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Fusion gene ID: 15944 |
FusionGeneSummary for HDAC4_THAP4 |
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Fusion gene information | Fusion gene name: HDAC4_THAP4 | Fusion gene ID: 15944 | Hgene | Tgene | Gene symbol | HDAC4 | THAP4 | Gene ID | 9759 | 51078 |
Gene name | histone deacetylase 4 | THAP domain containing 4 | |
Synonyms | AHO3|BDMR|HA6116|HD4|HDAC-4|HDAC-A|HDACA | CGI-36|PP238 | |
Cytomap | 2q37.3 | 2q37.3 | |
Type of gene | protein-coding | protein-coding | |
Description | histone deacetylase 4histone deacetylase A | THAP domain-containing protein 4 | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P56524 | Q8WY91 | |
Ensembl transtripts involved in fusion gene | ENST00000345617, ENST00000543185, ENST00000541256, ENST00000553145, | ENST00000402136, ENST00000407315, ENST00000402545, ENST00000497486, | |
Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 5 X 5 X 5=125 |
# samples | 8 | 5 | |
** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HDAC4 [Title/Abstract] AND THAP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HDAC4 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10869435|16236793 |
Hgene | HDAC4 | GO:0006338 | chromatin remodeling | 18850004 |
Hgene | HDAC4 | GO:0006476 | protein deacetylation | 27708256 |
Hgene | HDAC4 | GO:0016575 | histone deacetylation | 10869435 |
Hgene | HDAC4 | GO:0033235 | positive regulation of protein sumoylation | 17696781 |
Hgene | HDAC4 | GO:0034983 | peptidyl-lysine deacetylation | 18614528 |
Hgene | HDAC4 | GO:0045892 | negative regulation of transcription, DNA-templated | 10869435 |
Hgene | HDAC4 | GO:0070932 | histone H3 deacetylation | 12590135 |
Hgene | HDAC4 | GO:0070933 | histone H4 deacetylation | 12590135 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-CC-A3MA-01A | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000345617 | ENST00000402136 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
In-frame | ENST00000345617 | ENST00000407315 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
In-frame | ENST00000345617 | ENST00000402545 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
5CDS-intron | ENST00000345617 | ENST00000497486 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000543185 | ENST00000402136 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000543185 | ENST00000407315 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000543185 | ENST00000402545 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-intron | ENST00000543185 | ENST00000497486 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000541256 | ENST00000402136 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000541256 | ENST00000407315 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000541256 | ENST00000402545 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-intron | ENST00000541256 | ENST00000497486 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000553145 | ENST00000402136 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000553145 | ENST00000407315 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-3CDS | ENST00000553145 | ENST00000402545 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
intron-intron | ENST00000553145 | ENST00000497486 | HDAC4 | chr2 | 240274373 | - | THAP4 | chr2 | 242545888 | - |
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FusionProtFeatures for HDAC4_THAP4 |
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Hgene | Tgene |
HDAC4 | THAP4 |
Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Involved in musclematuration via its interaction with the myocyte enhancer factorssuch as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediatedepigenetic regulation of ESR1 expression in breast cancer.Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to theirpreferential binding to co-chaperone STUB1 (PubMed:27708256).{ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532,ECO:0000269|PubMed:27708256}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >THAP4 | chr2:240274373 | chr2:242545888 | ENST00000402136 | - | 0 | 5 | 235_238 | 1 | 166 | Motif | HCFC1-binding motif (HBM) |
Tgene | >THAP4 | chr2:240274373 | chr2:242545888 | ENST00000402136 | - | 0 | 5 | 1_85 | 1 | 166 | Zinc finger | THAP-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >HDAC4 | chr2:240274373 | chr2:242545888 | ENST00000345617 | - | 2 | 27 | 67_177 | 7 | 1085 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >HDAC4 | chr2:240274373 | chr2:242545888 | ENST00000345617 | - | 2 | 27 | 1051_1084 | 7 | 1085 | Motif | Nuclear export signal |
Hgene | >HDAC4 | chr2:240274373 | chr2:242545888 | ENST00000345617 | - | 2 | 27 | 655_1084 | 7 | 1085 | Region | Note=Histone deacetylase |
Tgene | THAP4 | chr2:240274373 | chr2:242545888 | ENST00000407315 | - | 1 | 6 | 235_238 | 413 | 578 | Motif | HCFC1-binding motif (HBM) |
Tgene | THAP4 | chr2:240274373 | chr2:242545888 | ENST00000407315 | - | 1 | 6 | 1_85 | 413 | 578 | Zinc finger | THAP-type |
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FusionGeneSequence for HDAC4_THAP4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000402136_chr2_242545888_-_172aa MSSQSHPEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVA >In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000407315_chr2_242545888_-_172aa MSSQSHPEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVA >In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000402545_chr2_242545888_-_199aa MSSQSHPEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVA FVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQVSPALLPARSCLLFAAVCGVSLFLFREITRKFRLNSEGKLEQTVSMAT |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000402136_chr2_242545888_-_516nt ATGAGCTCCCAAAGCCATCCAGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCA CCTGGAGCCGGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTC TCGTTCAACTCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCC TTTGTCAGCGCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCC AGGATCTCCTTCGCCAAGGAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCC >In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000407315_chr2_242545888_-_516nt ATGAGCTCCCAAAGCCATCCAGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCA CCTGGAGCCGGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTC TCGTTCAACTCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCC TTTGTCAGCGCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCC AGGATCTCCTTCGCCAAGGAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCC >In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000402545_chr2_242545888_-_597nt ATGAGCTCCCAAAGCCATCCAGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCA CCTGGAGCCGGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTC TCGTTCAACTCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCC TTTGTCAGCGCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCC AGGATCTCCTTCGCCAAGGAGCCCCACGTAGAGCAGGTGAGCCCAGCCCTGCTCCCAGCACGCTCCTGTCTTCTGTTTGCAGCGGTCTGT GGAGTCAGCCTCTTCCTCTTCCGTGAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGCAACC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000402136_chr2_242545888_-_1509nt GGAGGTTGTGGGGCCGCCGCCGCGGAGCACCGTCCCCGCCGCCGCCCGAGCCCGAGCCCGAGCCCGCGCACCCGCCCGCGCCGCCGCCGC CGCCGCCCGAACAGCCTCCCAGCCTGGGCCCCCGGCGGCGCCGTGGCCGCGTCCCGGCTGTCGCCGCCCGAGCCCGAGCCCGCGCGCCGG CGGGTGGCGGCGCAGGCTGAGGAGATGCGGCGCGGAGCGCCGGAGCAGGGCTAGAGCCGGCCGCCGCCGCCCGCCGCGGTAAGCGCAGCC CCGGCCCGGCGCCCGCGGGCCATTGTCCGCCGCCCGCCCCGCGCCCCGCGCAGCCTGCAGGCCTTGGAGCCCGCGGCAGGTGGACGCCGC CGGTCCACACCCGCCCCGCGCGCGGCCGTGGGAGGCGGGGGCCAGCGCTGGCCGCGCGCCGTGGGACCCGCCGGTCCCCAGGGCCGCCCG GCCCCTTCTGGACCTTTCCACCCGCGCCGCGAGGCGGCTTCGCCCGCCGGGGCGGGGGCGCGGGGGTGGGCACGGCAGGCAGCGGCGCCG TCTCCCGGTGCGGGGCCCGCGCCCCCCGAGCAGGTTCATCTGCAGAAGCCAGCGGACGCCTCTGTTCAACTTGTGGGTTACCTGGCTCAT GAGACCTTGCCGGCGAGGCTCGGCGCTTGAACGTCTGTGACCCAGCCCTCACCGTCCCGGTACTTGTATGTGTTGGTGGGAGTTTGGAGC TCGTTGGAGCTATCGTTTCCGTGGAAATTTTGAGCCATTTCGAATCACTTAAAGGAGTGGACATTGCTAGCAATGAGCTCCCAAAGCCAT CCAGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCACCTGGAGCCGGGACCTAC CCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTCTCGTTCAACTCCTTCCAC CCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCCTTTGTCAGCGCCCAGAAC ACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCCAGGATCTCCTTCGCCAAG GAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGCAACCACGACACAG CCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCCTCGGGAGGGCCTGGCTACTGTG CCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCAGGCTCAAGAGTGTTGTCCAGAT >In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000407315_chr2_242545888_-_1509nt GGAGGTTGTGGGGCCGCCGCCGCGGAGCACCGTCCCCGCCGCCGCCCGAGCCCGAGCCCGAGCCCGCGCACCCGCCCGCGCCGCCGCCGC CGCCGCCCGAACAGCCTCCCAGCCTGGGCCCCCGGCGGCGCCGTGGCCGCGTCCCGGCTGTCGCCGCCCGAGCCCGAGCCCGCGCGCCGG CGGGTGGCGGCGCAGGCTGAGGAGATGCGGCGCGGAGCGCCGGAGCAGGGCTAGAGCCGGCCGCCGCCGCCCGCCGCGGTAAGCGCAGCC CCGGCCCGGCGCCCGCGGGCCATTGTCCGCCGCCCGCCCCGCGCCCCGCGCAGCCTGCAGGCCTTGGAGCCCGCGGCAGGTGGACGCCGC CGGTCCACACCCGCCCCGCGCGCGGCCGTGGGAGGCGGGGGCCAGCGCTGGCCGCGCGCCGTGGGACCCGCCGGTCCCCAGGGCCGCCCG GCCCCTTCTGGACCTTTCCACCCGCGCCGCGAGGCGGCTTCGCCCGCCGGGGCGGGGGCGCGGGGGTGGGCACGGCAGGCAGCGGCGCCG TCTCCCGGTGCGGGGCCCGCGCCCCCCGAGCAGGTTCATCTGCAGAAGCCAGCGGACGCCTCTGTTCAACTTGTGGGTTACCTGGCTCAT GAGACCTTGCCGGCGAGGCTCGGCGCTTGAACGTCTGTGACCCAGCCCTCACCGTCCCGGTACTTGTATGTGTTGGTGGGAGTTTGGAGC TCGTTGGAGCTATCGTTTCCGTGGAAATTTTGAGCCATTTCGAATCACTTAAAGGAGTGGACATTGCTAGCAATGAGCTCCCAAAGCCAT CCAGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCACCTGGAGCCGGGACCTAC CCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTCTCGTTCAACTCCTTCCAC CCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCCTTTGTCAGCGCCCAGAAC ACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCCAGGATCTCCTTCGCCAAG GAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGCAACCACGACACAG CCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCCTCGGGAGGGCCTGGCTACTGTG CCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCAGGCTCAAGAGTGTTGTCCAGAT >In-frame_HDAC4_ENST00000345617_chr2_240274373_-_THAP4_ENST00000402545_chr2_242545888_-_1568nt GGAGGTTGTGGGGCCGCCGCCGCGGAGCACCGTCCCCGCCGCCGCCCGAGCCCGAGCCCGAGCCCGCGCACCCGCCCGCGCCGCCGCCGC CGCCGCCCGAACAGCCTCCCAGCCTGGGCCCCCGGCGGCGCCGTGGCCGCGTCCCGGCTGTCGCCGCCCGAGCCCGAGCCCGCGCGCCGG CGGGTGGCGGCGCAGGCTGAGGAGATGCGGCGCGGAGCGCCGGAGCAGGGCTAGAGCCGGCCGCCGCCGCCCGCCGCGGTAAGCGCAGCC CCGGCCCGGCGCCCGCGGGCCATTGTCCGCCGCCCGCCCCGCGCCCCGCGCAGCCTGCAGGCCTTGGAGCCCGCGGCAGGTGGACGCCGC CGGTCCACACCCGCCCCGCGCGCGGCCGTGGGAGGCGGGGGCCAGCGCTGGCCGCGCGCCGTGGGACCCGCCGGTCCCCAGGGCCGCCCG GCCCCTTCTGGACCTTTCCACCCGCGCCGCGAGGCGGCTTCGCCCGCCGGGGCGGGGGCGCGGGGGTGGGCACGGCAGGCAGCGGCGCCG TCTCCCGGTGCGGGGCCCGCGCCCCCCGAGCAGGTTCATCTGCAGAAGCCAGCGGACGCCTCTGTTCAACTTGTGGGTTACCTGGCTCAT GAGACCTTGCCGGCGAGGCTCGGCGCTTGAACGTCTGTGACCCAGCCCTCACCGTCCCGGTACTTGTATGTGTTGGTGGGAGTTTGGAGC TCGTTGGAGCTATCGTTTCCGTGGAAATTTTGAGCCATTTCGAATCACTTAAAGGAGTGGACATTGCTAGCAATGAGCTCCCAAAGCCAT CCAGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCACCTGGAGCCGGGACCTAC CCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTCTCGTTCAACTCCTTCCAC CCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCCTTTGTCAGCGCCCAGAAC ACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCCAGGATCTCCTTCGCCAAG GAGCCCCACGTAGAGCAGGTGAGCCCAGCCCTGCTCCCAGCACGCTCCTGTCTTCTGTTTGCAGCGGTCTGTGGAGTCAGCCTCTTCCTC TTCCGTGAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGCAACCACGACACAGCCAATGACT CAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCCTCGGGAGGGCCTGGCTACTGTGCCTCAACGG TTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCAGGCTCAAGAGTGTTGTCCAGATGTTTCTGTA |
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FusionGenePPI for HDAC4_THAP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HDAC4 | ZBTB16, SFN, CTBP1, GATA1, RARA, RXRA, NR2C1, NR2C2, AR, PPARD, PPARG, IKZF2, ZNF354A, HDAC9, MEF2A, MEF2C, MEF2D, HDAC4, RBBP4, HDAC3, NCOR1, NCOR2, YWHAE, YWHAG, YWHAZ, BCL6, BCOR, IKZF1, IKZF3, IKZF4, YWHAB, MECOM, SUV39H1, UBE2I, MAPK3, MAPK1, FOXP3, DNAJB6, DNAJB8, ATF2, MORC2, RUNX2, SENP1, CDK5, PARK2, NR1H2, SIN3A, HIF1A, CAMK2D, ESR1, YY1, LZTR1, SS18L1, SP1, REST, MARK3, GATA3, CAMK1, GCM1, NUP214, DNAJB5, SYK, ESCO2, GNB1, CTNNB1, TP53BP1, SRF, SIRT1, LCOR, HNF4A, CDKN1A, RANBP2, SMAD3, YWHAQ, ANKRA2, ATRX, REV3L, MAP1S, RFXANK, CIITA, RFX5, RFXAP, IFRD1, PPP2CA, NFKBIA, NFKBIE, HDAC5, CAMK4, CSRP3, HDAC7, PPP2R4, AHRR, CEBPD, BCORL1, NUP155, ACTA1, NPPB, CACNA1C, ATXN1, HIC1, NFKB1, SF1, KDM5B, ELAVL1, PPP2R1A, STAT1, ZEB2, NFATC1, BRMS1, NACC1, JDP2, ATF3, APP, ZBTB7B, YWHAH, TBL1XR1, MIF4GD, GSK3B, CDR2, GOLGA2, KRT31, KRT38, PNMA1, MTUS2, LDOC1, EFEMP2, RINT1, CCDC136, KRT40, CUL7, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, EIF4E2, MAST3, SIPA1L1, PPM1H, DENND4C, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, MAPKAP1, NF1, AGAP1, CBY1, CDC25B, CDK16, NADK, CDC25C, FAM110B, USP21, GIGYF2, CAMSAP2, FAM53C, ANKRD34A, LPIN3, TIAM1, KIAA1804, RASAL2, PHLDB2, RALGPS2, FAM110A, PLEKHA7, KIF1C, GAB2, NAV1, MELK, SH3RF3, PTPN14, STARD13, DENND4A, OSBPL6, INPP5E, NR1H3 | THAP4 | MAPK6, APP, HSP90AA1, CORO2A, AIFM1, ACTBL2, HSPA2, GFER, ACTB, HSPA8, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | HDAC4 | chr2:240274373 | chr2:242545888 | ENST00000345617 | - | 2 | 27 | 118_313 | 7 | 1085 | MEF2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HDAC4_THAP4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | HDAC4 | P56524 | DB01593 | Zinc | Histone deacetylase 4 | small molecule | approved|investigational |
Hgene | HDAC4 | P56524 | DB06176 | Romidepsin | Histone deacetylase 4 | small molecule | approved|investigational |
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RelatedDiseases for HDAC4_THAP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HDAC4 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | HDAC4 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | HDAC4 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | HDAC4 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | HDAC4 | C0221357 | Brachydactyly | 1 | CTD_human;HPO |
Hgene | HDAC4 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Hgene | HDAC4 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human |
Hgene | HDAC4 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | HDAC4 | C0525045 | Mood Disorders | 1 | PSYGENET |
Hgene | HDAC4 | C1862102 | BRACHYDACTYLY, TYPE E1 | 1 | CTD_human |
Hgene | HDAC4 | C2931817 | Chromosome 2q37 deletion syndrome | 1 | CTD_human;ORPHANET |
Hgene | HDAC4 | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |