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Fusion gene ID: 16188 |
FusionGeneSummary for HINT1_USP34 |
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Fusion gene information | Fusion gene name: HINT1_USP34 | Fusion gene ID: 16188 | Hgene | Tgene | Gene symbol | HINT1 | USP34 | Gene ID | 3094 | 9736 |
Gene name | histidine triad nucleotide binding protein 1 | ubiquitin specific peptidase 34 | |
Synonyms | HINT|NMAN|PKCI-1|PRKCNH1 | - | |
Cytomap | 5q23.3 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | histidine triad nucleotide-binding protein 1adenosine 5'-monophosphoramidaseprotein kinase C inhibitor 1protein kinase C-interacting protein 1 | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P49773 | Q70CQ2 | |
Ensembl transtripts involved in fusion gene | ENST00000304043, ENST00000506207, ENST00000508488, ENST00000506908, ENST00000513012, | ENST00000398571, ENST00000472689, | |
Fusion gene scores | * DoF score | 4 X 6 X 1=24 | 6 X 7 X 2=84 |
# samples | 6 | 7 | |
** MAII score | log2(6/24*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HINT1 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HINT1 | GO:0009154 | purine ribonucleotide catabolic process | 16835243 |
Tgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
Tgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
Tgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA997458 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000304043 | ENST00000398571 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-intron | ENST00000304043 | ENST00000472689 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-3CDS | ENST00000506207 | ENST00000398571 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-intron | ENST00000506207 | ENST00000472689 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-3CDS | ENST00000508488 | ENST00000398571 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-intron | ENST00000508488 | ENST00000472689 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-3CDS | ENST00000506908 | ENST00000398571 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-intron | ENST00000506908 | ENST00000472689 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-3CDS | ENST00000513012 | ENST00000398571 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
intron-intron | ENST00000513012 | ENST00000472689 | HINT1 | chr5 | 130498054 | - | USP34 | chr2 | 61415659 | + |
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FusionProtFeatures for HINT1_USP34 |
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Hgene | Tgene |
HINT1 | USP34 |
Hydrolyzes purine nucleotide phosphoramidates with asingle phosphate group, including adenosine 5'monophosphoramidate(AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate)and guanosine 5'monophosphomorpholidate (GMP-morpholidate).Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methylester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysinemethyl ester)) and AMP-N-alanine methyl ester. Can also convertadenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphateswith concomitant release of hydrogen sulfide. In addition,functions as scaffolding protein that modulates transcriptionalactivation by the LEF1/TCF1-CTNNB1 complex and by the complexformed with MITF and CTNNB1. Modulates p53/TP53 levels andp53/TP53-mediated apoptosis. Modulates proteasomal degradation oftarget proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15703176,ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243,ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685,ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:9323207}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HINT1_USP34 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HINT1_USP34 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HINT1_USP34 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HINT1_USP34 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HINT1 | C0036341 | Schizophrenia | 2 | CTD_human |
Hgene | HINT1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | HINT1 | C0026848 | Myopathy | 1 | CTD_human |
Hgene | HINT1 | C0242287 | Isaacs syndrome | 1 | ORPHANET;UNIPROT |
Hgene | HINT1 | C1861063 | TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) | 1 | CTD_human |
Hgene | HINT1 | C2932678 | Inherited Peripheral Neuropathy | 1 | CTD_human |