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Fusion gene ID: 16158 |
FusionGeneSummary for HHIP_DDX46 |
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Fusion gene information | Fusion gene name: HHIP_DDX46 | Fusion gene ID: 16158 | Hgene | Tgene | Gene symbol | HHIP | DDX46 | Gene ID | 64399 | 9879 |
Gene name | hedgehog interacting protein | DEAD-box helicase 46 | |
Synonyms | HIP | PRPF5|Prp5 | |
Cytomap | 4q31.21 | 5q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | hedgehog-interacting protein | probable ATP-dependent RNA helicase DDX46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46DEAD box protein 46PRP5 homologPrp5-like DEAD-box proteinRNA helicase | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q96QV1 | Q7L014 | |
Ensembl transtripts involved in fusion gene | ENST00000296575, ENST00000434550, ENST00000511314, | ENST00000452510, ENST00000354283, ENST00000509178, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 6 X 3=90 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HHIP [Title/Abstract] AND DDX46 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HHIP | GO:0009968 | negative regulation of signal transduction | 19561609 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA881233 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000296575 | ENST00000452510 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
5UTR-intron | ENST00000296575 | ENST00000354283 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
5UTR-intron | ENST00000296575 | ENST00000509178 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
5UTR-3CDS | ENST00000434550 | ENST00000452510 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
5UTR-intron | ENST00000434550 | ENST00000354283 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
5UTR-intron | ENST00000434550 | ENST00000509178 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
intron-3CDS | ENST00000511314 | ENST00000452510 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
intron-intron | ENST00000511314 | ENST00000354283 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
intron-intron | ENST00000511314 | ENST00000509178 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
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FusionProtFeatures for HHIP_DDX46 |
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Hgene | Tgene |
HHIP | DDX46 |
Modulates hedgehog signaling in several cell typesincluding brain and lung through direct interaction with membersof the hedgehog family. {ECO:0000269|PubMed:11472839,ECO:0000269|PubMed:19561609}. | Plays an essential role in splicing, either prior to, orduring splicing A complex formation.{ECO:0000269|PubMed:12234937}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HHIP_DDX46 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HHIP_DDX46 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HHIP_DDX46 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HHIP_DDX46 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HHIP | C2239176 | Liver carcinoma | 1 | CTD_human |