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Fusion gene ID: 16135 |
FusionGeneSummary for HEYL_MORC4 |
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Fusion gene information | Fusion gene name: HEYL_MORC4 | Fusion gene ID: 16135 | Hgene | Tgene | Gene symbol | HEYL | MORC4 | Gene ID | 26508 | 79710 |
Gene name | hes related family bHLH transcription factor with YRPW motif-like | MORC family CW-type zinc finger 4 | |
Synonyms | HESR3|HEY3|HRT3|bHLHb33 | ZCW4|ZCWCC2|dJ75H8.2 | |
Cytomap | 1p34.2 | Xq22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | hairy/enhancer-of-split related with YRPW motif-like proteinHEY-like proteinHRT-3class B basic helix-loop-helix protein 33hHRT3hHeyLhairy-related transcription factor 3hairy/enhancer-of-split related with YRPW motif 3 | MORC family CW-type zinc finger protein 4zinc finger CW-type coiled-coil domain protein 2zinc finger CW-type domain protein 4zinc finger, CW type with coiled-coil domain 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NQ87 | Q8TE76 | |
Ensembl transtripts involved in fusion gene | ENST00000372852, ENST00000535435, | ENST00000355610, ENST00000535534, ENST00000255495, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: HEYL [Title/Abstract] AND MORC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HEYL | GO:0007219 | Notch signaling pathway | 10964718 |
Hgene | HEYL | GO:0045892 | negative regulation of transcription, DNA-templated | 15485867|21454491 |
Hgene | HEYL | GO:0045944 | positive regulation of transcription by RNA polymerase II | 21290414 |
Hgene | HEYL | GO:0060766 | negative regulation of androgen receptor signaling pathway | 21454491 |
Hgene | HEYL | GO:2000824 | negative regulation of androgen receptor activity | 21454491 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI058396 | HEYL | chr1 | 40095907 | - | MORC4 | chrX | 106185927 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000372852 | ENST00000355610 | HEYL | chr1 | 40095907 | - | MORC4 | chrX | 106185927 | + |
intron-3CDS | ENST00000372852 | ENST00000535534 | HEYL | chr1 | 40095907 | - | MORC4 | chrX | 106185927 | + |
intron-3CDS | ENST00000372852 | ENST00000255495 | HEYL | chr1 | 40095907 | - | MORC4 | chrX | 106185927 | + |
intron-3CDS | ENST00000535435 | ENST00000355610 | HEYL | chr1 | 40095907 | - | MORC4 | chrX | 106185927 | + |
intron-3CDS | ENST00000535435 | ENST00000535534 | HEYL | chr1 | 40095907 | - | MORC4 | chrX | 106185927 | + |
intron-3CDS | ENST00000535435 | ENST00000255495 | HEYL | chr1 | 40095907 | - | MORC4 | chrX | 106185927 | + |
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FusionProtFeatures for HEYL_MORC4 |
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Hgene | Tgene |
HEYL | MORC4 |
Downstream effector of Notch signaling which may berequired for cardiovascular development (By similarity).Transcriptional repressor which binds preferentially to thecanonical E box sequence 5'-CACGTG-3' (By similarity). Repressestranscription by the cardiac transcriptional activators GATA4 andGATA6. {ECO:0000250, ECO:0000269|PubMed:15485867}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HEYL_MORC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HEYL_MORC4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HEYL_MORC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HEYL_MORC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HEYL | C1458155 | Mammary Neoplasms | 1 | CTD_human |