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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 15925

FusionGeneSummary for HDAC1_KPNA6

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC1_KPNA6
Fusion gene ID: 15925
HgeneTgene
Gene symbol

HDAC1

KPNA6

Gene ID

3065

23633

Gene namehistone deacetylase 1karyopherin subunit alpha 6
SynonymsGON-10|HD1|RPD3|RPD3L1IPOA7|KPNA7
Cytomap

1p35.2-p35.1

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 1reduced potassium dependency, yeast homolog-like 1importin subunit alpha-7importin alpha 7 subunitimportin-alpha-S2karyopherin alpha 6 (importin alpha 7)
Modification date2018052320180523
UniProtAcc

Q13547

O60684

Ensembl transtripts involved in fusion geneENST00000373548, ENST00000373541, 
ENST00000490081, 
ENST00000373625, 
ENST00000537234, ENST00000469790, 
ENST00000545542, 
Fusion gene scores* DoF score9 X 6 X 7=3785 X 5 X 3=75
# samples 96
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HDAC1 [Title/Abstract] AND KPNA6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC1

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

HgeneHDAC1

GO:0006476

protein deacetylation

17172643|23629966

HgeneHDAC1

GO:0045893

positive regulation of transcription, DNA-templated

16762839

HgeneHDAC1

GO:0045944

positive regulation of transcription by RNA polymerase II

16762839

HgeneHDAC1

GO:0060766

negative regulation of androgen receptor signaling pathway

15919722

HgeneHDAC1

GO:0070932

histone H3 deacetylation

12590135

HgeneHDAC1

GO:0070933

histone H4 deacetylation

12590135


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0B9-01AHDAC1chr1

32790154

+KPNA6chr1

32620189

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373548ENST00000373625HDAC1chr1

32790154

+KPNA6chr1

32620189

+
5CDS-5UTRENST00000373548ENST00000537234HDAC1chr1

32790154

+KPNA6chr1

32620189

+
5CDS-3UTRENST00000373548ENST00000469790HDAC1chr1

32790154

+KPNA6chr1

32620189

+
5CDS-3UTRENST00000373548ENST00000545542HDAC1chr1

32790154

+KPNA6chr1

32620189

+
5UTR-3CDSENST00000373541ENST00000373625HDAC1chr1

32790154

+KPNA6chr1

32620189

+
5UTR-5UTRENST00000373541ENST00000537234HDAC1chr1

32790154

+KPNA6chr1

32620189

+
5UTR-3UTRENST00000373541ENST00000469790HDAC1chr1

32790154

+KPNA6chr1

32620189

+
5UTR-3UTRENST00000373541ENST00000545542HDAC1chr1

32790154

+KPNA6chr1

32620189

+
intron-3CDSENST00000490081ENST00000373625HDAC1chr1

32790154

+KPNA6chr1

32620189

+
intron-5UTRENST00000490081ENST00000537234HDAC1chr1

32790154

+KPNA6chr1

32620189

+
intron-3UTRENST00000490081ENST00000469790HDAC1chr1

32790154

+KPNA6chr1

32620189

+
intron-3UTRENST00000490081ENST00000545542HDAC1chr1

32790154

+KPNA6chr1

32620189

+

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FusionProtFeatures for HDAC1_KPNA6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC1

Q13547

KPNA6

O60684

Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Deacetylates SPproteins, SP1 and SP3, and regulates their function. Component ofthe BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calciumstimulation, HDAC1 is released from the complex and CREBBP isrecruited, which facilitates transcriptional activation.Deacetylates TSHZ3 and regulates its transcriptional repressoractivity. Deacetylates 'Lys-310' in RELA and thereby inhibits thetranscriptional activity of NF-kappa-B. Deacetylates NR1D2 andabrogates the effect of KAT5-mediated relieving of NR1D2transcription repression activity. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histonedeacetylase (HDAC) recruitment, a number of genes implicated inmultilineage blood cell development. Involved in CIART-mediatedtranscriptional repression of the circadian transcriptionalactivator: CLOCK-ARNTL/BMAL1 heterodimer. Required for thetranscriptional repression of circadian target genes, such asPER1, mediated by the large PER complex or CRY1 through histonedeacetylation. {ECO:0000269|PubMed:12837748,ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:17000776,ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965,ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227}. Functions in nuclear protein import as an adapterprotein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLSmotif. Docking of the importin/substrate complex to the nuclearpore complex (NPC) is mediated by KPNB1 through binding tonucleoporin FxFG repeats and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to importin-beta and the three components separate andimportin-alpha and -beta are re-exported from the nucleus to thecytoplasm where GTP hydrolysis releases Ran from importin. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+0141_601537DomainIBB
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+01445_541537MotifNuclear localization signal
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014147_2391537RegionNLS binding site (major)
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014316_4041537RegionNLS binding site (minor)
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014116_1591537RepeatNote=ARM 2
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014160_2041537RepeatNote=ARM 3
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014205_2431537RepeatNote=ARM 4
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014244_2881537RepeatNote=ARM 5
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014289_3281537RepeatNote=ARM 6
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014329_3701537RepeatNote=ARM 7
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014371_4101537RepeatNote=ARM 8
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014411_4531537RepeatNote=ARM 9
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+014457_5021537RepeatNote=ARM 10%3B atypical
TgeneKPNA6chr1:32790154chr1:32620189ENST00000373625+01476_1151537RepeatNote=ARM 1%3B truncated

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDAC1chr1:32790154chr1:32620189ENST00000373548+4149_321118483RegionNote=Histone deacetylase


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FusionGeneSequence for HDAC1_KPNA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HDAC1_ENST00000373548_chr1_32790154_+_KPNA6_ENST00000373625_chr1_32620189_+_654aa
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQ
MQRFNVGEDCPVFDGLFEFCQLSTGGSVETMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMF
DSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIA
SGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNP
PPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVIL
NCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCI
KPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HDAC1_ENST00000373548_chr1_32790154_+_KPNA6_ENST00000373625_chr1_32620189_+_1962nt
ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATG
AAGCCTCACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT
GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAG
ATGCAGAGATTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGAGACC
ATGGCGAGCCCAGGGAAAGACAATTATCGAATGAAGAGCTATAAGAACAATGCTCTAAACCCTGAAGAAATGAGACGAAGAAGAGAGGAA
GAGGGCATTCAGCTCCGGAAGCAGAAGCGAGAGCAACAACTTTTTAAACGGAGAAATGTGGAGCTGATTAATGAAGAAGCTGCCATGTTC
GATAGTCTTCTCATGGACTCTTATGTGAGCTCTACCACTGGGGAGAGTGTGATCACAAGAGAGATGGTGGAGATGCTCTTTTCTGATGAT
TCTGACCTGCAGTTAGCAACCACACAGAAATTCCGGAAACTGCTCTCCAAAGAGCCTAGTCCTCCAATAGATGAAGTTATCAACACTCCA
AGAGTGGTGGATCGGTTCGTGGAGTTTCTGAAGAGGAATGAGAATTGTACATTACAGTTTGAAGCTGCCTGGGCTCTAACGAATATTGCC
TCTGGAACCTCTCAGCAGACCAAAATTGTCATTGAAGCAGGGGCTGTCCCCATTTTTATAGAGCTGCTTAATTCAGACTTTGAGGATGTT
CAGGAACAGGCAGTCTGGGCACTGGGAAACATAGCTGGAGATAGCTCTGTTTGCCGAGATTACGTCTTGAACTGTTCCATCCTTAATCCT
TTGTTAACACTCCTTACCAAGTCCACACGACTGACGATGACACGGAATGCAGTCTGGGCCCTGTCAAATCTCTGCCGAGGGAAAAACCCA
CCCCCAGAGTTTGCAAAGGTCTCTCCTTGTTTGCCTGTACTGTCTCGCCTACTCTTCAGCAGCGACTCGGACTTGCTGGCAGATGCTTGC
TGGGCCCTTTCTTATCTGTCTGATGGCCCCAATGAGAAGATCCAGGCAGTCATAGACTCCGGAGTCTGCCGGAGATTGGTAGAGCTGCTG
ATGCACAATGATTACAAAGTGGCTTCTCCTGCCCTGAGAGCCGTGGGTAACATCGTCACTGGGGATGACATCCAGACCCAGGTCATTCTT
AACTGTTCAGCCCTACCTTGCCTTCTCCACTTGTTGAGCAGTCCCAAGGAGTCAATCCGGAAGGAAGCTTGCTGGACTATTTCAAATATT
ACTGCTGGCAACAGGGCTCAAATACAGGCTGTTATAGATGCAAATATCTTCCCTGTGTTGATCGAAATCCTTCAGAAAGCAGAGTTTCGT
ACAAGGAAAGAGGCAGCCTGGGCCATCACCAATGCCACATCAGGAGGAACCCCTGAGCAGATCAGGTACCTGGTCTCACTGGGCTGCATC
AAACCCCTATGTGACTTGCTGACTGTAATGGATTCGAAGATTGTGCAAGTGGCCCTCAATGGACTGGAGAACATCCTGCGGCTTGGAGAG
CAAGAGGGCAAGCGCAGTGGCTCAGGGGTCAATCCTTATTGTGGCCTCATAGAGGAAGCCTATGGCTTGGATAAAATTGAGTTTCTCCAG
AGCCACGAGAACCAGGAGATCTACCAGAAGGCCTTCGACCTCATTGAGCACTACTTTGGTGTAGAAGACGATGATAGCAGCCTGGCTCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_HDAC1_ENST00000373548_chr1_32790154_+_KPNA6_ENST00000373625_chr1_32620189_+_7720nt
CTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCG
CAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCT
CACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAG
GAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAG
AGATTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGAGACCATGGCG
AGCCCAGGGAAAGACAATTATCGAATGAAGAGCTATAAGAACAATGCTCTAAACCCTGAAGAAATGAGACGAAGAAGAGAGGAAGAGGGC
ATTCAGCTCCGGAAGCAGAAGCGAGAGCAACAACTTTTTAAACGGAGAAATGTGGAGCTGATTAATGAAGAAGCTGCCATGTTCGATAGT
CTTCTCATGGACTCTTATGTGAGCTCTACCACTGGGGAGAGTGTGATCACAAGAGAGATGGTGGAGATGCTCTTTTCTGATGATTCTGAC
CTGCAGTTAGCAACCACACAGAAATTCCGGAAACTGCTCTCCAAAGAGCCTAGTCCTCCAATAGATGAAGTTATCAACACTCCAAGAGTG
GTGGATCGGTTCGTGGAGTTTCTGAAGAGGAATGAGAATTGTACATTACAGTTTGAAGCTGCCTGGGCTCTAACGAATATTGCCTCTGGA
ACCTCTCAGCAGACCAAAATTGTCATTGAAGCAGGGGCTGTCCCCATTTTTATAGAGCTGCTTAATTCAGACTTTGAGGATGTTCAGGAA
CAGGCAGTCTGGGCACTGGGAAACATAGCTGGAGATAGCTCTGTTTGCCGAGATTACGTCTTGAACTGTTCCATCCTTAATCCTTTGTTA
ACACTCCTTACCAAGTCCACACGACTGACGATGACACGGAATGCAGTCTGGGCCCTGTCAAATCTCTGCCGAGGGAAAAACCCACCCCCA
GAGTTTGCAAAGGTCTCTCCTTGTTTGCCTGTACTGTCTCGCCTACTCTTCAGCAGCGACTCGGACTTGCTGGCAGATGCTTGCTGGGCC
CTTTCTTATCTGTCTGATGGCCCCAATGAGAAGATCCAGGCAGTCATAGACTCCGGAGTCTGCCGGAGATTGGTAGAGCTGCTGATGCAC
AATGATTACAAAGTGGCTTCTCCTGCCCTGAGAGCCGTGGGTAACATCGTCACTGGGGATGACATCCAGACCCAGGTCATTCTTAACTGT
TCAGCCCTACCTTGCCTTCTCCACTTGTTGAGCAGTCCCAAGGAGTCAATCCGGAAGGAAGCTTGCTGGACTATTTCAAATATTACTGCT
GGCAACAGGGCTCAAATACAGGCTGTTATAGATGCAAATATCTTCCCTGTGTTGATCGAAATCCTTCAGAAAGCAGAGTTTCGTACAAGG
AAAGAGGCAGCCTGGGCCATCACCAATGCCACATCAGGAGGAACCCCTGAGCAGATCAGGTACCTGGTCTCACTGGGCTGCATCAAACCC
CTATGTGACTTGCTGACTGTAATGGATTCGAAGATTGTGCAAGTGGCCCTCAATGGACTGGAGAACATCCTGCGGCTTGGAGAGCAAGAG
GGCAAGCGCAGTGGCTCAGGGGTCAATCCTTATTGTGGCCTCATAGAGGAAGCCTATGGCTTGGATAAAATTGAGTTTCTCCAGAGCCAC
GAGAACCAGGAGATCTACCAGAAGGCCTTCGACCTCATTGAGCACTACTTTGGTGTAGAAGACGATGATAGCAGCCTGGCTCCCCAAGTC
GATGAAACGCAACAGCAGTTCATCTTCCAGCAGCCTGAGGCCCCCATGGAGGGCTTCCAGCTATAATATCTGCCTCCAGGGAGGGGAGGG
GATGGGAAGCACCACCAGCCAGCGGAAGAGCAGCCCTCTGGTGGGCGGGAAACCAGTGTCCCCACCATCAGCCACCACACACCTCTGCTG
CCCTGGAGACTGTGCTCTTGACCTGCTCCGCCCCCTTCCCTGGAGGGAGCACCCTCTGGACAGACAGAACCATCTGAGGCTCACCTTTGG
GTTTTGTGACAAGAAGGGGACGTGTTGGGTTTTTCTTCCTTACACTATATTTTGGCTGCACACATGTCTTTAACCCAGGAGCCCAGGGGT
AGACAAAGGAGGACTAAGGTAATCAATTTGCACCTTTTTTTATTTTTATTTTTTTTCTTTTTTTCTTCAGTGGTGACTTCCTTCCCTTTA
TCTTTTTTCATTCTTCCCGGTCCTCTGCCCTGATCTGTGTAACTCTTATCTTGGGTACTTGAGCAGACGGTATATTCCAGAGGTGGGAGG
TGGGAGGGGAAGGGAGAAATCCAAAACAAAGTGTTCTTGCTCTGACAGAATATTAATCTTGTACGCTTGGATTGAGTTATTTAATTTTTT
TTTCTTTTGCACATTTTTCTTGTATTAAGATTGCTCTTCCCAAGAGCCACAAGTTCCTGGTTTTAGTAAACCCAGCTGCCTGCATTGCCT
GGGACTAGAGGCTGGGGAGGCTACCATGAAACAAAGGTCCCTCCCTCCCTCTGACTCTTTGCCCAGACCTCTTTAGTTTGGGGGATCCTC
CTCACTCTCCTGAAGTGTCTCAAGTATACCAGTGGGAGTGCAGGGGAGGAGCACAGGCCTTCAGATGGGGCTTCCCACGTGTAGCTACTG
ATCCCATATTTCCTACTCACCTTCCAAATGGTGCGACCCAACTTCATTTGTTTACTTGAAAATTCCCCCTCGAGGTTGAGAGAACCTCTG
AGGTGGCTGTATTTTCTCCTAAGCTTGAGATAGGGGGCTGTGGTCCTTCCTTTCTCCTGAGGAGAAAGTCCTTGCTCTGGTGACCTGTAA
GTTGCAGAGGAGGGTGGAGTGAGAGTGTCATGTATTGGGATAGTCAGGGATCCCTGCCTTTGGCCTTTCTTCTTCTTCTTCTTCCTCTTC
CATAGTTGGATCATGTATATTTTACTTCTAAAGGAGAGAATGTCAAAAAGTTCTGTATTTTTTTATATTCTATATATTAGGTAGGTCAAT
CTTAATTGGTCTCAAGAGGAAGAACTGTCTGTCATTTCGGTAAGTAGGATACTGTGAGGAAGACCAAAAAGAGATATGGATGCTTCCTCG
CTCAGGAGGCCTGAGCTTGGTCCTTTTCCTCTCTGCTTGGATTCTGGACCACCACCTGGGACCAACCTTCAGCTCTGGAACCTTCATAAA
GCAGGTCAGCGTGGCCTGATTGTCCCAGGACCTGAAGGGAGCAAGGATGGCCTCAGGGCCTGGTGAAGTCTGCTACTCTGTCCTTACTGC
TGAACATCCTGCTTGTATCAGGAAACTCAGAAGCAGTTTGCCTTGTCAAATTCAATCTCAATGGCCATTGTCCACATAACTGATCACCCA
TGGCTGCCTCTCCTATTATCTATTATCACTGAAACTTAGTAGCCTGCTTTTTTTTTTTTTTTTTTTAGAGCTATTGCGTATCTTCCCTGT
TTGGGATCCTTGTACCTGGTTTGGGTTTTCCCTTCCTTGTGACAATTATAATCCAGATGCCTCTTCTTTCTGTTTGAATTACGGTAGTGC
ATTGCCTTAGTGGCTTGCCTGTGCCTCTGGGTGGATTACATATGATAGTAAAGCCCACCTGTTTGGATGGGAGTAGAGGAAGTTGGTGTA
GACCAGCTGTGGAGCTGAAGGCACAGTCTGCCCCACCCCCACCTCCCCACTGTGGTTAGTCAGAGGCATCCTGCTCCAAGCTCTGCTTTT
CCTTCCTCTGAAACAATGCCATTCTTGCTTCTATTGCTACACATCTCCTTCTGGCTCAGGTGAAATCCATGCCCTTCTGCTTATAGACCT
AAAGTTCAGGTACTTATTATTGGCCATTGATCTTGAATTTGCCCTCTCCTAGTGCTGCAGTCCCACTTCAAAGCCATTTTCTGAGGAGGA
TGGTTTAGGTCTGGCAATTGTCCTTGAAAAATCCCACCCATGTTGTACCACCTTGGTGAGTCATATGCCACTCATCAGCTTGGGAATGAT
GGCTGCCAACTCCCAATCTCCCAGGAAGGCAGGGGGCAGAATCTTTTTTTCACTTGGCCTGCTACCTCCATTAAAAAACCATTCTCTTAC
AGTTTAAAAAAAAAAAAAAAAAAAAAGCCTTCCCCTACCCAACCTCCGCCCATTGTTCTCTTCCAAAGGGCAATTTAGTAGGATCTACTT
TGTACATCTCAAGTAAGAGTTAAGTCCCTGATACAGGGACCAGTTTCTTAGTGTAAGACATACACATCCTGCTTGTCCAGCTGTTCCTCC
AAAATCTACTTTGGCTTCAGCTCCGGGTCCTGTACCAGATGGAAAATGTTTTTGGTGATCTGGCTGCTGCTTAAAGCCAGTTTTCCCTAA
GAACTCCAAAGGCTAAAGTCTACTAGGGGCAGAGTGTGAGGATAGATTTCTAATCAGAGAAAAGTGGCCTCCAGGAGCTTTCATTTATGT
CTTCTCCAGACCAGGTTTTCCTGTTATCTTCCTTTAATCCCCTTTCAACCAACAGGTGAAGTTCTTCCAGCCCACAGAGGTAGTAATATC
ATCTTTTCTATCTCCTCCTCTCCTTTGGCCATGTAATGAAGCAAAATATTATTTATTTAGCCCAGGCTTGAGAGCCACTGTTTGTGGACA
GTCTTCATCTAGATTCCATACCCTGGCCTAGGCGAGGTAAGGCTCTCTGGTTATTGCCAGGATGGAGCCCCTCTACCCCAGTCTGCTGTA
GGGAATACCCTAATTAGTTGAGGCATGCTTTTGGAATCCTGGCATGTTGGCATATGGCTGGTCTATCCTTTTTAAGATCTCTGGTTGGGG
GTATCTGGATATGGATTAGGAGGGACAAGGAGCCTTTTTCTTGGCTAATGTTTTCCAATACTTTTTTGAATGGTGCCAGCCCCTCCAGGC
ATCCCACCCCCAAATCATCATCTTTAGTACTAACAGGGTGTCTGGTCTTAGAAGCCTCCCTTCAGATCCCAGCTGACCCTGGTGACTGCC
TGGCCTTGATGTTGGCTGCAGCCTTCTGATAGAACCACATGGATTCCACCCACAGCTGGCCAGGCTTGTTACATGGGTCAGGGAATACAA
ATGGCCCCCCCCCAGGGAGCAGGTGTTGGCCTCAGTTTTCAGGGACCCTTGGTGTTGCTCCTTACCTAGAGCCCATTAATCTACCCCATC
AACTCTCTGCCATGAAAGCCATCTTCCAGGAGCCCTGTTTTTTGGAGCTGAACTGCACAGATTATAGCTGCTATTGTACTTAAATAAGGG
AGAGGAAAAGAAGGTTCTCAGGCACAGACTTTCTATTTTTCTCAAGCCAAACCAGTTTAAAATGTCTAGCAGAATGAACTGTATTTCCAT
TTCTTCATGTCTACCTGCCTTCCCCCCACACCCTAAAGTTGTACTTGTTTCTAGCAAACTAGAAGGAAAAGATAGGAAAGCCTGGCACTA
CTAACCTCACCTCTCATACACCTCTTTGAAGGCCCCAGCTCTTTTGTTCAGGCCTCTCTTCTCCCCTAGACTCACTCAGCTTGGTATCCA
TCATCTTGAGCATTCTTCAGTAGATTCATCTAGGGTTCAGATTCCAGACTCTCAGCTGAAGACAGGGAGCCAATTTCCCCCAGGTCCCTG
CAGGTAATCCAGGGACCCCATAGGGAGAACAGGCTGACTGGGGCATTAGGAATGTTTGTACCTCTCTGCTTCCCTGGCAGCCTGGGGAAG
GGTGCAGGGCTCAGTGCGCTAAACCATGGTAAACATCTTCAATAGAACTACCCTAGAATTTAGTGAGTGTGAGACTGAGATATTGCTCAG
AATAAATTTATTCCATAGCCATTTAGGATTGCATGTTCTGGACCAACCTTGTCCAGTATGTTTTCTGTTTGAGCTTTTTCATTCTTTTGT
TAAGCCAACAAGTTGAGAATTTGGCCCTGCTGGGATCCATGTAGTGGGCACTAGCTGCTCTTTGGCCAAGGCCTTCATAAATGATTCAGT
CTCTCATTATCTGTCCTCTAGCCCCACACCCTGATTTAGACCGTGGCAAAGGAAGAACTTGAGGTCAAGACCAACCAAATCTGTGAATTA
AAGCTGTTATTTTTTTCTCTGCAAGGGCGCTTTGCTTCAGGTCTGGGCTATGTGCAGAACCTAAGCAGGCTGTGAGAGTTAGAAGAGGCA
GTATTACATGTTAGGCCCAGAACACCATGGGAAAAGGTTTATGTAGTGTATCTTAGTGGCCTGCCTAGCTGCCTCTGGGCCAGGCTGACT
TCTGATGTCCACATTAGCTCGTACCTGAACCCTGTTGCTGAATGCCAGCCCTGTTCTCCTGTAACTATTATATACGCCATGGCCTGGGGG
GCATTGAAGGAAGTAAGCTCTCAGAGATCCTAACACTGGCTGGGAACCTCTGACTCAGAGCATGTCTTTAAAGAGTCCACATCTGGCCAG
GCGCGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGCAACA
TAGTGAAACCCCATCTCTAATAAAAATACAAAAAATTAGCTGGGCGTGGTGGCAGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGAC
AGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCTTGGGTGACAGTGCGAGACTCCA
TCTCAAAAAAAAAAAAAAAAAAAAAATCCACATCTTCAGCTGGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGC
GGGCAGATCACTTGAGGTTAGGGGTTCAAAACCAGCCTGACCAACATAGTAAAACCCCGTCCCTACAAAAATAAAAAAATAAAAAAAATA
AGCCAGGTGTGGTGGTGGGCACCTGTGATCTCAGCTACGTGGGAGGCTGAGGCAGGAGAATCTCTTGAACCTAGGAGGCAGAGGTTGCAG
TGAGCCAAGATTGTGCCAGCCTGGGCGACAGGGTGAGGCTCTTGTCTCAAAAAAAAAAGTCCACATCTTCATGAACCCTCAGACTCTGGA
GTTGGGTGTCGGCTTTTTTAGCCAGCTTTTGTGGGAATTGCCTTTGACCTATTAAAGAAGGAAAGTGGGTAATGGAGTCCCAGCCACTCA
AGAGACTGGATATCCCCCGAGAATGGCTTGGGTTACCAGCTATGGACCCTTGGAAGATGAATCTAATCCTTCTCACTGGTTTTTCTTTGC
AAATTCATTTGCTTTTATTTTTCTAATAACAATAAACTCTATTTTCCATGTTCTCAGGGCCCCTGGGTAGACAGACACAGCTTGATTTCA
GAGCAGACATAGGCGAAGAAAACATGGCATTGAGTGTGCTGAGTCCAGACAAATGTTATTTATATACACATCCAAATTTGAAGAGAAAAT


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FusionGenePPI for HDAC1_KPNA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HDAC1ZBTB16, MBD3L1, BUB1, BUB1B, BUB3, CDC20, CDH1, MAD1L1, KDM1A, HMG20B, RCOR1, PHF21A, HDAC2, RB1, CTBP1, TGIF1, DDX5, DDX17, DNMT3B, GATA1, PHB, CDYL, SIN3A, RBBP4, MTA1, MTA2, HDAC1, CHD4, RBBP7, CHD1, SP1, KMT2A, TXNIP, SAP30, SAP130, ARID4B, SUDS3, HCFC1, PTMA, EFCAB6, AR, YY1, GTF2I, MBD3, MBD2, TAB2, GATAD2B, HDAC9, HSPD1, HSPA4, TOP2B, TOP2A, RELA, NCOR2, ATR, PML, RFC1, BRCA1, MYOD1, NFKB1, MDM2, TP53, SMARCB1, SMARCA2, PCNA, DNMT1, RBL1, FKBP3, NFIX, PPARD, RBL2, E2F4, BCOR, MIER1, TGIF2, DAXX, CBFA2T3, SIN3B, HBP1, E2F1, IKZF1, CHD3, MECOM, KLF11, SMAD2, DNMT3L, BCL6, CABIN1, VHL, HIF1AN, HIF1A, DNMT3A, SATB1, HUS1, RAD9A, PHF12, ING1, RUNX1T1, SP3, SUV39H1, EED, EZH2, TPD52L1, TAL1, NR2F2, SPEN, TLE4, HR, HEY2, IFRD1, MXD1, DZIP3, UHRF1, PADI4, MECP2, SPI1, MBD4, WHSC1, ING2, ZMYND11, H2AFY, KDM5C, ETHE1, ZMYM2, REST, PRDM1, FRA10F, CDKN1A, GLI1, GLI2, KCTD11, APBB1, BNIP3, SFPQ, ZBTB7A, MKX, CHFR, TLE1, CDK5R1, SMARCA4, PPP1CC, DACH1, NUDT21, PAPOLA, HSF1, BANF1, ZFP36, MBTPS1, CEBPB, APPL1, BACH1, ADD1, POU2F1, CREM, JUN, SMAD7, HELLS, DACT1, NKX2-5, BRMS1, SERPINB5, HOXA11, FOSL1, SAP30L, EP300, PAX3, CREBBP, NR3C1, GATAD2A, RUNX2, RUVBL2, NKX3-1, RUNX1, NUP98, NUP54, GRIP1, PLAGL1, NFE4, MAPK8, MAPK9, MAPK10, INSM1, CEBPD, REPIN1, GCM1, RERE, RFX1, TRIM27, NFYC, SNAI1, SNAI2, SNAI3, NKX3-2, MEN1, ESR1, BCL3, LMO4, SYK, GFI1, CRYAB, ESCO2, CTNNB1, PARP1, E4F1, MTA3, CIITA, HES1, BCL6B, STAT5A, CREB1, LCOR, PITX2, TAF6, GLI3, SMARCE1, SMARCC2, HSD11B2, BCL11B, BCL11A, BAZ2A, TFCP2, HIST1H3A, MYT1, KDM4A, STAT3, NR0B2, CCND1, CEBPA, MBD3L2, NKX2-2, KLF5, CSNK2A1, PFDN5, HNRNPD, NR2E1, KLF4, KLF1, NFKBIA, SATB2, MNT, MYC, TBX3, MAFK, PRKACA, TBP, SMAD3, ARID4A, ELK1, HDAC7, TP73, UHRF2, ACTA1, PBX1, LEF1, SENP1, ATM, ENO1, PHB2, TAF1B, ZEB2, SKIL, ZFPM2, UBASH3B, PIAS4, NR1D2, BHLHE41, NONO, SOX6, ZNF395, SMAD1, SMAD5, SMAD4, SMEK1, ZNF148, NPM1, PRDM5, EMD, CCDC6, OVOL1, SAMSN1, GABPA, MORF4L1, MORF4L2, DMAP1, ATF3, PPARG, MEF2D, MEF2A, SMC4, CCT8, TCP1, VIM, TRIM21, ESCO1, PARK7, TSC22D3, CDK2AP1, TADA2A, BANP, NFYB, IRF5, DEC1, HIST2H2AA3, PPP6R3, PPP2R1B, PPP2R1A, HDAC5, KAT5, BRINP1, HIST1H4A, HIST3H3, THAP11, PRKG1, NFYA, DDIT3, SMARCAD1, SOX2, KDM5B, HDGF, FOXP3, WISP2, PRDM4, GPS2, UBTF, PCGF6, RNF2, HIST3H2BB, CDKN2A, NR2C1, NR2C2, POLD3, TRIM28, KDM4C, NFATC1, TFAP4, BAHD1, VPRBP, AIRE, BRMS1L, MAGEA1, JDP2, ZNF76, SMARCC1, SMARCA5, SMARCD1, NOTCH1, FN1, SS18, SSX2, DNTTIP1, GSE1, HMG20A, RCOR3, ELMSAN1, TRERF1, E2F3, TMEM54, EID3, STAT1, BHLHE40, ADNP, ADH5, ARID5B, BEND3, CSNK2B, TBL1XR1, GATAD1, EHMT2, BBX, KPNA1, KPNA3, KPNA4, KPNA6, IDH2, KDM5A, ACADM, MIER2, MIER3, PFDN2, VBP1, PFDN6, C11orf30, FAM60A, ZMYND8, PWWP2A, RREB1, RCOR2, ESD, TNRC18, TRMT61A, C16orf87, WDR5, ZBTB2, ZMYM3, ZNF217, ZNF512B, ZNF516, ZNF521, ZNF592, ZNF609, ZNF687, ZNF827, IKZF2, PRRG4, HEXIM1, UBE2I, ZGPAT, BRCC3, SF3A1, HNRNPR, LARP7, PAAF1, RABEP2, NACC2, RARA, FEZF2, HAUS2, PRDM6, NFE2L2, DDB1, CUL4B, APEX1, PHF6, LOXL2, SUZ12, SUMO2, SIRT6, MAP1LC3B, HIST1H2AA, HIST1H2BA, ZNF219, PHF20L1, C22orf31, DDB2, PHF1, CHD5, EP400, MAPK11, MAPK14, POLR3A, PIN1, TLE3, PPP1CA, RAP1A, NRIP1, RUNX3, HIST1H3E, ALDH1B1, CCT6A, E2F6, ERCC6, H3F3A, IPO5, AFF1, PEX10, PIK3CA, RING1, SRPR, TCF20, CCT3, TRPS1, CDC42BPA, NOLC1, PHF14, DNAJC6, PARP2, CCT7, CCT4, CCT2, ZNF273, RALBP1, TRAK1, CCT5, EXOSC7, PHLPP1, MGA, COG4, TIMM13, DESI1, SNX9, TRPM7, BCAS3, ZFP64, BAHCC1, GPAM, EHMT1, CCNL2, ASCC2, HSDL2, ANKRD13B, C2orf69, FOXK1, PGBD3, STRAP, KMT2E, NF2, USP37, FOXK2, MAGEB2, CCNB1, NFATC2, RNF138, USP19, RORC, CDK4, EGFR, L3MBTL2, CASP8AP2, SFMBT1, CCDC71, PHF21B, TFDP1, PWWP2B, ZNF608, CCT6B, ZNF800, CYBRD1, ZNF639, RYBP, C9orf41, WIZ, RFX3, XYLT2, RTCB, PTOV1, DDX1, TBC1D32, TAF6L, CDK20, FOXJ1, HSD17B10, RNF157, YAP1KPNA6SPOP, RELB, KPNB1, MEPCE, RAC1, CREBBP, KEAP1, CHD4, ELAVL1, SKP2, CUL3, TAF9, ANP32A, ZNF131, CDKN1B, HDAC1, KPNA2, GFPT1, KPNA3, LMNA, PRKAR2A, TTC1, XRN2, NOP2, NUP50, FRG1B, SURF2, UNK, EXOSC4, IPO5, FBL, HMGB1, NOP58, MORF4L1, MORF4L2, NOP56, PRMT1, PSMC2, RAN, RANBP6, RPL11, NTRK1, MUS81, PTTG1, CDK2AP1, NUP153, NCBP2, CHD8, GSG2, NAF1, CHMP4B, CENPU, FOXE1, MCM2, IKBKG, PHB2, METTL16, MDM2, PTPN2, RNMT, MEAF6, SREK1IP1, KBTBD4, CD2BP2, G3BP1, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDAC1_KPNA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHDAC1Q13547DB01169Arsenic trioxideHistone deacetylase 1small moleculeapproved|investigational
HgeneHDAC1Q13547DB01593ZincHistone deacetylase 1small moleculeapproved|investigational
HgeneHDAC1Q13547DB02546VorinostatHistone deacetylase 1small moleculeapproved|investigational
HgeneHDAC1Q13547DB05015BelinostatHistone deacetylase 1small moleculeapproved|investigational
HgeneHDAC1Q13547DB06176RomidepsinHistone deacetylase 1small moleculeapproved|investigational
HgeneHDAC1Q13547DB06603PanobinostatHistone deacetylase 1small moleculeapproved|investigational
HgeneHDAC1Q13547DB08868FingolimodHistone deacetylase 1small moleculeapproved|investigational

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RelatedDiseases for HDAC1_KPNA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDAC1C0036341Schizophrenia2PSYGENET
HgeneHDAC1C0007137Squamous cell carcinoma1CTD_human
HgeneHDAC1C0014175Endometriosis1CTD_human
HgeneHDAC1C0018799Heart Diseases1CTD_human
HgeneHDAC1C0340543Familial primary pulmonary hypertension1CTD_human
HgeneHDAC1C0525045Mood Disorders1PSYGENET