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Fusion gene ID: 1624 |
FusionGeneSummary for AMOTL1_SLCO2B1 |
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Fusion gene information | Fusion gene name: AMOTL1_SLCO2B1 | Fusion gene ID: 1624 | Hgene | Tgene | Gene symbol | AMOTL1 | SLCO2B1 | Gene ID | 154810 | 11309 |
Gene name | angiomotin like 1 | solute carrier organic anion transporter family member 2B1 | |
Synonyms | JEAP | OATP-B|OATP2B1|OATPB|SLC21A9 | |
Cytomap | 11q21 | 11q13.4 | |
Type of gene | protein-coding | protein-coding | |
Description | angiomotin-like protein 1junction-enriched and associated protein | solute carrier organic anion transporter family member 2B1OATP-RP2organic anion transporter Borganic anion transporter polypeptide-related protein 2solute carrier family 21 (organic anion transporter), member 9 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IY63 | O94956 | |
Ensembl transtripts involved in fusion gene | ENST00000317829, ENST00000317837, ENST00000433060, ENST00000539727, | ENST00000526660, ENST00000289575, ENST00000341411, ENST00000532236, ENST00000531756, ENST00000525650, ENST00000454962, ENST00000428359, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 5 X 2 X 4=40 |
# samples | 6 | 5 | |
** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AMOTL1 [Title/Abstract] AND SLCO2B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-BT-A0S7-01A | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000317829 | ENST00000526660 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000317829 | ENST00000289575 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-5UTR | ENST00000317829 | ENST00000341411 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000317829 | ENST00000532236 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000317829 | ENST00000531756 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000317829 | ENST00000525650 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000317829 | ENST00000454962 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-5UTR | ENST00000317829 | ENST00000428359 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000317837 | ENST00000526660 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000317837 | ENST00000289575 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-5UTR | ENST00000317837 | ENST00000341411 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000317837 | ENST00000532236 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000317837 | ENST00000531756 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000317837 | ENST00000525650 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000317837 | ENST00000454962 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-5UTR | ENST00000317837 | ENST00000428359 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000433060 | ENST00000526660 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000433060 | ENST00000289575 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-5UTR | ENST00000433060 | ENST00000341411 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000433060 | ENST00000532236 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000433060 | ENST00000531756 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000433060 | ENST00000525650 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-intron | ENST00000433060 | ENST00000454962 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
5CDS-5UTR | ENST00000433060 | ENST00000428359 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000539727 | ENST00000526660 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000539727 | ENST00000289575 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-5UTR | ENST00000539727 | ENST00000341411 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000539727 | ENST00000532236 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000539727 | ENST00000531756 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000539727 | ENST00000525650 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-intron | ENST00000539727 | ENST00000454962 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
intron-5UTR | ENST00000539727 | ENST00000428359 | AMOTL1 | chr11 | 94528326 | + | SLCO2B1 | chr11 | 74873700 | + |
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FusionProtFeatures for AMOTL1_SLCO2B1 |
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Hgene | Tgene |
AMOTL1 | SLCO2B1 |
Inhibits the Wnt/beta-catenin signaling pathway,probably by recruiting CTNNB1 to recycling endosomes and hencepreventing its translocation to the nucleus.{ECO:0000269|PubMed:22362771}. | Mediates the Na(+)-independent transport of organicanions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2,leukotriene C4, thromboxane B2 and iloprost. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AMOTL1_SLCO2B1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AMOTL1_SLCO2B1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AMOTL1 | AMOT, NEDD4L, LATS1, LATS2, YAP1, HECW2, NEDD4, WWOX, SHMT2, MOV10, NXF1, SUZ12, FHL3, MAGEA4, WWP2, TEAD4, RAB3IL1, WWTR1, RNF166, NF2, MPP5, CAPZA2, COG6, ALOX5, IFFO1, COBLL1, CDADC1, SCML1, HMBOX1, DDHD1, TLK2, UHRF1BP1L, WWC1, USP9X | SLCO2B1 | APP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AMOTL1_SLCO2B1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SLCO2B1 | O94956 | DB01045 | Rifampicin | Solute carrier organic anion transporter family member 2B1 | small molecule | approved |
Tgene | SLCO2B1 | O94956 | DB05521 | Telaprevir | Solute carrier organic anion transporter family member 2B1 | small molecule | approved|withdrawn |
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RelatedDiseases for AMOTL1_SLCO2B1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |