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Fusion gene ID: 16102 |
FusionGeneSummary for HERC2P9_TRPM1 |
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Fusion gene information | Fusion gene name: HERC2P9_TRPM1 | Fusion gene ID: 16102 | Hgene | Tgene | Gene symbol | HERC2P9 | TRPM1 | Gene ID | 440248 | 4308 |
Gene name | hect domain and RLD 2 pseudogene 9 | transient receptor potential cation channel subfamily M member 1 | |
Synonyms | - | CSNB1C|LTRPC1|MLSN1 | |
Cytomap | 15q13.1 | 15q13.3 | |
Type of gene | pseudo | protein-coding | |
Description | - | transient receptor potential cation channel subfamily M member 1long transient receptor potential channel 1melastatin-1transient receptor potential melastatin family | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q7Z4N2 | ||
Ensembl transtripts involved in fusion gene | ENST00000528584, | ENST00000397795, ENST00000256552, ENST00000542188, ENST00000559179, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HERC2P9 [Title/Abstract] AND TRPM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TRPM1 | GO:0060402 | calcium ion transport into cytosol | 23452348 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-K4-A4AB-01B | HERC2P9 | chr15 | 28835406 | + | TRPM1 | chr15 | 31369187 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000528584 | ENST00000397795 | HERC2P9 | chr15 | 28835406 | + | TRPM1 | chr15 | 31369187 | - |
intron-5UTR | ENST00000528584 | ENST00000256552 | HERC2P9 | chr15 | 28835406 | + | TRPM1 | chr15 | 31369187 | - |
intron-5UTR | ENST00000528584 | ENST00000542188 | HERC2P9 | chr15 | 28835406 | + | TRPM1 | chr15 | 31369187 | - |
intron-5UTR | ENST00000528584 | ENST00000559179 | HERC2P9 | chr15 | 28835406 | + | TRPM1 | chr15 | 31369187 | - |
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FusionProtFeatures for HERC2P9_TRPM1 |
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Hgene | Tgene |
HERC2P9 | TRPM1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HERC2P9_TRPM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HERC2P9_TRPM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HERC2P9 | APP | TRPM1 | TRPM1, BCOR, NANOG, POU5F1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HERC2P9_TRPM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HERC2P9_TRPM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRPM1 | C2750747 | NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C | 3 | UNIPROT |
Tgene | TRPM1 | C0036341 | Schizophrenia | 1 | PSYGENET |