![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 16182 |
FusionGeneSummary for HIF3A_DNMT1 |
![]() |
Fusion gene information | Fusion gene name: HIF3A_DNMT1 | Fusion gene ID: 16182 | Hgene | Tgene | Gene symbol | HIF3A | DNMT1 | Gene ID | 64344 | 1786 |
Gene name | hypoxia inducible factor 3 subunit alpha | DNA methyltransferase 1 | |
Synonyms | HIF-3A|HIF3-alpha-1|IPAS|MOP7|PASD7|bHLHe17 | ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|m.HsaI | |
Cytomap | 19q13.32 | 19p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | hypoxia-inducible factor 3-alphaPAS domain-containing protein 7basic-helix-loop-helix-PAS protein MOP7class E basic helix-loop-helix protein 17hypoxia inducible factor 3 alpha subunitinhibitory PAS domain proteinmember of PAS protein 7 | DNA (cytosine-5)-methyltransferase 1CXXC-type zinc finger protein 9DNA (cytosine-5-)-methyltransferase 1DNA MTase HsaIDNA methyltransferase HsaI | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9Y2N7 | P26358 | |
Ensembl transtripts involved in fusion gene | ENST00000377670, ENST00000244303, ENST00000339613, ENST00000472815, ENST00000300862, ENST00000600383, ENST00000420102, ENST00000525854, | ENST00000340748, ENST00000540357, ENST00000359526, ENST00000589538, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 1 X 2=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: HIF3A [Title/Abstract] AND DNMT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DNMT1 | GO:0010216 | maintenance of DNA methylation | 18754681|21745816 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-MJ-A68H-01A | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000377670 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000377670 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000377670 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
5CDS-intron | ENST00000377670 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000244303 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000244303 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000244303 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
5CDS-intron | ENST00000244303 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000339613 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000339613 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000339613 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
5CDS-intron | ENST00000339613 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000472815 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000472815 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000472815 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
5CDS-intron | ENST00000472815 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000300862 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000300862 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000300862 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
5CDS-intron | ENST00000300862 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000600383 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000600383 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000600383 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
5CDS-intron | ENST00000600383 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000420102 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000420102 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Frame-shift | ENST00000420102 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
5CDS-intron | ENST00000420102 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
intron-3CDS | ENST00000525854 | ENST00000340748 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
intron-3CDS | ENST00000525854 | ENST00000540357 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
intron-3CDS | ENST00000525854 | ENST00000359526 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
intron-intron | ENST00000525854 | ENST00000589538 | HIF3A | chr19 | 46838243 | + | DNMT1 | chr19 | 10277361 | - |
Top |
FusionProtFeatures for HIF3A_DNMT1 |
![]() |
Hgene | Tgene |
HIF3A | DNMT1 |
Methylates CpG residues. Preferentially methylateshemimethylated DNA. Associates with DNA replication sites in Sphase maintaining the methylation pattern in the newly synthesizedstrand, that is essential for epigenetic inheritance. Associateswith chromatin during G2 and M phases to maintain DNA methylationindependently of replication. It is responsible for maintainingmethylation patterns established in development. DNA methylationis coordinated with methylation of histones. Mediatestranscriptional repression by direct binding to HDAC2. Inassociation with DNMT3B and via the recruitment of CTCFL/BORIS,involved in activation of BAG1 gene expression by modulatingdimethylation of promoter histone H3 at H3K4 and H3K9. Probablyforms a corepressor complex required for activated KRAS-mediatedpromoter hypermethylation and transcriptional silencing of tumorsuppressor genes (TSGs) or other tumor-related genes in colorectalcancer (CRC) cells (PubMed:24623306). Also required to maintain atranscriptionally repressive state of genes in undifferentiatedembryonic stem cells (ESCs) (PubMed:24623306). Associates atpromoter regions of tumor suppressor genes (TSGs) leading to theirgene silencing (PubMed:24623306). Promotes tumor growth(PubMed:24623306). {ECO:0000269|PubMed:16357870,ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681,ECO:0000269|PubMed:24623306}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HIF3A_DNMT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HIF3A_DNMT1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HIF3A | VHL, HSP90AA1, EPAS1 | DNMT1 | RGS6, DNMT3B, CBX5, SUV39H1, CBX1, PCNA, HDAC2, DMAP1, RB1, E2F1, HDAC1, TRIM27, DNMT3A, UHRF1, MBD2, MECP2, CXXC1, USP7, SETD7, SP1, SP3, EHMT2, EZH2, EED, BAZ2A, STAT3, SMARCA5, TP53, CHEK1, HELLS, WT1, SUZ12, TCF3, HSPA4, SNRPG, HSPA5, RAD9A, AKT1, KAT5, GSK3B, CSNK2B, RPS6KA6, DAXX, GADD45A, UHRF2, TRIM28, ZFP57, SIRT1, DNMT1, RUNX1T1, RUNX1, SIRT7, SH3KBP1, KDM1A, NR2C1, NR2C2, MTA1, MTA2, CHD4, RBBP4, MBD3, POLD3, HDAC3, CBX6, RELB, KIAA0101, NRIP1, CTBP1, YWHAQ, PARP1, BRCA1, CDKL4, DNAJC2, GCN1L1, ZFR, NTRK1, HIST3H3, HIST2H2AC, B9D2, HIST1H3E, CDK2, MYH14, BRAP, MKL1, CCNB1, SNAI1, CDC14B, LASP1, FOXA1, BRD1, PRKAA2, RBBP7 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HIF3A_DNMT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | DNMT1 | P26358 | DB01035 | Procainamide | DNA (cytosine-5)-methyltransferase 1 | small molecule | approved |
Tgene | DNMT1 | P26358 | DB00928 | Azacitidine | DNA (cytosine-5)-methyltransferase 1 | small molecule | approved|investigational |
Tgene | DNMT1 | P26358 | DB01099 | Flucytosine | DNA (cytosine-5)-methyltransferase 1 | small molecule | approved|investigational |
Tgene | DNMT1 | P26358 | DB01262 | Decitabine | DNA (cytosine-5)-methyltransferase 1 | small molecule | approved|investigational |
Top |
RelatedDiseases for HIF3A_DNMT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DNMT1 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | DNMT1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | DNMT1 | C0038356 | Stomach Neoplasms | 2 | CTD_human |
Tgene | DNMT1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | DNMT1 | C0003469 | Anxiety Disorders | 1 | CTD_human |
Tgene | DNMT1 | C0004096 | Asthma | 1 | CTD_human |
Tgene | DNMT1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | DNMT1 | C0025149 | Medulloblastoma | 1 | CTD_human |
Tgene | DNMT1 | C0027889 | Hereditary Sensory and Autonomic Neuropathies | 1 | CTD_human |
Tgene | DNMT1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | DNMT1 | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
Tgene | DNMT1 | C0497327 | Dementia | 1 | CTD_human;HPO |
Tgene | DNMT1 | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | DNMT1 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Tgene | DNMT1 | C1384666 | hearing impairment | 1 | CTD_human |
Tgene | DNMT1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | DNMT1 | C3279885 | Hereditary Sensory and Autonomic Neuropathy Type Ie | 1 | ORPHANET;UNIPROT |
Tgene | DNMT1 | C3807295 | CEREBELLAR ATAXIA, DEAFNESS, AND NARCOLEPSY, AUTOSOMAL DOMINANT | 1 | ORPHANET;UNIPROT |