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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15947

FusionGeneSummary for HDAC5_MSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC5_MSR1
Fusion gene ID: 15947
HgeneTgene
Gene symbol

HDAC5

MSR1

Gene ID

10014

4481

Gene namehistone deacetylase 5macrophage scavenger receptor 1
SynonymsHD5|NY-CO-9CD204|SCARA1|SR-A|SR-AI|SR-AII|SR-AIII|SRA|phSR1|phSR2
Cytomap

17q21.31

8p22

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 5antigen NY-CO-9macrophage scavenger receptor types I and IImacrophage acetylated LDL receptor I and IImacrophage scavenger receptor type IIIscavenger receptor class A member 1
Modification date2018052220180523
UniProtAcc

Q9UQL6

P21757

Ensembl transtripts involved in fusion geneENST00000225983, ENST00000393622, 
ENST00000336057, ENST00000586802, 
ENST00000350896, ENST00000262101, 
ENST00000445506, ENST00000355282, 
ENST00000518343, ENST00000381998, 
ENST00000536385, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 2 X 1=6
# samples 63
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/6*10)=2.32192809488736
Context

PubMed: HDAC5 [Title/Abstract] AND MSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC5

GO:0000122

negative regulation of transcription by RNA polymerase II

16236793

HgeneHDAC5

GO:0016575

histone deacetylation

10869435


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1RF-01AHDAC5chr17

42155965

-MSR1chr8

15978115

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000225983ENST00000350896HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000225983ENST00000262101HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000225983ENST00000445506HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000225983ENST00000355282HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000225983ENST00000518343HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000225983ENST00000381998HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000225983ENST00000536385HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000393622ENST00000350896HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000393622ENST00000262101HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000393622ENST00000445506HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000393622ENST00000355282HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000393622ENST00000518343HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000393622ENST00000381998HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000393622ENST00000536385HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000336057ENST00000350896HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000336057ENST00000262101HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000336057ENST00000445506HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000336057ENST00000355282HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000336057ENST00000518343HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000336057ENST00000381998HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000336057ENST00000536385HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000586802ENST00000350896HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000586802ENST00000262101HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000586802ENST00000445506HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000586802ENST00000355282HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000586802ENST00000518343HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000586802ENST00000381998HDAC5chr17

42155965

-MSR1chr8

15978115

-
intron-intronENST00000586802ENST00000536385HDAC5chr17

42155965

-MSR1chr8

15978115

-

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FusionProtFeatures for HDAC5_MSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC5

Q9UQL6

MSR1

P21757

Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Involved in musclematuration by repressing transcription of myocyte enhancer MEF2C.During muscle differentiation, it shuttles into the cytoplasm,allowing the expression of myocyte enhancer factors. Involved inthe MTA1-mediated epigenetic regulation of ESR1 expression inbreast cancer. {ECO:0000269|PubMed:24413532}. Membrane glycoproteins implicated in the pathologicdeposition of cholesterol in arterial walls during atherogenesis.Two types of receptor subunits exist. These receptors mediate theendocytosis of a diverse group of macromolecules, includingmodified low density lipoproteins (LDL) (PubMed:2251254). IsoformIII does not internalize acetylated LDL (PubMed:9548586).{ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:9548586}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HDAC5_MSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDAC5_MSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HDAC5ZBTB16, YWHAQ, PRKD1, CTBP1, NRIP1, GATA1, MEF2D, GATA2, TAB2, HDAC3, NCOR1, TBL1X, GPS2, BCL6, IKZF1, IKZF3, IKZF2, IKZF4, NCOR2, MEF2A, YWHAB, YWHAE, SUV39H1, EEF1G, GABARAP, HR, PKN2, PKN1, RUNX2, HIF1A, ESR1, GATA3, SMAD7, HOXC11, MAFF, YWHAG, REST, SIN3A, MARK3, KLF4, YY1, CAMK1, CAMTA2, GCM1, NUP214, GNB1, UBE2I, SMAD3, RFXANK, ANKRA2, CIITA, PPP2CA, DYRK1B, NFKBIA, NFKBIE, HDAC5, HDAC4, CAMK2A, TBX3, SLC2A4RG, MEF2C, HDAC7, PRKAB1, PHB2, MYEF2, AHRR, H3F3A, NR2E1, BCORL1, NFATC1, PRKCD, RBM25, TBL1XR1, HDAC1, RBBP7, RBBP4, MTA2, PRKD2, PPP2R1A, PPP2R2A, YWHAH, YWHAZ, PRKDC, TP53, TUBB, TUBA1A, HSP90AB1, RBM39, HSPA1A, HNRNPA2B1, NUMA1, HIST4H4, HIST2H2AC, HIST1H2BK, HIST3H3, PRKD3, RAD50, MAP1B, USP9X, USP7, IARS, PSMA5, PRPF39, HCFC1, RUVBL1, BAG2, CCAR2, UPF1, PSMC5, NUDC, GCN1L1, PSMD11, NEU1, CDK1, SF3A1, PSMC6, LTA4H, ETFA, COPB2, PCMT1, TNPO1, CSNK2A1, OGT, PGAM5, SF3B1, PSMD1, WDR5, GOT2, XPOT, RPL9, PRMT1, EIF3L, CAND1, DDX20, AHCY, HSD17B10, PPP2CB, LGALS3BP, SMC1A, STRAP, RPN2, DDOST, PSMD2, PSMC4, SF3B2, ECH1, TPI1, PSMD6, TUFM, PSMD3, PCNA, CS, SLC25A11, RAN, HSP90B1, RPL7, UQCRC2, SF3B3, RPL13, PRMT5, PHB, SMC3, RPL10A, LDHA, MDH2, PSMB5, HSPD1, HNRNPF, DDB1, SFXN1, ATP5A1, FLNA, OAT, VDAC1, HSPA4, TRAP1, ATP5B, PPP2R2D, RPN1, MTHFD1, PDIA6, PHGDH, CCT2, NME1, LARS, PCBP2, ALDOA, TRIM28, GANAB, ACTN4, HSP90AA1, DARS, ATP1A1, CANX, PGK1, P4HB, RPS8, RPLP0, CCT6A, PRPF19, HNRNPH2, PA2G4, FXR1, LRPPRC, VDAC2, CSE1L, PKM, RPL3, PRDX3, ACAT1, COPB1, DNAJB11, EIF4A3, PPIA, C1QBP, MCM3, TCP1, MCM4, IMPDH2, RPSA, EIF4A1, CCT7, DDX39B, ATP2A2, MCM2, IRS4, SLC25A1, EPRS, SLC25A3, PRDX4, EIF3F, EIF3C, XRCC5, RUVBL2, NFS1, HNRNPLL, PRPF8, CLTC, CCT4, EFTUD2, CCT5, GLUD1, XRCC6, MARS, XPO1, UBA1, TARS, RPS3A, FASN, KPNB1, MCM6, ACLY, SRSF1, HNRNPD, SLC25A6, CCT8, CAD, NPEPPS, CCT3, TUBB4B, EIF3B, PRDX6, ILF2, CDC5L, SHMT2, DNAJA1, PTBP1, HSPA9, RPS11, APLP2, DHX15, RPL5, RPS3, RARS, CKB, ALDH18A1, PPP1CA, NONO, SNRNP200, DDX1, VCP, HSPA5, DDX17, RPL7A, TKT, PABPC1, MCM5, TFRC, EMD, QARS, MCM7, RPS4X, RPL4, CKMT1B, NUP93, HNRNPL, SFPQ, RBM14, PARP1, ADAR, ILF3, NPM1, DHX9, HIST1H1C, IGF2BP1, DDX3X, MYH9, HNRNPA1, HADHA, HNRNPA3, DDX47, HNRNPR, NOP2, RBMX, TOP1, NFKB1, SF1, KDM5B, BRMS1, SIK2, PRKAA1, JDP2, ATF3, ZBTB7B, SIK1, SFN, APPL1, MYCN, SIK3, AURKB, CEP250, HAUS2, GNB2, DDIT3, HIST1H3A, LTBR, CUL7, RUNX3, TFEB, KCTD3, KIF13B, CGN, ZBTB21, KSR1, CBY1MSR1HSPA1A, TRAF6, IQCB1, ATP6V0C, NKG7, MALL, LEPROTL1, SEC22A, IKBIP, COL4A2, COLGALT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDAC5_MSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HDAC5_MSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDAC5C0011570Mental Depression2PSYGENET
HgeneHDAC5C0011581Depressive disorder2PSYGENET
HgeneHDAC5C0001546Adjustment Disorders1CTD_human
HgeneHDAC5C0041696Unipolar Depression1PSYGENET
HgeneHDAC5C0236736Cocaine-Related Disorders1CTD_human
HgeneHDAC5C0340543Familial primary pulmonary hypertension1CTD_human
HgeneHDAC5C1269683Major Depressive Disorder1PSYGENET
TgeneMSR1C0022661Kidney Failure, Chronic1CTD_human
TgeneMSR1C0033578Prostatic Neoplasms1CTD_human