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Fusion gene ID: 16235 |
FusionGeneSummary for HIST1H2AC_TNFRSF21 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HIST1H2AC_TNFRSF21 | Fusion gene ID: 16235 | Hgene | Tgene | Gene symbol | HIST1H2AC | TNFRSF21 | Gene ID | 8334 | 27242 |
| Gene name | histone cluster 1 H2A family member c | TNF receptor superfamily member 21 | |
| Synonyms | H2A/l|H2AFL|dJ221C16.4 | BM-018|CD358|DR6 | |
| Cytomap | 6p22.2 | 6p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone H2A type 1-CH2A histone family, member Lhistone 1, H2achistone H2A/lhistone H2AChistone cluster 1, H2ac | tumor necrosis factor receptor superfamily member 21TNFR-related death receptor 6death receptor 6 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q93077 | O75509 | |
| Ensembl transtripts involved in fusion gene | ENST00000377791, ENST00000602637, | ENST00000296861, | |
| Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 4 X 4 X 5=80 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/80*10)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HIST1H2AC [Title/Abstract] AND TNFRSF21 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TNFRSF21 | GO:0071356 | cellular response to tumor necrosis factor | 19654028 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-FS-A1ZT-06A | HIST1H2AC | chr6 | 26124977 | + | TNFRSF21 | chr6 | 47254331 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000377791 | ENST00000296861 | HIST1H2AC | chr6 | 26124977 | + | TNFRSF21 | chr6 | 47254331 | - |
| intron-3CDS | ENST00000602637 | ENST00000296861 | HIST1H2AC | chr6 | 26124977 | + | TNFRSF21 | chr6 | 47254331 | - |
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FusionProtFeatures for HIST1H2AC_TNFRSF21 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HIST1H2AC | TNFRSF21 |
| Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. | Promotes apoptosis, possibly via a pathway that involvesthe activation of NF-kappa-B. Can also promote apoptosis mediatedby BAX and by the release of cytochrome c from the mitochondriainto the cytoplasm. Plays a role in neuronal apoptosis, includingapoptosis in response to amyloid peptides derived from APP, and isrequired for both normal cell body death and axonal pruning.Trophic-factor deprivation triggers the cleavage of surface APP bybeta-secretase to release sAPP-beta which is further cleaved torelease an N-terminal fragment of APP (N-APP). N-APP bindsTNFRSF21; this triggers caspase activation and degeneration ofboth neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation andmyelination. Plays a role in signaling cascades triggered bystimulation of T-cell receptors, in the adaptive immune responseand in the regulation of T-cell differentiation and proliferation.Negatively regulates T-cell responses and the release of cytokinessuch as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negativelyregulates the production of IgG, IgM and IgM in response toantigens. May inhibit the activation of JNK in response to T-cellstimulation. {ECO:0000269|PubMed:21725297,ECO:0000269|PubMed:22761420, ECO:0000269|PubMed:9714541}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HIST1H2AC_TNFRSF21 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HIST1H2AC_TNFRSF21 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HIST1H2AC | AIRE, ITGA4, HEMGN, MCM2, MCM5, MTNR1A | TNFRSF21 | TRADD, MATR3, WASH2P, STX11, ELAVL1, CLIP3, NSD1, MOV10, PSMD4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HIST1H2AC_TNFRSF21 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HIST1H2AC_TNFRSF21 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TNFRSF21 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
| Tgene | TNFRSF21 | C0017639 | Gliosis | 1 | CTD_human |
| Tgene | TNFRSF21 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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