|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16171 |
FusionGeneSummary for HID1_SUMO2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HID1_SUMO2 | Fusion gene ID: 16171 | Hgene | Tgene | Gene symbol | HID1 | SUMO2 | Gene ID | 283987 | 6613 |
| Gene name | HID1 domain containing | small ubiquitin-like modifier 2 | |
| Synonyms | 17orf28|C17orf28|DMC1|HID-1 | HSMT3|SMT3B|SMT3H2|SUMO3|Smt3A | |
| Cytomap | 17q25.1 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein HID1HID1 domain-containing proteinUPF0663 transmembrane protein C17orf28down-regulated in multiple cancers 1downregulated in multiple cancer 1protein hid-1 homolog | small ubiquitin-related modifier 2SMT3 homolog 2SMT3 suppressor of mif two 3 homolog 2sentrin 2ubiquitin-like protein SMT3Aubiquitin-like protein SMT3B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IV36 | P61956 | |
| Ensembl transtripts involved in fusion gene | ENST00000425042, ENST00000532900, | ENST00000420826, ENST00000314523, ENST00000578238, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: HID1 [Title/Abstract] AND SUMO2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HID1 | GO:0006886 | intracellular protein transport | 21337012 |
| Hgene | HID1 | GO:0031001 | response to brefeldin A | 21337012 |
| Tgene | SUMO2 | GO:0016925 | protein sumoylation | 17081986|17696781|21965678|24105744 |
| Tgene | SUMO2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 18408734 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-FD-A3SN-01A | HID1 | chr17 | 72968686 | - | SUMO2 | chr17 | 73177283 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000425042 | ENST00000420826 | HID1 | chr17 | 72968686 | - | SUMO2 | chr17 | 73177283 | - |
| In-frame | ENST00000425042 | ENST00000314523 | HID1 | chr17 | 72968686 | - | SUMO2 | chr17 | 73177283 | - |
| 5CDS-5UTR | ENST00000425042 | ENST00000578238 | HID1 | chr17 | 72968686 | - | SUMO2 | chr17 | 73177283 | - |
| intron-3CDS | ENST00000532900 | ENST00000420826 | HID1 | chr17 | 72968686 | - | SUMO2 | chr17 | 73177283 | - |
| intron-3CDS | ENST00000532900 | ENST00000314523 | HID1 | chr17 | 72968686 | - | SUMO2 | chr17 | 73177283 | - |
| intron-5UTR | ENST00000532900 | ENST00000578238 | HID1 | chr17 | 72968686 | - | SUMO2 | chr17 | 73177283 | - |
Top |
FusionProtFeatures for HID1_SUMO2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HID1 | SUMO2 |
| May play an important role in the development of cancersin a broad range of tissues. {ECO:0000269|PubMed:11281419}. | Ubiquitin-like protein that can be covalently attachedto proteins as a monomer or as a lysine-linked polymer. Covalentattachment via an isopeptide bond to its substrates requires prioractivation by the E1 complex SAE1-SAE2 and linkage to the E2enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4,RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translationalmodification on lysine residues of proteins plays a crucial rolein a number of cellular processes such as nuclear transport, DNAreplication and repair, mitosis and signal transduction. PolymericSUMO2 chains are also susceptible to polyubiquitination whichfunctions as a signal for proteasomal degradation of modifiedproteins (PubMed:18408734, PubMed:18538659, PubMed:21965678,PubMed:9556629). Plays a role in the regulation of sumoylationstatus of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734,ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678,ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494,ECO:0000269|PubMed:9556629}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SUMO2 | chr17:72968686 | chr17:73177283 | ENST00000314523 | - | 0 | 3 | 16_95 | 7 | 72 | Domain | Ubiquitin-like |
| Tgene | >SUMO2 | chr17:72968686 | chr17:73177283 | ENST00000420826 | - | 0 | 4 | 16_95 | 7 | 96 | Domain | Ubiquitin-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HID1_SUMO2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HID1_ENST00000425042_chr17_72968686_-_SUMO2_ENST00000420826_chr17_73177283_-_111aa MGSTDSKLNFRKAVIQLTTKTQEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQ >In-frame_HID1_ENST00000425042_chr17_72968686_-_SUMO2_ENST00000314523_chr17_73177283_-_87aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HID1_ENST00000425042_chr17_72968686_-_SUMO2_ENST00000420826_chr17_73177283_-_333nt ATGGGGTCGACCGACTCCAAGCTGAACTTCCGGAAGGCGGTGATCCAGCTCACCACCAAGACGCAGGAAGGAGTCAAGACTGAGAACAAC GATCATATTAATTTGAAGGTGGCGGGGCAGGATGGTTCTGTGGTGCAGTTTAAGATTAAGAGGCATACACCACTTAGTAAACTAATGAAA GCCTATTGTGAACGACAGGGATTGTCAATGAGGCAGATCAGATTCCGATTTGACGGGCAACCAATCAATGAAACAGACACACCTGCACAG >In-frame_HID1_ENST00000425042_chr17_72968686_-_SUMO2_ENST00000314523_chr17_73177283_-_261nt ATGGGGTCGACCGACTCCAAGCTGAACTTCCGGAAGGCGGTGATCCAGCTCACCACCAAGACGCAGGAAGGAGTCAAGACTGAGAACAAC GATCATATTAATTTGAAGGTGGCGGGGCAGGATGGTTCTGTGGTGCAGTTTAAGATTAAGAGGCATACACCACTTAGTAAACTAATGAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HID1_ENST00000425042_chr17_72968686_-_SUMO2_ENST00000420826_chr17_73177283_-_1437nt GCGGAGCTGGAGCCGGAGCTGAAGCCGGAGCCGGGTTGGAGTCTGGGCGGGGGCCGGGCCGGAGCGGGCTCCAGAGACATGGGGTCGACC GACTCCAAGCTGAACTTCCGGAAGGCGGTGATCCAGCTCACCACCAAGACGCAGGAAGGAGTCAAGACTGAGAACAACGATCATATTAAT TTGAAGGTGGCGGGGCAGGATGGTTCTGTGGTGCAGTTTAAGATTAAGAGGCATACACCACTTAGTAAACTAATGAAAGCCTATTGTGAA CGACAGGGATTGTCAATGAGGCAGATCAGATTCCGATTTGACGGGCAACCAATCAATGAAACAGACACACCTGCACAGTTGGAAATGGAG GATGAAGATACAATTGATGTGTTCCAACAGCAGACGGGAGGTGTCTACTGAAAAGGGAACCTGCTTCTTTACTCCAGAACTCTGTTCTTT AAAGACCAAGATTACATTCTCAATTAGAAAACTGCAATTTGGTTCCACCACATCCTGACTACTACCGTATAGTTTTCTCTATTCTTTCAT TTCCCCCTTCCCCATTCCTTTATTGTACATAAAGTAACTGGTATATGTGCACAAGCATATTGCATTTTTTTTTTTTTTAACTAAACAGCC AATGGTATGTTTTGATTGACATCAAGTGGAGACGGGATGGGGAAAAATACTGATTCTGTGAAAATACCCCCTTTCTCCATTAGTGGCATG CTCATTCAGCTCTTATCTTTATATTCCAGTAAGTTATTTTGCTCTCACTGTTTTAACAAAAAAAAAAAACAACAACATAAAAATCCTTGC ATACCTTGTTCAATTGGAGAATTTTAATGTTTTTCATTTATCATTGTAAAACCAAGGACAATTTTATAACTTTTTTGTACGTAGCTGTTA CATGTAGGGCAATCTGTCTTTAAGTAGGGATAAATTACTCTAAAACAAAAAAGAATCCTAGATAGTTTTCCCTTCAAGTCAAGCGTCTTG TTGTTTAAATAAACTTCTTGTTTAAAATGAGCTGTTTTCTTTATTCTGAGAAATATTAAATAGAAAATTGAGGCTTAGAAAAAACATAAA TAGGCCTGCTTAGAAGTAACATTTCAAGAAGGAAATAAAGCTACTTGGTGTTTCTGACAGACTGATACTGATGCCAAACAAAGAATAACA GTTTTATAAATATCACCTTGTTCCAAAAGTTTCTCTAGGTCCCATGTTAATATGCAAGTATACTAGCAGAAAAATTGGGCCATAGTATCG TGGATTTCCAGGTATTTTCTGTATATTAAGTGAGGCACGGAGCATAGGGTATAGGGTAGCACATGTGGCAAGGAAAAAGTTCTGATTTTG >In-frame_HID1_ENST00000425042_chr17_72968686_-_SUMO2_ENST00000314523_chr17_73177283_-_810nt GCGGAGCTGGAGCCGGAGCTGAAGCCGGAGCCGGGTTGGAGTCTGGGCGGGGGCCGGGCCGGAGCGGGCTCCAGAGACATGGGGTCGACC GACTCCAAGCTGAACTTCCGGAAGGCGGTGATCCAGCTCACCACCAAGACGCAGGAAGGAGTCAAGACTGAGAACAACGATCATATTAAT TTGAAGGTGGCGGGGCAGGATGGTTCTGTGGTGCAGTTTAAGATTAAGAGGCATACACCACTTAGTAAACTAATGAAAGCCTATTGTGAA CGACAGTTGGAAATGGAGGATGAAGATACAATTGATGTGTTCCAACAGCAGACGGGAGGTGTCTACTGAAAAGGGAACCTGCTTCTTTAC TCCAGAACTCTGTTCTTTAAAGACCAAGATTACATTCTCAATTAGAAAACTGCAATTTGGTTCCACCACATCCTGACTACTACCGTATAG TTTTCTCTATTCTTTCATTTCCCCCTTCCCCATTCCTTTATTGTACATAAAGTAACTGGTATATGTGCACAAGCATATTGCATTTTTTTT TTTTTTAACTAAACAGCCAATGGTATGTTTTGATTGACATCAAGTGGAGACGGGATGGGGAAAAATACTGATTCTGTGAAAATACCCCCT TTCTCCATTAGTGGCATGCTCATTCAGCTCTTATCTTTATATTCCAGTAAGTTATTTTGCTCTCACTGTTTTAACAAAAAAAAAAAACAA CAACATAAAAATCCTTGCATACCTTGTTCAATTGGAGAATTTTAATGTTTTTCATTTATCATTGTAAAACCAAGGACAATTTTATAACTT |
Top |
FusionGenePPI for HID1_SUMO2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HID1 | BEGAIN, RBBP8, CBS, RCN3, INPPL1, CSDE1, NLGN3, PTPRN2, DENND2C | SUMO2 | MAF1, VIM, CHD3, TRIM63, SENP3, ZMYM2, PIAS1, USP28, SAE1, UBA2, UBE2I, CHAF1A, RCOR1, KDM1A, RNF4, CMTM6, BAD, CSNK2B, SETDB1, ALAS1, PML, DAXX, ELAVL1, UIMC1, BRCA1, BRE, FAM175A, BRCC3, ATXN7, USP25, SENP6, PIAS4, PIAS2, USPL1, PIAS3, IGBP1, SSSCA1, AHCYL1, CTSA, SELENBP1, PSAP, ATIC, SDHAF2, RNF111, CASP8AP2, SIMC1, VCP, MYB, NFE2L2, SLC22A2, TEAD3, SP100, TNIP1, MAST2, TDG, TOPORS, RANBP2, ZCCHC7, ZCCHC12, ZMYM5, ZHX1, SETX, BLM, WRN, TDP2, C18orf25, SENP1, SUMO2, SHFM1, SENP7, IRF7, SENP5, HOMEZ, SENP2, TANK, EP300, UBC, ZBTB1, ZBTB21, KRT5, NOP58, SOBP, HIPK2, AHNAK, ANXA1, ATF7IP, ATRX, BAZ1A, BAZ1B, SLX4, SLX4IP, CAD, CARS, CHAF1B, CHD4, CTNND1, CUX1, DCD, DDX17, DDX21, DDX3X, PRKDC, EEF1A1, EEF1G, EME1, ENO1, ERCC4, EXOSC10, EXOSC9, GATAD2B, HDAC1, HDAC2, HNRNPF, HNRNPH1, HNRNPK, HP1BP3, HSP90AB1, HSPA1A, HSPA8, HSPA9, IPO5, LAS1L, MDC1, MDN1, MKI67, MRE11A, MSH2, MTA1, MTA2, MUS81, NBN, NOL9, NOP2, NUMA1, PARN, PELP1, PFKM, PHF5A, PHF8, POGZ, RAD50, RAD54L2, RBBP4, RBBP7, RCOR2, RCOR3, RPL3, RPL4, RUVBL1, SMCHD1, SSRP1, SUPT16H, TEX10, TMPO, TOP2A, TOP2B, TP53BP1, TPR, TRAF1, TRIM26, TRIM28, TRIML2, TUBA1B, TUBB, TUBB4B, TUBB6, XRCC5, XRCC6, ZBED1, ZBTB2, ZBTB25, ZBTB33, ZMAT3, ZMYM4, ZNF451, ZNF496, CHAMP1, ZMYM3, ALDOA, NPEPL1, PGD, SEC23A, SEC23B, ENO2, EWSR1, NUP153, RNF168, USP11, USP7, DNM1L, HSD17B10, SOD1, RNF8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HID1_SUMO2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HID1_SUMO2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|