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Fusion gene ID: 15997 |
FusionGeneSummary for HDLBP_RPS14 |
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Fusion gene information | Fusion gene name: HDLBP_RPS14 | Fusion gene ID: 15997 | Hgene | Tgene | Gene symbol | HDLBP | RPS14 | Gene ID | 3069 | 6208 |
Gene name | high density lipoprotein binding protein | ribosomal protein S14 | |
Synonyms | HBP|PRO2900|VGL | EMTB|S14 | |
Cytomap | 2q37.3 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | vigilinHDL-binding protein | 40S ribosomal protein S14emetine resistancesmall ribosomal subunit protein uS11 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q00341 | P62263 | |
Ensembl transtripts involved in fusion gene | ENST00000391976, ENST00000310931, ENST00000391975, ENST00000427183, ENST00000476807, | ENST00000401695, ENST00000407193, ENST00000312037, | |
Fusion gene scores | * DoF score | 21 X 18 X 6=2268 | 3 X 3 X 1=9 |
# samples | 23 | 3 | |
** MAII score | log2(23/2268*10)=-3.30171487399785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: HDLBP [Title/Abstract] AND RPS14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RPS14 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 7867928 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA450315 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000391976 | ENST00000401695 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000391976 | ENST00000407193 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000391976 | ENST00000312037 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000310931 | ENST00000401695 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000310931 | ENST00000407193 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000310931 | ENST00000312037 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000391975 | ENST00000401695 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000391975 | ENST00000407193 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000391975 | ENST00000312037 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000427183 | ENST00000401695 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000427183 | ENST00000407193 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000427183 | ENST00000312037 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000476807 | ENST00000401695 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000476807 | ENST00000407193 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
intron-3CDS | ENST00000476807 | ENST00000312037 | HDLBP | chr2 | 242176108 | - | RPS14 | chr5 | 149823912 | - |
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FusionProtFeatures for HDLBP_RPS14 |
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Hgene | Tgene |
HDLBP | RPS14 |
Appears to play a role in cell sterol metabolism. It mayfunction to protect cells from over-accumulation of cholesterol. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HDLBP_RPS14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HDLBP_RPS14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HDLBP_RPS14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HDLBP_RPS14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HDLBP | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | HDLBP | C2931817 | Chromosome 2q37 deletion syndrome | 1 | CTD_human |
Tgene | RPS14 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | RPS14 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | RPS14 | C0242184 | Hypoxia | 1 | CTD_human |