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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16108

FusionGeneSummary for HERC3_PSPH

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC3_PSPH
Fusion gene ID: 16108
HgeneTgene
Gene symbol

HERC3

PSPH

Gene ID

8916

5723

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 3phosphoserine phosphatase
Synonyms-PSP|PSPHD
Cytomap

4q22.1

7p11.2

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC3HECT domain and RCC1-like domain-containing protein 3HECT-type E3 ubiquitin transferase HERC3hect domain and RLD 3phosphoserine phosphataseL-3-phosphoserine phosphataseO-phosphoserine phosphohydrolasePSPase
Modification date2018052220180523
UniProtAcc

Q15034

P78330

Ensembl transtripts involved in fusion geneENST00000402738, ENST00000407637, 
ENST00000601319, ENST00000264345, 
ENST00000543130, 
ENST00000275605, 
ENST00000395471, ENST00000459834, 
Fusion gene scores* DoF score4 X 4 X 2=3212 X 13 X 4=624
# samples 414
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(14/624*10)=-2.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HERC3 [Title/Abstract] AND PSPH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePSPH

GO:0006563

L-serine metabolic process

15291819


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DC340871HERC3chr4

89606033

-PSPHchr7

56131998

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000402738ENST00000275605HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000402738ENST00000395471HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000402738ENST00000459834HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000407637ENST00000275605HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000407637ENST00000395471HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000407637ENST00000459834HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000601319ENST00000275605HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000601319ENST00000395471HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000601319ENST00000459834HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000264345ENST00000275605HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000264345ENST00000395471HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000264345ENST00000459834HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000543130ENST00000275605HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000543130ENST00000395471HERC3chr4

89606033

-PSPHchr7

56131998

+
intron-intronENST00000543130ENST00000459834HERC3chr4

89606033

-PSPHchr7

56131998

+

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FusionProtFeatures for HERC3_PSPH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC3

Q15034

PSPH

P78330

E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.{ECO:0000250}. Catalyzes the last step in the biosynthesis of serinefrom carbohydrates. The reaction mechanism proceeds via theformation of a phosphoryl-enzyme intermediates.{ECO:0000269|PubMed:12777757}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HERC3_PSPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HERC3_PSPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HERC3_PSPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePSPHP78330DB01593ZincPhosphoserine phosphatasesmall moleculeapproved|investigational

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RelatedDiseases for HERC3_PSPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHERC3C0023903Liver neoplasms1CTD_human
TgenePSPHC0002514Amino Acid Metabolism, Inborn Errors1CTD_human
TgenePSPHC1291463Deficiency of phosphoserine phosphatase1ORPHANET;UNIPROT