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Fusion gene ID: 15954 |
FusionGeneSummary for HDAC7_CHUK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HDAC7_CHUK | Fusion gene ID: 15954 | Hgene | Tgene | Gene symbol | HDAC7 | CHUK | Gene ID | 51564 | 1147 |
| Gene name | histone deacetylase 7 | conserved helix-loop-helix ubiquitous kinase | |
| Synonyms | HD7|HD7A|HDAC7A | IKBKA|IKK-alpha|IKK1|IKKA|NFKBIKA|TCF16 | |
| Cytomap | 12q13.11 | 10q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone deacetylase 7histone deacetylase 7A | inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase 1I-kappa-B kinase-alphaIKK-a kinaseIkB kinase alpha subunitNuclear factor NFkappaB inhibitor kinase alphaTCF-16transcription factor 16 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8WUI4 | O15111 | |
| Ensembl transtripts involved in fusion gene | ENST00000080059, ENST00000354334, ENST00000552960, ENST00000380610, ENST00000427332, ENST00000488927, | ENST00000370397, ENST00000590930, | |
| Fusion gene scores | * DoF score | 9 X 6 X 6=324 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: HDAC7 [Title/Abstract] AND CHUK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HDAC7 | GO:0032703 | negative regulation of interleukin-2 production | 17360565 |
| Tgene | CHUK | GO:0006468 | protein phosphorylation | 20434986 |
| Tgene | CHUK | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055 |
| Tgene | CHUK | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA482203 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000080059 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| 5CDS-intron | ENST00000080059 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| In-frame | ENST00000354334 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| 5CDS-intron | ENST00000354334 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| In-frame | ENST00000552960 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| 5CDS-intron | ENST00000552960 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-3CDS | ENST00000380610 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-intron | ENST00000380610 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-3CDS | ENST00000427332 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-intron | ENST00000427332 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-3CDS | ENST00000488927 | ENST00000370397 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
| intron-intron | ENST00000488927 | ENST00000590930 | HDAC7 | chr12 | 48213550 | - | CHUK | chr10 | 101969547 | - |
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FusionProtFeatures for HDAC7_CHUK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HDAC7 | CHUK |
| Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimulisuch as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. Acts as part of the canonicalIKK complex in the conventional pathway of NF-kappa-B activationand phosphorylates inhibitors of NF-kappa-B on serine residues.These modifications allow polyubiquitination of the inhibitors andsubsequent degradation by the proteasome. In turn, free NF-kappa-Bis translocated into the nucleus and activates the transcriptionof hundreds of genes involved in immune response, growth control,or protection against apoptosis. Negatively regulates the pathwayby phosphorylating the scaffold protein TAXBP1 and thus promotingthe assembly of the A20/TNFAIP3 ubiquitin-editing complex(composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH andRNF11). Therefore, CHUK plays a key role in the negative feedbackof NF-kappa-B canonical signaling to limit inflammatory geneactivation. As part of the non-canonical pathway of NF-kappa-Bactivation, the MAP3K14-activated CHUK/IKKA homodimerphosphorylates NFKB2/p100 associated with RelB, inducing itsproteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genesencoding molecules involved in B-cell survival and lymphoidorganogenesis. Participates also in the negative feedback of thenon-canonical NF-kappa-B signaling pathway by phosphorylating anddestabilizing MAP3K14/NIK. Within the nucleus, phosphorylatesCREBBP and consequently increases both its transcriptional andhistone acetyltransferase activities. Modulates chromatinaccessibility at NF-kappa-B-responsive promoters byphosphorylating histones H3 at 'Ser-10' that are subsequentlyacetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates theCREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 andmay regulate this pro-apoptotic transcription factor(PubMed:15084260). {ECO:0000269|PubMed:12789342,ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128,ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937,ECO:0000269|PubMed:21765415}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CHUK | chr12:48213550 | chr10:101969547 | ENST00000370397 | - | 8 | 21 | 455_476 | 311 | 746 | Region | Note=Leucine-zipper |
| Tgene | >CHUK | chr12:48213550 | chr10:101969547 | ENST00000370397 | - | 8 | 21 | 738_743 | 311 | 746 | Region | Note=NEMO-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 197_203 | 6 | 992 | Compositional bias | Note=Poly-Ser |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 368_373 | 6 | 992 | Compositional bias | Note=Poly-Pro |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 197_203 | 6 | 955 | Compositional bias | Note=Poly-Ser |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 368_373 | 6 | 955 | Compositional bias | Note=Poly-Pro |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 197_203 | -53 | 953 | Compositional bias | Note=Poly-Ser |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 368_373 | -53 | 953 | Compositional bias | Note=Poly-Pro |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 197_203 | 6 | 975 | Compositional bias | Note=Poly-Ser |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 368_373 | 6 | 975 | Compositional bias | Note=Poly-Pro |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 918_952 | 6 | 992 | Motif | Nuclear export signal |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 918_952 | 6 | 955 | Motif | Nuclear export signal |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 918_952 | -53 | 953 | Motif | Nuclear export signal |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 918_952 | 6 | 975 | Motif | Nuclear export signal |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 1_268 | 6 | 992 | Region | Transcription repression 1 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 218_546 | 6 | 992 | Region | Transcription repression 2 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 518_865 | 6 | 992 | Region | Note=Histone deacetylase |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 1_268 | 6 | 955 | Region | Transcription repression 1 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 218_546 | 6 | 955 | Region | Transcription repression 2 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 518_865 | 6 | 955 | Region | Note=Histone deacetylase |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 1_268 | -53 | 953 | Region | Transcription repression 1 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 218_546 | -53 | 953 | Region | Transcription repression 2 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 518_865 | -53 | 953 | Region | Note=Histone deacetylase |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 1_268 | 6 | 975 | Region | Transcription repression 1 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 218_546 | 6 | 975 | Region | Transcription repression 2 |
| Hgene | >HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 518_865 | 6 | 975 | Region | Note=Histone deacetylase |
| Tgene | CHUK | chr12:48213550 | chr10:101969547 | ENST00000370397 | - | 8 | 21 | 15_302 | 311 | 746 | Domain | Protein kinase |
| Tgene | CHUK | chr12:48213550 | chr10:101969547 | ENST00000370397 | - | 8 | 21 | 21_29 | 311 | 746 | Nucleotide binding | ATP |
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FusionGeneSequence for HDAC7_CHUK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HDAC7_ENST00000080059_chr12_48213550_-_CHUK_ENST00000370397_chr10_101969547_-_2624nt ATGCACAGCCCCGGCGCTGATAGTACACATCCTAAATATGACTTCTGCAAAGATAATTTCTTTTCTGTTACCACCTGATGAAAGTCTTCA TTCACTACAGTCTCGTATTGAGCGTGAAACTGGAATAAATACTGGTTCTCAAGAACTTCTTTCAGAGACAGGAATTTCTCTGGATCCTCG GAAACCAGCCTCTCAATGTGTTCTAGATGGAGTTAGAGGCTGTGATAGCTATATGGTTTATTTGTTTGATAAAAGTAAAACTGTATATGA AGGGCCATTTGCTTCCAGAAGTTTATCTGATTGTGTAAATTATATTGTACAGGACAGCAAAATACAGCTTCCAATTATACAGCTGCGTAA AGTGTGGGCTGAAGCAGTGCACTATGTGTCTGGACTAAAAGAAGACTATAGCAGGCTCTTTCAGGGACAAAGGGCAGCAATGTTAAGTCT TCTTAGATATAATGCTAACTTAACAAAAATGAAGAACACTTTGATCTCAGCATCACAACAACTGAAAGCTAAATTGGAGTTTTTTCACAA AAGCATTCAGCTTGACTTGGAGAGATACAGCGAGCAGATGACGTATGGGATATCTTCAGAAAAAATGCTAAAAGCATGGAAAGAAATGGA AGAAAAGGCCATCCACTATGCTGAGGTTGGTGTCATTGGATACCTGGAGGATCAGATTATGTCTTTGCATGCTGAAATCATGGAGCTACA GAAGAGCCCCTATGGAAGACGTCAGGGAGACTTGATGGAATCTCTGGAACAGCGTGCCATTGATCTATATAAGCAGTTAAAACACAGACC TTCAGATCACTCCTACAGTGACAGCACAGAGATGGTGAAAATCATTGTGCACACTGTGCAGAGTCAGGACCGTGTGCTCAAGGAGCTGTT TGGTCATTTGAGCAAGTTGTTGGGCTGTAAGCAGAAGATTATTGATCTACTCCCTAAGGTGGAAGTGGCCCTCAGTAATATCAAAGAAGC TGACAATACTGTCATGTTCATGCAGGGAAAAAGGCAGAAAGAAATATGGCATCTCCTTAAAATTGCCTGTACACAGAGTTCTGCCCGGTC CCTTGTAGGATCCAGTCTAGAAGGTGCAGTAACCCCTCAGACATCAGCATGGCTGCCCCCGACTTCAGCAGAACATGATCATTCTCTGTC ATGTGTGGTAACTCCTCAAGATGGGGAGACTTCAGCACAAATGATAGAAGAAAATTTGAACTGCCTTGGCCATTTAAGCACTATTATTCA TGAGGCAAATGAGGAACAGGGCAATAGTATGATGAATCTTGATTGGAGTTGGTTAACAGAATGAGTTGTCACTTGTTCACTGTCCCCAAA CCTATGGAAGTTGTTGCTATACATGTTGGAAATGTGTTTTTCCCCCATGAAACCATTCTTCAGACATCAGTCAATGGAAGAAATGGCTAT GAACAGAAACTACATTTCTACTATGATCAGAAGAACATGATTTTACAAGTATAACAGTTTTGAGTAATTCAAGCCTCTAAACAGACAGGA ATTTAGAAAAAGTCAATGTACTTGTTTGAATATTTGTTTTAATACCACAGCTATTTAGAAGCATCATCACGACACATTTGCCTTCAGTCT TGGTAAAACATTACTTATTTAACTGATTAAAAATACCTTCTATGTATTAGTGTCAACTTTTAACTTTTGGGCGTAAGACCAAATGTAGTT TTGTATACAGAGAAGAAAACCTCAAGTAATAGGCATTTTAAGTAAAAGTCTACCTGTGTTTTTTTCTAAAAAGGCTGCTCACAAGTTCTA TTTCTTGAAGAATAAATTCTACCTCCTTGTGTTGCACTGAACAGGTTCTCTTCCTGGCATCATAAGGAGTTGGTGTAATCATTTTAAATT CCACTGAAAATTTAACAGTATCCCCTTCTCATCGAAGGGATTGTGTATCTGTGCTTCTAATATTAGTTGGCTTTCATAAATCATGTTGTT GTGTGTATATGTATTTAAGATGTACATTTAATAATATCAAAGAGAAGATGCCTGTTAATTTATAATGTATTTGAAAATTACATGTTTTTT CATTTGTAAAAATGAGTCATTTGTTTAAACAATCTTTCATGTCTTGTCATACAAATTTATAAAGGTCTGCACTCCTTTATCTGTAATTGT AATTCCAAAATCCAAAAAGCTCTGAAAACAAGGTTTCCATAAGCTTGGTGACAAAATTCATTTGCTTGCAATCTAATCTGAACTGACCTT GAATCTTTTTATCCCATTTAGTGTGAATATTCCTTTATTTTGCTGCTTGATGATGAGAGGGAGGGCTGCTGCCACAGACTGTGGTGAGGG CTGGTTAATGTAGTATGGTATATGCACAAAACTACTTTTCTAAAATCTAAAATTTCATAATTCTGAAACAACTTGCCCCAAGGGTTTCAG AGAAAGGACTGTGGACCTCTATCATCTGCTAAGTAATTTAGAAGATATTATTTGTCTTAAAAAATGTGAAATGCTTTTATATTCTAATAG TTTTTCACTTTGTGTATTAAATGGTTTTTAAATTACTTTCTTGATCTCTATTCATTATAAAAATCAGATTATAATAAAACAGTTGAATAT >In-frame_HDAC7_ENST00000354334_chr12_48213550_-_CHUK_ENST00000370397_chr10_101969547_-_2705nt GGCGACTGGGGGGATGTGAGGCCGGCGCCCCAGCCCCCCGCCCCGCCATGAGCCCCCCGCTCTGAGGGCCCCGGCCCCTGGATGCACAGC CCCGGCGCTGATAGTACACATCCTAAATATGACTTCTGCAAAGATAATTTCTTTTCTGTTACCACCTGATGAAAGTCTTCATTCACTACA GTCTCGTATTGAGCGTGAAACTGGAATAAATACTGGTTCTCAAGAACTTCTTTCAGAGACAGGAATTTCTCTGGATCCTCGGAAACCAGC CTCTCAATGTGTTCTAGATGGAGTTAGAGGCTGTGATAGCTATATGGTTTATTTGTTTGATAAAAGTAAAACTGTATATGAAGGGCCATT TGCTTCCAGAAGTTTATCTGATTGTGTAAATTATATTGTACAGGACAGCAAAATACAGCTTCCAATTATACAGCTGCGTAAAGTGTGGGC TGAAGCAGTGCACTATGTGTCTGGACTAAAAGAAGACTATAGCAGGCTCTTTCAGGGACAAAGGGCAGCAATGTTAAGTCTTCTTAGATA TAATGCTAACTTAACAAAAATGAAGAACACTTTGATCTCAGCATCACAACAACTGAAAGCTAAATTGGAGTTTTTTCACAAAAGCATTCA GCTTGACTTGGAGAGATACAGCGAGCAGATGACGTATGGGATATCTTCAGAAAAAATGCTAAAAGCATGGAAAGAAATGGAAGAAAAGGC CATCCACTATGCTGAGGTTGGTGTCATTGGATACCTGGAGGATCAGATTATGTCTTTGCATGCTGAAATCATGGAGCTACAGAAGAGCCC CTATGGAAGACGTCAGGGAGACTTGATGGAATCTCTGGAACAGCGTGCCATTGATCTATATAAGCAGTTAAAACACAGACCTTCAGATCA CTCCTACAGTGACAGCACAGAGATGGTGAAAATCATTGTGCACACTGTGCAGAGTCAGGACCGTGTGCTCAAGGAGCTGTTTGGTCATTT GAGCAAGTTGTTGGGCTGTAAGCAGAAGATTATTGATCTACTCCCTAAGGTGGAAGTGGCCCTCAGTAATATCAAAGAAGCTGACAATAC TGTCATGTTCATGCAGGGAAAAAGGCAGAAAGAAATATGGCATCTCCTTAAAATTGCCTGTACACAGAGTTCTGCCCGGTCCCTTGTAGG ATCCAGTCTAGAAGGTGCAGTAACCCCTCAGACATCAGCATGGCTGCCCCCGACTTCAGCAGAACATGATCATTCTCTGTCATGTGTGGT AACTCCTCAAGATGGGGAGACTTCAGCACAAATGATAGAAGAAAATTTGAACTGCCTTGGCCATTTAAGCACTATTATTCATGAGGCAAA TGAGGAACAGGGCAATAGTATGATGAATCTTGATTGGAGTTGGTTAACAGAATGAGTTGTCACTTGTTCACTGTCCCCAAACCTATGGAA GTTGTTGCTATACATGTTGGAAATGTGTTTTTCCCCCATGAAACCATTCTTCAGACATCAGTCAATGGAAGAAATGGCTATGAACAGAAA CTACATTTCTACTATGATCAGAAGAACATGATTTTACAAGTATAACAGTTTTGAGTAATTCAAGCCTCTAAACAGACAGGAATTTAGAAA AAGTCAATGTACTTGTTTGAATATTTGTTTTAATACCACAGCTATTTAGAAGCATCATCACGACACATTTGCCTTCAGTCTTGGTAAAAC ATTACTTATTTAACTGATTAAAAATACCTTCTATGTATTAGTGTCAACTTTTAACTTTTGGGCGTAAGACCAAATGTAGTTTTGTATACA GAGAAGAAAACCTCAAGTAATAGGCATTTTAAGTAAAAGTCTACCTGTGTTTTTTTCTAAAAAGGCTGCTCACAAGTTCTATTTCTTGAA GAATAAATTCTACCTCCTTGTGTTGCACTGAACAGGTTCTCTTCCTGGCATCATAAGGAGTTGGTGTAATCATTTTAAATTCCACTGAAA ATTTAACAGTATCCCCTTCTCATCGAAGGGATTGTGTATCTGTGCTTCTAATATTAGTTGGCTTTCATAAATCATGTTGTTGTGTGTATA TGTATTTAAGATGTACATTTAATAATATCAAAGAGAAGATGCCTGTTAATTTATAATGTATTTGAAAATTACATGTTTTTTCATTTGTAA AAATGAGTCATTTGTTTAAACAATCTTTCATGTCTTGTCATACAAATTTATAAAGGTCTGCACTCCTTTATCTGTAATTGTAATTCCAAA ATCCAAAAAGCTCTGAAAACAAGGTTTCCATAAGCTTGGTGACAAAATTCATTTGCTTGCAATCTAATCTGAACTGACCTTGAATCTTTT TATCCCATTTAGTGTGAATATTCCTTTATTTTGCTGCTTGATGATGAGAGGGAGGGCTGCTGCCACAGACTGTGGTGAGGGCTGGTTAAT GTAGTATGGTATATGCACAAAACTACTTTTCTAAAATCTAAAATTTCATAATTCTGAAACAACTTGCCCCAAGGGTTTCAGAGAAAGGAC TGTGGACCTCTATCATCTGCTAAGTAATTTAGAAGATATTATTTGTCTTAAAAAATGTGAAATGCTTTTATATTCTAATAGTTTTTCACT TTGTGTATTAAATGGTTTTTAAATTACTTTCTTGATCTCTATTCATTATAAAAATCAGATTATAATAAAACAGTTGAATATGGCTTAGGA >In-frame_HDAC7_ENST00000552960_chr12_48213550_-_CHUK_ENST00000370397_chr10_101969547_-_2725nt ACAGTCGCTCTGCAGCCTCCGGCGACTGGGGGGATGTGAGGCCGGCGCCCCAGCCCCCCGCCCCGCCATGAGCCCCCCGCTCTGAGGGCC CCGGCCCCTGGATGCACAGCCCCGGCGCTGATAGTACACATCCTAAATATGACTTCTGCAAAGATAATTTCTTTTCTGTTACCACCTGAT GAAAGTCTTCATTCACTACAGTCTCGTATTGAGCGTGAAACTGGAATAAATACTGGTTCTCAAGAACTTCTTTCAGAGACAGGAATTTCT CTGGATCCTCGGAAACCAGCCTCTCAATGTGTTCTAGATGGAGTTAGAGGCTGTGATAGCTATATGGTTTATTTGTTTGATAAAAGTAAA ACTGTATATGAAGGGCCATTTGCTTCCAGAAGTTTATCTGATTGTGTAAATTATATTGTACAGGACAGCAAAATACAGCTTCCAATTATA CAGCTGCGTAAAGTGTGGGCTGAAGCAGTGCACTATGTGTCTGGACTAAAAGAAGACTATAGCAGGCTCTTTCAGGGACAAAGGGCAGCA ATGTTAAGTCTTCTTAGATATAATGCTAACTTAACAAAAATGAAGAACACTTTGATCTCAGCATCACAACAACTGAAAGCTAAATTGGAG TTTTTTCACAAAAGCATTCAGCTTGACTTGGAGAGATACAGCGAGCAGATGACGTATGGGATATCTTCAGAAAAAATGCTAAAAGCATGG AAAGAAATGGAAGAAAAGGCCATCCACTATGCTGAGGTTGGTGTCATTGGATACCTGGAGGATCAGATTATGTCTTTGCATGCTGAAATC ATGGAGCTACAGAAGAGCCCCTATGGAAGACGTCAGGGAGACTTGATGGAATCTCTGGAACAGCGTGCCATTGATCTATATAAGCAGTTA AAACACAGACCTTCAGATCACTCCTACAGTGACAGCACAGAGATGGTGAAAATCATTGTGCACACTGTGCAGAGTCAGGACCGTGTGCTC AAGGAGCTGTTTGGTCATTTGAGCAAGTTGTTGGGCTGTAAGCAGAAGATTATTGATCTACTCCCTAAGGTGGAAGTGGCCCTCAGTAAT ATCAAAGAAGCTGACAATACTGTCATGTTCATGCAGGGAAAAAGGCAGAAAGAAATATGGCATCTCCTTAAAATTGCCTGTACACAGAGT TCTGCCCGGTCCCTTGTAGGATCCAGTCTAGAAGGTGCAGTAACCCCTCAGACATCAGCATGGCTGCCCCCGACTTCAGCAGAACATGAT CATTCTCTGTCATGTGTGGTAACTCCTCAAGATGGGGAGACTTCAGCACAAATGATAGAAGAAAATTTGAACTGCCTTGGCCATTTAAGC ACTATTATTCATGAGGCAAATGAGGAACAGGGCAATAGTATGATGAATCTTGATTGGAGTTGGTTAACAGAATGAGTTGTCACTTGTTCA CTGTCCCCAAACCTATGGAAGTTGTTGCTATACATGTTGGAAATGTGTTTTTCCCCCATGAAACCATTCTTCAGACATCAGTCAATGGAA GAAATGGCTATGAACAGAAACTACATTTCTACTATGATCAGAAGAACATGATTTTACAAGTATAACAGTTTTGAGTAATTCAAGCCTCTA AACAGACAGGAATTTAGAAAAAGTCAATGTACTTGTTTGAATATTTGTTTTAATACCACAGCTATTTAGAAGCATCATCACGACACATTT GCCTTCAGTCTTGGTAAAACATTACTTATTTAACTGATTAAAAATACCTTCTATGTATTAGTGTCAACTTTTAACTTTTGGGCGTAAGAC CAAATGTAGTTTTGTATACAGAGAAGAAAACCTCAAGTAATAGGCATTTTAAGTAAAAGTCTACCTGTGTTTTTTTCTAAAAAGGCTGCT CACAAGTTCTATTTCTTGAAGAATAAATTCTACCTCCTTGTGTTGCACTGAACAGGTTCTCTTCCTGGCATCATAAGGAGTTGGTGTAAT CATTTTAAATTCCACTGAAAATTTAACAGTATCCCCTTCTCATCGAAGGGATTGTGTATCTGTGCTTCTAATATTAGTTGGCTTTCATAA ATCATGTTGTTGTGTGTATATGTATTTAAGATGTACATTTAATAATATCAAAGAGAAGATGCCTGTTAATTTATAATGTATTTGAAAATT ACATGTTTTTTCATTTGTAAAAATGAGTCATTTGTTTAAACAATCTTTCATGTCTTGTCATACAAATTTATAAAGGTCTGCACTCCTTTA TCTGTAATTGTAATTCCAAAATCCAAAAAGCTCTGAAAACAAGGTTTCCATAAGCTTGGTGACAAAATTCATTTGCTTGCAATCTAATCT GAACTGACCTTGAATCTTTTTATCCCATTTAGTGTGAATATTCCTTTATTTTGCTGCTTGATGATGAGAGGGAGGGCTGCTGCCACAGAC TGTGGTGAGGGCTGGTTAATGTAGTATGGTATATGCACAAAACTACTTTTCTAAAATCTAAAATTTCATAATTCTGAAACAACTTGCCCC AAGGGTTTCAGAGAAAGGACTGTGGACCTCTATCATCTGCTAAGTAATTTAGAAGATATTATTTGTCTTAAAAAATGTGAAATGCTTTTA TATTCTAATAGTTTTTCACTTTGTGTATTAAATGGTTTTTAAATTACTTTCTTGATCTCTATTCATTATAAAAATCAGATTATAATAAAA |
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FusionGenePPI for HDAC7_CHUK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HDAC7 | SFN, KAT5, EDNRA, HDAC3, NCOR1, NCOR2, BCL6, ZBTB16, IKZF1, IKZF3, IKZF4, FOXP3, CTNNB1, YWHAE, YWHAH, YWHAZ, ESR1, FOXA1, ZFP36, PRKD1, YWHAQ, MARK3, MARK2, ACTN4, MEF2A, AR, UBE2I, PML, MEF2C, CASP8, PPP2CA, HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, RUNX2, PRKD2, NR2E1, KLF4, BCORL1, PPP1R12A, PPP1CB, YWHAB, YWHAG, KDM5B, AKAP12, HIF1A, TBL1X, TBL1XR1, REL, CALCOCO2, RIPPLY1, SHMT2, MOV10, NXF1, EGFR, FLYWCH2, ZYG11B, HINT1, ZMYM6, TTF2, RAP1GDS1, MOCOS, UGP2, DCAF10, ADNP, WDR73, GNMT, RHOA, CBWD6, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, MAST3, EIF4E2, SIPA1L1, PPM1H, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, CBY1, INPP5E | CHUK | FANCA, TRPC4AP, PPM1B, MAP3K14, TRAF2, IKBKG, MAP3K8, NFKBIA, MAP3K7, NFKB1, IRS1, IKBKB, NLRP4, AKT2, CDC37, PRKDC, CHUK, TANK, CTNNB1, IRAK1, AKT1, MAP3K11, EIF2AK2, CASP8, NCOA3, IKBKAP, TNFAIP3, UBE2I, TRAF3IP2, NFKBIB, UBE2N, CUL1, TP73, NFKB2, EP300, PRKCQ, RELA, NCOR2, CUEDC2, HIST2H3C, TNF, PRKCA, PRKCI, PRKCD, DUSP1, HTT, COPS5, IRF5, TRIM40, TRAF6, TAB2, ARRB2, HSP90AA1, ERC1, TP63, PIAS1, IKBKE, CSNK2A1, CLU, MAP3K1, TNIP2, SRC, NLRP2, TRIM27, PPP2CA, FOXO3, STAP2, TNFRSF1A, TNFRSF1B, TRAF1, BTRC, CREBBP, TRADD, RIPK1, BCL2, MAGED1, BCL10, CARD11, SMAD3, SMAD2, ESR1, DHX40, DHX29, MYC, ELAVL1, HSPB1, NCOR1, PYCARD, NLRC5, TRAF4, RIPK2, ERBB2IP, MAP3K4, AURKA, TPX2, PPP1CA, ATG16L2, COPS3, SASH1, EGLN3, RPL27, PAX8, SRPK2, SRPK1, CDC73, MYH14, MYL12A, PAF1, STUB1, HNRNPA1, PSMD9, FKBP5, MTOR, RPTOR, TP53, RICTOR, SHARPIN, CD40, NTRK1, XPO1, MAP3K3, PRKCB, COMMD7, GLI1, USP18, SMN1, KLHL21, TRIM22, PSG1, FAM196A, SHC4, UBC, BCL3, IFIT5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 49_149 | 6 | 992 | MEF2A |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 49_149 | 6 | 955 | MEF2A |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 49_149 | -53 | 953 | MEF2A |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 49_149 | 6 | 975 | MEF2A |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 1_98 | 6 | 992 | MEF2C |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 1_98 | 6 | 955 | MEF2C |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 1_98 | -53 | 953 | MEF2C |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 1_98 | 6 | 975 | MEF2C |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000080059 | - | 1 | 26 | 877_952 | 6 | 992 | SIN3A |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000354334 | - | 1 | 25 | 877_952 | 6 | 955 | SIN3A |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000427332 | - | 1 | 26 | 877_952 | -53 | 953 | SIN3A |
| Hgene | HDAC7 | chr12:48213550 | chr10:101969547 | ENST00000552960 | - | 1 | 25 | 877_952 | 6 | 975 | SIN3A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HDAC7_CHUK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CHUK | O15111 | DB00233 | Aminosalicylic Acid | Inhibitor of nuclear factor kappa-B kinase subunit alpha | small molecule | approved |
| Tgene | CHUK | O15111 | DB00244 | Mesalazine | Inhibitor of nuclear factor kappa-B kinase subunit alpha | small molecule | approved |
| Tgene | CHUK | O15111 | DB00795 | Sulfasalazine | Inhibitor of nuclear factor kappa-B kinase subunit alpha | small molecule | approved |
| Tgene | CHUK | O15111 | DB06151 | Acetylcysteine | Inhibitor of nuclear factor kappa-B kinase subunit alpha | small molecule | approved|investigational |
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RelatedDiseases for HDAC7_CHUK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CHUK | C0015929 | Fetal Diseases | 4 | CTD_human |
| Tgene | CHUK | C0206762 | Limb Deformities, Congenital | 4 | CTD_human |
| Tgene | CHUK | C0037268 | Skin Abnormalities | 3 | CTD_human |
| Tgene | CHUK | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
| Tgene | CHUK | C0008925 | Cleft Palate | 1 | CTD_human |
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