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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16135

FusionGeneSummary for HEYL_MORC4

check button Fusion gene summary
Fusion gene informationFusion gene name: HEYL_MORC4
Fusion gene ID: 16135
HgeneTgene
Gene symbol

HEYL

MORC4

Gene ID

26508

79710

Gene namehes related family bHLH transcription factor with YRPW motif-likeMORC family CW-type zinc finger 4
SynonymsHESR3|HEY3|HRT3|bHLHb33ZCW4|ZCWCC2|dJ75H8.2
Cytomap

1p34.2

Xq22.3

Type of geneprotein-codingprotein-coding
Descriptionhairy/enhancer-of-split related with YRPW motif-like proteinHEY-like proteinHRT-3class B basic helix-loop-helix protein 33hHRT3hHeyLhairy-related transcription factor 3hairy/enhancer-of-split related with YRPW motif 3MORC family CW-type zinc finger protein 4zinc finger CW-type coiled-coil domain protein 2zinc finger CW-type domain protein 4zinc finger, CW type with coiled-coil domain 2
Modification date2018052320180519
UniProtAcc

Q9NQ87

Q8TE76

Ensembl transtripts involved in fusion geneENST00000372852, ENST00000535435, 
ENST00000355610, ENST00000535534, 
ENST00000255495, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 51
** MAII scorelog2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: HEYL [Title/Abstract] AND MORC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHEYL

GO:0007219

Notch signaling pathway

10964718

HgeneHEYL

GO:0045892

negative regulation of transcription, DNA-templated

15485867|21454491

HgeneHEYL

GO:0045944

positive regulation of transcription by RNA polymerase II

21290414

HgeneHEYL

GO:0060766

negative regulation of androgen receptor signaling pathway

21454491

HgeneHEYL

GO:2000824

negative regulation of androgen receptor activity

21454491


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI058396HEYLchr1

40095907

-MORC4chrX

106185927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000372852ENST00000355610HEYLchr1

40095907

-MORC4chrX

106185927

+
intron-3CDSENST00000372852ENST00000535534HEYLchr1

40095907

-MORC4chrX

106185927

+
intron-3CDSENST00000372852ENST00000255495HEYLchr1

40095907

-MORC4chrX

106185927

+
intron-3CDSENST00000535435ENST00000355610HEYLchr1

40095907

-MORC4chrX

106185927

+
intron-3CDSENST00000535435ENST00000535534HEYLchr1

40095907

-MORC4chrX

106185927

+
intron-3CDSENST00000535435ENST00000255495HEYLchr1

40095907

-MORC4chrX

106185927

+

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FusionProtFeatures for HEYL_MORC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HEYL

Q9NQ87

MORC4

Q8TE76

Downstream effector of Notch signaling which may berequired for cardiovascular development (By similarity).Transcriptional repressor which binds preferentially to thecanonical E box sequence 5'-CACGTG-3' (By similarity). Repressestranscription by the cardiac transcriptional activators GATA4 andGATA6. {ECO:0000250, ECO:0000269|PubMed:15485867}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HEYL_MORC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HEYL_MORC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HEYL_MORC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HEYL_MORC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHEYLC1458155Mammary Neoplasms1CTD_human