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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 16093

FusionGeneSummary for HERC1_DAPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC1_DAPK2
Fusion gene ID: 16093
HgeneTgene
Gene symbol

HERC1

DAPK2

Gene ID

8925

23604

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase family member 1death associated protein kinase 2
SynonymsMDFPMR|p532|p619DRP-1|DRP1
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC1HECT domain and RCC1-like domain-containing protein 1HECT-type E3 ubiquitin transferase HERC1guanine nucleotide exchange factor p532hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHCdeath-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoform
Modification date2018051920180526
UniProtAcc

Q15751

Q9UIK4

Ensembl transtripts involved in fusion geneENST00000443617, ENST00000261891, 
ENST00000457488, ENST00000558069, 
ENST00000558482, 
Fusion gene scores* DoF score10 X 11 X 9=9906 X 7 X 7=294
# samples 1410
** MAII scorelog2(14/990*10)=-2.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/294*10)=-1.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HERC1 [Title/Abstract] AND DAPK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDAPK2

GO:0006468

protein phosphorylation

10376525

TgeneDAPK2

GO:0035556

intracellular signal transduction

10376525


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5JC-01AHERC1chr15

63956669

-DAPK2chr15

64275953

-
TCGARVBLCATCGA-DK-A3X2-01AHERC1chr15

64126026

-DAPK2chr15

64231560

-
TCGARVBRCATCGA-D8-A1JK-01AHERC1chr15

64126026

-DAPK2chr15

64204396

-
TCGARVLIHCTCGA-NI-A8LF-01AHERC1chr15

64126026

-DAPK2chr15

64332466

-
TCGARVSTADTCGA-VQ-A8E2-01AHERC1chr15

63988323

-DAPK2chr15

64263760

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000443617ENST00000261891HERC1chr15

63956669

-DAPK2chr15

64275953

-
Frame-shitENST00000443617ENST00000457488HERC1chr15

63956669

-DAPK2chr15

64275953

-
Frame-shitENST00000443617ENST00000558069HERC1chr15

63956669

-DAPK2chr15

64275953

-
5CDS-5UTRENST00000443617ENST00000558482HERC1chr15

63956669

-DAPK2chr15

64275953

-
5UTR-3CDSENST00000443617ENST00000261891HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-3CDSENST00000443617ENST00000457488HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-3CDSENST00000443617ENST00000558069HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-5UTRENST00000443617ENST00000558482HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-3CDSENST00000443617ENST00000261891HERC1chr15

64126026

-DAPK2chr15

64204396

-
5UTR-3CDSENST00000443617ENST00000457488HERC1chr15

64126026

-DAPK2chr15

64204396

-
5UTR-intronENST00000443617ENST00000558069HERC1chr15

64126026

-DAPK2chr15

64204396

-
5UTR-intronENST00000443617ENST00000558482HERC1chr15

64126026

-DAPK2chr15

64204396

-
5UTR-3CDSENST00000443617ENST00000261891HERC1chr15

64126026

-DAPK2chr15

64332466

-
5UTR-5UTRENST00000443617ENST00000457488HERC1chr15

64126026

-DAPK2chr15

64332466

-
5UTR-5UTRENST00000443617ENST00000558069HERC1chr15

64126026

-DAPK2chr15

64332466

-
5UTR-5UTRENST00000443617ENST00000558482HERC1chr15

64126026

-DAPK2chr15

64332466

-
In-frameENST00000443617ENST00000261891HERC1chr15

63988323

-DAPK2chr15

64263760

-
In-frameENST00000443617ENST00000457488HERC1chr15

63988323

-DAPK2chr15

64263760

-
In-frameENST00000443617ENST00000558069HERC1chr15

63988323

-DAPK2chr15

64263760

-
5CDS-5UTRENST00000443617ENST00000558482HERC1chr15

63988323

-DAPK2chr15

64263760

-

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FusionProtFeatures for HERC1_DAPK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC1

Q15751

DAPK2

Q9UIK4

Involved in membrane trafficking via some guaninenucleotide exchange factor (GEF) activity and its ability to bindclathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDPfor free GTP. Binds phosphatidylinositol 4,5-bisphosphate, whichis required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directlytransfers the ubiquitin to targeted substrates.{ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955,ECO:0000269|PubMed:9233772}. Calcium/calmodulin-dependent serine/threonine kinaseinvolved in multiple cellular signaling pathways that trigger cellsurvival, apoptosis, and autophagy. Regulates both type Iapoptotic and type II autophagic cell death signals, depending onthe cellular setting. The former is caspase-dependent, while thelatter is caspase-independent and is characterized by theaccumulation of autophagic vesicles. Acts as a mediator of anoikisand a suppressor of beta-catenin-dependent anchorage-independentgrowth of malignant epithelial cells. May play a role ingranulocytic maturation (PubMed:17347302). Regulates granulocyticmotility by controlling cell spreading and polarization(PubMed:24163421). {ECO:0000269|PubMed:17347302,ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}. Isoform 2 is not regulated by calmodulin. It canphosphorylate MYL9. It can induce membrane blebbing and autophagiccell death.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27781349_137817074862Compositional biasNote=Glu-rich
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778371_42017074862RepeatNote=RCC1 1
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778421_47517074862RepeatNote=RCC1 2
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778476_52817074862RepeatNote=RCC1 3
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778529_57817074862RepeatNote=RCC1 4
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778580_63117074862RepeatNote=RCC1 5
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778633_68217074862RepeatNote=RCC1 6
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778683_73517074862RepeatNote=RCC1 7
TgeneDAPK2chr15:63988323chr15:64263760ENST00000261891-111277_344104371RegionNote=Calmodulin-binding
TgeneDAPK2chr15:63988323chr15:64263760ENST00000261891-111292_301104371RegionAutoinhibitory domain
TgeneDAPK2chr15:63988323chr15:64263760ENST00000457488-212277_344104371RegionNote=Calmodulin-binding
TgeneDAPK2chr15:63988323chr15:64263760ENST00000457488-212292_301104371RegionAutoinhibitory domain
TgeneDAPK2chr15:63988323chr15:64263760ENST00000558069-210277_344104489RegionNote=Calmodulin-binding
TgeneDAPK2chr15:63988323chr15:64263760ENST00000558069-210292_301104489RegionAutoinhibitory domain

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27782002_219317074862DomainB30.2/SPRY
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784501_484817074862DomainHECT
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783426_346517074862RepeatNote=WD 1
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783484_352217074862RepeatNote=WD 2
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783524_357217074862RepeatNote=WD 3
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783580_361917074862RepeatNote=WD 4
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783624_366317074862RepeatNote=WD 5
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783667_371317074862RepeatNote=WD 6
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783745_378417074862RepeatNote=WD 7
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783996_404417074862RepeatNote=RCC1 8
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784046_409917074862RepeatNote=RCC1 9
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784101_415117074862RepeatNote=RCC1 10
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784153_420317074862RepeatNote=RCC1 11
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784205_425617074862RepeatNote=RCC1 12
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784258_430817074862RepeatNote=RCC1 13
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784310_436017074862RepeatNote=RCC1 14
TgeneDAPK2chr15:63988323chr15:64263760ENST00000261891-11123_285104371DomainProtein kinase
TgeneDAPK2chr15:63988323chr15:64263760ENST00000457488-21223_285104371DomainProtein kinase
TgeneDAPK2chr15:63988323chr15:64263760ENST00000558069-21023_285104489DomainProtein kinase
TgeneDAPK2chr15:63988323chr15:64263760ENST00000261891-11129_37104371Nucleotide bindingATP
TgeneDAPK2chr15:63988323chr15:64263760ENST00000457488-21229_37104371Nucleotide bindingATP
TgeneDAPK2chr15:63988323chr15:64263760ENST00000558069-21029_37104489Nucleotide bindingATP


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FusionGeneSequence for HERC1_DAPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000261891_chr15_64263760_-_1973aa
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT
STGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGV
ATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLC
SLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTA
YWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEE
AEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSG
RRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQSVW
RRALRFPGPEGVTEXGGGHQLHXADPGWGELPSHKENCSLXSQARKHYVVRQEYSHSTHQADXLWSGSRNRRWSXIXEYFWDAGICCSRN
CELRAPGSGGXHVEHRRHHLHPLKWSIPFPGRHEAGNTGKYHSSELRLXXGILQPDERAGQGLYSEASGXRDPETAHNPRGSQTPLDHAG

>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000457488_chr15_64263760_-_1973aa
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT
STGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGV
ATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLC
SLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTA
YWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEE
AEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSG
RRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQSVW
RRALRFPGPEGVTEXGGGHQLHXADPGWGELPSHKENCSLXSQARKHYVVRQEYSHSTHQADXLWSGSRNRRWSXIXEYFWDAGICCSRN
CELRAPGSGGXHVEHRRHHLHPLKWSIPFPGRHEAGNTGKYHSSELRLXXGILQPDERAGQGLYSEASGXRDPETAHNPRGSQTPLDHAG

>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000558069_chr15_64263760_-_2091aa
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT
STGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGV
ATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLC
SLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTA
YWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEE
AEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSG
RRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQSVW
RRALRFPGPEGVTEXGGGHQLHXADPGWGELPSHKENCSLXSQARKHYVVRQEYSHSTHQADXLWSGSRNRRWSXIXEYFWDAGICCSRN
CELRAPGSGGXHVEHRRHHLHPLKWSIPFPGRHEAGNTGKYHSSELRLXXGILQPDERAGQGLYSEASGXRDPETAHNPRGSQTPLDHVK
RRRQSPXTAEDRAHPAEDQAPERVHSQMPLKHASQQLLCQLRAFCLCGGRRGSGRPGMPCPGGGPRYHPGRCGGPGLHLQXEGSLVPRGE
XERPAXPVPAQVXVPQGGVIEEAAARRHPGHGMXPRKHGQETGPSASPVXDSEAGALRRPAVDSGAGGQLPAGEWELXGPGLHILPGHQX


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000261891_chr15_64263760_-_5920nt
ATGGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACA
AGAGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCA
CAGTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCA
AAGATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAA
TACCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCC
CGGTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCT
GTGTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAAT
GAAAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGAC
ACTTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATG
GCTTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATG
ACCATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGC
TCCCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATT
CAGACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAG
GAGAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACG
GATGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACA
TTCGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTC
AGTTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGA
AAGGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTT
GGAAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGT
TCACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAAC
AGAGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACA
TCAACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAA
GAACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGC
AATAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATT
CAGCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGT
GTAGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCT
TTCCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTA
GCTACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAG
GTGGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAA
GGACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCC
TCCCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGC
ACTCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTT
GGAGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGT
TCACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAG
CTTTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTA
AGAGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCT
TTATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTA
CAGTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGAT
CTAGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCA
TATTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCA
CTTTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAA
GAGCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTG
GACACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGT
AAACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCA
TCATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAA
GCTGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATG
ACAGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCT
GGGGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCT
GCATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGA
CAGTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCAC
ACAAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGC
AGACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCT
CGCCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACT
TTGATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCC
CAGGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGG
ATGGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAG
TTCCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGG
AGGAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAA
CTACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAA
GCTGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAAT
TGTGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCT
GGGAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGC
CAAGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGCCGGT
GGACAACCAGCAAGCCATGGTGCGCAGGGAGTCTGTGGTCAATCTGGAGAACTTCAGGAAGCAGTATGTCCGCAGGCGGTGGAAGCTTTC
CTTCAGCATCGTGTCCCTGTGCAACCACCTCACCCGCTCGCTGATGAAGAAGGTGCACCTGAGGCCGGATGAGGACCTGAGGAACTGTGA

>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000457488_chr15_64263760_-_5920nt
ATGGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACA
AGAGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCA
CAGTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCA
AAGATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAA
TACCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCC
CGGTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCT
GTGTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAAT
GAAAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGAC
ACTTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATG
GCTTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATG
ACCATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGC
TCCCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATT
CAGACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAG
GAGAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACG
GATGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACA
TTCGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTC
AGTTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGA
AAGGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTT
GGAAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGT
TCACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAAC
AGAGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACA
TCAACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAA
GAACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGC
AATAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATT
CAGCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGT
GTAGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCT
TTCCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTA
GCTACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAG
GTGGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAA
GGACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCC
TCCCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGC
ACTCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTT
GGAGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGT
TCACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAG
CTTTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTA
AGAGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCT
TTATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTA
CAGTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGAT
CTAGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCA
TATTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCA
CTTTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAA
GAGCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTG
GACACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGT
AAACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCA
TCATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAA
GCTGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATG
ACAGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCT
GGGGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCT
GCATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGA
CAGTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCAC
ACAAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGC
AGACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCT
CGCCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACT
TTGATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCC
CAGGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGG
ATGGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAG
TTCCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGG
AGGAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAA
CTACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAA
GCTGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAAT
TGTGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCT
GGGAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGC
CAAGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGCCGGT
GGACAACCAGCAAGCCATGGTGCGCAGGGAGTCTGTGGTCAATCTGGAGAACTTCAGGAAGCAGTATGTCCGCAGGCGGTGGAAGCTTTC
CTTCAGCATCGTGTCCCTGTGCAACCACCTCACCCGCTCGCTGATGAAGAAGGTGCACCTGAGGCCGGATGAGGACCTGAGGAACTGTGA

>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000558069_chr15_64263760_-_6274nt
ATGGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACA
AGAGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCA
CAGTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCA
AAGATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAA
TACCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCC
CGGTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCT
GTGTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAAT
GAAAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGAC
ACTTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATG
GCTTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATG
ACCATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGC
TCCCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATT
CAGACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAG
GAGAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACG
GATGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACA
TTCGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTC
AGTTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGA
AAGGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTT
GGAAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGT
TCACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAAC
AGAGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACA
TCAACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAA
GAACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGC
AATAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATT
CAGCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGT
GTAGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCT
TTCCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTA
GCTACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAG
GTGGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAA
GGACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCC
TCCCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGC
ACTCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTT
GGAGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGT
TCACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAG
CTTTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTA
AGAGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCT
TTATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTA
CAGTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGAT
CTAGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCA
TATTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCA
CTTTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAA
GAGCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTG
GACACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGT
AAACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCA
TCATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAA
GCTGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATG
ACAGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCT
GGGGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCT
GCATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGA
CAGTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCAC
ACAAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGC
AGACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCT
CGCCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACT
TTGATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCC
CAGGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGG
ATGGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAG
TTCCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGG
AGGAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAA
CTACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAA
GCTGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAAT
TGTGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCT
GGGAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGC
CAAGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGTCAAA
AGGAGAAGGCAGAGCCCCTGAACAGCGGAAGACAGAGCCCACCCAGCTGAAGACCAAGCACCTGAGAGAGTACACTCTCAAATGCCACTC
AAGCATGCCTCCCAACAACTCCTATGTCAACTTCGAGCGTTTTGCCTGTGTGGTGGAAGACGTGGCTCGGGTCGACCTGGGATGCCGTGC
CCTGGTGGAGGCCCACGATACCATCCAGGACGATGTGGAGGCCCTGGTCTCCATCTTCAATGAGAAGGAAGCTTGGTACCGAGAGGAGAA
TGAGAGCGCCCGGCATGACCTGTCCCAGCTCAGGTATGAGTTCCGCAAGGTGGAGTCATTGAAGAAGCTGCTGCGAGAAGACATCCAGGC
CACGGGATGTAGCCTCGGAAGCATGGCCAGGAAACTGGACCATCTGCAAGCCCAGTTTGAGATTCTGAGGCAGGAGCTCTCCGCAGACCT
GCAGTGGATTCAGGAGCTGGTGGGCAGCTTCCAGCTGGAGAGTGGGAGCTCTGAGGGCCTGGGCTCCACATTCTACCAGGACACCAGTGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000261891_chr15_64263760_-_7492nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAAGA
ACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGCAA
TAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATTCA
GCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGTGT
AGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCTTT
CCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTAGC
TACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAGGT
GGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAAGG
ACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCCTC
CCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGCAC
TCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTTGG
AGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGTTC
ACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAGCT
TTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTAAG
AGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCTTT
ATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTACA
GTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGATCT
AGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCATA
TTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCACT
TTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAAGA
GCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTGGA
CACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGTAA
ACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCATC
ATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAAGC
TGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATGAC
AGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCTGG
GGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCTGC
ATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGACA
GTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCACAC
AAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGCAG
ACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCTCG
CCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACTTT
GATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCCCA
GGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGGAT
GGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAGTT
CCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGGAG
GAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAACT
ACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAAGC
TGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAATTG
TGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCTGG
GAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGCCA
AGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGCCGGTGG
ACAACCAGCAAGCCATGGTGCGCAGGGAGTCTGTGGTCAATCTGGAGAACTTCAGGAAGCAGTATGTCCGCAGGCGGTGGAAGCTTTCCT
TCAGCATCGTGTCCCTGTGCAACCACCTCACCCGCTCGCTGATGAAGAAGGTGCACCTGAGGCCGGATGAGGACCTGAGGAACTGTGAGA
GTGACACTGAGGAGGACATCGCCAGGAGGAAAGCCCTCCACCCACGGAGGAGGAGCAGCACCTCCTAACTGGCCTGACCTGCAGTGGCCG
CCAGGGAGGTCTGGGCCCAGCGGGGCTCCCTTCTGTGCAGACTTTTGGACCCAGCTCAGCACCAGCACCCGGGCGTCCTGAGCACTTTGC
AAGAGAGATGGGCCCAAGGAATTCAGAAGAGCTTGCAGGCAAGCCAGGAGACCCTGGGAGCTGTGGCTGTCTTCTGTGGAGGAGGCTCCA
GCATTCCCAAAGCTCTTAATTCTCCATAAAATGGGCTTTCCTCTGTCTGCCATCCTCAGAGTCTGGGGTGGGAGTGTGGACTTAGGAAAA
CAATATAAAGGACATCCTCATCATCACGGGGTGAAGGTCAGACTAAGGCAGCCTTCTTCACAGGCTGAGGGGGTTCAGAACCAGCCTGGC
CAAAAATTACACCAGAGAGACAGAGTCCTCCCCATTGGGAACAGGGTGATTGAGGAAAGTGAACCTTGGGTGTGAGGGACCAATCCTGTG
ACCTCCCAGAACCATGGAAGCCAGGACGTCAGGCTGACCAACACCTCAGACCTTCTGAAGCAGCCCATTGCTGGCCCGCCATGTTGTAAT
TTTGCTCATTTTTATTAAACTTCTGGTTTACCTGATGCTTGGCTTCTTTTAGGGCTACCCCCATCTCATTTCCTTTAGCCCGTGTGCCTG
TAACTCTGAGGGGGGGCACCCAGTGGGGTGCTGAGTGGGCAGAATCTCAGAAGGTCCTCCTGAACCGTCCGCGCAGGCCTGCAGTGGGCC
TGCCTCCTCCTTGCTTCCCTAACAGGAAGGTGTCCAGTTCAAGAGAACCCACCCAGAGACTGGGAGTGGTGGCTCACGCCTATAATCCCT
GCGCTTTGGCAGTCCGAGGCAGGGGAATTGCTTGAACTCAGGAGTTGGAGACCAGCCTGGGCAACATGGCAAAACGCAGTCTGTACAAAA
AATACAAAAAATTAGCCAGGTGTAGGGGTAGGCACCTGGCATCCCAGCTACTCCAGGGGCTGAGGTGACAGCATTGCTTAAGCCCAGAAG
GTCGAGGCTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGTCTGGGTGACAGAGAGAGACCATATCCAAAAAAAAAAAAAGTTGCCAG
AGACGAGTATGCCCATGCTCCCTCTACCTCACTGCCACCACTCCTGCTGTTAGGAGCTGAGTGTGTCTCCCTAAAATTTCTATGTTGAAG
TCTTAACCCTTGGTACCACAGAATATCACTGTATTTGGAGATGGGGTCTTTAGAAAGGCACTTAAATTAAAATGAGCTCACTGATATGGG
CCCCGATGCAATATAATTGGTGTCCTTATAAGAAGGGGAGGTTAGGACACGCAGGAAAGACCACATGAAGGCCCAGGAGTGGGAGGGGGA
ATAGCCATCGACAAACTAAGGGGGCCTCAGAGGAAACCAACCCTGCTGACACCTCAATCTTAGACTCTGGCCTCAAAAATTGTAAGAAAA

>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000457488_chr15_64263760_-_6605nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAAGA
ACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGCAA
TAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATTCA
GCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGTGT
AGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCTTT
CCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTAGC
TACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAGGT
GGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAAGG
ACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCCTC
CCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGCAC
TCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTTGG
AGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGTTC
ACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAGCT
TTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTAAG
AGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCTTT
ATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTACA
GTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGATCT
AGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCATA
TTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCACT
TTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAAGA
GCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTGGA
CACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGTAA
ACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCATC
ATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAAGC
TGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATGAC
AGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCTGG
GGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCTGC
ATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGACA
GTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCACAC
AAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGCAG
ACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCTCG
CCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACTTT
GATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCCCA
GGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGGAT
GGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAGTT
CCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGGAG
GAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAACT
ACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAAGC
TGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAATTG
TGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCTGG
GAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGCCA
AGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGCCGGTGG
ACAACCAGCAAGCCATGGTGCGCAGGGAGTCTGTGGTCAATCTGGAGAACTTCAGGAAGCAGTATGTCCGCAGGCGGTGGAAGCTTTCCT
TCAGCATCGTGTCCCTGTGCAACCACCTCACCCGCTCGCTGATGAAGAAGGTGCACCTGAGGCCGGATGAGGACCTGAGGAACTGTGAGA
GTGACACTGAGGAGGACATCGCCAGGAGGAAAGCCCTCCACCCACGGAGGAGGAGCAGCACCTCCTAACTGGCCTGACCTGCAGTGGCCG
CCAGGGAGGTCTGGGCCCAGCGGGGCTCCCTTCTGTGCAGACTTTTGGACCCAGCTCAGCACCAGCACCCGGGCGTCCTGAGCACTTTGC
AAGAGAGATGGGCCCAAGGAATTCAGAAGAGCTTGCAGGCAAGCCAGGAGACCCTGGGAGCTGTGGCTGTCTTCTGTGGAGGAGGCTCCA
GCATTCCCAAAGCTCTTAATTCTCCATAAAATGGGCTTTCCTCTGTCTGCCATCCTCAGAGTCTGGGGTGGGAGTGTGGACTTAGGAAAA
CAATATAAAGGACATCCTCATCATCACGGGGTGAAGGTCAGACTAAGGCAGCCTTCTTCACAGGCTGAGGGGGTTCAGAACCAGCCTGGC
CAAAAATTACACCAGAGAGACAGAGTCCTCCCCATTGGGAACAGGGTGATTGAGGAAAGTGAACCTTGGGTGTGAGGGACCAATCCTGTG
ACCTCCCAGAACCATGGAAGCCAGGACGTCAGGCTGACCAACACCTCAGACCTTCTGAAGCAGCCCATTGCTGGCCCGCCATGTTGTAAT

>In-frame_HERC1_ENST00000443617_chr15_63988323_-_DAPK2_ENST00000558069_chr15_64263760_-_6362nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAAGA
ACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGCAA
TAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATTCA
GCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGTGT
AGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCTTT
CCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTAGC
TACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAGGT
GGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAAGG
ACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCCTC
CCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGCAC
TCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTTGG
AGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGTTC
ACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAGCT
TTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTAAG
AGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCTTT
ATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTACA
GTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGATCT
AGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCATA
TTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCACT
TTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAAGA
GCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTGGA
CACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGTAA
ACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCATC
ATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAAGC
TGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATGAC
AGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCTGG
GGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCTGC
ATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGACA
GTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCACAC
AAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGCAG
ACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCTCG
CCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACTTT
GATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCCCA
GGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGGAT
GGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAGTT
CCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGGAG
GAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAACT
ACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAAGC
TGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAATTG
TGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCTGG
GAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGCCA
AGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGTCAAAAG
GAGAAGGCAGAGCCCCTGAACAGCGGAAGACAGAGCCCACCCAGCTGAAGACCAAGCACCTGAGAGAGTACACTCTCAAATGCCACTCAA
GCATGCCTCCCAACAACTCCTATGTCAACTTCGAGCGTTTTGCCTGTGTGGTGGAAGACGTGGCTCGGGTCGACCTGGGATGCCGTGCCC
TGGTGGAGGCCCACGATACCATCCAGGACGATGTGGAGGCCCTGGTCTCCATCTTCAATGAGAAGGAAGCTTGGTACCGAGAGGAGAATG
AGAGCGCCCGGCATGACCTGTCCCAGCTCAGGTATGAGTTCCGCAAGGTGGAGTCATTGAAGAAGCTGCTGCGAGAAGACATCCAGGCCA
CGGGATGTAGCCTCGGAAGCATGGCCAGGAAACTGGACCATCTGCAAGCCCAGTTTGAGATTCTGAGGCAGGAGCTCTCCGCAGACCTGC
AGTGGATTCAGGAGCTGGTGGGCAGCTTCCAGCTGGAGAGTGGGAGCTCTGAGGGCCTGGGCTCCACATTCTACCAGGACACCAGTGAAT


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FusionGenePPI for HERC1_DAPK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HERC1DFFA, PKM, EP300, ARF1, TSC2, CLTC, NOS2, SOX9, UBE2D3, BYSL, GRIPAP1, KCMF1, MYL12A, BAK1, BRCA1, MORC1, RSPH10B2, MLF1, ECHS1, RAPSN, DNM3, USP18, TFDP3, ARHGAP29, TTLL1, UNK, HERC2, HERC1, UBE2S, EGFR, SSH3, IFIT1B, WDFY3, TIGD6, CCDC65, GCNT3, TRPC4AP, CSNK1A1, NEUROG3, C1orf87, RAPGEF5, ZBBX, SMOX, TPTE2, ZNF610, FMO5, ZNF223, ZNF571, VPS36, ZNF555, RABGEF1, ZNF563, UBCDAPK2DAPK2, APP, FAM9B, LLGL2, RACGAP1, TUBGCP5, KLC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HERC1_DAPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HERC1_DAPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource