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Fusion gene ID: 16184 |
FusionGeneSummary for HILPDA_SND1 |
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Fusion gene information | Fusion gene name: HILPDA_SND1 | Fusion gene ID: 16184 | Hgene | Tgene | Gene symbol | HILPDA | SND1 | Gene ID | 29923 | 27044 |
Gene name | hypoxia inducible lipid droplet associated | staphylococcal nuclease and tudor domain containing 1 | |
Synonyms | C7orf68|HIG-2|HIG2 | TDRD11|Tudor-SN|p100 | |
Cytomap | 7q32.1 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | hypoxia-inducible lipid droplet-associated proteinhypoxia inducible gene 2hypoxia-inducible gene 2 proteinhypoxia-inducible protein 2 | staphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y5L2 | Q7KZF4 | |
Ensembl transtripts involved in fusion gene | ENST00000435296, ENST00000257696, ENST00000481454, | ENST00000354725, ENST00000467238, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 20 X 15 X 10=3000 |
# samples | 1 | 21 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(21/3000*10)=-3.83650126771712 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HILPDA [Title/Abstract] AND SND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HILPDA | GO:0001819 | positive regulation of cytokine production | 20624928 |
Hgene | HILPDA | GO:0008284 | positive regulation of cell proliferation | 15930302 |
Hgene | HILPDA | GO:0010884 | positive regulation of lipid storage | 20624928 |
Hgene | HILPDA | GO:0035425 | autocrine signaling | 15930302 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E9-A243-01A | HILPDA | chr7 | 128096077 | + | SND1 | chr7 | 127729541 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000435296 | ENST00000354725 | HILPDA | chr7 | 128096077 | + | SND1 | chr7 | 127729541 | + |
intron-intron | ENST00000435296 | ENST00000467238 | HILPDA | chr7 | 128096077 | + | SND1 | chr7 | 127729541 | + |
5UTR-3CDS | ENST00000257696 | ENST00000354725 | HILPDA | chr7 | 128096077 | + | SND1 | chr7 | 127729541 | + |
5UTR-intron | ENST00000257696 | ENST00000467238 | HILPDA | chr7 | 128096077 | + | SND1 | chr7 | 127729541 | + |
3UTR-3CDS | ENST00000481454 | ENST00000354725 | HILPDA | chr7 | 128096077 | + | SND1 | chr7 | 127729541 | + |
3UTR-intron | ENST00000481454 | ENST00000467238 | HILPDA | chr7 | 128096077 | + | SND1 | chr7 | 127729541 | + |
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FusionProtFeatures for HILPDA_SND1 |
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Hgene | Tgene |
HILPDA | SND1 |
Increases intracellular lipid accumulation. Stimulatesexpression of cytokines including IL6, MIF and VEGFA. Enhancescell growth and proliferation. {ECO:0000269|PubMed:15930302,ECO:0000269|PubMed:20624928}. | Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HILPDA_SND1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HILPDA_SND1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HILPDA | ASNA1 | SND1 | IKBKE, SNW1, RBPJ, GTF2E2, GTF2E1, MYB, PIM1, STAT6, POLR2A, USP22, PDPK1, PRKAA1, UBA5, LZTR1, DHX9, CREBBP, RBM39, SIRT7, CUL3, CDK2, CAND1, APP, RPS3, HNRNPM, TOMM22, RPL19, MYBBP1A, SMNDC1, RPS20, NENF, RPL4, VDAC2, ILF2, SRSF3, HNRNPU, RPN1, HNRNPR, SSR3, FN1, VCAM1, CSNK2A1, ITGA4, G3BP1, PRPF8, RNU1-1, RNU2-1, RNU4-1, RNU6-1, RNU5A-1, MAK, TARDBP, EIF3CL, RPS11, RPS2, RPS6, RPS9, DDX3X, RPL23A, RPL35, RPS16, RPS26, RPS27, RPS3A, SHFM1, LIN28A, HUWE1, RAPGEF2, MDM2, CUL7, OBSL1, CCDC8, UBE2I, ESR1, MMP28, TDRD3, TXNDC5, NTRK1, NPM1, RPL10, CNOT1, MCM2, U2AF2, CDH1, PTP4A1, MTDH, PA2G4, TRAP1, ANXA5, SNRPB2, EIF5B, GPI, IDH2, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, CPNE3, CS, PYGL, SF3A3, DNAJC8, PLS3, CPSF6, NANS, SF3A1, ECHS1, SRP68, MYL12B, AIMP1, CYLD, DLD, DLST, PDHA1, SOD1, TRIM25, BRCA1, YAP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HILPDA_SND1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HILPDA_SND1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SND1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | SND1 | C0024121 | Lung Neoplasms | 1 | CTD_human |