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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16102

FusionGeneSummary for HERC2P9_TRPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC2P9_TRPM1
Fusion gene ID: 16102
HgeneTgene
Gene symbol

HERC2P9

TRPM1

Gene ID

440248

4308

Gene namehect domain and RLD 2 pseudogene 9transient receptor potential cation channel subfamily M member 1
Synonyms-CSNB1C|LTRPC1|MLSN1
Cytomap

15q13.1

15q13.3

Type of genepseudoprotein-coding
Description-transient receptor potential cation channel subfamily M member 1long transient receptor potential channel 1melastatin-1transient receptor potential melastatin family
Modification date2018051920180519
UniProtAcc

Q7Z4N2

Ensembl transtripts involved in fusion geneENST00000528584, ENST00000397795, 
ENST00000256552, ENST00000542188, 
ENST00000559179, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 4 X 4=80
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HERC2P9 [Title/Abstract] AND TRPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRPM1

GO:0060402

calcium ion transport into cytosol

23452348


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-K4-A4AB-01BHERC2P9chr15

28835406

+TRPM1chr15

31369187

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000528584ENST00000397795HERC2P9chr15

28835406

+TRPM1chr15

31369187

-
intron-5UTRENST00000528584ENST00000256552HERC2P9chr15

28835406

+TRPM1chr15

31369187

-
intron-5UTRENST00000528584ENST00000542188HERC2P9chr15

28835406

+TRPM1chr15

31369187

-
intron-5UTRENST00000528584ENST00000559179HERC2P9chr15

28835406

+TRPM1chr15

31369187

-

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FusionProtFeatures for HERC2P9_TRPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC2P9

TRPM1

Q7Z4N2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HERC2P9_TRPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HERC2P9_TRPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HERC2P9APPTRPM1TRPM1, BCOR, NANOG, POU5F1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HERC2P9_TRPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HERC2P9_TRPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRPM1C2750747NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C3UNIPROT
TgeneTRPM1C0036341Schizophrenia1PSYGENET