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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1615

FusionGeneSummary for AMMECR1_ELL3

check button Fusion gene summary
Fusion gene informationFusion gene name: AMMECR1_ELL3
Fusion gene ID: 1615
HgeneTgene
Gene symbol

AMMECR1

ELL3

Gene ID

9949

80237

Gene nameAlport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1elongation factor for RNA polymerase II 3
SynonymsAMMERC1|MFHIEN-
Cytomap

Xq23

15q15.3

Type of geneprotein-codingprotein-coding
DescriptionAMME syndrome candidate gene 1 proteinAlport syndrome mental retardation midface hypoplasia and elliptocytosis chromosomal region protein 1RNA polymerase II elongation factor ELL3elongation factor RNA polymerase II-like 3
Modification date2018051920180519
UniProtAcc

Q9Y4X0

Q9HB65

Ensembl transtripts involved in fusion geneENST00000262844, ENST00000372059, 
ENST00000372057, ENST00000496695, 
ENST00000319359, ENST00000497465, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 5 X 1=20
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AMMECR1 [Title/Abstract] AND ELL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneELL3

GO:0006354

DNA-templated transcription, elongation

10882741

TgeneELL3

GO:0006368

transcription elongation from RNA polymerase II promoter

10882741

TgeneELL3

GO:0032786

positive regulation of DNA-templated transcription, elongation

10882741

TgeneELL3

GO:0045944

positive regulation of transcription by RNA polymerase II

10882741


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE171379AMMECR1chrX

109657370

-ELL3chr15

44086050

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000262844ENST00000319359AMMECR1chrX

109657370

-ELL3chr15

44086050

-
intron-intronENST00000262844ENST00000497465AMMECR1chrX

109657370

-ELL3chr15

44086050

-
intron-intronENST00000372059ENST00000319359AMMECR1chrX

109657370

-ELL3chr15

44086050

-
intron-intronENST00000372059ENST00000497465AMMECR1chrX

109657370

-ELL3chr15

44086050

-
intron-intronENST00000372057ENST00000319359AMMECR1chrX

109657370

-ELL3chr15

44086050

-
intron-intronENST00000372057ENST00000497465AMMECR1chrX

109657370

-ELL3chr15

44086050

-
intron-intronENST00000496695ENST00000319359AMMECR1chrX

109657370

-ELL3chr15

44086050

-
intron-intronENST00000496695ENST00000497465AMMECR1chrX

109657370

-ELL3chr15

44086050

-

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FusionProtFeatures for AMMECR1_ELL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AMMECR1

Q9Y4X0

ELL3

Q9HB65

Enhancer-binding elongation factor that specificallybinds enhancers in embryonic stem cells (ES cells), marks them,and is required for their future activation during stem cellspecification. Does not only bind to enhancer regions of activegenes, but also marks the enhancers that are in a poised orinactive state in ES cells and is required for establishing properRNA polymerase II occupancy at developmentally regulated genes ina cohesin-dependent manner. Probably required for primingdevelopmentally regulated genes for later recruitment of the superelongation complex (SEC), for transcriptional activation duringdifferentiation. Required for recruitment of P-TEFb within SECduring differentiation. Probably preloaded on germ cell chromatin,suggesting that it may prime gene activation by marking enhancersas early as in the germ cells. Promoting epithelial-mesenchymaltransition (EMT) (By similarity). Elongation factor component ofthe super elongation complex (SEC), a complex required to increasethe catalytic rate of RNA polymerase II transcription bysuppressing transient pausing by the polymerase at multiple sitesalong the DNA. Component of the little elongation complex (LEC), acomplex required to regulate small nuclear RNA (snRNA) genetranscription by RNA polymerase II and III (PubMed:22195968).{ECO:0000250, ECO:0000269|PubMed:10882741,ECO:0000269|PubMed:22195968}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AMMECR1_ELL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AMMECR1_ELL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AMMECR1_ELL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AMMECR1_ELL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource