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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 16106

FusionGeneSummary for HERC2_TMEM145

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC2_TMEM145
Fusion gene ID: 16106
HgeneTgene
Gene symbol

HERC2

TMEM145

Gene ID

8924

284339

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 2transmembrane protein 145
SynonymsD15F37S1|MRT38|SHEP1|jdf2|p528-
Cytomap

15q13.1

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HERC2HECT-type E3 ubiquitin transferase HERC2hect domain and RCC1-like domain-containing protein 2hect domain and RLD 2probable E3 ubiquitin-protein ligase HERC2transmembrane protein 145
Modification date2018052320180329
UniProtAcc

O95714

Q8NBT3

Ensembl transtripts involved in fusion geneENST00000261609, ENST00000563945, 
ENST00000301204, ENST00000598766, 
ENST00000601020, 
Fusion gene scores* DoF score4 X 4 X 4=641 X 1 X 1=1
# samples 41
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: HERC2 [Title/Abstract] AND TMEM145 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHERC2

GO:0006974

cellular response to DNA damage stimulus

22508508

HgeneHERC2

GO:0016567

protein ubiquitination

20304803


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-V1-A8WS-01AHERC2chr15

28544548

-TMEM145chr19

42818424

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261609ENST00000301204HERC2chr15

28544548

-TMEM145chr19

42818424

+
In-frameENST00000261609ENST00000598766HERC2chr15

28544548

-TMEM145chr19

42818424

+
In-frameENST00000261609ENST00000601020HERC2chr15

28544548

-TMEM145chr19

42818424

+
intron-3CDSENST00000563945ENST00000301204HERC2chr15

28544548

-TMEM145chr19

42818424

+
intron-3CDSENST00000563945ENST00000598766HERC2chr15

28544548

-TMEM145chr19

42818424

+
intron-3CDSENST00000563945ENST00000601020HERC2chr15

28544548

-TMEM145chr19

42818424

+

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FusionProtFeatures for HERC2_TMEM145


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC2

O95714

TMEM145

Q8NBT3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+015175_19540494TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+015207_22740494TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+015241_26140494TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+015282_30240494TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+015318_33840494TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+015349_36940494TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+015381_40140494TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393948_980624835Coiled coilOntology_term=ECO:0000255
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3931207_1283624835DomainCytochrome b5 heme-binding
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3931859_1932624835DomainMIB/HERC2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932759_2936624835DomainDOC
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934457_4794624835DomainHECT
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932958_3009624835RepeatRCC1 2-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933010_3064624835RepeatRCC1 2-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933065_3116624835RepeatRCC1 2-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933118_3168624835RepeatRCC1 2-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933171_3222624835RepeatRCC1 2-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933224_3274624835RepeatRCC1 2-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933275_3326624835RepeatRCC1 2-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933951_4002624835RepeatRCC1 3-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934004_4056624835RepeatRCC1 3-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934058_4108624835RepeatRCC1 3-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934110_4162624835RepeatRCC1 3-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393415_461624835RepeatRCC1 1-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934164_4214624835RepeatRCC1 3-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934216_4266624835RepeatRCC1 3-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934268_4318624835RepeatRCC1 3-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393462_512624835RepeatRCC1 1-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393513_568624835RepeatRCC1 1-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393569_620624835RepeatRCC1 1-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393623_674624835RepeatRCC1 1-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393675_726624835RepeatRCC1 1-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393728_778624835RepeatRCC1 1-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932702_2749624835Zinc fingerZZ-type
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204+0159_2940494TransmembraneHelical


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FusionGeneSequence for HERC2_TMEM145


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000301204_chr19_42818424_+_516aa
MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPPRKGLGVPDKILFPLGLRPTGLPFPLPXGQV
LSEHPPLFXXPIPVASRVQGRGQGLPGQGVSDPAGEQPGHQPHHPVCLVRLSGGIRGGNPLPELLQWPQLPLRXWIAAGVXDGPHQWQVL
LDTTLLRXXVWDPGDRCDLPPHLHPHLLPLLLLWIFAERSSVAPHNLXNVHGRSRSRGPEPPIFLHLLGSICHRWHWQRECEDLGQAALL
LQLPHLPADAYPPGEGIHGDTGPHQPRGLREVVCLHDPVHAHPCGAAHLRGGILXPRPGTVHVXVAGRLRAHWTAGGGLRVVLLCCACLT
ATLSXEAAFLCALLCCLYPLVLCGSCHGPDCQFRHPQVGPGEDCQWHPAGDPLVRPWRVSDHDPPISGQQELPVPRAHVADRFSRSPWTR

>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000598766_chr19_42818424_+_511aa
MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPPRKGLGVPDKILFPLGLRPTGLPFPLPXAPG
PQHLWSAGQVLSEHPPLFXXPIPVASRVQGRGQGLPGQGVSDPAGEQPGHQPHHPVCLVRLSGGIRGGNPLPELLQWPQLPLSAXTVVVY
CAQQVWGXWIAAGVXDGPHQWQVLLDTTLLRXXVWDPGDRCDLPPHLHPHLLPLLLLWIFAERSSVAPHNLXNVHGRSRSRGPEPPIFLH
LLGSICHRWHWQRECEDLGQAALLLQLPHLPADAYPPGEGIHGDTGPHQPRGLREVVCLHDPVHAHPCGAAHLRGGILXPRPGTVHVXVA
GRLRAHWTAGGGLRVVLLCCACLTATLSXEAAFLCALLCCLYPLVLCGSCHGPDCQFRHPQVGPGEDCQWHPAGDPLVRPWRVSDSSISL

>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000601020_chr19_42818424_+_90aa
MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPPRKGXWIAAGVXDGPHQWQVLLDTTLLRXXV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000301204_chr19_42818424_+_1549nt
ATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACAGCTTGCATTCACAAGAGAT
GGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCAGAACGGAGAGCTCCCTCCT
AGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCCGCTACCCTGAGGCCAAGTG
CTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGCAGGGGACAAGGACTGCCTGGCCAAGGAGTC
AGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGGCTGTCAGGTGGTATCAGAGGAGGGAACCCG
CTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGGTGATGGATTGCAGCTGGAGTATGAGATGGTCCTCACCAATGGCAAGTCCTT
CTGGACACGACACTTCTCCGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCATCCTCATCTTCTTCCTCTC
TTGTTACTTTGGATATTTGCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAGCAGGAGTAGAGGTCCTGAG
CCTCCTATTTTTCTGCATCTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCTTGGCCAAGCTGCTCTTCTC
CTCCAGCTTCCTCATCTTCCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCATCAGCCACGCGGGCTCCGT
GAAGTTGTCTGTCTACATGACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCTTTGACCCAGGCCAGGTACT
GTACACGTATGAGTCGCCGGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCTATGCTGTGCTTGTCTCACT
GCGACACTTTCCTGAGAAGCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGGTTCCTGTCATGGCCCTGAT
TGCCAATTTCGGCATCCCCAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGTACGCCCATGGCGTGTTTCT
GATCATGACCCGCCCATCAGCGGCCAACAAGAACTTCCCGTACCACGTGCGCACGTCGCAGATCGCTTCAGCCGGAGTCCCTGGACCCGG
AGGGAGCCAATCCGCTGACAAGGCCTTCCCGCAGCACGTCTATGGGAACGTGACGTTTATCAGCGACTCGGTGCCCAACTTCACGGAGCT
CTTCTCCATCCCCCCGCCCGCCACCTCCCCCCTGCCCCGAGCGGCGCCGGATTCTGGGCTCCCGCTGTTCCGTGACCTCCGGCCCCCTGG

>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000598766_chr19_42818424_+_1534nt
ATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACAGCTTGCATTCACAAGAGAT
GGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCAGAACGGAGAGCTCCCTCCT
AGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCCGCTACCCTGAGCTCCCGGT
CCCCAACATCTCTGGTCTGCAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGC
AGGGGACAAGGACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGG
CTGTCAGGTGGTATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGTGCGTGAACGGTGGTGGTATAT
TGCGCTCAGCAAGTGTGGGGGTGATGGATTGCAGCTGGAGTATGAGATGGTCCTCACCAATGGCAAGTCCTTCTGGACACGACACTTCTC
CGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCATCCTCATCTTCTTCCTCTCTTGTTACTTTGGATATTT
GCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAGCAGGAGTAGAGGTCCTGAGCCTCCTATTTTTCTGCAT
CTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCTTGGCCAAGCTGCTCTTCTCCTCCAGCTTCCTCATCTT
CCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCATCAGCCACGCGGGCTCCGTGAAGTTGTCTGTCTACAT
GACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCTTTGACCCAGGCCAGGTACTGTACACGTATGAGTCGCC
GGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCTATGCTGTGCTTGTCTCACTGCGACACTTTCCTGAGAA
GCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGGTTCCTGTCATGGCCCTGATTGCCAATTTCGGCATCCC
CAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGTACGCCCATGGCGTGTTTCTGATTCTTCCATTTCTCTT
TTGTATCCCCACTGCCTTCCCCACCCTCCTTGATCTCTCCACTCTCCCCCTGCCCCTGCCCAAATTCTGCCATCACAGGCCACTGTTCAG
GAAGAAGCATCTGGGGTGGCACAGGGTGAAGCTTTTGGGCTCCTGGGTCGGCAACAGGAGGGTACAGCACCACATCTTTTTTTTTTTTTT

>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000601020_chr19_42818424_+_272nt
ATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACAGCTTGCATTCACAAGAGAT
GGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCAGAACGGAGAGCTCCCTCCT
AGAAAAGGGTGATGGATTGCAGCTGGAGTATGAGATGGTCCTCACCAATGGCAAGTCCTTCTGGACACGACACTTCTCCGCTGATGAGTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000301204_chr19_42818424_+_1903nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGCAGGGGACAAGG
ACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGGCTGTCAGGTGG
TATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGGTGATGGATTGCAGCTGGAGTATGAGATGGTCC
TCACCAATGGCAAGTCCTTCTGGACACGACACTTCTCCGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCA
TCCTCATCTTCTTCCTCTCTTGTTACTTTGGATATTTGCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAG
CAGGAGTAGAGGTCCTGAGCCTCCTATTTTTCTGCATCTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCT
TGGCCAAGCTGCTCTTCTCCTCCAGCTTCCTCATCTTCCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCA
TCAGCCACGCGGGCTCCGTGAAGTTGTCTGTCTACATGACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCT
TTGACCCAGGCCAGGTACTGTACACGTATGAGTCGCCGGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCT
ATGCTGTGCTTGTCTCACTGCGACACTTTCCTGAGAAGCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGG
TTCCTGTCATGGCCCTGATTGCCAATTTCGGCATCCCCAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGT
ACGCCCATGGCGTGTTTCTGATCATGACCCGCCCATCAGCGGCCAACAAGAACTTCCCGTACCACGTGCGCACGTCGCAGATCGCTTCAG
CCGGAGTCCCTGGACCCGGAGGGAGCCAATCCGCTGACAAGGCCTTCCCGCAGCACGTCTATGGGAACGTGACGTTTATCAGCGACTCGG
TGCCCAACTTCACGGAGCTCTTCTCCATCCCCCCGCCCGCCACCTCCCCCCTGCCCCGAGCGGCGCCGGATTCTGGGCTCCCGCTGTTCC
GTGACCTCCGGCCCCCTGGCCCCCTTCGAGACCTCTGACCCCGCTGGACTCCGGAACACCCGTGGTGACCGCCGGGACCCTGCCTGTGAC
TCTCCAGGACTCTGCGACCCCGGGATGGATATTGCGATGCTGGTCTCGACCCTGAAACCCTCCCTCGGATCTGTGACCTCGGACCCGTAC
TCCATCTGCCGCATCTCCATTCCGGGGGCCTTCCCTCGGGTCCCTGGCAGAAAGACATTTTACCCCTTCTTGCCAAAATAAAAAAGGATT

>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000598766_chr19_42818424_+_2187nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGCTCCCGGTCCCCAACATCTCTGGTCTGCAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGT
GGCCAGCCGTGTACAAGGCAGGGGACAAGGACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCA
CCCAGTATGCCTGGTCCGGCTGTCAGGTGGTATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGTGC
GTGAACGGTGGTGGTATATTGCGCTCAGCAAGTGTGGGGGTGATGGATTGCAGCTGGAGTATGAGATGGTCCTCACCAATGGCAAGTCCT
TCTGGACACGACACTTCTCCGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCATCCTCATCTTCTTCCTCT
CTTGTTACTTTGGATATTTGCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAGCAGGAGTAGAGGTCCTGA
GCCTCCTATTTTTCTGCATCTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCTTGGCCAAGCTGCTCTTCT
CCTCCAGCTTCCTCATCTTCCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCATCAGCCACGCGGGCTCCG
TGAAGTTGTCTGTCTACATGACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCTTTGACCCAGGCCAGGTAC
TGTACACGTATGAGTCGCCGGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCTATGCTGTGCTTGTCTCAC
TGCGACACTTTCCTGAGAAGCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGGTTCCTGTCATGGCCCTGA
TTGCCAATTTCGGCATCCCCAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGTACGCCCATGGCGTGTTTC
TGATTCTTCCATTTCTCTTTTGTATCCCCACTGCCTTCCCCACCCTCCTTGATCTCTCCACTCTCCCCCTGCCCCTGCCCAAATTCTGCC
ATCACAGGCCACTGTTCAGGAAGAAGCATCTGGGGTGGCACAGGGTGAAGCTTTTGGGCTCCTGGGTCGGCAACAGGAGGGTACAGCACC
ACATCTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACTAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAACCTCCAC
CTCCCAGGTTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGGAGCACGCCACCATGCCCGGTTAAGTGGTTTTTTTTTTTTTTTT
TTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGAGGTGCGATCTCGGCTCACTGCAACTTCTGCCTCCCAAGTTCATGC
CATTCCCCTGCCTCAGCCTCCCTAGTAGCTGGGACTACAGGCGCCCACCACCACGCCTAGCAAATTTTTTTTGTATTTTTAGTAGAGACG
GGGTTTCACTATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGT
GAGCCACTGCGCCTGGCCCCCACCACGTCTATTCTTTGCCCTGGTTCACATCCTATCTGACATTCTTGGTGACAGTTCTAATATTCATTA

>In-frame_HERC2_ENST00000261609_chr15_28544548_-_TMEM145_ENST00000601020_chr19_42818424_+_648nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGCAGGGGACAAGG
ACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGGCTGTCAGGTGG
TATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGTGCGTGAACGGTGGTGGTATATTGCGCTCAGCA


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FusionGenePPI for HERC2_TMEM145


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HERC2DBNL, MPDU1, ZRANB1, USP19, USP20, USP16, USP42, PMS1, CDC42, BRCA1, RNF8, MDC1, UBE2N, RNF168, SIRT3, CALM1, PIAS4, UBC, UBE3A, SIRT7, ATRIP, CLSPN, CCP110, NEURL4, SSSCA1, ECI2, RPA3, RPA1, CEP170, SRGAP2, TBK1, TANK, SEC23IP, KTN1, HERC2, STK33, UBE2D3, XPA, CDK8, MAPK6, TP53, FBXL5, CEP250, PSMD14, CCDC8, EIF3I, UCHL5, DNAJA1, BIRC6, GET4, FAM63A, RIPK1, RNF115, DNAJB5, HOXD13, CCDC88A, HERC3, HOOK1, RABEP1, FAM83H, RYBP, CCDC151, SPZ1, RNF166, ETFA, INPP4A, MUS81, CCDC22, AGAP3, ARHGEF5, EME1, HERC1, KIF20A, HPS3, HPS5, TUBA1C, KMT2D, RAB34, ZDHHC17, EPHA7, ZBTB5, NUP153, GTF3C2, MLF2, ARNT, RNGTT, CCDC186, TRMT2A, IGHV1OR15-9, FDFT1, ASAH1, MAVS, CST4, SPTLC2, ZG16B, NCCRP1, HLA-A, HM13, VDAC2, KRT80, CSTA, BLMH, PSMB4, PSMD1, PSMD11, PELP1, TEX10, ITPR2, PTPN1, GNA13, FNDC3A, EPCAM, NCOA4, LACTB, NEK11, HLA-E, LMNB2, FTH1, MLEC, LMNA, URI1, PPM1B, COPB2, OBSL1, COPG2, COPG1, COPA, BICD1, BICD2, ZFYVE9, SNAPIN, SLC30A9, PCM1, FHOD3, AKAP9, NIN, NUDCD2, SLC27A4, ASPM, PEX1, ETAA1, PRR14L, RIC8A, PHKG2, SCO2, WDR62, GNAS, PHKB, PHKA2, ENPP1, EIF3H, MIOS, EIF3A, OCRL, MTMR3, EIF3E, PHKA1, WDR59, EIF3B, EIF3L, EIF3M, EIF4G1, EIF3G, EIF3C, EIF3K, EIF3D, CTNNA1, CTNNB1, WDR24, GCC2, LCP1, SELO, SPECC1L, SNX6, ARAF, TUBB3, RAF1, ABR, RER1, TXLNG, CBX2, SENP1, ATP4A, EXD2, SSX2IP, CDC25C, MYO9B, CXorf57, SOGA1, FLII, FASTKD5, CPT1A, AURKB, WDR92, COPZ1, FTL, COPE, PRKAR2B, CEP290, CEP162, CEP104, MARK2, KIFC3, PSMC1, SMC3, GTSE1, CHMP4B, NPRL2, LRRK2, RAB5A, RAB5B, ATOH1, SIRT1, STK11, UBE2D1, EGFR, DUSP26, MAP7D2, CCDC136, PRIMPOL, ZNF286A, APBB1, FAM98A, LGALS3BP, ARID3A, SOST, HSDL2, FARP2, CCDC65, KNOP1, APBA2, ERG, TRIM25TMEM145


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HERC2_TMEM145


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HERC2_TMEM145


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHERC2C0009324Ulcerative Colitis1CTD_human
HgeneHERC2C0036341Schizophrenia1PSYGENET
HgeneHERC2C0264423Asthma, Occupational1CTD_human
HgeneHERC2C3809753MENTAL RETARDATION, AUTOSOMAL RECESSIVE 381ORPHANET;UNIPROT