 | chr19 | 1775152 | + |
Frame-shift | ENST00000409174 | ENST00000382349 | HK2 | chr2 | 75101576 | + | ONECUT3 | chr19 | 1775152 | + |
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FusionProtFeatures for HK2_ONECUT3 |
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Hgene | Tgene |
HK2 | ONECUT3 |
Transcriptional activator. Binds the consensus DNAsequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters suchas those of HNF3B and TTR (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HK2_ONECUT3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HK2_ONECUT3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HK2 | UBQLN1, PRKCE, ELAVL1, SLC2A4, UBQLN4, NUDCD3, ITGA4, PARK2, FBXO6, ARIH2, FNTA, H2AFV, HEXB, IPO5, NUBP1, PDLIM1, WDR61, PYGL, EGFR, MAGEA12, CNBP, BUB3, HYOU1, PPME1, SRM, TBCB, TPP2, MARS, SEPT10, SEPT6, NTRK1, HSP90AA1, RAD18, IRF3, FOXB1, FOXH1, FOXI2, FOXL1, FOXL2, COQ9, NDUFA4, C15orf48, HK1, HK3, TES | ONECUT3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HK2_ONECUT3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HK2_ONECUT3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HK2 | C0028754 | Obesity | 1 | CTD_human |
Hgene | HK2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |