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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 16178

FusionGeneSummary for HIF1A_PRKCH

check button Fusion gene summary
Fusion gene informationFusion gene name: HIF1A_PRKCH
Fusion gene ID: 16178
HgeneTgene
Gene symbol

HIF1A

PRKCH

Gene ID

3091

5583

Gene namehypoxia inducible factor 1 subunit alphaprotein kinase C eta
SynonymsHIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78PKC-L|PKCL|PRKCL|nPKC-eta
Cytomap

14q23.2

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionhypoxia-inducible factor 1-alphaARNT interacting proteinPAS domain-containing protein 8basic-helix-loop-helix-PAS protein MOP1class E basic helix-loop-helix protein 78hypoxia inducible factor 1 alpha subunithypoxia inducible factor 1, alpha subunit protein kinase C eta type
Modification date2018052720180523
UniProtAcc

Q16665

P24723

Ensembl transtripts involved in fusion geneENST00000394997, ENST00000337138, 
ENST00000323441, ENST00000557538, 
ENST00000539097, ENST00000557206, 
ENST00000332981, ENST00000555082, 
ENST00000556245, 
Fusion gene scores* DoF score9 X 8 X 7=5049 X 7 X 8=504
# samples 1314
** MAII scorelog2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/504*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HIF1A [Title/Abstract] AND PRKCH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIF1A

GO:0001666

response to hypoxia

8756616|9887100|11782478|15261140|18419598

HgeneHIF1A

GO:0006355

regulation of transcription, DNA-templated

11782478|15261140

HgeneHIF1A

GO:0010468

regulation of gene expression

18419598

HgeneHIF1A

GO:0010573

vascular endothelial growth factor production

12958148

HgeneHIF1A

GO:0010575

positive regulation of vascular endothelial growth factor production

8756616

HgeneHIF1A

GO:0010628

positive regulation of gene expression

15459207|24244340

HgeneHIF1A

GO:0032364

oxygen homeostasis

16956324

HgeneHIF1A

GO:0043619

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

8089148|8387214

HgeneHIF1A

GO:0045893

positive regulation of transcription, DNA-templated

8089148|9887100

HgeneHIF1A

GO:0045944

positive regulation of transcription by RNA polymerase II

11573933|25043030

HgeneHIF1A

GO:0046886

positive regulation of hormone biosynthetic process

1448077

HgeneHIF1A

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

22735262

HgeneHIF1A

GO:0071456

cellular response to hypoxia

11573933|19528298|20889502

HgeneHIF1A

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

24899725


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-2668-01AHIF1Achr14

62207906

+PRKCHchr14

61995793

+
TCGARVOVTCGA-20-0987-01AHIF1Achr14

62162557

+PRKCHchr14

61909829

+
TCGARVSTADTCGA-HU-A4GH-01AHIF1Achr14

62162557

+PRKCHchr14

61857943

+
TCGARVUCECTCGA-EO-A22U-01AHIF1Achr14

62162557

+PRKCHchr14

61995793

+
ChiTaRS3.1DB202604HIF1Achr14

62162558

+PRKCHchr14

61952220

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394997ENST00000332981HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000394997ENST00000555082HIF1Achr14

62207906

+PRKCHchr14

61995793

+
5CDS-intronENST00000394997ENST00000556245HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000337138ENST00000332981HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000337138ENST00000555082HIF1Achr14

62207906

+PRKCHchr14

61995793

+
5CDS-intronENST00000337138ENST00000556245HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000323441ENST00000332981HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000323441ENST00000555082HIF1Achr14

62207906

+PRKCHchr14

61995793

+
5CDS-intronENST00000323441ENST00000556245HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000557538ENST00000332981HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000557538ENST00000555082HIF1Achr14

62207906

+PRKCHchr14

61995793

+
5CDS-intronENST00000557538ENST00000556245HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000539097ENST00000332981HIF1Achr14

62207906

+PRKCHchr14

61995793

+
In-frameENST00000539097ENST00000555082HIF1Achr14

62207906

+PRKCHchr14

61995793

+
5CDS-intronENST00000539097ENST00000556245HIF1Achr14

62207906

+PRKCHchr14

61995793

+
intron-3CDSENST00000557206ENST00000332981HIF1Achr14

62207906

+PRKCHchr14

61995793

+
intron-3CDSENST00000557206ENST00000555082HIF1Achr14

62207906

+PRKCHchr14

61995793

+
intron-intronENST00000557206ENST00000556245HIF1Achr14

62207906

+PRKCHchr14

61995793

+
Frame-shiftENST00000394997ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61909829

+
5CDS-5UTRENST00000394997ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61909829

+
5CDS-intronENST00000394997ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61909829

+
Frame-shiftENST00000337138ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61909829

+
5CDS-5UTRENST00000337138ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61909829

+
5CDS-intronENST00000337138ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61909829

+
Frame-shiftENST00000323441ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61909829

+
5CDS-5UTRENST00000323441ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61909829

+
5CDS-intronENST00000323441ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-3CDSENST00000557538ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-5UTRENST00000557538ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-intronENST00000557538ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-3CDSENST00000539097ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-5UTRENST00000539097ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-intronENST00000539097ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-3CDSENST00000557206ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-5UTRENST00000557206ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61909829

+
intron-intronENST00000557206ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61909829

+
Frame-shiftENST00000394997ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61857943

+
5CDS-5UTRENST00000394997ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61857943

+
5CDS-intronENST00000394997ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61857943

+
Frame-shiftENST00000337138ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61857943

+
5CDS-5UTRENST00000337138ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61857943

+
5CDS-intronENST00000337138ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61857943

+
Frame-shiftENST00000323441ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61857943

+
5CDS-5UTRENST00000323441ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61857943

+
5CDS-intronENST00000323441ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-3CDSENST00000557538ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-5UTRENST00000557538ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-intronENST00000557538ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-3CDSENST00000539097ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-5UTRENST00000539097ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-intronENST00000539097ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-3CDSENST00000557206ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-5UTRENST00000557206ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61857943

+
intron-intronENST00000557206ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61857943

+
In-frameENST00000394997ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61995793

+
In-frameENST00000394997ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61995793

+
5CDS-intronENST00000394997ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61995793

+
In-frameENST00000337138ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61995793

+
In-frameENST00000337138ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61995793

+
5CDS-intronENST00000337138ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61995793

+
In-frameENST00000323441ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61995793

+
In-frameENST00000323441ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61995793

+
5CDS-intronENST00000323441ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-3CDSENST00000557538ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-3CDSENST00000557538ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-intronENST00000557538ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-3CDSENST00000539097ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-3CDSENST00000539097ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-intronENST00000539097ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-3CDSENST00000557206ENST00000332981HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-3CDSENST00000557206ENST00000555082HIF1Achr14

62162557

+PRKCHchr14

61995793

+
intron-intronENST00000557206ENST00000556245HIF1Achr14

62162557

+PRKCHchr14

61995793

+
Frame-shiftENST00000394997ENST00000332981HIF1Achr14

62162558

+PRKCHchr14

61952220

+
Frame-shiftENST00000394997ENST00000555082HIF1Achr14

62162558

+PRKCHchr14

61952220

+
5CDS-intronENST00000394997ENST00000556245HIF1Achr14

62162558

+PRKCHchr14

61952220

+
Frame-shiftENST00000337138ENST00000332981HIF1Achr14

62162558

+PRKCHchr14

61952220

+
Frame-shiftENST00000337138ENST00000555082HIF1Achr14

62162558

+PRKCHchr14

61952220

+
5CDS-intronENST00000337138ENST00000556245HIF1Achr14

62162558

+PRKCHchr14

61952220

+
Frame-shiftENST00000323441ENST00000332981HIF1Achr14

62162558

+PRKCHchr14

61952220

+
Frame-shiftENST00000323441ENST00000555082HIF1Achr14

62162558

+PRKCHchr14

61952220

+
5CDS-intronENST00000323441ENST00000556245HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-3CDSENST00000557538ENST00000332981HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-3CDSENST00000557538ENST00000555082HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-intronENST00000557538ENST00000556245HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-3CDSENST00000539097ENST00000332981HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-3CDSENST00000539097ENST00000555082HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-intronENST00000539097ENST00000556245HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-3CDSENST00000557206ENST00000332981HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-3CDSENST00000557206ENST00000555082HIF1Achr14

62162558

+PRKCHchr14

61952220

+
intron-intronENST00000557206ENST00000556245HIF1Achr14

62162558

+PRKCHchr14

61952220

+

Top

FusionProtFeatures for HIF1A_PRKCH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIF1A

Q16665

PRKCH

P24723

Functions as a master transcriptional regulator of theadaptive response to hypoxia. Under hypoxic conditions, activatesthe transcription of over 40 genes, including erythropoietin,glucose transporters, glycolytic enzymes, vascular endothelialgrowth factor, HILPDA, and other genes whose protein productsincrease oxygen delivery or facilitate metabolic adaptation tohypoxia. Plays an essential role in embryonic vascularization,tumor angiogenesis and pathophysiology of ischemic disease.Heterodimerizes with ARNT; heterodimer binds to core DNA sequence5'-TACGTG-3' within the hypoxia response element (HRE) of targetgene promoters (By similarity). Activation requires recruitment oftranscriptional coactivators such as CREBBP and EP300. Activity isenhanced by interaction with both, NCOA1 or NCOA2. Interactionwith redox regulatory protein APEX seems to activate CTAD andpotentiates activation by NCOA1 and CREBBP. Involved in the axonaldistribution and transport of mitochondria in neurons duringhypoxia. {ECO:0000250|UniProtKB:Q61221,ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883,ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236,ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843,ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928,ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:9887100}. Calcium-independent, phospholipid- and diacylglycerol(DAG)-dependent serine/threonine-protein kinase that is involvedin the regulation of cell differentiation in keratinocytes andpre-B cell receptor, mediates regulation of epithelial tightjunction integrity and foam cell formation, and is required forglioblastoma proliferation and apoptosis prevention in MCF-7cells. In keratinocytes, binds and activates the tyrosine kinaseFYN, which in turn blocks epidermal growth factor receptor (EGFR)signaling and leads to keratinocyte growth arrest anddifferentiation. Associates with the cyclin CCNE1-CDK2-CDKN1Bcomplex and inhibits CDK2 kinase activity, leading to RB1dephosphorylation and thereby G1 arrest in keratinocytes. Inassociation with RALA activates actin depolymerization, which isnecessary for keratinocyte differentiation. In the pre-B cellreceptor signaling, functions downstream of BLNK by up-regulatingIRF4, which in turn activates L chain gene rearrangement.Regulates epithelial tight junctions (TJs) by phosphorylatingoccludin (OCLN) on threonine residues, which is necessary for theassembly and maintenance of TJs. In association with PLD2 and viaTLR4 signaling, is involved in lipopolysaccharide (LPS)-inducedRGS2 down-regulation and foam cell formation. Upon PMAstimulation, mediates glioblastoma cell proliferation byactivating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection ofglioblastoma cells from irradiation-induced apoptosis bypreventing caspase-9 activation. In camptothecin-treated MCF-7cells, regulates NF-kappa-B upstream signaling by activatingIKBKB, and confers protection against DNA damage-inducedapoptosis. Promotes oncogenic functions of ATF2 in the nucleuswhile blocking its apoptotic function at mitochondria.Phosphorylates ATF2 which promotes its nuclear retention andtranscriptional activity and negatively regulates itsmitochondrial localization. {ECO:0000269|PubMed:10806212,ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428,ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445,ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660,ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409,ECO:0000269|PubMed:22304920}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214615_621697736Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215615_621697827Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215615_621721851Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+121417_70697736DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214228_298697736DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214302_345697736DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+121485_158697736DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+121517_70697827DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215228_298697827DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215302_345697827DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+121585_158697827DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+121517_70721851DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215228_298721851DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215302_345721851DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+121585_158721851DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215718_721721851MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214170_191697736RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+121421_30697736RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214380_417697736RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214401_603697736RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214531_575697736RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214556_572697736RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215170_191697827RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+121521_30697827RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215380_417697827RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215401_603697827RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215531_575697827RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215556_572697827RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215170_191721851RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+121521_30721851RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215380_417721851RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215401_603721851RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215531_575721851RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215556_572721851RegionNote=C-terminal VHL recognition site
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981+914615_683477684DomainNote=AGC-kinase C-terminal
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981+914615_683477684DomainNote=AGC-kinase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114615_62111736Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115615_62111827Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115615_621-77851Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+11417_7011736DomainbHLH
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114228_29811736DomainPAS 2
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114302_34511736DomainNote=PAC
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+11485_15811736DomainPAS 1
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+11517_7011827DomainbHLH
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115228_29811827DomainPAS 2
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115302_34511827DomainNote=PAC
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+11585_15811827DomainPAS 1
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+11517_70-77851DomainbHLH
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115228_298-77851DomainPAS 2
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115302_345-77851DomainNote=PAC
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+11585_158-77851DomainPAS 1
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114718_72111736MotifNuclear localization signal
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115718_72111827MotifNuclear localization signal
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115718_721-77851MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214718_721697736MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215718_721697827MotifNuclear localization signal
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114170_19111736RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+11421_3011736RegionDNA-binding
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114380_41711736RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114401_60311736RegionNote=ODD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114531_57511736RegionNote=NTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114556_57211736RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114576_78511736RegionNote=ID
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+114786_82611736RegionNote=CTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115170_19111827RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+11521_3011827RegionDNA-binding
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115380_41711827RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115401_60311827RegionNote=ODD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115531_57511827RegionNote=NTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115556_57211827RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115576_78511827RegionNote=ID
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+115786_82611827RegionNote=CTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115170_191-77851RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+11521_30-77851RegionDNA-binding
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115380_417-77851RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115401_603-77851RegionNote=ODD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115531_575-77851RegionNote=NTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115556_572-77851RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115576_785-77851RegionNote=ID
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+115786_826-77851RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214576_785697736RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214786_826697736RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215576_785697827RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215786_826697827RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215576_785721851RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215786_826721851RegionNote=CTAD
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981+91412_113477684DomainC2
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981+914355_614477684DomainProtein kinase
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981+91412_113477684DomainC2
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981+914355_614477684DomainProtein kinase
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981+914361_369477684Nucleotide bindingATP
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981+914361_369477684Nucleotide bindingATP
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981+914171_222477684Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981+914245_295477684Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981+914171_222477684Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981+914245_295477684Zinc fingerPhorbol-ester/DAG-type 2


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FusionGeneSequence for HIF1A_PRKCH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HIF1A_ENST00000394997_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_905aa
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

>In-frame_HIF1A_ENST00000394997_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_905aa
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

>In-frame_HIF1A_ENST00000337138_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_904aa
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

>In-frame_HIF1A_ENST00000337138_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_904aa
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

>In-frame_HIF1A_ENST00000323441_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_904aa
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

>In-frame_HIF1A_ENST00000323441_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_904aa
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

>In-frame_HIF1A_ENST00000557538_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_845aa
MRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLT
HRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDS
KTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKN
SQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTE
TDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQS
SPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTV
TVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPN
VLSVALSQRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENE
DDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFI

>In-frame_HIF1A_ENST00000557538_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_845aa
MRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLT
HRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDS
KTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKN
SQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTE
TDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQS
SPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTV
TVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPN
VLSVALSQRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENE
DDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFI

>In-frame_HIF1A_ENST00000539097_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_928aa
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

>In-frame_HIF1A_ENST00000539097_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_928aa
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

>In-frame_HIF1A_ENST00000394997_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_218aa
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

>In-frame_HIF1A_ENST00000394997_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_218aa
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

>In-frame_HIF1A_ENST00000337138_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_218aa
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

>In-frame_HIF1A_ENST00000337138_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_218aa
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

>In-frame_HIF1A_ENST00000323441_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_218aa
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

>In-frame_HIF1A_ENST00000323441_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_218aa
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HIF1A_ENST00000394997_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_2715nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAATAGGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGG
CGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTG
ATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAAT
TGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATAC
ATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACA
CACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGA
AGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAG
TGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGC
AAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAA
CTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAA
GTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAAT
TCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGT
GTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAA
CTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAA
ACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCA
ATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAA
CCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGT
TCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTT
TTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGAT
GATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTT
ACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAA
GACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATAT
AGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAAC
GTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGA
ATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATG
CTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAA
GATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATG
ACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGG
GCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATA
AAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCA

>In-frame_HIF1A_ENST00000394997_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_2715nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAATAGGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGG
CGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTG
ATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAAT
TGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATAC
ATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACA
CACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGA
AGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAG
TGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGC
AAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAA
CTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAA
GTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAAT
TCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGT
GTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAA
CTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAA
ACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCA
ATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAA
CCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGT
TCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTT
TTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGAT
GATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTT
ACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAA
GACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATAT
AGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAAC
GTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGA
ATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATG
CTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAA
GATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATG
ACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGG
GCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATA
AAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCA

>In-frame_HIF1A_ENST00000337138_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_2712nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGA
AGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATG
AGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGC
TTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATG
GGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACAC
AGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGA
ACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGT
GGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAG
ACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTT
TTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTC
ACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCT
CAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTC
CTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTT
AAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACT
GATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATG
TCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCA
AATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCA
CCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTT
GCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGAT
GACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACA
GTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGAC
CGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGA
GATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTG
TTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATG
TGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTG
TACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGAT
GACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACC
AAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCC
CAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAG
GAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAA

>In-frame_HIF1A_ENST00000337138_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_2712nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGA
AGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATG
AGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGC
TTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATG
GGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACAC
AGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGA
ACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGT
GGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAG
ACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTT
TTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTC
ACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCT
CAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTC
CTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTT
AAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACT
GATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATG
TCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCA
AATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCA
CCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTT
GCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGAT
GACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACA
GTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGAC
CGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGA
GATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTG
TTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATG
TGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTG
TACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGAT
GACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACC
AAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCC
CAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAG
GAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAA

>In-frame_HIF1A_ENST00000323441_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_2712nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGA
AGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATG
AGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGC
TTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATG
GGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACAC
AGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGA
ACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGT
GGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAG
ACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTT
TTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTC
ACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCT
CAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTC
CTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTT
AAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACT
GATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATG
TCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCA
AATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCA
CCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTT
GCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGAT
GACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACA
GTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGAC
CGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGA
GATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTG
TTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATG
TGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTG
TACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGAT
GACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACC
AAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCC
CAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAG
GAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAA

>In-frame_HIF1A_ENST00000323441_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_2712nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGA
AGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATG
AGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGC
TTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATG
GGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACAC
AGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGA
ACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGT
GGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAG
ACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTT
TTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTC
ACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCT
CAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTC
CTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTT
AAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACT
GATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATG
TCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCA
AATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCA
CCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTT
GCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGAT
GACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACA
GTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGAC
CGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGA
GATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTG
TTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATG
TGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTG
TACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGAT
GACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACC
AAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCC
CAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAG
GAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAA

>In-frame_HIF1A_ENST00000557538_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_2535nt
ATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAAT
TGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATAC
ATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACA
CACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGA
AGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAG
TGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGC
AAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAA
CTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAA
GTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAAT
TCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGT
GTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAA
CTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAA
ACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCA
ATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAA
CCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGT
TCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTT
TTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGAT
GATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTT
ACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAA
GACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATAT
AGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAAC
GTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGA
ATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATG
CTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAA
GATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATG
ACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGG
GCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATA
AAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCA

>In-frame_HIF1A_ENST00000557538_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_2535nt
ATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAAT
TGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATAC
ATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACA
CACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGA
AGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAG
TGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGC
AAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAA
CTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAA
GTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAAT
TCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGT
GTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAA
CTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAA
ACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCA
ATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAA
CCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGT
TCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTT
TTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGAT
GATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTT
ACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAA
GACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATAT
AGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAAC
GTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGA
ATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATG
CTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAA
GATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATG
ACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGG
GCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATA
AAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCA

>In-frame_HIF1A_ENST00000539097_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_2784nt
ATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTTTTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATC
AGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTT
TTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTAT
TTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTG
GATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAA
CTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAA
AAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCT
GCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCT
ATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACAC
AGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTAT
GAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGG
ATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTA
TGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCT
TCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCT
TTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAG
GAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCT
GAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAA
CTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCC
AGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCA
AAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCC
TTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAA
ATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAA
ATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACA
GCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGT
CAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGC
AATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGAC
TGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATA
CTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGC
TTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAA
ATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACT

>In-frame_HIF1A_ENST00000539097_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_2784nt
ATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTTTTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATC
AGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTT
TTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTAT
TTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTG
GATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAA
CTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAA
AAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCT
GCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCT
ATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACAC
AGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTAT
GAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGG
ATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTA
TGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCT
TCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCT
TTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAG
GAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCT
GAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAA
CTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCC
AGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCA
AAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCC
TTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAA
ATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAA
ATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACA
GCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGT
CAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGC
AATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGAC
TGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATA
CTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGC
TTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAA
ATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACT

>In-frame_HIF1A_ENST00000394997_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_654nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCA
GACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTC
CAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCA
GAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAA
TCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAA
ATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCT
GACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTAT

>In-frame_HIF1A_ENST00000394997_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_654nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCA
GACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTC
CAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCA
GAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAA
TCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAA
ATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCT
GACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTAT

>In-frame_HIF1A_ENST00000337138_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_654nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCA
GACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTC
CAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCA
GAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAA
TCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAA
ATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCT
GACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTAT

>In-frame_HIF1A_ENST00000337138_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_654nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCA
GACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTC
CAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCA
GAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAA
TCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAA
ATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCT
GACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTAT

>In-frame_HIF1A_ENST00000323441_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_654nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCA
GACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTC
CAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCA
GAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAA
TCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAA
ATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCT
GACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTAT

>In-frame_HIF1A_ENST00000323441_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_654nt
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCA
GACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTC
CAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCA
GAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAA
TCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAA
ATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCT
GACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_HIF1A_ENST00000394997_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_4125nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAATAGGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAG
TAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAG
GCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTT
TTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGG
ATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAG
AAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAAC
TATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGG
GTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGAC
TTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTT
AGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCAC
CACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCA
ACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCT
TAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAA
GAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACTGA
TGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATGTC
TCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCAAA
TCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCACC
TGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTTGC
TGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGATGA
CTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACAGT
ATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGACCG
TATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGAGA
TACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTGTT
ATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTG
CAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTA
CGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGA
CCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAA
GAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCA
GCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGA
AGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATT
GCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCC
CAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGA
GTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGT
GGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAAT
TCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTC
TTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTA
TCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCT
TTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTC
ATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATA
ACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTG
ATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGT
TTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGAT

>In-frame_HIF1A_ENST00000394997_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_4125nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAATAGGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAG
TAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAG
GCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTT
TTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGG
ATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAG
AAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAAC
TATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGG
GTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGAC
TTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTT
AGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCAC
CACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCA
ACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCT
TAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAA
GAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACTGA
TGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATGTC
TCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCAAA
TCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCACC
TGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTTGC
TGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGATGA
CTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACAGT
ATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGACCG
TATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGAGA
TACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTGTT
ATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTG
CAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTA
CGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGA
CCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAA
GAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCA
GCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGA
AGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATT
GCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCC
CAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGA
GTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGT
GGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAAT
TCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTC
TTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTA
TCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCT
TTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTC
ATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATA
ACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTG
ATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGT
TTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGAT

>In-frame_HIF1A_ENST00000337138_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_4122nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAA
AGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCT
TACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTTTTA
TTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGGATT
AACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAGAAA
TGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAACTAT
GAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGGGTA
TAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGACTTT
CCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTTAGG
CCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCACCAC
AGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCAACC
ACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAA
ACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAA
GGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACTGATGA
CCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATGTCTCC
ATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCAAATCC
AGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGA
GCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGA
AGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGATGACTT
CCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATT
CCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGACCGTAT
GGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGAGATAC
TCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATC
TGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAA
GGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGG
GCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCT
CTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAA
CCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCT
GAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGA
GCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCA
ACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAG
CATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTC
CAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGG
CTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCA
AGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTA
ATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCT
CTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTA
ATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATT
CTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATAACT
CTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATC
TTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTA
TTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGATGAC

>In-frame_HIF1A_ENST00000337138_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_4122nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAA
AGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCT
TACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTTTTA
TTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGGATT
AACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAGAAA
TGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAACTAT
GAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGGGTA
TAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGACTTT
CCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTTAGG
CCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCACCAC
AGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCAACC
ACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAA
ACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAA
GGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACTGATGA
CCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATGTCTCC
ATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCAAATCC
AGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGA
GCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGA
AGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGATGACTT
CCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATT
CCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGACCGTAT
GGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGAGATAC
TCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATC
TGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAA
GGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGG
GCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCT
CTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAA
CCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCT
GAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGA
GCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCA
ACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAG
CATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTC
CAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGG
CTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCA
AGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTA
ATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCT
CTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTA
ATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATT
CTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATAACT
CTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATC
TTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTA
TTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGATGAC

>In-frame_HIF1A_ENST00000323441_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_3885nt
GTGAAGACATCGCGGGGACCGATTCACCATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAA
GTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAG
TTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGA
AGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTA
CATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCA
TGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAAT
GAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATA
TGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATC
AAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGA
ATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCA
TCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGC
AACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGAT
TTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGA
AGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTT
AGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGA
AAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAA
TCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCC
TTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATT
CAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGAT
GTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGA
AAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCAC
TGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAAC
TACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGA
AAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGG
TCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATAT
CGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCA
CGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGC
CACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACA
TCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGT
CAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTT
TAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGAT
TCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAG
GATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTAT
ACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTG
AGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAAC
CCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAA
TGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTG
CTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAAC
AACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACG
TTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGG
TGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGA
CCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATG
GATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAATAAATG

>In-frame_HIF1A_ENST00000323441_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_3885nt
GTGAAGACATCGCGGGGACCGATTCACCATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAA
GTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAG
TTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGA
AGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTA
CATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCA
TGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAAT
GAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATA
TGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATC
AAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGA
ATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCA
TCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGC
AACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGAT
TTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGA
AGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTT
AGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGA
AAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAA
TCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCC
TTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATT
CAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGAT
GTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGA
AAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCAC
TGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAAC
TACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGA
AAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGG
TCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATAT
CGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCA
CGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGC
CACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACA
TCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGT
CAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTT
TAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGAT
TCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAG
GATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTAT
ACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTG
AGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAAC
CCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAA
TGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTG
CTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAAC
AACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACG
TTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGG
TGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGA
CCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATG
GATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAATAAATG

>In-frame_HIF1A_ENST00000557538_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_4158nt
ATTTGAAAACTTGGCAACCTTGGATTGGATGGATTCATATTTCTTAGTATAGAAGTTCTTGATATAACTGAAAAATTAAGTTAAACACTT
AATAAGTGGTGGTTACTCAGCACTTTTAGATGCTGTTTATAATAGATGACCTTTTCTAACTAATTTACAGTTTTTTGAAAGATAACTGAG
AGGTTGAGGGACGGAGATTTTCTTCAAGCAATTTTTTTTTTCATTTTAAATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTT
TTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATCAGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGA
AAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGT
GAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATAT
TGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGAT
TTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGA
CCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAG
AATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGT
ATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCC
ATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTAC
CGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAAC
TCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCA
AGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTT
GATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATC
AGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATC
TTTAGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAA
CGAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACT
CAATCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAG
TCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGA
ATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGA
GATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCC
TGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCAC
CACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGA
AACTACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGAC
AGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGA
GGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTA
TATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGG
TCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGA
TGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAG
ACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGA
TGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGA
GTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGA
GATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTG
AAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAG
TATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGAT
CTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATG
AACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATA
GAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGA
CTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTA
AACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCC
ACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTAC
AGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAG
TGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAA
ATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAATAA

>In-frame_HIF1A_ENST00000557538_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_4158nt
ATTTGAAAACTTGGCAACCTTGGATTGGATGGATTCATATTTCTTAGTATAGAAGTTCTTGATATAACTGAAAAATTAAGTTAAACACTT
AATAAGTGGTGGTTACTCAGCACTTTTAGATGCTGTTTATAATAGATGACCTTTTCTAACTAATTTACAGTTTTTTGAAAGATAACTGAG
AGGTTGAGGGACGGAGATTTTCTTCAAGCAATTTTTTTTTTCATTTTAAATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTT
TTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATCAGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGA
AAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGT
GAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATAT
TGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGAT
TTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGA
CCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAG
AATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGT
ATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCC
ATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTAC
CGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAAC
TCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCA
AGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTT
GATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATC
AGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATC
TTTAGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAA
CGAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACT
CAATCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAG
TCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGA
ATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGA
GATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCC
TGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCAC
CACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGA
AACTACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGAC
AGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGA
GGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTA
TATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGG
TCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGA
TGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAG
ACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGA
TGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGA
GTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGA
GATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTG
AAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAG
TATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGAT
CTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATG
AACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATA
GAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGA
CTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTA
AACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCC
ACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTAC
AGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAG
TGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAA
ATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAATAA

>In-frame_HIF1A_ENST00000539097_chr14_62207906_+_PRKCH_ENST00000332981_chr14_61995793_+_4158nt
ATTTGAAAACTTGGCAACCTTGGATTGGATGGATTCATATTTCTTAGTATAGAAGTTCTTGATATAACTGAAAAATTAAGTTAAACACTT
AATAAGTGGTGGTTACTCAGCACTTTTAGATGCTGTTTATAATAGATGACCTTTTCTAACTAATTTACAGTTTTTTGAAAGATAACTGAG
AGGTTGAGGGACGGAGATTTTCTTCAAGCAATTTTTTTTTTCATTTTAAATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTT
TTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATCAGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGA
AAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGT
GAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATAT
TGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGAT
TTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGA
CCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAG
AATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGT
ATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCC
ATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTAC
CGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAAC
TCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCA
AGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTT
GATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATC
AGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATC
TTTAGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAA
CGAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACT
CAATCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAG
TCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGA
ATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGA
GATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCC
TGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCAC
CACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGA
AACTACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGAC
AGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGA
GGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTA
TATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGG
TCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGA
TGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAG
ACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGA
TGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGA
GTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGA
GATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTG
AAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAG
TATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGAT
CTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATG
AACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATA
GAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGA
CTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTA
AACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCC
ACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTAC
AGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAG
TGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAA
ATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAATAA

>In-frame_HIF1A_ENST00000539097_chr14_62207906_+_PRKCH_ENST00000555082_chr14_61995793_+_4158nt
ATTTGAAAACTTGGCAACCTTGGATTGGATGGATTCATATTTCTTAGTATAGAAGTTCTTGATATAACTGAAAAATTAAGTTAAACACTT
AATAAGTGGTGGTTACTCAGCACTTTTAGATGCTGTTTATAATAGATGACCTTTTCTAACTAATTTACAGTTTTTTGAAAGATAACTGAG
AGGTTGAGGGACGGAGATTTTCTTCAAGCAATTTTTTTTTTCATTTTAAATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTT
TTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATCAGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGA
AAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGT
GAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATAT
TGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGAT
TTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGA
CCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAG
AATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGT
ATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCC
ATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTAC
CGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAAC
TCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCA
AGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTT
GATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATC
AGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATC
TTTAGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAA
CGAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACT
CAATCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAG
TCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGA
ATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGA
GATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCC
TGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCAC
CACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGA
AACTACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGAC
AGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGA
GGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTA
TATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGG
TCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGA
TGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAG
ACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGA
TGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGA
GTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGA
GATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTG
AAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAG
TATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGAT
CTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATG
AACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATA
GAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGA
CTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTA
AACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCC
ACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTAC
AGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAG
TGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAA
ATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAATAA

>In-frame_HIF1A_ENST00000394997_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_2064nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTT
CGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGA
AATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAA
CGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTT
CATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGA
CTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTT
CATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTC
TCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATG
GGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAA
CTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTC
TGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGG
CTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACA
AGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAA
ACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCC
TTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAG
CTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGT
CTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTG
GGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAAC
ATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATAT

>In-frame_HIF1A_ENST00000394997_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_2064nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTT
CGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGA
AATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAA
CGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTT
CATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGA
CTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTT
CATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTC
TCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATG
GGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAA
CTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTC
TGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGG
CTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACA
AGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAA
ACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCC
TTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAG
CTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGT
CTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTG
GGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAAC
ATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATAT

>In-frame_HIF1A_ENST00000337138_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_2064nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTT
CGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGA
AATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAA
CGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTT
CATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGA
CTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTT
CATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTC
TCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATG
GGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAA
CTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTC
TGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGG
CTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACA
AGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAA
ACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCC
TTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAG
CTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGT
CTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTG
GGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAAC
ATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATAT

>In-frame_HIF1A_ENST00000337138_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_2064nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTT
CGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGA
AATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAA
CGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTT
CATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGA
CTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTT
CATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTC
TCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATG
GGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAA
CTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTC
TGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGG
CTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACA
AGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAA
ACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCC
TTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAG
CTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGT
CTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTG
GGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAAC
ATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATAT

>In-frame_HIF1A_ENST00000323441_chr14_62162557_+_PRKCH_ENST00000332981_chr14_61995793_+_1827nt
GTGAAGACATCGCGGGGACCGATTCACCATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTT
GGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCAC
GCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGAT
GCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCT
CCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGC
CATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATC
CCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAA
CCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAA
GGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAG
AACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGAT
TTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAAT
AAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTT
AAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCT
TTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCA
CCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCC
AGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAA
TGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGG
GTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCAC
TCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAA
TAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGAC

>In-frame_HIF1A_ENST00000323441_chr14_62162557_+_PRKCH_ENST00000555082_chr14_61995793_+_1827nt
GTGAAGACATCGCGGGGACCGATTCACCATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAAGATCTGAAACTGGACAATGTCCTGTT
GGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCAC
GCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGAT
GCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCT
CCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGC
CATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATC
CCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAA
CCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAA
GGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAG
AACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGAT
TTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAAT
AAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTT
AAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCT
TTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCA
CCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCC
AGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAA
TGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGG
GTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCAC
TCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAA
TAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGAC


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FusionGenePPI for HIF1A_PRKCH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HIF1ASSX4, VHL, PSMC3, ZNF197, MDM2, TP53, HIF1AN, HDAC1, HDAC2, HDAC3, EP300, CREBBP, PSMA7, DAP3, NCOA1, APEX1, JUN, ARNT, HSP90AA1, ARNTL, STAT3, NR4A1, SAT1, GNB2L1, MTA1, NAA10, SAT2, TCEB1, CUL2, HSPA4, SEPT9, EGLN1, BANP, HDAC4, HDAC5, USP20, OS9, EGLN3, HDAC6, VHLL, SHC1, PARP1, EGLN2, SMARCA2, SMARCA4, MYC, MAX, RUVBL2, MCM7, MCM3, HSP90AB1, COMMD1, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, VCP, STUB1, TCEB2, FBXW7, SP1, RAD23B, KDM3A, BCR, DNAJB1, RWDD3, USP19, UBE2D1, CDC34, PTGES3, COPS5, HDAC7, KAT2B, F12, BHLHE41, RUNX2, BRCA1, CAPN1, LAMP2, BCL2, NDN, CDKN2A, ESR1, RPTOR, RELA, PKM, EPAS1, SMAD3, SRC, MAFG, MAFK, RBX1, DCUN1D1, PCGF2, RB1, HSPA8, HEXIM1, SQSTM1, TRAF6, ARNT2, TRIM28, SIN3A, SART3, ATM, SENP3, FHL2, MAPK1, PLD1, CTNNB1, WWOX, WWTR1, UBE2I, CDK8, MED12, MED13, MED13L, MED14, MED15, MED23, EAF2, FDX1, FN1, TTC1, PIAS1, ZNF518A, CEP350, NES, MID2, PLEKHA5, UACA, NLN, NBEAL1, GKAP1, UTP23, C19orf70, TCEANC2, LYSMD2, OTUD7B, PLD2, PSMD10, ING1, GPLD1, RHOBTB3, ZC3H12A, SPRY2, MYH6, MYH2, MYH1, MYH3, ACTA1, MYH4, MYL1, H2AFX, PSMA4, LINC01139, PTK6, LRRK2, FASN, IKBKG, IKBKB, HSPA1LPRKCHCDK2, ZBTB8OS, MGMT, NFE2L2, PRKCH, VHL, PPP1R14A, HSP90AA1, GSK3A, BANP, AKAP13, PRKCA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+12141_401697736TSGA10
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+12151_401697827TSGA10
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+12151_401721851TSGA10


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441+1141_40111736TSGA10
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138+1151_40111827TSGA10
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097+1151_401-77851TSGA10


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HIF1A_PRKCH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHIF1AQ16665DB01136CarvedilolHypoxia-inducible factor 1-alpha {ECO:0000303|PubMed:7539918}small moleculeapproved|investigational

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RelatedDiseases for HIF1A_PRKCH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHIF1AC0027055Myocardial Reperfusion Injury2CTD_human
HgeneHIF1AC0002793Anaplasia1CTD_human
HgeneHIF1AC0004114Astrocytoma1CTD_human
HgeneHIF1AC0005586Bipolar Disorder1PSYGENET
HgeneHIF1AC0007124Noninfiltrating Intraductal Carcinoma1CTD_human
HgeneHIF1AC0007786Brain Ischemia1CTD_human
HgeneHIF1AC0008313Cholangitis, Sclerosing1CTD_human
HgeneHIF1AC0011570Mental Depression1PSYGENET
HgeneHIF1AC0017636Glioblastoma1CTD_human
HgeneHIF1AC0018798Congenital Heart Defects1CTD_human
HgeneHIF1AC0018800Cardiomegaly1CTD_human
HgeneHIF1AC0018801Heart failure1CTD_human
HgeneHIF1AC0020507Hyperplasia1CTD_human
HgeneHIF1AC0020538Hypertensive disease1CTD_human
HgeneHIF1AC0020542Pulmonary Hypertension1CTD_human
HgeneHIF1AC0023892Biliary cirrhosis1CTD_human
HgeneHIF1AC0024115Lung diseases1CTD_human
HgeneHIF1AC0027626Neoplasm Invasiveness1CTD_human
HgeneHIF1AC0030297Pancreatic Neoplasm1CTD_human
HgeneHIF1AC0033578Prostatic Neoplasms1CTD_human
HgeneHIF1AC0037286Skin Neoplasms1CTD_human
HgeneHIF1AC0040136Thyroid Neoplasm1CTD_human
HgeneHIF1AC0041696Unipolar Depression1PSYGENET
HgeneHIF1AC0206734Hemangioblastoma1CTD_human
HgeneHIF1AC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneHIF1AC0342257Complications of Diabetes Mellitus1CTD_human
HgeneHIF1AC0525045Mood Disorders1PSYGENET
HgeneHIF1AC0752308Hypoxia-Ischemia, Brain1CTD_human
HgeneHIF1AC1176475Ductal Carcinoma1CTD_human
HgeneHIF1AC1269683Major Depressive Disorder1PSYGENET
HgeneHIF1AC1449861Micronuclei, Chromosome-Defective1CTD_human
HgeneHIF1AC1458155Mammary Neoplasms1CTD_human
TgenePRKCHC0028754Obesity1CTD_human
TgenePRKCHC0236969Substance-Related Disorders1CTD_human