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Fusion gene ID: 15932 |
FusionGeneSummary for HDAC1_ZBTB8B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HDAC1_ZBTB8B | Fusion gene ID: 15932 | Hgene | Tgene | Gene symbol | HDAC1 | ZBTB8B | Gene ID | 3065 | 728116 |
| Gene name | histone deacetylase 1 | zinc finger and BTB domain containing 8B | |
| Synonyms | GON-10|HD1|RPD3|RPD3L1 | ZNF916B | |
| Cytomap | 1p35.2-p35.1 | 1p35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone deacetylase 1reduced potassium dependency, yeast homolog-like 1 | zinc finger and BTB domain-containing protein 8Bputative zinc finger and BTB domain-containing protein 8B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13547 | Q8NAP8 | |
| Ensembl transtripts involved in fusion gene | ENST00000373548, ENST00000373541, ENST00000490081, | ENST00000609129, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: HDAC1 [Title/Abstract] AND ZBTB8B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HDAC1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18854353 |
| Hgene | HDAC1 | GO:0006476 | protein deacetylation | 17172643|23629966 |
| Hgene | HDAC1 | GO:0045893 | positive regulation of transcription, DNA-templated | 16762839 |
| Hgene | HDAC1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16762839 |
| Hgene | HDAC1 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 15919722 |
| Hgene | HDAC1 | GO:0070932 | histone H3 deacetylation | 12590135 |
| Hgene | HDAC1 | GO:0070933 | histone H4 deacetylation | 12590135 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1Y0-01A | HDAC1 | chr1 | 32782383 | + | ZBTB8B | chr1 | 32946492 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000373548 | ENST00000609129 | HDAC1 | chr1 | 32782383 | + | ZBTB8B | chr1 | 32946492 | + |
| 5UTR-3CDS | ENST00000373541 | ENST00000609129 | HDAC1 | chr1 | 32782383 | + | ZBTB8B | chr1 | 32946492 | + |
| intron-3CDS | ENST00000490081 | ENST00000609129 | HDAC1 | chr1 | 32782383 | + | ZBTB8B | chr1 | 32946492 | + |
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FusionProtFeatures for HDAC1_ZBTB8B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HDAC1 | ZBTB8B |
| Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Deacetylates SPproteins, SP1 and SP3, and regulates their function. Component ofthe BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calciumstimulation, HDAC1 is released from the complex and CREBBP isrecruited, which facilitates transcriptional activation.Deacetylates TSHZ3 and regulates its transcriptional repressoractivity. Deacetylates 'Lys-310' in RELA and thereby inhibits thetranscriptional activity of NF-kappa-B. Deacetylates NR1D2 andabrogates the effect of KAT5-mediated relieving of NR1D2transcription repression activity. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histonedeacetylase (HDAC) recruitment, a number of genes implicated inmultilineage blood cell development. Involved in CIART-mediatedtranscriptional repression of the circadian transcriptionalactivator: CLOCK-ARNTL/BMAL1 heterodimer. Required for thetranscriptional repression of circadian target genes, such asPER1, mediated by the large PER complex or CRY1 through histonedeacetylation. {ECO:0000269|PubMed:12837748,ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:17000776,ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965,ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227}. | May be involved in transcriptional regulation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ZBTB8B | chr1:32782383 | chr1:32946492 | ENST00000609129 | + | 1 | 4 | 341_363 | 330 | 496 | Zinc finger | C2H2-type 1 |
| Tgene | >ZBTB8B | chr1:32782383 | chr1:32946492 | ENST00000609129 | + | 1 | 4 | 369_392 | 330 | 496 | Zinc finger | C2H2-type 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HDAC1 | chr1:32782383 | chr1:32946492 | ENST00000373548 | + | 3 | 14 | 9_321 | 93 | 483 | Region | Note=Histone deacetylase |
| Tgene | ZBTB8B | chr1:32782383 | chr1:32946492 | ENST00000609129 | + | 1 | 4 | 132_153 | 330 | 496 | Compositional bias | Note=Poly-Ala |
| Tgene | ZBTB8B | chr1:32782383 | chr1:32946492 | ENST00000609129 | + | 1 | 4 | 24_92 | 330 | 496 | Domain | BTB |
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FusionGeneSequence for HDAC1_ZBTB8B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HDAC1_ENST00000373548_chr1_32782383_+_ZBTB8B_ENST00000609129_chr1_32946492_+_259aa MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQ MQRCDVLVVPIKLHKCPFCPYTAKQKGILKRHIRSHTGERPYPCETCGKRFTRQEHLRSHALSVHRSNRPIICKGCRRTFTSHLSQGLRR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HDAC1_ENST00000373548_chr1_32782383_+_ZBTB8B_ENST00000609129_chr1_32946492_+_777nt ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATG AAGCCTCACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAG ATGCAGAGATGTGATGTGCTGGTGGTCCCCATCAAGCTCCACAAGTGTCCTTTCTGCCCTTACACTGCCAAACAGAAGGGCATCCTCAAG CGGCACATCCGTTCACACACAGGCGAGCGGCCCTACCCCTGTGAGACCTGCGGCAAGAGGTTCACTCGACAAGAGCACCTGCGGAGCCAC GCACTGAGTGTCCACAGATCCAACCGTCCAATCATCTGCAAGGGCTGCAGGAGAACATTCACGAGTCACCTGTCCCAGGGGCTGCGGCGC TTCGGGCTGTGTGACAGCTGCACCTGCGTTACAGACACACCCGATGATGATGATGATTTGATGCCCATCAACCTTAGCTTGGTGGAGGCT TCATCTGAAAGCCAAGAAAAGAGCGACACAGACAATGACTGGCCAATCTATGTGGAGTCGGGTGAGGAAAATGACCCTGCTGGAGATGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HDAC1_ENST00000373548_chr1_32782383_+_ZBTB8B_ENST00000609129_chr1_32946492_+_12129nt CTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCG CAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCT CACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAG GAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAG AGATGTGATGTGCTGGTGGTCCCCATCAAGCTCCACAAGTGTCCTTTCTGCCCTTACACTGCCAAACAGAAGGGCATCCTCAAGCGGCAC ATCCGTTCACACACAGGCGAGCGGCCCTACCCCTGTGAGACCTGCGGCAAGAGGTTCACTCGACAAGAGCACCTGCGGAGCCACGCACTG AGTGTCCACAGATCCAACCGTCCAATCATCTGCAAGGGCTGCAGGAGAACATTCACGAGTCACCTGTCCCAGGGGCTGCGGCGCTTCGGG CTGTGTGACAGCTGCACCTGCGTTACAGACACACCCGATGATGATGATGATTTGATGCCCATCAACCTTAGCTTGGTGGAGGCTTCATCT GAAAGCCAAGAAAAGAGCGACACAGACAATGACTGGCCAATCTATGTGGAGTCGGGTGAGGAAAATGACCCTGCTGGAGATGATTCTGAT GACAAACCACAAATTCAGCCTAACTTATCAGACCGAGAGACACTTACGTAGCAATAAATTGGTGGGGAAGAGGAGGTTTTAAAACTTGTT AGTGCTCGTTCTGTTGTTGAAAGATACCATTTGTCCAATTTTGTGGAACCCTGAGAGGAACATTTTTTCACTGTTATTATATGTGCATTT TTATTAGACTATCTGATAGAGGTTGGATTTTGTGACTCAAAGGACAGATAACCTTTTTGTGTGGTGCCCTTGGTTTCTGAGGGCTTTGCT GGCCACTCCTTAATTCTGAGTGAGTCAAAGCAGGCCCTGAGGTCTCCTGTTTTTCTTGCTGTGTGTCCAAACTCTGGTTAGGAGAAAGAT AAGAAAATCTCCAGGCTTGTTTTTATATTGATTCAGTCCTCTGCATTCCTTTGTTATCATCCTCTTTCTCTAAAAACCATTAAGTTTTGG GATCAAGTTTACCTTTGCCAAGCCTTTCCTAATGAATTCCACATTAAATTTTCTGGCAAAGTATTAAAGAGAAACCTTCATTGATATAAA GCAGGCAGGGCGGTCTGGCTACATGATCATAAAAGGTACTCCCTAAATCTAGAACAATTTTAAAGGCTTGGAATACTTATGGGCAGACGA ACATGGGAATGATCTGAAAGGCTCATTATGGCATCCTGACTTGCCCAGTTGAATTAAATTTTAAGTTAGCCCTGAGAAGGGAGGCTATGA CCCCAGGTCTGGATGGTTTCCCTGTCTGGTTTGGCATTTGACGATTCTACACATACAACCTGTTCTGTTATCATAAAACAACTCATTTGG GCAAAACTCAAAATGCTCCCCTACTTTTTCCAGCAATTTCCAAAAGCTGGAGCTGTGTAACTTGGAAATGTAGCTGCCTCTGGCATTCTT TTACTTAGTTTATGCTGATGTAGGGCAGGTGAGCCCAAAAATTGGGGCTTAGCCCAGAGGAGTTCTTGGCTTCACCCAGGAAAGAATTCA AGGGCAAGCCAGTGGTGTTAGACAGCAGCTTGTATTGAAGCAGCAGTGCCCAACAGCAGCTAAGGGGCCGCTCCTCGTGGAGCAGGGCTA CACCATAGGCAGTGTGCCCAGAGTAGTAGCTCAGAGGCAGGTCGGCACTTATATTTATACCCACTTTTAGTTACATGCAAATTAAGGGGC AGATTATGCAGCAATATTTAGGAAAATGGTGGTAACTTCCAAGCCGCTGGGTGGTTGCCATGATAAGGGGCAGTGACTTCCAGGTGTTGC CATGGCAATGGTAATTGACATGGCACAGTGATAAGTGTTTCTTATGGAAATCTGCTTCCTGCACCACCCTCCCACCACCGCCCTGTTTTA GCTAGTCCTCAATTTGGTCCATGTCCGAGTCCGGCCTTTGGAGTTGAGTCCTGCCTTCTACCTCCTTGCCTAGAACTTTAATTGGAGGGA AAGTATAAGCCCATAATGCCAAGTAACATTTCTAAAATGTTCATCTTTTAAAAGATCTTCATGAGGGAAAGGGAAGGTTAGTAGCAGAAC AGGTTTTTAAAAGCAGTCTACCTTTCGCCCACTTTCCAGCCACACAATTATTGTAACAAAAGAGGCTGAACTCTTTAAAGGGCTAAAGGG CAGGCAGTGTTAGGAATTCGGAATGTAATTGAAGGCAATTTCCATAATTTTGTCTTATGTTAAAATATCCAAAATGGATTTTAAAAGAAA TCTTCTTGTCTTCCTTTAAGTGTAGTTGTCTTTCAAAAGGTGGTAAAAGTCACTTTTATTTCTACCTCTTGAACAACAAAAAAGTCAAAA ACATTATAAATTGGCTTGTAAATGTTAGCCAAAGCATTAGACAGGTGTTTAAGTCGTACTTCTCAATAGTAGTTAAAACTGGAACAGTGC AACTCAAACTCTGGCCCACAGAGAGGCCCTGTTCTGTAAACTGTTTTCTACCAGTCTGCTACAAGGAAAGTCAGAAATTAAGAATACACA TATAGAAATGTTGATAACACTTTGACATTGCTGTGACTCATGGCTTTGTCTTCTTGAGTGAGGTATGGACCAGTTCAGTTCTGGTCAGCT AGAGGGCCACATGGTGCAGAGGTTGGATACCAGCCTGTACAGCAGGACCACGTATTGGTCTGCAGTAGAATGGAAAATTTAAAACTTCTC TTATCACAGGTAGTTCGATAAATATCATTCTTGGCTGTGTGCGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCAGATG GAACACTTGAGGTCAGGAGTTCGATACCAGCCTGACCAACATGGCGAAACCCCGTCTCTAGCAAAAATACAAAAATTAGTCAGGAGTGGT GGCATGTGCCTGTAATCCCAGCTACTCAGGAGGCTGTGGCGAGAGGAACACTTGAGCCTGGAAAAGGTTGCAGTGAGCTGGAATCGTGCC ACTCCACTCCAGCCTGGGCAACAGTGTGAGACCTTGTCTCAAAAAAATAATAATAAAATAAATAAATAAAAGAAAAATATTCTAGATCAA GAGTTACTCATTGAAAATTATCAGGGACCAGAGATATTTGTCTTATCTGAAATAAAAATACTAGCTGTGGCCAGGCGCAGTGGCTCACGC CTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCCCG TCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGCGCATGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGA ACCCAGGAGGCGGAGGTTGCTGTGAGCCGACATCACACCACTGCACTCCAGCCTGGGCAACAAGAGCGAAACTGTCTCCAAAAATGTATA CATATATTTGCTGTTATTTTAAAAGAGGGATCTCAGCAAAAAGGAAACCTAAATGGATGTGTAGAAGATTTACTTGGCCAGGAACAGTGT TTGATATTTTTGCTTTCTCTGTTTAAATTATCTCTGATGTTTTAATGACTTTTCTACCTCATAGTTCAGCCTCTTTGCCTGCTTTCTCCA GTGGAGCTATGATCCTCTTCAGTGATTCCGTGACCTCTTCATATCCCTGGGTAAAACATTTTACATTAGAGATTTCACTGTAGGACAGTG ATTCTCAGTTGGGGGTGATTTCGTGCCTTGCAGGTGGCTACTGGCATCTAGTGGGTAGAGGCCAGGGAAGCTGCCAAACATCCTGAAATG CACAGGACAGTCCCCACAACAATGAATTCTCCAATTCAAAATGTCAGTAATACCAATGTTGAGAAACTCTGCTGTAAGATAAAGTAGGAT TTTTTAAAGGATCTTTAATGAGTGGACTTAATTTTGTGTTCTATTTTAAGCTACCTTTTACCTGCATAATATTTATTTATTTTTAATTTT ATTTTATGTATTTATTTATTTATTTTGAGATGGAGTTTCATCTTTGTCACCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCAA CCTCCACCTCCCAGGTTCAAGAGATTCTTCTGTCTCAGCCTCTTGAGTAGTTGGGATTATAGGCACGCGCCACCACGCCTGGCCAATTTT TGTATTTTTAGTAGAAATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCGCCTGCCTCAGCCTCCCA AAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCTGACCTTCATAATATTTAGTAGCCCCTTATACTCTCGCAAATTTTAGAAAAT AGTGGATTAGTAAAATGAAGCGCTGAGGCCAGATGGTTCATAGCTTGCCCAAGATCTGATTTAGGTTTATAATGTGGAAACTTAGAAAAT TCTGACTCATTCATACACCCAGAATCGTTACTAGGTTCTGATCATTTTGTTAATTTTTAAAGTAGCAGAATCACTGGGAAGAAAACAGAA TGTGACACCTAATGTTTAAATGATTCTCTTTCTTTCGTAATATCTCAGATTGTTGCATTTCTGGTGGACTATTTGGAGTTTGTGTATAGG CACTGGCAATAACTGGATCACTGAGTTCTATCACTTTTAAAGGAGATACTTCCTCTGTCTAGACTATCAGATCATAAATTGGTCCCCTTT AGGTGGTCAGTATTTATAATCACAGTGTCTTTGAGGTTTAATTTGTGGGGTTGGTGGTATTTTTATACTAAGTAAATTTACAGTTGAGCC CAACACAGACCGTTAGTGGTTTAGTTTCTATTCTGGCACATTCCACCCAAGTTCACAAAGGGATATTTTCGTCTCATATTAGATGTATTG CATGAATGGGAACAGGACTCTTACTTGTAATGGAATTCCAAAATGGCATTCTTGGGAAGTTATTTCTCTTGGGGGATGAGGACCCCCTTC TCAAAAGTTGAGAAGGAATGTAAATAGGGCCTTACCTATAATAATTAAGAAATGACATAGTGCATCATGATTCTGATCATTTGGCAGAAA GATGCCGTTCTGATGTAAATATTTTGGTGGCCACCAGACTTTGAATATTCCTTAAGGAAGCTGCTGACCTAGTGTTCTGCAACATGTTAT GGAATTGAGTATTCTGGTGGTTTGGAATACTGAGATGGGTTTTTTTTGTTATTGTTCATTGATGTCGTGACAAACCCCAGGGAGAGAAAG GCAACAGGTAGGGCTGCATGCACTGATTCTGGGAGCCGTAGGAAAGAGTGGAGTGGCCTTTGGTTAACTGAACTCAGACTGTTTTATTTG GAACTCTAGATTTTTCTTGTGTGTGTCCCTTGTGCATTAAGAGAATGATCTCTGTGAAGTCTAGTGTAATGGGGTAGGGAGGGGCAAAGG GTTGGGATGGGTGAGAAGTTCCTATTATGCTCTGTTTTGAGCATTCCCACTGTGCTTCCTGTTGTTGCTGGTCTCTTGTAGCTTGCCTTG TGTTTTCATGTGATCACACTATCTTCTAACCTGATAAAGGGACACTTTATTCAGGTGCATATGATGGGCACTGTTTTCATTGATTTCTGT TGCTTTTGTAGTTCTCTCCACTCAACAGTACTGTGTTCCACAAACCTTTCATTGTAGTGCTGGAAATTTGAATTCTTTTCTTCAAATGAT GTTTCTGTAGAGAAAAACGAAAAGTGTTTTGGGGTCAGAGTAGTTTGGTTGGTTCCTAAACATGTCCTAGTTTTTGTTGTTGTTGTTGTT TTTCTTTTCTTTTTTTTTCTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGC CTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCATGCCCAGCTAATTTTTTGTATT TTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATAGTCTCAATATCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTA GGATTACAGGCGTGAGCCACCGCGCCCGGCCTAAATATATCCTAGTTTTAAAAGGTGACAGTAACTCACATGACTGCATGATCGGATGAC ATGGAAACTTCATAACTGAAGGAGAACATTTAGCATCCGTCTTGACCCTCCAGGTAGATTATTTTACTACTGCCAATTCTTCATTGACAA TTGTGGTTTTAGGGGGGGCAATTTTTATATCCATCATTTGATTTCTGGACCTTTGTCAGTTAATCAGTGGAGGTTAGGGCAGGGATTATG TGCTTTGATGAGGAAGGTTTAGTAGTAACAAGCTTGGGGATTTTGAAGGAAGGCATCAATTTCATATACAGGTCTTGGTGACATGTAATG GATATGGATTATCTGTCATGCATACAGTGAAGGGTATGGTCAGGATTTTTTTGGAAGTAGAAAAACATACCAAACAGTTTCACATCTTTT ACCATCCATAGCCCCTGAGGAGCATCTACTGCCATCAGAAAAACATGCAAATAATACTGCAGTGCCCTCCAAGGGTCTTAGGCCCAACTG AAGGTTTAGAAACATTCAAATTTATAAACTGCCACACTTGGCATCAGATTCACTTAAAAGGATATAGAATGGGAAGCACTGCTTACTAGC AAGGCAGAACCAGTTGCTCTTCTCTGAAAGTCTCTGCAGCTGTCTGTGTGGCATAGTGCAGGTGCAAGGAGACAGATCTACATGGGGCAA GTATGGAAGCTTCCCCGGCTTAAGAGCCCCTTGTCCCACAGGAACAAGTATCTCTTATAACAGCTTCATAGACATGGCCTCCAGTGTCCC TATAAAAGACATGCCTGTTCCAAGCGTCACTGTACTTAGGGATGCCCAGAGCTGAGGCTTCCTATCAGGCATTTATAGTTCTCCCAGTCC AGATGCAGTTTACCAATTGGGCATCATGTCTACCATATGTAACATTGCCTAGCAGTTGACATATGAATTTTTATTAGGTTGCCAGGGGAA CAGAGCTAGAAAGTTAACAAAGGTAAAATTCTCATGCAGAAGGGAAAGAGGCTTTGTTAATACTTTGCCAAACACTATGCTAAGCAATTG CATAACAGATATTACACCTAATTCCTATAGAATATAGCCAGAGGAATTTCCTAGTAAAATATAACCCACCCTAACTCATTTTTCCTTTCT TGAATAGTGTTGTTGGTGCTTAGTTGCTTGTGATTAATAGACAGTTTGCAAATTTTGGTAAGGTGTGTGTAAGAGTTGGCTTAACAGTCA AAATGATCCTAGCCAAAATATCATGTATCCTTTGGTGTCACTCATAATAGGTGAGTATAGTATGTCGTACTGTAGGGACATTATTGAATG GACATGTCTGAGTATTCCATCAGTCATATTTTGATGGGAGCCTTTGGCCATCTGGCAAACACCAAACACAGGCTCTTGGTAACCGTGCCT TTTTTTTTTTTTTTTTTTTTTTAAAGATGGAGTTTCACTCTTGTTGCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACCACAACCTC CGCCTCCTGGATTGAAGCGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTGTA TTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGATCTCGGCCTGACCTCAGGCAATCCGCCTCTGCCTCCCAAAGTGCTGGGA TTACAGGCGTGAGTCACTGCGTCCGGCCTGCTCTTGGAAACCGTGCCTCTTATTCCTGTGTCATGTGGTGCTACTCTTGCCTGCTTCTGT TGCTCCCAGCAGATCAATGAGTGAAGATGGCTGGTTACTCATTCAGTAGTTATCAAACAATTATTTATGGAGTCTTTACTGTATGTCAAG CACGAAGGGTACTTCAGTGAACCAGCACCATCCCTGCCCTCAAGGATCCTGCAGTGTGTAATCACAGAGACTGGCAGTTATAACACGGCA TGTTGGGTGTGACAACAGGGACAAGCACAGGGTACTCTGAGAACGCGTGGGTCGGGTACCTAGCCAGTCATAGAGCCTCAGAGACGCTTT CTGTCTAAGCTACTCTTCCTATCCAGTAAACTTCCAGCTTTGGCATACTATATTTATAAGCAGTTTAAACAGTTGCTGAAATTTATTGCC TTTTCTCAAACATGGTGGCTTTGGTCACTAACAGTGTTTAAATTATGTGTTTTATTCAGTTATGCAAAAATATATACTATACATAGAATA TCAGAATGTTGTAGTCTTTAGGAAATATGCATCAGGTTTGTTTTTTTTGTTTTTTTGACAGACTCTCACTCTGTCGCCAGGCTGGAGTGC AGTGGCGCGATCTTGGCTCACTGCAACCTCCGTATCCCAGGTTCAAGTGATTCCCCTGCCTCAGCCTCCCGAGTAGCTGGCACTACAGGC GTGTGCCACCACGCCCAGCTAATTTTTTGTATTTTATAAGAGATGGCGTGTCACCATGTTGACCAGGATGGTCTTGATCTCCTGACCTCG TGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCTGACTGGGTGGTTTTCTTTTTTAAAAAATAAT ATGGTTTTCTGGCCGGGAGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAACGGGGGTGGATCACCTGAGGTCAGGAGTTA AAGACCAGCCTGGCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAAACAGGAGAATCGCTTGAACTCGGGAGGTAGAGGTTGCAG TGAGCTGAGATAATGCCACTGCACTCCAGCCTGGGCGACGGAGTGAGACTCCATCTCAAAAAAATAAAAAATAATAATAATATGGTTTTC TTATTTAAAAAATAATATAGTATGTAAATTATTTTTCAAGTAAAAATGAAATGACAACAACAGATAACTTCCCATTATGTTGATCCAGTG TACTGTGACAGATGGGGAGGAGCCCCACTGCATCTGGAGTGGGTCTTGGCTGGCCATGTGAACTAATTAATACCCCAGAAATCAGGATAC ATGCCAGGCGTCGGGGCTTACGCCTGTAATCCCAGCATTTTGGGAGGCTAAGGTGGGTGGATCCCTTGAGGTCAGGAGTTTGAGACCAGC CTGACCAACATGGTGAAACCCCATCTCTACTAAAAATATACAAAATTAGCCTGTAATTCCAGCTACTTGGGAAGCTGAGGAAGGAGAATT GCTTGAGCCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTGCACTTCAGCCTGGGCAACGAGAGCAAAACTCCATCTCAAAA AAAAAAAAAAAAAAAAAAAAGAAATCAGGATACATATAGGACAGAACCATTAAATCAAGAGATTTGAAAGTTAGAAGGGACAGGAGAGAT AGTCTAGTCCAACTCCATGTGACAGATGAAATGACGTTTCTAGTTCTCACACAGCTGGTTAGGATCAGAAACCAGGTCCTGCCAGGCCAG TCCTGATAATAGACAGACATGTTTGGGCAGGCAGAAAAGACCATTCATAGATAACATTTGTTTCCCTGGGTATCCATCAGACCAGAGGCA CAGGAGAGGAAAATGCTGTTTTGGCCTCATATGATAAAGTATGCATTGTGTGATTATGGTCTGCATTCTTGCAATGCTTAGACAGGGAGG GGGAAATCACATTTTGAGCATGGGGGAGTTAATTTCTTTGTCCTGTAATACCACACATATCTAAAACATAAACCACCATGGAACACACTC ACACTCACATACACACAAAAGGCAAATTAAAATATTTATTGTCCACTTAATATGTGTTCTGTGTTTGATTGTAATGTATTCATTTTACTT ATAAAAAATTTCAAAAGTAAAAATATATATATTATTAACTTGAAGTGATTTTTTCCAACCTCGCTGATTTTTTTCCTTCTTTCTTTTTTG AGACAGAGTTCCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCCCACTGCAATCTCCGCCTCCAGAGTTCAAAGAGTTCT CATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAGGTATGCCACCATGCCCGGCTAATTTTTGTATTTTTAGAAGAGATGGGGTTTCAT TTTGGTCAGGCTGGTCTCGAACTCCTAACCTCAGGTGATACACCCGCCTCAGCCTTCCAAAGTGCTGAGATTACAGGTGTGAGCCACCAT GTCCGGCCTCTAACTGATTTTTGAAATATAAATTGGGTGTGATTCAGGGAATGTAACAAGAACAATCTTATTTGAAACAGAAAACCACAT ATTTTTAAGTCAGCAGCCCACATGATAAGATGGTATTGAGTAAAAATGTATTCTTAGGTATTTCTTGACTCAGTGGATTTTAATCAGTCT ACTGCAAAAGCTAGTTTTATTTAAAGGGCTGCAATTATATATAAGAATTATTAGAAAAACAGATTAGCCACTTAATCTAAAAATACCTAG ATGCAGTATTCCTGGTTTTTAATGAAATATTTATCTAGTTTGGGATTAAAATTAACTTAGGGCCATCAAAAATGCAAATTATCTTTAATT TGGTTAAATCAACCTGGGAGTAAATGGAAATAATCTCAAGCTAAATTTTTGTTTTGATTTATATACAGTCAGATTGAAACACCCTAGTTA CAAGTTTAGAATAGGAGTGGCCTCAACAAAGGAAAAAGTCCTTTGTTCCTCTGTTGCTCATTTTGTCCTCGGAAACAAATACAATTTAAC TATTTTCTGTACCGTCCCAAATTTGAAGCTGACCTGAATTTGGTACCTATAAATTTAAAATGGCTAAGGTTAAAATAGTTAAAACAGTTT CTTTAGAATGAGTTGTTAGCTGGGTGTGGTAGTGTACACCTGTAGTCCCAGCTACTCCAAAGGCTGAGGCAGGAGGATTGCTTGAGCCCA GAAGTTCAAAGCTGCAGTGAACTAGGATCATGTCACCACACTCCAGCGTGGGCAACAGAATGAGACCCTGTCTCAAAAAAAAAGGTTTTT TTTTAATTGAATGAATGCAATAAGGAATTGAGGATCGTCTCACATTAATGAGTGAATAACCCTTCATAATTTTAGTTACTGTTTTTCTCA GGGCAATTATTTTATATAAAATTCTAATGGAGAATTTTATGGACAAGATTTTAGTTAAGGAAAAAAATAACCCCACAAAATAAAGAGAAC TATTAGAGCTCTAAACAGAAGAAGCTTCCATCAAACCGTTTTTCCCACTTTTTTGTCCCACGGTCTTAGGACCAACAATTTAGTAATACG AGACAATTTCTGGCAGACTATCCCAAGCTGGGACATTTTAGATTCTGTGAAAGAAGACTGACTACTGTCTGATGAATGGGTAATTGATGA TGCAATGTATGAAAAAAGTAAGGCAGACAACTCAAAAATCACAGGAAGTGCAGCCATTCTACGTGCCGAGCTCTACAGTTACACACTGTC CAACAGCTCTCGGAAGAAAAACAGAAACTGACTTTATCTTTGCCTGCCAAGTTTGCAAATGGATTAGTTCATTACAAAGGCACTTGTCAA AACATATTTATTAAAAAGAGGAGCCAGAGTTGGAAATCATCTTGACCATTAAAAAAATAGCAACTGATACCTTGTTTAACAAGTAAGACA GTTTCTGCTTTTTGGAATTGAATTGGTTTTTAAGTGGTAATGTACCAGGTCTGTTTATATAGGTCAGTGTTGCCCAGGTTGTATTGTTTT |
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FusionGenePPI for HDAC1_ZBTB8B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HDAC1 | ZBTB16, MBD3L1, BUB1, BUB1B, BUB3, CDC20, CDH1, MAD1L1, KDM1A, HMG20B, RCOR1, PHF21A, HDAC2, RB1, CTBP1, TGIF1, DDX5, DDX17, DNMT3B, GATA1, PHB, CDYL, SIN3A, RBBP4, MTA1, MTA2, HDAC1, CHD4, RBBP7, CHD1, SP1, KMT2A, TXNIP, SAP30, SAP130, ARID4B, SUDS3, HCFC1, PTMA, EFCAB6, AR, YY1, GTF2I, MBD3, MBD2, TAB2, GATAD2B, HDAC9, HSPD1, HSPA4, TOP2B, TOP2A, RELA, NCOR2, ATR, PML, RFC1, BRCA1, MYOD1, NFKB1, MDM2, TP53, SMARCB1, SMARCA2, PCNA, DNMT1, RBL1, FKBP3, NFIX, PPARD, RBL2, E2F4, BCOR, MIER1, TGIF2, DAXX, CBFA2T3, SIN3B, HBP1, E2F1, IKZF1, CHD3, MECOM, KLF11, SMAD2, DNMT3L, BCL6, CABIN1, VHL, HIF1AN, HIF1A, DNMT3A, SATB1, HUS1, RAD9A, PHF12, ING1, RUNX1T1, SP3, SUV39H1, EED, EZH2, TPD52L1, TAL1, NR2F2, SPEN, TLE4, HR, HEY2, IFRD1, MXD1, DZIP3, UHRF1, PADI4, MECP2, SPI1, MBD4, WHSC1, ING2, ZMYND11, H2AFY, KDM5C, ETHE1, ZMYM2, REST, PRDM1, FRA10F, CDKN1A, GLI1, GLI2, KCTD11, APBB1, BNIP3, SFPQ, ZBTB7A, MKX, CHFR, TLE1, CDK5R1, SMARCA4, PPP1CC, DACH1, NUDT21, PAPOLA, HSF1, BANF1, ZFP36, MBTPS1, CEBPB, APPL1, BACH1, ADD1, POU2F1, CREM, JUN, SMAD7, HELLS, DACT1, NKX2-5, BRMS1, SERPINB5, HOXA11, FOSL1, SAP30L, EP300, PAX3, CREBBP, NR3C1, GATAD2A, RUNX2, RUVBL2, NKX3-1, RUNX1, NUP98, NUP54, GRIP1, PLAGL1, NFE4, MAPK8, MAPK9, MAPK10, INSM1, CEBPD, REPIN1, GCM1, RERE, RFX1, TRIM27, NFYC, SNAI1, SNAI2, SNAI3, NKX3-2, MEN1, ESR1, BCL3, LMO4, SYK, GFI1, CRYAB, ESCO2, CTNNB1, PARP1, E4F1, MTA3, CIITA, HES1, BCL6B, STAT5A, CREB1, LCOR, PITX2, TAF6, GLI3, SMARCE1, SMARCC2, HSD11B2, BCL11B, BCL11A, BAZ2A, TFCP2, HIST1H3A, MYT1, KDM4A, STAT3, NR0B2, CCND1, CEBPA, MBD3L2, NKX2-2, KLF5, CSNK2A1, PFDN5, HNRNPD, NR2E1, KLF4, KLF1, NFKBIA, SATB2, MNT, MYC, TBX3, MAFK, PRKACA, TBP, SMAD3, ARID4A, ELK1, HDAC7, TP73, UHRF2, ACTA1, PBX1, LEF1, SENP1, ATM, ENO1, PHB2, TAF1B, ZEB2, SKIL, ZFPM2, UBASH3B, PIAS4, NR1D2, BHLHE41, NONO, SOX6, ZNF395, SMAD1, SMAD5, SMAD4, SMEK1, ZNF148, NPM1, PRDM5, EMD, CCDC6, OVOL1, SAMSN1, GABPA, MORF4L1, MORF4L2, DMAP1, ATF3, PPARG, MEF2D, MEF2A, SMC4, CCT8, TCP1, VIM, TRIM21, ESCO1, PARK7, TSC22D3, CDK2AP1, TADA2A, BANP, NFYB, IRF5, DEC1, HIST2H2AA3, PPP6R3, PPP2R1B, PPP2R1A, HDAC5, KAT5, BRINP1, HIST1H4A, HIST3H3, THAP11, PRKG1, NFYA, DDIT3, SMARCAD1, SOX2, KDM5B, HDGF, FOXP3, WISP2, PRDM4, GPS2, UBTF, PCGF6, RNF2, HIST3H2BB, CDKN2A, NR2C1, NR2C2, POLD3, TRIM28, KDM4C, NFATC1, TFAP4, BAHD1, VPRBP, AIRE, BRMS1L, MAGEA1, JDP2, ZNF76, SMARCC1, SMARCA5, SMARCD1, NOTCH1, FN1, SS18, SSX2, DNTTIP1, GSE1, HMG20A, RCOR3, ELMSAN1, TRERF1, E2F3, TMEM54, EID3, STAT1, BHLHE40, ADNP, ADH5, ARID5B, BEND3, CSNK2B, TBL1XR1, GATAD1, EHMT2, BBX, KPNA1, KPNA3, KPNA4, KPNA6, IDH2, KDM5A, ACADM, MIER2, MIER3, PFDN2, VBP1, PFDN6, C11orf30, FAM60A, ZMYND8, PWWP2A, RREB1, RCOR2, ESD, TNRC18, TRMT61A, C16orf87, WDR5, ZBTB2, ZMYM3, ZNF217, ZNF512B, ZNF516, ZNF521, ZNF592, ZNF609, ZNF687, ZNF827, IKZF2, PRRG4, HEXIM1, UBE2I, ZGPAT, BRCC3, SF3A1, HNRNPR, LARP7, PAAF1, RABEP2, NACC2, RARA, FEZF2, HAUS2, PRDM6, NFE2L2, DDB1, CUL4B, APEX1, PHF6, LOXL2, SUZ12, SUMO2, SIRT6, MAP1LC3B, HIST1H2AA, HIST1H2BA, ZNF219, PHF20L1, C22orf31, DDB2, PHF1, CHD5, EP400, MAPK11, MAPK14, POLR3A, PIN1, TLE3, PPP1CA, RAP1A, NRIP1, RUNX3, HIST1H3E, ALDH1B1, CCT6A, E2F6, ERCC6, H3F3A, IPO5, AFF1, PEX10, PIK3CA, RING1, SRPR, TCF20, CCT3, TRPS1, CDC42BPA, NOLC1, PHF14, DNAJC6, PARP2, CCT7, CCT4, CCT2, ZNF273, RALBP1, TRAK1, CCT5, EXOSC7, PHLPP1, MGA, COG4, TIMM13, DESI1, SNX9, TRPM7, BCAS3, ZFP64, BAHCC1, GPAM, EHMT1, CCNL2, ASCC2, HSDL2, ANKRD13B, C2orf69, FOXK1, PGBD3, STRAP, KMT2E, NF2, USP37, FOXK2, MAGEB2, CCNB1, NFATC2, RNF138, USP19, RORC, CDK4, EGFR, L3MBTL2, CASP8AP2, SFMBT1, CCDC71, PHF21B, TFDP1, PWWP2B, ZNF608, CCT6B, ZNF800, CYBRD1, ZNF639, RYBP, C9orf41, WIZ, RFX3, XYLT2, RTCB, PTOV1, DDX1, TBC1D32, TAF6L, CDK20, FOXJ1, HSD17B10, RNF157, YAP1 | ZBTB8B | KIF5B, ILF2, CPSF6, PPIP5K2, LSM7, PPIP5K1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HDAC1_ZBTB8B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HDAC1 | Q13547 | DB01169 | Arsenic trioxide | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB01593 | Zinc | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB02546 | Vorinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB05015 | Belinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB06176 | Romidepsin | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB06603 | Panobinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB08868 | Fingolimod | Histone deacetylase 1 | small molecule | approved|investigational |
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RelatedDiseases for HDAC1_ZBTB8B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HDAC1 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | HDAC1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | HDAC1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | HDAC1 | C0018799 | Heart Diseases | 1 | CTD_human |
| Hgene | HDAC1 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human |
| Hgene | HDAC1 | C0525045 | Mood Disorders | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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