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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16188

FusionGeneSummary for HINT1_USP34

check button Fusion gene summary
Fusion gene informationFusion gene name: HINT1_USP34
Fusion gene ID: 16188
HgeneTgene
Gene symbol

HINT1

USP34

Gene ID

3094

9736

Gene namehistidine triad nucleotide binding protein 1ubiquitin specific peptidase 34
SynonymsHINT|NMAN|PKCI-1|PRKCNH1-
Cytomap

5q23.3

2p15

Type of geneprotein-codingprotein-coding
Descriptionhistidine triad nucleotide-binding protein 1adenosine 5'-monophosphoramidaseprotein kinase C inhibitor 1protein kinase C-interacting protein 1ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34
Modification date2018051920180523
UniProtAcc

P49773

Q70CQ2

Ensembl transtripts involved in fusion geneENST00000304043, ENST00000506207, 
ENST00000508488, ENST00000506908, 
ENST00000513012, 
ENST00000398571, 
ENST00000472689, 
Fusion gene scores* DoF score4 X 6 X 1=246 X 7 X 2=84
# samples 67
** MAII scorelog2(6/24*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HINT1 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHINT1

GO:0009154

purine ribonucleotide catabolic process

16835243

TgeneUSP34

GO:0016579

protein deubiquitination

14715245

TgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

TgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA997458HINT1chr5

130498054

-USP34chr2

61415659

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000304043ENST00000398571HINT1chr5

130498054

-USP34chr2

61415659

+
intron-intronENST00000304043ENST00000472689HINT1chr5

130498054

-USP34chr2

61415659

+
intron-3CDSENST00000506207ENST00000398571HINT1chr5

130498054

-USP34chr2

61415659

+
intron-intronENST00000506207ENST00000472689HINT1chr5

130498054

-USP34chr2

61415659

+
intron-3CDSENST00000508488ENST00000398571HINT1chr5

130498054

-USP34chr2

61415659

+
intron-intronENST00000508488ENST00000472689HINT1chr5

130498054

-USP34chr2

61415659

+
intron-3CDSENST00000506908ENST00000398571HINT1chr5

130498054

-USP34chr2

61415659

+
intron-intronENST00000506908ENST00000472689HINT1chr5

130498054

-USP34chr2

61415659

+
intron-3CDSENST00000513012ENST00000398571HINT1chr5

130498054

-USP34chr2

61415659

+
intron-intronENST00000513012ENST00000472689HINT1chr5

130498054

-USP34chr2

61415659

+

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FusionProtFeatures for HINT1_USP34


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HINT1

P49773

USP34

Q70CQ2

Hydrolyzes purine nucleotide phosphoramidates with asingle phosphate group, including adenosine 5'monophosphoramidate(AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate)and guanosine 5'monophosphomorpholidate (GMP-morpholidate).Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methylester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysinemethyl ester)) and AMP-N-alanine methyl ester. Can also convertadenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphateswith concomitant release of hydrogen sulfide. In addition,functions as scaffolding protein that modulates transcriptionalactivation by the LEF1/TCF1-CTNNB1 complex and by the complexformed with MITF and CTNNB1. Modulates p53/TP53 levels andp53/TP53-mediated apoptosis. Modulates proteasomal degradation oftarget proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15703176,ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243,ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685,ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:9323207}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HINT1_USP34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HINT1_USP34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HINT1_USP34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HINT1_USP34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHINT1C0036341Schizophrenia2CTD_human
HgeneHINT1C0005586Bipolar Disorder1PSYGENET
HgeneHINT1C0026848Myopathy1CTD_human
HgeneHINT1C0242287Isaacs syndrome1ORPHANET;UNIPROT
HgeneHINT1C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)1CTD_human
HgeneHINT1C2932678Inherited Peripheral Neuropathy1CTD_human