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Fusion gene ID: 16121 |
FusionGeneSummary for HES4_AFF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HES4_AFF1 | Fusion gene ID: 16121 | Hgene | Tgene | Gene symbol | HES4 | AFF1 | Gene ID | 57801 | 4299 |
| Gene name | hes family bHLH transcription factor 4 | AF4/FMR2 family member 1 | |
| Synonyms | bHLHb42 | AF4|MLLT2|PBM1 | |
| Cytomap | 1p36.33 | 4q21.3-q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor HES-4bHLH factor Hes4class B basic helix-loop-helix protein 42hHES4hairy and enhancer of split 4 | AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HCC6 | P51825 | |
| Ensembl transtripts involved in fusion gene | ENST00000428771, ENST00000304952, ENST00000484667, | ENST00000395146, ENST00000307808, ENST00000544085, ENST00000511996, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 25 X 4=1000 |
| # samples | 1 | 31 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(31/1000*10)=-1.68965987938785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HES4 [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-A3-3373-01A | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000428771 | ENST00000395146 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| In-frame | ENST00000428771 | ENST00000307808 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| 5CDS-5UTR | ENST00000428771 | ENST00000544085 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| 5CDS-intron | ENST00000428771 | ENST00000511996 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| In-frame | ENST00000304952 | ENST00000395146 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| In-frame | ENST00000304952 | ENST00000307808 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| 5CDS-5UTR | ENST00000304952 | ENST00000544085 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| 5CDS-intron | ENST00000304952 | ENST00000511996 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| intron-3CDS | ENST00000484667 | ENST00000395146 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| intron-3CDS | ENST00000484667 | ENST00000307808 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| intron-5UTR | ENST00000484667 | ENST00000544085 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
| intron-intron | ENST00000484667 | ENST00000511996 | HES4 | chr1 | 935072 | - | AFF1 | chr4 | 88005272 | + |
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FusionProtFeatures for HES4_AFF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HES4 | AFF1 |
| Transcriptional repressor. Binds DNA on N-box motifs:5'-CACNAG-3' (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000307808 | + | 2 | 20 | 483_492 | 346 | 1211 | Compositional bias | Note=Poly-Ser |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000307808 | + | 2 | 20 | 835_843 | 346 | 1211 | Compositional bias | Note=Poly-Ser |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000307808 | + | 2 | 20 | 866_869 | 346 | 1211 | Compositional bias | Note=Poly-Pro |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000307808 | + | 2 | 20 | 871_874 | 346 | 1211 | Compositional bias | Note=Poly-Ser |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000395146 | + | 3 | 21 | 483_492 | 353 | 1219 | Compositional bias | Note=Poly-Ser |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000395146 | + | 3 | 21 | 835_843 | 353 | 1219 | Compositional bias | Note=Poly-Ser |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000395146 | + | 3 | 21 | 866_869 | 353 | 1219 | Compositional bias | Note=Poly-Pro |
| Tgene | >AFF1 | chr1:935072 | chr4:88005272 | ENST00000395146 | + | 3 | 21 | 871_874 | 353 | 1219 | Compositional bias | Note=Poly-Ser |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HES4 | chr1:935072 | chr4:88005272 | ENST00000304952 | - | 2 | 4 | 152_218 | 68 | 222 | Compositional bias | Note=Pro-rich |
| Hgene | >HES4 | chr1:935072 | chr4:88005272 | ENST00000304952 | - | 2 | 4 | 110_143 | 68 | 222 | Domain | Orange |
| Hgene | >HES4 | chr1:935072 | chr4:88005272 | ENST00000304952 | - | 2 | 4 | 34_91 | 68 | 222 | Domain | bHLH |
| Hgene | >HES4 | chr1:935072 | chr4:88005272 | ENST00000304952 | - | 2 | 4 | 216_219 | 68 | 222 | Motif | Note=WRPW motif |
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FusionGeneSequence for HES4_AFF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HES4_ENST00000428771_chr1_935072_-_AFF1_ENST00000395146_chr4_88005272_+_960aa MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDA LRKEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDS EDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKV SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKAS ARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA LVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPP AGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPAL KRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAK KMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAM FRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSH >In-frame_HES4_ENST00000428771_chr1_935072_-_AFF1_ENST00000307808_chr4_88005272_+_959aa MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDA LRKEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDS EDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKV SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKAS ARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA LVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPP AGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPAL KRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAK KMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAM FRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHV >In-frame_HES4_ENST00000304952_chr1_935072_-_AFF1_ENST00000395146_chr4_88005272_+_934aa MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKEQTYSNEVHCVEEILKEMTHSWP PPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLP EPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSS DSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQT SKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAV VVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEA ERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHK DSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSF IECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVA QAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLS >In-frame_HES4_ENST00000304952_chr1_935072_-_AFF1_ENST00000307808_chr4_88005272_+_933aa MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKEQTYSNEVHCVEEILKEMTHSWP PPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLP EPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSS DSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQT SKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAV VVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEA ERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHK DSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSF IECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVA QAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLST |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HES4_ENST00000428771_chr1_935072_-_AFF1_ENST00000395146_chr4_88005272_+_2880nt ATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGC GCGGCCGAGCACCGCAAGGTGGGGTCCCGGCCGGGCGTGAGGGGGGCGACCGGGGGGCGGGAGGGACGCGGGACTCAGCCGGTGCCCGAC CCGCAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTCATCCTGGACGCC CTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACA GCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAA AAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGT GAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCA TCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGC GAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTC AGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACG AGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAG AGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCT GCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAG CCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCAC AAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCT CTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAG GACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATG GTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCC GCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGT GATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCC TCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTT AAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATT CCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTG CCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAA AAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGA ATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTA AAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATG TTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCT CCATGCATTGCAAGAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGC AGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCAT GTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGC ACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAAACACCTTAA >In-frame_HES4_ENST00000428771_chr1_935072_-_AFF1_ENST00000307808_chr4_88005272_+_2877nt ATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGC GCGGCCGAGCACCGCAAGGTGGGGTCCCGGCCGGGCGTGAGGGGGGCGACCGGGGGGCGGGAGGGACGCGGGACTCAGCCGGTGCCCGAC CCGCAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTCATCCTGGACGCC CTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACA GCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAA AAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGT GAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCA TCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGC GAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTC AGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACG AGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAG AGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCT GCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAG CCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCAC AAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCT CTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAG GACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATG GTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCC GCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGT GATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCC TCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTT AAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATT CCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTG CCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAA AAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGA ATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTA AAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATG TTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCT CCATGCATTGCAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGCAGT GTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCATGTT CTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGCACC >In-frame_HES4_ENST00000304952_chr1_935072_-_AFF1_ENST00000395146_chr4_88005272_+_2802nt ATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGC GCGGCCGAGCACCGCAAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTC ATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCG CCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTA ACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAG CTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCA GAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGT TCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGG CTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGC GACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCC CACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCT GTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACT TCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAG AAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCT GAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTG GTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCA CAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGAT AAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCA GAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCT AAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCC AAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAA GACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAAT CCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATG AGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTC ATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTC ATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTG AACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCC CAGGCACCTTCTCCATGCATTGCAAGAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAG TCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACC ATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGC ACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACC >In-frame_HES4_ENST00000304952_chr1_935072_-_AFF1_ENST00000307808_chr4_88005272_+_2799nt ATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGC GCGGCCGAGCACCGCAAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTC ATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCG CCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTA ACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAG CTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCA GAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGT TCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGG CTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGC GACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCC CACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCT GTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACT TCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAG AAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCT GAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTG GTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCA CAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGAT AAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCA GAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCT AAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCC AAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAA GACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAAT CCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATG AGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTC ATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTC ATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTG AACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCC CAGGCACCTTCTCCATGCATTGCAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCA AGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATC ACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACA AATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HES4_ENST00000428771_chr1_935072_-_AFF1_ENST00000395146_chr4_88005272_+_8432nt GGGAAAGAATGCGGAGCCGGGTTCACACACCCCGCGGCGGCGAGGCCTTAAATAGGGAAACGGCCTGAGGCGCGCGCGGGCCTGGAGCCG GGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTGGTCCGTGGCGGCGCGCTCCACCCGGCACG GGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGAC CCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGGTGGGGTCCCGGCCGGGCGTGAGGGGGGCGACCGGGGGGCGGGAGGGACGCGG GACTCAGCCGGTGCCCGACCCGCAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAA AACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTC ATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAG TTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGA CCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTC CCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGA GAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGA CAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGG CAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGA AGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAA AAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGA CCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTC CAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAG GACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCA AGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCC TCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGC AGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGG TGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGA ATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAA GCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAA CCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATAC TGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCT TCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTT GTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCAT TAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTC CATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAA AGTCGCCCAGGCACCTTCTCCATGCATTGCAAGAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGG GTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTA TGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCG GCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGA ATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGAC ATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGA TCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAG TGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGA GGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACA ATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGT AAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAA ATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGT GCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGC CATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCT CCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGG TGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTT CTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAA CTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCT AGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAA AATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATT ACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATC TCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGG GAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGAT GTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTT GGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGA TGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTT AAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGG CTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCT AGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGC AAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTT TGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACT ACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGG TAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCAC TTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGA GTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCT TGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAA GTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATT ATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATC ACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACC TTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATT TCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTAC TAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAA AACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAG TTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGA GTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTT TCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCT GTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCT CACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCC AGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGA GGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCC AGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAG TTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACG TCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGA GCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCA GTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGC CATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGT ATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTT TTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTA TTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTG TGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACA AATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGT CGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCAC AGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGA >In-frame_HES4_ENST00000428771_chr1_935072_-_AFF1_ENST00000307808_chr4_88005272_+_8413nt GGGAAAGAATGCGGAGCCGGGTTCACACACCCCGCGGCGGCGAGGCCTTAAATAGGGAAACGGCCTGAGGCGCGCGCGGGCCTGGAGCCG GGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTGGTCCGTGGCGGCGCGCTCCACCCGGCACG GGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGAC CCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGGTGGGGTCCCGGCCGGGCGTGAGGGGGGCGACCGGGGGGCGGGAGGGACGCGG GACTCAGCCGGTGCCCGACCCGCAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAA AACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTC ATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAG TTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGA CCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTC CCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGA GAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGA CAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGG CAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGA AGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAA AAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGA CCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTC CAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAG GACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCA AGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCC TCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGC AGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGG TGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGA ATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAA GCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAA CCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATAC TGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCT TCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTT GTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCAT TAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTC CATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAA AGTCGCCCAGGCACCTTCTCCATGCATTGCAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTC CCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGT CACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCT CAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATT AACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATT TGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCA TTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGC AATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGA GAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATG ACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAA CCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATT GAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCT GAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCAT TTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCC TTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGC TGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTT AGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTC CCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGA TTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAAT GAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACT TTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCT ATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAG AACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTG TCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGT TGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGT GTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAA TGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTT TATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGA ACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAG CCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGT GGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACT TTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAG TGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTT TTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTA TGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGC CTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTG TTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATA CTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACA ATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTC ATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCA GGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAG CATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAAC TTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTT TTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTT GTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCT TGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTT TACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCAC TGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGT TGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGT GTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGT TGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTG ACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCA GAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCC TATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTG GCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCAT CGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATG TACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTT TTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTA TTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGG AATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAAT TAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGT TTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGA TCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGATCA >In-frame_HES4_ENST00000304952_chr1_935072_-_AFF1_ENST00000395146_chr4_88005272_+_8293nt GGCCTGAGGCGCGCGCGGGCCTGGAGCCGGGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTG GTCCGTGGCGGCGCGCTCCACCCGGCACGGGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATG GCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGTCCTCCAAGCCGGTCATGGAGAAG CGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAA GTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCA TCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCAC TCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAG AAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAA AGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCT CCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCC AGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCT CCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAG GAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAG GGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGG GCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCT CTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCA CCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCT TTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGG ATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGG AGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAA ATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAG GAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGT GGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGC TCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCA GGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACG GACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCC AAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACA CAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAG TATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCTCCATGCATTGCAAGAAGCACAGGCACACCA TCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACT ATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAG GCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGAC CTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGG AACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATG GCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGG CCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATT TTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGC CACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTT TGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGA ACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAG AGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATG GGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTC TCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAA GTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAA CTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAA AACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAA AACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCC ATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTT TCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAG AAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTT CCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAA TGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTG TGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCA GAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAG CCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGT GTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTA CTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGT TCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAG CCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGT CCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGA GAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGG TTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGT AGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACA AATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCT GCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGA GGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATA CTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAG ATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGC TGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTT AGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGA GAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACA TGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTC GGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCC AAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATA TTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGAT CAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGT ATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTG CAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATT GTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTA CTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTC TACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCAC TCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTT AAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAG TATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGA ATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTT TTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAA AATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGT AGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCA ACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGA AGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAAT GTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGATCAAGCTGTAAAAAAACAAAAAAATTAATAAAAATTTCGAGAAATCATT >In-frame_HES4_ENST00000304952_chr1_935072_-_AFF1_ENST00000307808_chr4_88005272_+_8274nt GGCCTGAGGCGCGCGCGGGCCTGGAGCCGGGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTG GTCCGTGGCGGCGCGCTCCACCCGGCACGGGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATG GCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGTCCTCCAAGCCGGTCATGGAGAAG CGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAA GTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCA TCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCAC TCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAG AAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAA AGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCT CCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCC AGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCT CCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAG GAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAG GGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGG GCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCT CTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCA CCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCT TTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGG ATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGG AGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAA ATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAG GAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGT GGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGC TCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCA GGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACG GACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCC AAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACA CAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAG TATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCTCCATGCATTGCAAGCACAGGCACACCATCC CCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATC AGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCC GAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTG GTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAAC TATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCC AGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCC CAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTT TTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCAC GCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGG GAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACA GTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGC GCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGG TGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCT AACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTG CTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTC AGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAAC TAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAAC TCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATA GTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCT TTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAG TAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCT ACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGC AGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGT GAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAG AATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCC TGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTC CATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTC CCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCT ATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCA GCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCC TTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAG TAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTG TATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGA TCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAAT GCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCT TTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCT AAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGA GTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTG AATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATT GGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGA AAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGA AGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAA AAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGG CTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGG TTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAA CACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTT TGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAA TTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATT TTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAA GTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTG AGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTG TCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTAC CTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCA TAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAG CAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTAT ACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATG TGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTT GCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAAT CACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGG GAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACT TGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGA AAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTA |
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FusionGenePPI for HES4_AFF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HES4 | PCBD1, PCBD2, LTN1, RGS3, COPG2, SHMT2 | AFF1 | MLLT1, CCNT1, NT5E, MLLT3, CDK9, AFF4, KMT2A, AFF1, BRD4, RELA, NPM1, PCSK1, MLLT10, DOT1L, POLR2A, DDX6, HEXIM1, HIST3H3, NSD1, CARM1, SIAH1, SIAH2, SMAD9, MED26, EAF1, ELL2, LARP7, ELL3, HDAC1, MYH7, SLC16A6, ZNF526, VDR, PIP4K2A, CAMKV, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HES4_AFF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HES4_AFF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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