FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15954

FusionGeneSummary for HDAC7_CHUK

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC7_CHUK
Fusion gene ID: 15954
HgeneTgene
Gene symbol

HDAC7

CHUK

Gene ID

51564

1147

Gene namehistone deacetylase 7conserved helix-loop-helix ubiquitous kinase
SynonymsHD7|HD7A|HDAC7AIKBKA|IKK-alpha|IKK1|IKKA|NFKBIKA|TCF16
Cytomap

12q13.11

10q24.31

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 7histone deacetylase 7Ainhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase 1I-kappa-B kinase-alphaIKK-a kinaseIkB kinase alpha subunitNuclear factor NFkappaB inhibitor kinase alphaTCF-16transcription factor 16
Modification date2018052220180523
UniProtAcc

Q8WUI4

O15111

Ensembl transtripts involved in fusion geneENST00000080059, ENST00000354334, 
ENST00000552960, ENST00000380610, 
ENST00000427332, ENST00000488927, 
ENST00000370397, ENST00000590930, 
Fusion gene scores* DoF score9 X 6 X 6=3241 X 1 X 1=1
# samples 101
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: HDAC7 [Title/Abstract] AND CHUK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC7

GO:0032703

negative regulation of interleukin-2 production

17360565

TgeneCHUK

GO:0006468

protein phosphorylation

20434986

TgeneCHUK

GO:0045944

positive regulation of transcription by RNA polymerase II

23091055

TgeneCHUK

GO:0071356

cellular response to tumor necrosis factor

23091055


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA482203HDAC7chr12

48213550

-CHUKchr10

101969547

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000080059ENST00000370397HDAC7chr12

48213550

-CHUKchr10

101969547

-
5CDS-intronENST00000080059ENST00000590930HDAC7chr12

48213550

-CHUKchr10

101969547

-
In-frameENST00000354334ENST00000370397HDAC7chr12

48213550

-CHUKchr10

101969547

-
5CDS-intronENST00000354334ENST00000590930HDAC7chr12

48213550

-CHUKchr10

101969547

-
In-frameENST00000552960ENST00000370397HDAC7chr12

48213550

-CHUKchr10

101969547

-
5CDS-intronENST00000552960ENST00000590930HDAC7chr12

48213550

-CHUKchr10

101969547

-
intron-3CDSENST00000380610ENST00000370397HDAC7chr12

48213550

-CHUKchr10

101969547

-
intron-intronENST00000380610ENST00000590930HDAC7chr12

48213550

-CHUKchr10

101969547

-
intron-3CDSENST00000427332ENST00000370397HDAC7chr12

48213550

-CHUKchr10

101969547

-
intron-intronENST00000427332ENST00000590930HDAC7chr12

48213550

-CHUKchr10

101969547

-
intron-3CDSENST00000488927ENST00000370397HDAC7chr12

48213550

-CHUKchr10

101969547

-
intron-intronENST00000488927ENST00000590930HDAC7chr12

48213550

-CHUKchr10

101969547

-

Top

FusionProtFeatures for HDAC7_CHUK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC7

Q8WUI4

CHUK

O15111

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimulisuch as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. Acts as part of the canonicalIKK complex in the conventional pathway of NF-kappa-B activationand phosphorylates inhibitors of NF-kappa-B on serine residues.These modifications allow polyubiquitination of the inhibitors andsubsequent degradation by the proteasome. In turn, free NF-kappa-Bis translocated into the nucleus and activates the transcriptionof hundreds of genes involved in immune response, growth control,or protection against apoptosis. Negatively regulates the pathwayby phosphorylating the scaffold protein TAXBP1 and thus promotingthe assembly of the A20/TNFAIP3 ubiquitin-editing complex(composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH andRNF11). Therefore, CHUK plays a key role in the negative feedbackof NF-kappa-B canonical signaling to limit inflammatory geneactivation. As part of the non-canonical pathway of NF-kappa-Bactivation, the MAP3K14-activated CHUK/IKKA homodimerphosphorylates NFKB2/p100 associated with RelB, inducing itsproteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genesencoding molecules involved in B-cell survival and lymphoidorganogenesis. Participates also in the negative feedback of thenon-canonical NF-kappa-B signaling pathway by phosphorylating anddestabilizing MAP3K14/NIK. Within the nucleus, phosphorylatesCREBBP and consequently increases both its transcriptional andhistone acetyltransferase activities. Modulates chromatinaccessibility at NF-kappa-B-responsive promoters byphosphorylating histones H3 at 'Ser-10' that are subsequentlyacetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates theCREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 andmay regulate this pro-apoptotic transcription factor(PubMed:15084260). {ECO:0000269|PubMed:12789342,ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128,ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937,ECO:0000269|PubMed:21765415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHUKchr12:48213550chr10:101969547ENST00000370397-821455_476311746RegionNote=Leucine-zipper
TgeneCHUKchr12:48213550chr10:101969547ENST00000370397-821738_743311746RegionNote=NEMO-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-126197_2036992Compositional biasNote=Poly-Ser
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-126368_3736992Compositional biasNote=Poly-Pro
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-125197_2036955Compositional biasNote=Poly-Ser
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-125368_3736955Compositional biasNote=Poly-Pro
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-126197_203-53953Compositional biasNote=Poly-Ser
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-126368_373-53953Compositional biasNote=Poly-Pro
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-125197_2036975Compositional biasNote=Poly-Ser
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-125368_3736975Compositional biasNote=Poly-Pro
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-126918_9526992MotifNuclear export signal
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-125918_9526955MotifNuclear export signal
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-126918_952-53953MotifNuclear export signal
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-125918_9526975MotifNuclear export signal
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-1261_2686992RegionTranscription repression 1
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-126218_5466992RegionTranscription repression 2
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-126518_8656992RegionNote=Histone deacetylase
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-1251_2686955RegionTranscription repression 1
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-125218_5466955RegionTranscription repression 2
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-125518_8656955RegionNote=Histone deacetylase
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-1261_268-53953RegionTranscription repression 1
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-126218_546-53953RegionTranscription repression 2
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-126518_865-53953RegionNote=Histone deacetylase
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-1251_2686975RegionTranscription repression 1
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-125218_5466975RegionTranscription repression 2
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-125518_8656975RegionNote=Histone deacetylase
TgeneCHUKchr12:48213550chr10:101969547ENST00000370397-82115_302311746DomainProtein kinase
TgeneCHUKchr12:48213550chr10:101969547ENST00000370397-82121_29311746Nucleotide bindingATP


Top

FusionGeneSequence for HDAC7_CHUK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).
>In-frame_HDAC7_ENST00000080059_chr12_48213550_-_CHUK_ENST00000370397_chr10_101969547_-_2624nt
ATGCACAGCCCCGGCGCTGATAGTACACATCCTAAATATGACTTCTGCAAAGATAATTTCTTTTCTGTTACCACCTGATGAAAGTCTTCA
TTCACTACAGTCTCGTATTGAGCGTGAAACTGGAATAAATACTGGTTCTCAAGAACTTCTTTCAGAGACAGGAATTTCTCTGGATCCTCG
GAAACCAGCCTCTCAATGTGTTCTAGATGGAGTTAGAGGCTGTGATAGCTATATGGTTTATTTGTTTGATAAAAGTAAAACTGTATATGA
AGGGCCATTTGCTTCCAGAAGTTTATCTGATTGTGTAAATTATATTGTACAGGACAGCAAAATACAGCTTCCAATTATACAGCTGCGTAA
AGTGTGGGCTGAAGCAGTGCACTATGTGTCTGGACTAAAAGAAGACTATAGCAGGCTCTTTCAGGGACAAAGGGCAGCAATGTTAAGTCT
TCTTAGATATAATGCTAACTTAACAAAAATGAAGAACACTTTGATCTCAGCATCACAACAACTGAAAGCTAAATTGGAGTTTTTTCACAA
AAGCATTCAGCTTGACTTGGAGAGATACAGCGAGCAGATGACGTATGGGATATCTTCAGAAAAAATGCTAAAAGCATGGAAAGAAATGGA
AGAAAAGGCCATCCACTATGCTGAGGTTGGTGTCATTGGATACCTGGAGGATCAGATTATGTCTTTGCATGCTGAAATCATGGAGCTACA
GAAGAGCCCCTATGGAAGACGTCAGGGAGACTTGATGGAATCTCTGGAACAGCGTGCCATTGATCTATATAAGCAGTTAAAACACAGACC
TTCAGATCACTCCTACAGTGACAGCACAGAGATGGTGAAAATCATTGTGCACACTGTGCAGAGTCAGGACCGTGTGCTCAAGGAGCTGTT
TGGTCATTTGAGCAAGTTGTTGGGCTGTAAGCAGAAGATTATTGATCTACTCCCTAAGGTGGAAGTGGCCCTCAGTAATATCAAAGAAGC
TGACAATACTGTCATGTTCATGCAGGGAAAAAGGCAGAAAGAAATATGGCATCTCCTTAAAATTGCCTGTACACAGAGTTCTGCCCGGTC
CCTTGTAGGATCCAGTCTAGAAGGTGCAGTAACCCCTCAGACATCAGCATGGCTGCCCCCGACTTCAGCAGAACATGATCATTCTCTGTC
ATGTGTGGTAACTCCTCAAGATGGGGAGACTTCAGCACAAATGATAGAAGAAAATTTGAACTGCCTTGGCCATTTAAGCACTATTATTCA
TGAGGCAAATGAGGAACAGGGCAATAGTATGATGAATCTTGATTGGAGTTGGTTAACAGAATGAGTTGTCACTTGTTCACTGTCCCCAAA
CCTATGGAAGTTGTTGCTATACATGTTGGAAATGTGTTTTTCCCCCATGAAACCATTCTTCAGACATCAGTCAATGGAAGAAATGGCTAT
GAACAGAAACTACATTTCTACTATGATCAGAAGAACATGATTTTACAAGTATAACAGTTTTGAGTAATTCAAGCCTCTAAACAGACAGGA
ATTTAGAAAAAGTCAATGTACTTGTTTGAATATTTGTTTTAATACCACAGCTATTTAGAAGCATCATCACGACACATTTGCCTTCAGTCT
TGGTAAAACATTACTTATTTAACTGATTAAAAATACCTTCTATGTATTAGTGTCAACTTTTAACTTTTGGGCGTAAGACCAAATGTAGTT
TTGTATACAGAGAAGAAAACCTCAAGTAATAGGCATTTTAAGTAAAAGTCTACCTGTGTTTTTTTCTAAAAAGGCTGCTCACAAGTTCTA
TTTCTTGAAGAATAAATTCTACCTCCTTGTGTTGCACTGAACAGGTTCTCTTCCTGGCATCATAAGGAGTTGGTGTAATCATTTTAAATT
CCACTGAAAATTTAACAGTATCCCCTTCTCATCGAAGGGATTGTGTATCTGTGCTTCTAATATTAGTTGGCTTTCATAAATCATGTTGTT
GTGTGTATATGTATTTAAGATGTACATTTAATAATATCAAAGAGAAGATGCCTGTTAATTTATAATGTATTTGAAAATTACATGTTTTTT
CATTTGTAAAAATGAGTCATTTGTTTAAACAATCTTTCATGTCTTGTCATACAAATTTATAAAGGTCTGCACTCCTTTATCTGTAATTGT
AATTCCAAAATCCAAAAAGCTCTGAAAACAAGGTTTCCATAAGCTTGGTGACAAAATTCATTTGCTTGCAATCTAATCTGAACTGACCTT
GAATCTTTTTATCCCATTTAGTGTGAATATTCCTTTATTTTGCTGCTTGATGATGAGAGGGAGGGCTGCTGCCACAGACTGTGGTGAGGG
CTGGTTAATGTAGTATGGTATATGCACAAAACTACTTTTCTAAAATCTAAAATTTCATAATTCTGAAACAACTTGCCCCAAGGGTTTCAG
AGAAAGGACTGTGGACCTCTATCATCTGCTAAGTAATTTAGAAGATATTATTTGTCTTAAAAAATGTGAAATGCTTTTATATTCTAATAG
TTTTTCACTTTGTGTATTAAATGGTTTTTAAATTACTTTCTTGATCTCTATTCATTATAAAAATCAGATTATAATAAAACAGTTGAATAT

>In-frame_HDAC7_ENST00000354334_chr12_48213550_-_CHUK_ENST00000370397_chr10_101969547_-_2705nt
GGCGACTGGGGGGATGTGAGGCCGGCGCCCCAGCCCCCCGCCCCGCCATGAGCCCCCCGCTCTGAGGGCCCCGGCCCCTGGATGCACAGC
CCCGGCGCTGATAGTACACATCCTAAATATGACTTCTGCAAAGATAATTTCTTTTCTGTTACCACCTGATGAAAGTCTTCATTCACTACA
GTCTCGTATTGAGCGTGAAACTGGAATAAATACTGGTTCTCAAGAACTTCTTTCAGAGACAGGAATTTCTCTGGATCCTCGGAAACCAGC
CTCTCAATGTGTTCTAGATGGAGTTAGAGGCTGTGATAGCTATATGGTTTATTTGTTTGATAAAAGTAAAACTGTATATGAAGGGCCATT
TGCTTCCAGAAGTTTATCTGATTGTGTAAATTATATTGTACAGGACAGCAAAATACAGCTTCCAATTATACAGCTGCGTAAAGTGTGGGC
TGAAGCAGTGCACTATGTGTCTGGACTAAAAGAAGACTATAGCAGGCTCTTTCAGGGACAAAGGGCAGCAATGTTAAGTCTTCTTAGATA
TAATGCTAACTTAACAAAAATGAAGAACACTTTGATCTCAGCATCACAACAACTGAAAGCTAAATTGGAGTTTTTTCACAAAAGCATTCA
GCTTGACTTGGAGAGATACAGCGAGCAGATGACGTATGGGATATCTTCAGAAAAAATGCTAAAAGCATGGAAAGAAATGGAAGAAAAGGC
CATCCACTATGCTGAGGTTGGTGTCATTGGATACCTGGAGGATCAGATTATGTCTTTGCATGCTGAAATCATGGAGCTACAGAAGAGCCC
CTATGGAAGACGTCAGGGAGACTTGATGGAATCTCTGGAACAGCGTGCCATTGATCTATATAAGCAGTTAAAACACAGACCTTCAGATCA
CTCCTACAGTGACAGCACAGAGATGGTGAAAATCATTGTGCACACTGTGCAGAGTCAGGACCGTGTGCTCAAGGAGCTGTTTGGTCATTT
GAGCAAGTTGTTGGGCTGTAAGCAGAAGATTATTGATCTACTCCCTAAGGTGGAAGTGGCCCTCAGTAATATCAAAGAAGCTGACAATAC
TGTCATGTTCATGCAGGGAAAAAGGCAGAAAGAAATATGGCATCTCCTTAAAATTGCCTGTACACAGAGTTCTGCCCGGTCCCTTGTAGG
ATCCAGTCTAGAAGGTGCAGTAACCCCTCAGACATCAGCATGGCTGCCCCCGACTTCAGCAGAACATGATCATTCTCTGTCATGTGTGGT
AACTCCTCAAGATGGGGAGACTTCAGCACAAATGATAGAAGAAAATTTGAACTGCCTTGGCCATTTAAGCACTATTATTCATGAGGCAAA
TGAGGAACAGGGCAATAGTATGATGAATCTTGATTGGAGTTGGTTAACAGAATGAGTTGTCACTTGTTCACTGTCCCCAAACCTATGGAA
GTTGTTGCTATACATGTTGGAAATGTGTTTTTCCCCCATGAAACCATTCTTCAGACATCAGTCAATGGAAGAAATGGCTATGAACAGAAA
CTACATTTCTACTATGATCAGAAGAACATGATTTTACAAGTATAACAGTTTTGAGTAATTCAAGCCTCTAAACAGACAGGAATTTAGAAA
AAGTCAATGTACTTGTTTGAATATTTGTTTTAATACCACAGCTATTTAGAAGCATCATCACGACACATTTGCCTTCAGTCTTGGTAAAAC
ATTACTTATTTAACTGATTAAAAATACCTTCTATGTATTAGTGTCAACTTTTAACTTTTGGGCGTAAGACCAAATGTAGTTTTGTATACA
GAGAAGAAAACCTCAAGTAATAGGCATTTTAAGTAAAAGTCTACCTGTGTTTTTTTCTAAAAAGGCTGCTCACAAGTTCTATTTCTTGAA
GAATAAATTCTACCTCCTTGTGTTGCACTGAACAGGTTCTCTTCCTGGCATCATAAGGAGTTGGTGTAATCATTTTAAATTCCACTGAAA
ATTTAACAGTATCCCCTTCTCATCGAAGGGATTGTGTATCTGTGCTTCTAATATTAGTTGGCTTTCATAAATCATGTTGTTGTGTGTATA
TGTATTTAAGATGTACATTTAATAATATCAAAGAGAAGATGCCTGTTAATTTATAATGTATTTGAAAATTACATGTTTTTTCATTTGTAA
AAATGAGTCATTTGTTTAAACAATCTTTCATGTCTTGTCATACAAATTTATAAAGGTCTGCACTCCTTTATCTGTAATTGTAATTCCAAA
ATCCAAAAAGCTCTGAAAACAAGGTTTCCATAAGCTTGGTGACAAAATTCATTTGCTTGCAATCTAATCTGAACTGACCTTGAATCTTTT
TATCCCATTTAGTGTGAATATTCCTTTATTTTGCTGCTTGATGATGAGAGGGAGGGCTGCTGCCACAGACTGTGGTGAGGGCTGGTTAAT
GTAGTATGGTATATGCACAAAACTACTTTTCTAAAATCTAAAATTTCATAATTCTGAAACAACTTGCCCCAAGGGTTTCAGAGAAAGGAC
TGTGGACCTCTATCATCTGCTAAGTAATTTAGAAGATATTATTTGTCTTAAAAAATGTGAAATGCTTTTATATTCTAATAGTTTTTCACT
TTGTGTATTAAATGGTTTTTAAATTACTTTCTTGATCTCTATTCATTATAAAAATCAGATTATAATAAAACAGTTGAATATGGCTTAGGA

>In-frame_HDAC7_ENST00000552960_chr12_48213550_-_CHUK_ENST00000370397_chr10_101969547_-_2725nt
ACAGTCGCTCTGCAGCCTCCGGCGACTGGGGGGATGTGAGGCCGGCGCCCCAGCCCCCCGCCCCGCCATGAGCCCCCCGCTCTGAGGGCC
CCGGCCCCTGGATGCACAGCCCCGGCGCTGATAGTACACATCCTAAATATGACTTCTGCAAAGATAATTTCTTTTCTGTTACCACCTGAT
GAAAGTCTTCATTCACTACAGTCTCGTATTGAGCGTGAAACTGGAATAAATACTGGTTCTCAAGAACTTCTTTCAGAGACAGGAATTTCT
CTGGATCCTCGGAAACCAGCCTCTCAATGTGTTCTAGATGGAGTTAGAGGCTGTGATAGCTATATGGTTTATTTGTTTGATAAAAGTAAA
ACTGTATATGAAGGGCCATTTGCTTCCAGAAGTTTATCTGATTGTGTAAATTATATTGTACAGGACAGCAAAATACAGCTTCCAATTATA
CAGCTGCGTAAAGTGTGGGCTGAAGCAGTGCACTATGTGTCTGGACTAAAAGAAGACTATAGCAGGCTCTTTCAGGGACAAAGGGCAGCA
ATGTTAAGTCTTCTTAGATATAATGCTAACTTAACAAAAATGAAGAACACTTTGATCTCAGCATCACAACAACTGAAAGCTAAATTGGAG
TTTTTTCACAAAAGCATTCAGCTTGACTTGGAGAGATACAGCGAGCAGATGACGTATGGGATATCTTCAGAAAAAATGCTAAAAGCATGG
AAAGAAATGGAAGAAAAGGCCATCCACTATGCTGAGGTTGGTGTCATTGGATACCTGGAGGATCAGATTATGTCTTTGCATGCTGAAATC
ATGGAGCTACAGAAGAGCCCCTATGGAAGACGTCAGGGAGACTTGATGGAATCTCTGGAACAGCGTGCCATTGATCTATATAAGCAGTTA
AAACACAGACCTTCAGATCACTCCTACAGTGACAGCACAGAGATGGTGAAAATCATTGTGCACACTGTGCAGAGTCAGGACCGTGTGCTC
AAGGAGCTGTTTGGTCATTTGAGCAAGTTGTTGGGCTGTAAGCAGAAGATTATTGATCTACTCCCTAAGGTGGAAGTGGCCCTCAGTAAT
ATCAAAGAAGCTGACAATACTGTCATGTTCATGCAGGGAAAAAGGCAGAAAGAAATATGGCATCTCCTTAAAATTGCCTGTACACAGAGT
TCTGCCCGGTCCCTTGTAGGATCCAGTCTAGAAGGTGCAGTAACCCCTCAGACATCAGCATGGCTGCCCCCGACTTCAGCAGAACATGAT
CATTCTCTGTCATGTGTGGTAACTCCTCAAGATGGGGAGACTTCAGCACAAATGATAGAAGAAAATTTGAACTGCCTTGGCCATTTAAGC
ACTATTATTCATGAGGCAAATGAGGAACAGGGCAATAGTATGATGAATCTTGATTGGAGTTGGTTAACAGAATGAGTTGTCACTTGTTCA
CTGTCCCCAAACCTATGGAAGTTGTTGCTATACATGTTGGAAATGTGTTTTTCCCCCATGAAACCATTCTTCAGACATCAGTCAATGGAA
GAAATGGCTATGAACAGAAACTACATTTCTACTATGATCAGAAGAACATGATTTTACAAGTATAACAGTTTTGAGTAATTCAAGCCTCTA
AACAGACAGGAATTTAGAAAAAGTCAATGTACTTGTTTGAATATTTGTTTTAATACCACAGCTATTTAGAAGCATCATCACGACACATTT
GCCTTCAGTCTTGGTAAAACATTACTTATTTAACTGATTAAAAATACCTTCTATGTATTAGTGTCAACTTTTAACTTTTGGGCGTAAGAC
CAAATGTAGTTTTGTATACAGAGAAGAAAACCTCAAGTAATAGGCATTTTAAGTAAAAGTCTACCTGTGTTTTTTTCTAAAAAGGCTGCT
CACAAGTTCTATTTCTTGAAGAATAAATTCTACCTCCTTGTGTTGCACTGAACAGGTTCTCTTCCTGGCATCATAAGGAGTTGGTGTAAT
CATTTTAAATTCCACTGAAAATTTAACAGTATCCCCTTCTCATCGAAGGGATTGTGTATCTGTGCTTCTAATATTAGTTGGCTTTCATAA
ATCATGTTGTTGTGTGTATATGTATTTAAGATGTACATTTAATAATATCAAAGAGAAGATGCCTGTTAATTTATAATGTATTTGAAAATT
ACATGTTTTTTCATTTGTAAAAATGAGTCATTTGTTTAAACAATCTTTCATGTCTTGTCATACAAATTTATAAAGGTCTGCACTCCTTTA
TCTGTAATTGTAATTCCAAAATCCAAAAAGCTCTGAAAACAAGGTTTCCATAAGCTTGGTGACAAAATTCATTTGCTTGCAATCTAATCT
GAACTGACCTTGAATCTTTTTATCCCATTTAGTGTGAATATTCCTTTATTTTGCTGCTTGATGATGAGAGGGAGGGCTGCTGCCACAGAC
TGTGGTGAGGGCTGGTTAATGTAGTATGGTATATGCACAAAACTACTTTTCTAAAATCTAAAATTTCATAATTCTGAAACAACTTGCCCC
AAGGGTTTCAGAGAAAGGACTGTGGACCTCTATCATCTGCTAAGTAATTTAGAAGATATTATTTGTCTTAAAAAATGTGAAATGCTTTTA
TATTCTAATAGTTTTTCACTTTGTGTATTAAATGGTTTTTAAATTACTTTCTTGATCTCTATTCATTATAAAAATCAGATTATAATAAAA


Top

FusionGenePPI for HDAC7_CHUK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HDAC7SFN, KAT5, EDNRA, HDAC3, NCOR1, NCOR2, BCL6, ZBTB16, IKZF1, IKZF3, IKZF4, FOXP3, CTNNB1, YWHAE, YWHAH, YWHAZ, ESR1, FOXA1, ZFP36, PRKD1, YWHAQ, MARK3, MARK2, ACTN4, MEF2A, AR, UBE2I, PML, MEF2C, CASP8, PPP2CA, HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, RUNX2, PRKD2, NR2E1, KLF4, BCORL1, PPP1R12A, PPP1CB, YWHAB, YWHAG, KDM5B, AKAP12, HIF1A, TBL1X, TBL1XR1, REL, CALCOCO2, RIPPLY1, SHMT2, MOV10, NXF1, EGFR, FLYWCH2, ZYG11B, HINT1, ZMYM6, TTF2, RAP1GDS1, MOCOS, UGP2, DCAF10, ADNP, WDR73, GNMT, RHOA, CBWD6, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, MAST3, EIF4E2, SIPA1L1, PPM1H, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, CBY1, INPP5ECHUKFANCA, TRPC4AP, PPM1B, MAP3K14, TRAF2, IKBKG, MAP3K8, NFKBIA, MAP3K7, NFKB1, IRS1, IKBKB, NLRP4, AKT2, CDC37, PRKDC, CHUK, TANK, CTNNB1, IRAK1, AKT1, MAP3K11, EIF2AK2, CASP8, NCOA3, IKBKAP, TNFAIP3, UBE2I, TRAF3IP2, NFKBIB, UBE2N, CUL1, TP73, NFKB2, EP300, PRKCQ, RELA, NCOR2, CUEDC2, HIST2H3C, TNF, PRKCA, PRKCI, PRKCD, DUSP1, HTT, COPS5, IRF5, TRIM40, TRAF6, TAB2, ARRB2, HSP90AA1, ERC1, TP63, PIAS1, IKBKE, CSNK2A1, CLU, MAP3K1, TNIP2, SRC, NLRP2, TRIM27, PPP2CA, FOXO3, STAP2, TNFRSF1A, TNFRSF1B, TRAF1, BTRC, CREBBP, TRADD, RIPK1, BCL2, MAGED1, BCL10, CARD11, SMAD3, SMAD2, ESR1, DHX40, DHX29, MYC, ELAVL1, HSPB1, NCOR1, PYCARD, NLRC5, TRAF4, RIPK2, ERBB2IP, MAP3K4, AURKA, TPX2, PPP1CA, ATG16L2, COPS3, SASH1, EGLN3, RPL27, PAX8, SRPK2, SRPK1, CDC73, MYH14, MYL12A, PAF1, STUB1, HNRNPA1, PSMD9, FKBP5, MTOR, RPTOR, TP53, RICTOR, SHARPIN, CD40, NTRK1, XPO1, MAP3K3, PRKCB, COMMD7, GLI1, USP18, SMN1, KLHL21, TRIM22, PSG1, FAM196A, SHC4, UBC, BCL3, IFIT5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-12649_1496992MEF2A
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-12549_1496955MEF2A
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-12649_149-53953MEF2A
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-12549_1496975MEF2A
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-1261_986992MEF2C
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-1251_986955MEF2C
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-1261_98-53953MEF2C
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-1251_986975MEF2C
HgeneHDAC7chr12:48213550chr10:101969547ENST00000080059-126877_9526992SIN3A
HgeneHDAC7chr12:48213550chr10:101969547ENST00000354334-125877_9526955SIN3A
HgeneHDAC7chr12:48213550chr10:101969547ENST00000427332-126877_952-53953SIN3A
HgeneHDAC7chr12:48213550chr10:101969547ENST00000552960-125877_9526975SIN3A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HDAC7_CHUK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCHUKO15111DB00233Aminosalicylic AcidInhibitor of nuclear factor kappa-B kinase subunit alphasmall moleculeapproved
TgeneCHUKO15111DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit alphasmall moleculeapproved
TgeneCHUKO15111DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit alphasmall moleculeapproved
TgeneCHUKO15111DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphasmall moleculeapproved|investigational

Top

RelatedDiseases for HDAC7_CHUK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHUKC0015929Fetal Diseases4CTD_human
TgeneCHUKC0206762Limb Deformities, Congenital4CTD_human
TgeneCHUKC0037268Skin Abnormalities3CTD_human
TgeneCHUKC0005941Bone Diseases, Developmental1CTD_human
TgeneCHUKC0008925Cleft Palate1CTD_human