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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16000

FusionGeneSummary for HDLBP_SPON2

check button Fusion gene summary
Fusion gene informationFusion gene name: HDLBP_SPON2
Fusion gene ID: 16000
HgeneTgene
Gene symbol

HDLBP

SPON2

Gene ID

3069

10417

Gene namehigh density lipoprotein binding proteinspondin 2
SynonymsHBP|PRO2900|VGLDIL-1|DIL1|M-SPONDIN|MINDIN
Cytomap

2q37.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionvigilinHDL-binding proteinspondin-2differentially expressed in cancerous and non-cancerous lung cells 1spondin 2, extracellular matrix protein
Modification date2018052220180519
UniProtAcc

Q00341

Q9BUD6

Ensembl transtripts involved in fusion geneENST00000391976, ENST00000310931, 
ENST00000391975, ENST00000427183, 
ENST00000476807, 
ENST00000290902, 
ENST00000431380, ENST00000400762, 
Fusion gene scores* DoF score21 X 18 X 6=22682 X 2 X 2=8
# samples 232
** MAII scorelog2(23/2268*10)=-3.30171487399785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: HDLBP [Title/Abstract] AND SPON2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7077-01AHDLBPchr2

242168877

-SPON2chr4

1198876

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000391976ENST00000290902HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000391976ENST00000431380HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-5UTRENST00000391976ENST00000400762HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000310931ENST00000290902HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000310931ENST00000431380HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-5UTRENST00000310931ENST00000400762HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000391975ENST00000290902HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000391975ENST00000431380HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-5UTRENST00000391975ENST00000400762HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000427183ENST00000290902HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000427183ENST00000431380HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-5UTRENST00000427183ENST00000400762HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000476807ENST00000290902HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-intronENST00000476807ENST00000431380HDLBPchr2

242168877

-SPON2chr4

1198876

-
intron-5UTRENST00000476807ENST00000400762HDLBPchr2

242168877

-SPON2chr4

1198876

-

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FusionProtFeatures for HDLBP_SPON2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDLBP

Q00341

SPON2

Q9BUD6

Appears to play a role in cell sterol metabolism. It mayfunction to protect cells from over-accumulation of cholesterol. Cell adhesion protein that promotes adhesion andoutgrowth of hippocampal embryonic neurons. Binds directly tobacteria and their components and functions as an opsonin formacrophage phagocytosis of bacteria. Essential in the initiationof the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (Bysimilarity). Binds bacterial lipopolysaccharide (LPS).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HDLBP_SPON2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDLBP_SPON2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HDLBPAKTIP, MAGEA6, XPOT, XRCC5, PRKDC, ADAR, DHX9, SOS1, SUV39H1, CBX5, ARRB1, SIRT7, CDK2, COPS5, PSMD12, VPS35, S100A11, VPS29, UPF1, VPS26A, VPS36, UBA6, VPS25, TTC4, TYRO3, UBE2A, PLAUR, TOPBP1, TTK, ATP6V1B2, S100A10, ZW10, UBE4B, ZNF598, VCP, CSNK2A1, SMAD4, FAM46A, DYNLL1, EIF2A, FAU, KCMF1, IKBKG, WWOX, LGR4, OBSL1, CCDC8, ESR1, SERPINB5, BPGM, TMEM171, PTCRA, ZCCHC7, SERPINB3, ACTL6A, CYP1A1, HSPB1, CLUH, DDX43, GLMN, SMS, SAC3D1, NTRK1, SCARNA22, ERBB2, KIF11, MLH1, YBX1, SNW1, CDC5L, CDH1, STYX, WDR59, SERPINB2, CCDC102B, GTF2E2, HDHD2, SNRNP27, FGB, HSPA8, IL20RA, USP47, SYNCRIP, DLD, PDHA1, SDHASPON2KRT31


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDLBP_SPON2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HDLBP_SPON2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDLBPC0004352Autistic Disorder1CTD_human
HgeneHDLBPC2931817Chromosome 2q37 deletion syndrome1CTD_human
TgeneSPON2C0033578Prostatic Neoplasms1CTD_human