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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16110

FusionGeneSummary for HERC3_STRAP

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC3_STRAP
Fusion gene ID: 16110
HgeneTgene
Gene symbol

HERC3

STRAP

Gene ID

8916

153443

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 3serum response factor binding protein 1
Synonyms-BUD22|P49|Rlb1|STRAP|p49/STRAP
Cytomap

4q22.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC3HECT domain and RCC1-like domain-containing protein 3HECT-type E3 ubiquitin transferase HERC3hect domain and RLD 3serum response factor-binding protein 1BUD22 homologSRF-dependent transcription regulation-associated protein
Modification date2018052220180523
UniProtAcc

Q15034

Q9Y3F4

Ensembl transtripts involved in fusion geneENST00000402738, ENST00000407637, 
ENST00000601319, ENST00000264345, 
ENST00000543130, 
ENST00000538352, 
ENST00000025399, ENST00000419869, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 6 X 2=60
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/60*10)=0
Context

PubMed: HERC3 [Title/Abstract] AND STRAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA065415HERC3chr4

89618774

-STRAPchr12

16035532

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000402738ENST00000538352HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000402738ENST00000025399HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000402738ENST00000419869HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000407637ENST00000538352HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000407637ENST00000025399HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000407637ENST00000419869HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000601319ENST00000538352HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000601319ENST00000025399HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000601319ENST00000419869HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000264345ENST00000538352HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000264345ENST00000025399HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000264345ENST00000419869HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000543130ENST00000538352HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000543130ENST00000025399HERC3chr4

89618774

-STRAPchr12

16035532

+
intron-5UTRENST00000543130ENST00000419869HERC3chr4

89618774

-STRAPchr12

16035532

+

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FusionProtFeatures for HERC3_STRAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC3

Q15034

STRAP

Q9Y3F4

E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.{ECO:0000250}. The SMN complex plays a catalyst role in the assembly ofsmall nuclear ribonucleoproteins (snRNPs), the building blocks ofthe spliceosome. Thereby, plays an important role in the splicingof cellular pre-mRNAs. Most spliceosomal snRNPs contain a commonset of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF andSNRPG that assemble in a heptameric protein ring on the Sm site ofthe small nuclear RNA to form the core snRNP. In the cytosol, theSm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped inan inactive 6S pICln-Sm complex by the chaperone CLNS1A thatcontrols the assembly of the core snRNP. Dissociation by the SMNcomplex of CLNS1A from the trapped Sm proteins and their transferto an SMN-Sm complex triggers the assembly of core snRNPs andtheir transport to the nucleus. STRAP plays a role in the cellulardistribution of the SMN complex. Negatively regulates TGF-betasignaling but positively regulates the PDPK1 kinase activity byenhancing its autophosphorylation and by significantly reducingthe association of PDPK1 with 14-3-3 protein.{ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HERC3_STRAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HERC3_STRAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HERC3_STRAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HERC3_STRAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHERC3C0023903Liver neoplasms1CTD_human
TgeneSTRAPC0009404Colorectal Neoplasms1CTD_human