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Fusion gene ID: 15925 |
FusionGeneSummary for HDAC1_KPNA6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HDAC1_KPNA6 | Fusion gene ID: 15925 | Hgene | Tgene | Gene symbol | HDAC1 | KPNA6 | Gene ID | 3065 | 23633 |
| Gene name | histone deacetylase 1 | karyopherin subunit alpha 6 | |
| Synonyms | GON-10|HD1|RPD3|RPD3L1 | IPOA7|KPNA7 | |
| Cytomap | 1p35.2-p35.1 | 1p35.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone deacetylase 1reduced potassium dependency, yeast homolog-like 1 | importin subunit alpha-7importin alpha 7 subunitimportin-alpha-S2karyopherin alpha 6 (importin alpha 7) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13547 | O60684 | |
| Ensembl transtripts involved in fusion gene | ENST00000373548, ENST00000373541, ENST00000490081, | ENST00000373625, ENST00000537234, ENST00000469790, ENST00000545542, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 5 X 5 X 3=75 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HDAC1 [Title/Abstract] AND KPNA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HDAC1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18854353 |
| Hgene | HDAC1 | GO:0006476 | protein deacetylation | 17172643|23629966 |
| Hgene | HDAC1 | GO:0045893 | positive regulation of transcription, DNA-templated | 16762839 |
| Hgene | HDAC1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16762839 |
| Hgene | HDAC1 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 15919722 |
| Hgene | HDAC1 | GO:0070932 | histone H3 deacetylation | 12590135 |
| Hgene | HDAC1 | GO:0070933 | histone H4 deacetylation | 12590135 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0B9-01A | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000373548 | ENST00000373625 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| 5CDS-5UTR | ENST00000373548 | ENST00000537234 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| 5CDS-3UTR | ENST00000373548 | ENST00000469790 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| 5CDS-3UTR | ENST00000373548 | ENST00000545542 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| 5UTR-3CDS | ENST00000373541 | ENST00000373625 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| 5UTR-5UTR | ENST00000373541 | ENST00000537234 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| 5UTR-3UTR | ENST00000373541 | ENST00000469790 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| 5UTR-3UTR | ENST00000373541 | ENST00000545542 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| intron-3CDS | ENST00000490081 | ENST00000373625 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| intron-5UTR | ENST00000490081 | ENST00000537234 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| intron-3UTR | ENST00000490081 | ENST00000469790 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
| intron-3UTR | ENST00000490081 | ENST00000545542 | HDAC1 | chr1 | 32790154 | + | KPNA6 | chr1 | 32620189 | + |
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FusionProtFeatures for HDAC1_KPNA6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HDAC1 | KPNA6 |
| Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Deacetylates SPproteins, SP1 and SP3, and regulates their function. Component ofthe BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calciumstimulation, HDAC1 is released from the complex and CREBBP isrecruited, which facilitates transcriptional activation.Deacetylates TSHZ3 and regulates its transcriptional repressoractivity. Deacetylates 'Lys-310' in RELA and thereby inhibits thetranscriptional activity of NF-kappa-B. Deacetylates NR1D2 andabrogates the effect of KAT5-mediated relieving of NR1D2transcription repression activity. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histonedeacetylase (HDAC) recruitment, a number of genes implicated inmultilineage blood cell development. Involved in CIART-mediatedtranscriptional repression of the circadian transcriptionalactivator: CLOCK-ARNTL/BMAL1 heterodimer. Required for thetranscriptional repression of circadian target genes, such asPER1, mediated by the large PER complex or CRY1 through histonedeacetylation. {ECO:0000269|PubMed:12837748,ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:17000776,ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965,ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227}. | Functions in nuclear protein import as an adapterprotein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLSmotif. Docking of the importin/substrate complex to the nuclearpore complex (NPC) is mediated by KPNB1 through binding tonucleoporin FxFG repeats and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to importin-beta and the three components separate andimportin-alpha and -beta are re-exported from the nucleus to thecytoplasm where GTP hydrolysis releases Ran from importin. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 1_60 | 1 | 537 | Domain | IBB |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 45_54 | 1 | 537 | Motif | Nuclear localization signal |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 147_239 | 1 | 537 | Region | NLS binding site (major) |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 316_404 | 1 | 537 | Region | NLS binding site (minor) |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 116_159 | 1 | 537 | Repeat | Note=ARM 2 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 160_204 | 1 | 537 | Repeat | Note=ARM 3 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 205_243 | 1 | 537 | Repeat | Note=ARM 4 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 244_288 | 1 | 537 | Repeat | Note=ARM 5 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 289_328 | 1 | 537 | Repeat | Note=ARM 6 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 329_370 | 1 | 537 | Repeat | Note=ARM 7 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 371_410 | 1 | 537 | Repeat | Note=ARM 8 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 411_453 | 1 | 537 | Repeat | Note=ARM 9 |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 457_502 | 1 | 537 | Repeat | Note=ARM 10%3B atypical |
| Tgene | >KPNA6 | chr1:32790154 | chr1:32620189 | ENST00000373625 | + | 0 | 14 | 76_115 | 1 | 537 | Repeat | Note=ARM 1%3B truncated |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HDAC1 | chr1:32790154 | chr1:32620189 | ENST00000373548 | + | 4 | 14 | 9_321 | 118 | 483 | Region | Note=Histone deacetylase |
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FusionGeneSequence for HDAC1_KPNA6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HDAC1_ENST00000373548_chr1_32790154_+_KPNA6_ENST00000373625_chr1_32620189_+_654aa MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQ MQRFNVGEDCPVFDGLFEFCQLSTGGSVETMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMF DSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIA SGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNP PPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVIL NCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCI KPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HDAC1_ENST00000373548_chr1_32790154_+_KPNA6_ENST00000373625_chr1_32620189_+_1962nt ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATG AAGCCTCACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAG ATGCAGAGATTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGAGACC ATGGCGAGCCCAGGGAAAGACAATTATCGAATGAAGAGCTATAAGAACAATGCTCTAAACCCTGAAGAAATGAGACGAAGAAGAGAGGAA GAGGGCATTCAGCTCCGGAAGCAGAAGCGAGAGCAACAACTTTTTAAACGGAGAAATGTGGAGCTGATTAATGAAGAAGCTGCCATGTTC GATAGTCTTCTCATGGACTCTTATGTGAGCTCTACCACTGGGGAGAGTGTGATCACAAGAGAGATGGTGGAGATGCTCTTTTCTGATGAT TCTGACCTGCAGTTAGCAACCACACAGAAATTCCGGAAACTGCTCTCCAAAGAGCCTAGTCCTCCAATAGATGAAGTTATCAACACTCCA AGAGTGGTGGATCGGTTCGTGGAGTTTCTGAAGAGGAATGAGAATTGTACATTACAGTTTGAAGCTGCCTGGGCTCTAACGAATATTGCC TCTGGAACCTCTCAGCAGACCAAAATTGTCATTGAAGCAGGGGCTGTCCCCATTTTTATAGAGCTGCTTAATTCAGACTTTGAGGATGTT CAGGAACAGGCAGTCTGGGCACTGGGAAACATAGCTGGAGATAGCTCTGTTTGCCGAGATTACGTCTTGAACTGTTCCATCCTTAATCCT TTGTTAACACTCCTTACCAAGTCCACACGACTGACGATGACACGGAATGCAGTCTGGGCCCTGTCAAATCTCTGCCGAGGGAAAAACCCA CCCCCAGAGTTTGCAAAGGTCTCTCCTTGTTTGCCTGTACTGTCTCGCCTACTCTTCAGCAGCGACTCGGACTTGCTGGCAGATGCTTGC TGGGCCCTTTCTTATCTGTCTGATGGCCCCAATGAGAAGATCCAGGCAGTCATAGACTCCGGAGTCTGCCGGAGATTGGTAGAGCTGCTG ATGCACAATGATTACAAAGTGGCTTCTCCTGCCCTGAGAGCCGTGGGTAACATCGTCACTGGGGATGACATCCAGACCCAGGTCATTCTT AACTGTTCAGCCCTACCTTGCCTTCTCCACTTGTTGAGCAGTCCCAAGGAGTCAATCCGGAAGGAAGCTTGCTGGACTATTTCAAATATT ACTGCTGGCAACAGGGCTCAAATACAGGCTGTTATAGATGCAAATATCTTCCCTGTGTTGATCGAAATCCTTCAGAAAGCAGAGTTTCGT ACAAGGAAAGAGGCAGCCTGGGCCATCACCAATGCCACATCAGGAGGAACCCCTGAGCAGATCAGGTACCTGGTCTCACTGGGCTGCATC AAACCCCTATGTGACTTGCTGACTGTAATGGATTCGAAGATTGTGCAAGTGGCCCTCAATGGACTGGAGAACATCCTGCGGCTTGGAGAG CAAGAGGGCAAGCGCAGTGGCTCAGGGGTCAATCCTTATTGTGGCCTCATAGAGGAAGCCTATGGCTTGGATAAAATTGAGTTTCTCCAG AGCCACGAGAACCAGGAGATCTACCAGAAGGCCTTCGACCTCATTGAGCACTACTTTGGTGTAGAAGACGATGATAGCAGCCTGGCTCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HDAC1_ENST00000373548_chr1_32790154_+_KPNA6_ENST00000373625_chr1_32620189_+_7720nt CTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCG CAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCT CACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAG GAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAG AGATTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGAGACCATGGCG AGCCCAGGGAAAGACAATTATCGAATGAAGAGCTATAAGAACAATGCTCTAAACCCTGAAGAAATGAGACGAAGAAGAGAGGAAGAGGGC ATTCAGCTCCGGAAGCAGAAGCGAGAGCAACAACTTTTTAAACGGAGAAATGTGGAGCTGATTAATGAAGAAGCTGCCATGTTCGATAGT CTTCTCATGGACTCTTATGTGAGCTCTACCACTGGGGAGAGTGTGATCACAAGAGAGATGGTGGAGATGCTCTTTTCTGATGATTCTGAC CTGCAGTTAGCAACCACACAGAAATTCCGGAAACTGCTCTCCAAAGAGCCTAGTCCTCCAATAGATGAAGTTATCAACACTCCAAGAGTG GTGGATCGGTTCGTGGAGTTTCTGAAGAGGAATGAGAATTGTACATTACAGTTTGAAGCTGCCTGGGCTCTAACGAATATTGCCTCTGGA ACCTCTCAGCAGACCAAAATTGTCATTGAAGCAGGGGCTGTCCCCATTTTTATAGAGCTGCTTAATTCAGACTTTGAGGATGTTCAGGAA CAGGCAGTCTGGGCACTGGGAAACATAGCTGGAGATAGCTCTGTTTGCCGAGATTACGTCTTGAACTGTTCCATCCTTAATCCTTTGTTA ACACTCCTTACCAAGTCCACACGACTGACGATGACACGGAATGCAGTCTGGGCCCTGTCAAATCTCTGCCGAGGGAAAAACCCACCCCCA GAGTTTGCAAAGGTCTCTCCTTGTTTGCCTGTACTGTCTCGCCTACTCTTCAGCAGCGACTCGGACTTGCTGGCAGATGCTTGCTGGGCC CTTTCTTATCTGTCTGATGGCCCCAATGAGAAGATCCAGGCAGTCATAGACTCCGGAGTCTGCCGGAGATTGGTAGAGCTGCTGATGCAC AATGATTACAAAGTGGCTTCTCCTGCCCTGAGAGCCGTGGGTAACATCGTCACTGGGGATGACATCCAGACCCAGGTCATTCTTAACTGT TCAGCCCTACCTTGCCTTCTCCACTTGTTGAGCAGTCCCAAGGAGTCAATCCGGAAGGAAGCTTGCTGGACTATTTCAAATATTACTGCT GGCAACAGGGCTCAAATACAGGCTGTTATAGATGCAAATATCTTCCCTGTGTTGATCGAAATCCTTCAGAAAGCAGAGTTTCGTACAAGG AAAGAGGCAGCCTGGGCCATCACCAATGCCACATCAGGAGGAACCCCTGAGCAGATCAGGTACCTGGTCTCACTGGGCTGCATCAAACCC CTATGTGACTTGCTGACTGTAATGGATTCGAAGATTGTGCAAGTGGCCCTCAATGGACTGGAGAACATCCTGCGGCTTGGAGAGCAAGAG GGCAAGCGCAGTGGCTCAGGGGTCAATCCTTATTGTGGCCTCATAGAGGAAGCCTATGGCTTGGATAAAATTGAGTTTCTCCAGAGCCAC GAGAACCAGGAGATCTACCAGAAGGCCTTCGACCTCATTGAGCACTACTTTGGTGTAGAAGACGATGATAGCAGCCTGGCTCCCCAAGTC GATGAAACGCAACAGCAGTTCATCTTCCAGCAGCCTGAGGCCCCCATGGAGGGCTTCCAGCTATAATATCTGCCTCCAGGGAGGGGAGGG GATGGGAAGCACCACCAGCCAGCGGAAGAGCAGCCCTCTGGTGGGCGGGAAACCAGTGTCCCCACCATCAGCCACCACACACCTCTGCTG CCCTGGAGACTGTGCTCTTGACCTGCTCCGCCCCCTTCCCTGGAGGGAGCACCCTCTGGACAGACAGAACCATCTGAGGCTCACCTTTGG GTTTTGTGACAAGAAGGGGACGTGTTGGGTTTTTCTTCCTTACACTATATTTTGGCTGCACACATGTCTTTAACCCAGGAGCCCAGGGGT AGACAAAGGAGGACTAAGGTAATCAATTTGCACCTTTTTTTATTTTTATTTTTTTTCTTTTTTTCTTCAGTGGTGACTTCCTTCCCTTTA TCTTTTTTCATTCTTCCCGGTCCTCTGCCCTGATCTGTGTAACTCTTATCTTGGGTACTTGAGCAGACGGTATATTCCAGAGGTGGGAGG TGGGAGGGGAAGGGAGAAATCCAAAACAAAGTGTTCTTGCTCTGACAGAATATTAATCTTGTACGCTTGGATTGAGTTATTTAATTTTTT TTTCTTTTGCACATTTTTCTTGTATTAAGATTGCTCTTCCCAAGAGCCACAAGTTCCTGGTTTTAGTAAACCCAGCTGCCTGCATTGCCT GGGACTAGAGGCTGGGGAGGCTACCATGAAACAAAGGTCCCTCCCTCCCTCTGACTCTTTGCCCAGACCTCTTTAGTTTGGGGGATCCTC CTCACTCTCCTGAAGTGTCTCAAGTATACCAGTGGGAGTGCAGGGGAGGAGCACAGGCCTTCAGATGGGGCTTCCCACGTGTAGCTACTG ATCCCATATTTCCTACTCACCTTCCAAATGGTGCGACCCAACTTCATTTGTTTACTTGAAAATTCCCCCTCGAGGTTGAGAGAACCTCTG AGGTGGCTGTATTTTCTCCTAAGCTTGAGATAGGGGGCTGTGGTCCTTCCTTTCTCCTGAGGAGAAAGTCCTTGCTCTGGTGACCTGTAA GTTGCAGAGGAGGGTGGAGTGAGAGTGTCATGTATTGGGATAGTCAGGGATCCCTGCCTTTGGCCTTTCTTCTTCTTCTTCTTCCTCTTC CATAGTTGGATCATGTATATTTTACTTCTAAAGGAGAGAATGTCAAAAAGTTCTGTATTTTTTTATATTCTATATATTAGGTAGGTCAAT CTTAATTGGTCTCAAGAGGAAGAACTGTCTGTCATTTCGGTAAGTAGGATACTGTGAGGAAGACCAAAAAGAGATATGGATGCTTCCTCG CTCAGGAGGCCTGAGCTTGGTCCTTTTCCTCTCTGCTTGGATTCTGGACCACCACCTGGGACCAACCTTCAGCTCTGGAACCTTCATAAA GCAGGTCAGCGTGGCCTGATTGTCCCAGGACCTGAAGGGAGCAAGGATGGCCTCAGGGCCTGGTGAAGTCTGCTACTCTGTCCTTACTGC TGAACATCCTGCTTGTATCAGGAAACTCAGAAGCAGTTTGCCTTGTCAAATTCAATCTCAATGGCCATTGTCCACATAACTGATCACCCA TGGCTGCCTCTCCTATTATCTATTATCACTGAAACTTAGTAGCCTGCTTTTTTTTTTTTTTTTTTTAGAGCTATTGCGTATCTTCCCTGT TTGGGATCCTTGTACCTGGTTTGGGTTTTCCCTTCCTTGTGACAATTATAATCCAGATGCCTCTTCTTTCTGTTTGAATTACGGTAGTGC ATTGCCTTAGTGGCTTGCCTGTGCCTCTGGGTGGATTACATATGATAGTAAAGCCCACCTGTTTGGATGGGAGTAGAGGAAGTTGGTGTA GACCAGCTGTGGAGCTGAAGGCACAGTCTGCCCCACCCCCACCTCCCCACTGTGGTTAGTCAGAGGCATCCTGCTCCAAGCTCTGCTTTT CCTTCCTCTGAAACAATGCCATTCTTGCTTCTATTGCTACACATCTCCTTCTGGCTCAGGTGAAATCCATGCCCTTCTGCTTATAGACCT AAAGTTCAGGTACTTATTATTGGCCATTGATCTTGAATTTGCCCTCTCCTAGTGCTGCAGTCCCACTTCAAAGCCATTTTCTGAGGAGGA TGGTTTAGGTCTGGCAATTGTCCTTGAAAAATCCCACCCATGTTGTACCACCTTGGTGAGTCATATGCCACTCATCAGCTTGGGAATGAT GGCTGCCAACTCCCAATCTCCCAGGAAGGCAGGGGGCAGAATCTTTTTTTCACTTGGCCTGCTACCTCCATTAAAAAACCATTCTCTTAC AGTTTAAAAAAAAAAAAAAAAAAAAAGCCTTCCCCTACCCAACCTCCGCCCATTGTTCTCTTCCAAAGGGCAATTTAGTAGGATCTACTT TGTACATCTCAAGTAAGAGTTAAGTCCCTGATACAGGGACCAGTTTCTTAGTGTAAGACATACACATCCTGCTTGTCCAGCTGTTCCTCC AAAATCTACTTTGGCTTCAGCTCCGGGTCCTGTACCAGATGGAAAATGTTTTTGGTGATCTGGCTGCTGCTTAAAGCCAGTTTTCCCTAA GAACTCCAAAGGCTAAAGTCTACTAGGGGCAGAGTGTGAGGATAGATTTCTAATCAGAGAAAAGTGGCCTCCAGGAGCTTTCATTTATGT CTTCTCCAGACCAGGTTTTCCTGTTATCTTCCTTTAATCCCCTTTCAACCAACAGGTGAAGTTCTTCCAGCCCACAGAGGTAGTAATATC ATCTTTTCTATCTCCTCCTCTCCTTTGGCCATGTAATGAAGCAAAATATTATTTATTTAGCCCAGGCTTGAGAGCCACTGTTTGTGGACA GTCTTCATCTAGATTCCATACCCTGGCCTAGGCGAGGTAAGGCTCTCTGGTTATTGCCAGGATGGAGCCCCTCTACCCCAGTCTGCTGTA GGGAATACCCTAATTAGTTGAGGCATGCTTTTGGAATCCTGGCATGTTGGCATATGGCTGGTCTATCCTTTTTAAGATCTCTGGTTGGGG GTATCTGGATATGGATTAGGAGGGACAAGGAGCCTTTTTCTTGGCTAATGTTTTCCAATACTTTTTTGAATGGTGCCAGCCCCTCCAGGC ATCCCACCCCCAAATCATCATCTTTAGTACTAACAGGGTGTCTGGTCTTAGAAGCCTCCCTTCAGATCCCAGCTGACCCTGGTGACTGCC TGGCCTTGATGTTGGCTGCAGCCTTCTGATAGAACCACATGGATTCCACCCACAGCTGGCCAGGCTTGTTACATGGGTCAGGGAATACAA ATGGCCCCCCCCCAGGGAGCAGGTGTTGGCCTCAGTTTTCAGGGACCCTTGGTGTTGCTCCTTACCTAGAGCCCATTAATCTACCCCATC AACTCTCTGCCATGAAAGCCATCTTCCAGGAGCCCTGTTTTTTGGAGCTGAACTGCACAGATTATAGCTGCTATTGTACTTAAATAAGGG AGAGGAAAAGAAGGTTCTCAGGCACAGACTTTCTATTTTTCTCAAGCCAAACCAGTTTAAAATGTCTAGCAGAATGAACTGTATTTCCAT TTCTTCATGTCTACCTGCCTTCCCCCCACACCCTAAAGTTGTACTTGTTTCTAGCAAACTAGAAGGAAAAGATAGGAAAGCCTGGCACTA CTAACCTCACCTCTCATACACCTCTTTGAAGGCCCCAGCTCTTTTGTTCAGGCCTCTCTTCTCCCCTAGACTCACTCAGCTTGGTATCCA TCATCTTGAGCATTCTTCAGTAGATTCATCTAGGGTTCAGATTCCAGACTCTCAGCTGAAGACAGGGAGCCAATTTCCCCCAGGTCCCTG CAGGTAATCCAGGGACCCCATAGGGAGAACAGGCTGACTGGGGCATTAGGAATGTTTGTACCTCTCTGCTTCCCTGGCAGCCTGGGGAAG GGTGCAGGGCTCAGTGCGCTAAACCATGGTAAACATCTTCAATAGAACTACCCTAGAATTTAGTGAGTGTGAGACTGAGATATTGCTCAG AATAAATTTATTCCATAGCCATTTAGGATTGCATGTTCTGGACCAACCTTGTCCAGTATGTTTTCTGTTTGAGCTTTTTCATTCTTTTGT TAAGCCAACAAGTTGAGAATTTGGCCCTGCTGGGATCCATGTAGTGGGCACTAGCTGCTCTTTGGCCAAGGCCTTCATAAATGATTCAGT CTCTCATTATCTGTCCTCTAGCCCCACACCCTGATTTAGACCGTGGCAAAGGAAGAACTTGAGGTCAAGACCAACCAAATCTGTGAATTA AAGCTGTTATTTTTTTCTCTGCAAGGGCGCTTTGCTTCAGGTCTGGGCTATGTGCAGAACCTAAGCAGGCTGTGAGAGTTAGAAGAGGCA GTATTACATGTTAGGCCCAGAACACCATGGGAAAAGGTTTATGTAGTGTATCTTAGTGGCCTGCCTAGCTGCCTCTGGGCCAGGCTGACT TCTGATGTCCACATTAGCTCGTACCTGAACCCTGTTGCTGAATGCCAGCCCTGTTCTCCTGTAACTATTATATACGCCATGGCCTGGGGG GCATTGAAGGAAGTAAGCTCTCAGAGATCCTAACACTGGCTGGGAACCTCTGACTCAGAGCATGTCTTTAAAGAGTCCACATCTGGCCAG GCGCGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGCAACA TAGTGAAACCCCATCTCTAATAAAAATACAAAAAATTAGCTGGGCGTGGTGGCAGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGAC AGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCTTGGGTGACAGTGCGAGACTCCA TCTCAAAAAAAAAAAAAAAAAAAAAATCCACATCTTCAGCTGGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGC GGGCAGATCACTTGAGGTTAGGGGTTCAAAACCAGCCTGACCAACATAGTAAAACCCCGTCCCTACAAAAATAAAAAAATAAAAAAAATA AGCCAGGTGTGGTGGTGGGCACCTGTGATCTCAGCTACGTGGGAGGCTGAGGCAGGAGAATCTCTTGAACCTAGGAGGCAGAGGTTGCAG TGAGCCAAGATTGTGCCAGCCTGGGCGACAGGGTGAGGCTCTTGTCTCAAAAAAAAAAGTCCACATCTTCATGAACCCTCAGACTCTGGA GTTGGGTGTCGGCTTTTTTAGCCAGCTTTTGTGGGAATTGCCTTTGACCTATTAAAGAAGGAAAGTGGGTAATGGAGTCCCAGCCACTCA AGAGACTGGATATCCCCCGAGAATGGCTTGGGTTACCAGCTATGGACCCTTGGAAGATGAATCTAATCCTTCTCACTGGTTTTTCTTTGC AAATTCATTTGCTTTTATTTTTCTAATAACAATAAACTCTATTTTCCATGTTCTCAGGGCCCCTGGGTAGACAGACACAGCTTGATTTCA GAGCAGACATAGGCGAAGAAAACATGGCATTGAGTGTGCTGAGTCCAGACAAATGTTATTTATATACACATCCAAATTTGAAGAGAAAAT |
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FusionGenePPI for HDAC1_KPNA6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HDAC1 | ZBTB16, MBD3L1, BUB1, BUB1B, BUB3, CDC20, CDH1, MAD1L1, KDM1A, HMG20B, RCOR1, PHF21A, HDAC2, RB1, CTBP1, TGIF1, DDX5, DDX17, DNMT3B, GATA1, PHB, CDYL, SIN3A, RBBP4, MTA1, MTA2, HDAC1, CHD4, RBBP7, CHD1, SP1, KMT2A, TXNIP, SAP30, SAP130, ARID4B, SUDS3, HCFC1, PTMA, EFCAB6, AR, YY1, GTF2I, MBD3, MBD2, TAB2, GATAD2B, HDAC9, HSPD1, HSPA4, TOP2B, TOP2A, RELA, NCOR2, ATR, PML, RFC1, BRCA1, MYOD1, NFKB1, MDM2, TP53, SMARCB1, SMARCA2, PCNA, DNMT1, RBL1, FKBP3, NFIX, PPARD, RBL2, E2F4, BCOR, MIER1, TGIF2, DAXX, CBFA2T3, SIN3B, HBP1, E2F1, IKZF1, CHD3, MECOM, KLF11, SMAD2, DNMT3L, BCL6, CABIN1, VHL, HIF1AN, HIF1A, DNMT3A, SATB1, HUS1, RAD9A, PHF12, ING1, RUNX1T1, SP3, SUV39H1, EED, EZH2, TPD52L1, TAL1, NR2F2, SPEN, TLE4, HR, HEY2, IFRD1, MXD1, DZIP3, UHRF1, PADI4, MECP2, SPI1, MBD4, WHSC1, ING2, ZMYND11, H2AFY, KDM5C, ETHE1, ZMYM2, REST, PRDM1, FRA10F, CDKN1A, GLI1, GLI2, KCTD11, APBB1, BNIP3, SFPQ, ZBTB7A, MKX, CHFR, TLE1, CDK5R1, SMARCA4, PPP1CC, DACH1, NUDT21, PAPOLA, HSF1, BANF1, ZFP36, MBTPS1, CEBPB, APPL1, BACH1, ADD1, POU2F1, CREM, JUN, SMAD7, HELLS, DACT1, NKX2-5, BRMS1, SERPINB5, HOXA11, FOSL1, SAP30L, EP300, PAX3, CREBBP, NR3C1, GATAD2A, RUNX2, RUVBL2, NKX3-1, RUNX1, NUP98, NUP54, GRIP1, PLAGL1, NFE4, MAPK8, MAPK9, MAPK10, INSM1, CEBPD, REPIN1, GCM1, RERE, RFX1, TRIM27, NFYC, SNAI1, SNAI2, SNAI3, NKX3-2, MEN1, ESR1, BCL3, LMO4, SYK, GFI1, CRYAB, ESCO2, CTNNB1, PARP1, E4F1, MTA3, CIITA, HES1, BCL6B, STAT5A, CREB1, LCOR, PITX2, TAF6, GLI3, SMARCE1, SMARCC2, HSD11B2, BCL11B, BCL11A, BAZ2A, TFCP2, HIST1H3A, MYT1, KDM4A, STAT3, NR0B2, CCND1, CEBPA, MBD3L2, NKX2-2, KLF5, CSNK2A1, PFDN5, HNRNPD, NR2E1, KLF4, KLF1, NFKBIA, SATB2, MNT, MYC, TBX3, MAFK, PRKACA, TBP, SMAD3, ARID4A, ELK1, HDAC7, TP73, UHRF2, ACTA1, PBX1, LEF1, SENP1, ATM, ENO1, PHB2, TAF1B, ZEB2, SKIL, ZFPM2, UBASH3B, PIAS4, NR1D2, BHLHE41, NONO, SOX6, ZNF395, SMAD1, SMAD5, SMAD4, SMEK1, ZNF148, NPM1, PRDM5, EMD, CCDC6, OVOL1, SAMSN1, GABPA, MORF4L1, MORF4L2, DMAP1, ATF3, PPARG, MEF2D, MEF2A, SMC4, CCT8, TCP1, VIM, TRIM21, ESCO1, PARK7, TSC22D3, CDK2AP1, TADA2A, BANP, NFYB, IRF5, DEC1, HIST2H2AA3, PPP6R3, PPP2R1B, PPP2R1A, HDAC5, KAT5, BRINP1, HIST1H4A, HIST3H3, THAP11, PRKG1, NFYA, DDIT3, SMARCAD1, SOX2, KDM5B, HDGF, FOXP3, WISP2, PRDM4, GPS2, UBTF, PCGF6, RNF2, HIST3H2BB, CDKN2A, NR2C1, NR2C2, POLD3, TRIM28, KDM4C, NFATC1, TFAP4, BAHD1, VPRBP, AIRE, BRMS1L, MAGEA1, JDP2, ZNF76, SMARCC1, SMARCA5, SMARCD1, NOTCH1, FN1, SS18, SSX2, DNTTIP1, GSE1, HMG20A, RCOR3, ELMSAN1, TRERF1, E2F3, TMEM54, EID3, STAT1, BHLHE40, ADNP, ADH5, ARID5B, BEND3, CSNK2B, TBL1XR1, GATAD1, EHMT2, BBX, KPNA1, KPNA3, KPNA4, KPNA6, IDH2, KDM5A, ACADM, MIER2, MIER3, PFDN2, VBP1, PFDN6, C11orf30, FAM60A, ZMYND8, PWWP2A, RREB1, RCOR2, ESD, TNRC18, TRMT61A, C16orf87, WDR5, ZBTB2, ZMYM3, ZNF217, ZNF512B, ZNF516, ZNF521, ZNF592, ZNF609, ZNF687, ZNF827, IKZF2, PRRG4, HEXIM1, UBE2I, ZGPAT, BRCC3, SF3A1, HNRNPR, LARP7, PAAF1, RABEP2, NACC2, RARA, FEZF2, HAUS2, PRDM6, NFE2L2, DDB1, CUL4B, APEX1, PHF6, LOXL2, SUZ12, SUMO2, SIRT6, MAP1LC3B, HIST1H2AA, HIST1H2BA, ZNF219, PHF20L1, C22orf31, DDB2, PHF1, CHD5, EP400, MAPK11, MAPK14, POLR3A, PIN1, TLE3, PPP1CA, RAP1A, NRIP1, RUNX3, HIST1H3E, ALDH1B1, CCT6A, E2F6, ERCC6, H3F3A, IPO5, AFF1, PEX10, PIK3CA, RING1, SRPR, TCF20, CCT3, TRPS1, CDC42BPA, NOLC1, PHF14, DNAJC6, PARP2, CCT7, CCT4, CCT2, ZNF273, RALBP1, TRAK1, CCT5, EXOSC7, PHLPP1, MGA, COG4, TIMM13, DESI1, SNX9, TRPM7, BCAS3, ZFP64, BAHCC1, GPAM, EHMT1, CCNL2, ASCC2, HSDL2, ANKRD13B, C2orf69, FOXK1, PGBD3, STRAP, KMT2E, NF2, USP37, FOXK2, MAGEB2, CCNB1, NFATC2, RNF138, USP19, RORC, CDK4, EGFR, L3MBTL2, CASP8AP2, SFMBT1, CCDC71, PHF21B, TFDP1, PWWP2B, ZNF608, CCT6B, ZNF800, CYBRD1, ZNF639, RYBP, C9orf41, WIZ, RFX3, XYLT2, RTCB, PTOV1, DDX1, TBC1D32, TAF6L, CDK20, FOXJ1, HSD17B10, RNF157, YAP1 | KPNA6 | SPOP, RELB, KPNB1, MEPCE, RAC1, CREBBP, KEAP1, CHD4, ELAVL1, SKP2, CUL3, TAF9, ANP32A, ZNF131, CDKN1B, HDAC1, KPNA2, GFPT1, KPNA3, LMNA, PRKAR2A, TTC1, XRN2, NOP2, NUP50, FRG1B, SURF2, UNK, EXOSC4, IPO5, FBL, HMGB1, NOP58, MORF4L1, MORF4L2, NOP56, PRMT1, PSMC2, RAN, RANBP6, RPL11, NTRK1, MUS81, PTTG1, CDK2AP1, NUP153, NCBP2, CHD8, GSG2, NAF1, CHMP4B, CENPU, FOXE1, MCM2, IKBKG, PHB2, METTL16, MDM2, PTPN2, RNMT, MEAF6, SREK1IP1, KBTBD4, CD2BP2, G3BP1, SMARCB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HDAC1_KPNA6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HDAC1 | Q13547 | DB01169 | Arsenic trioxide | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB01593 | Zinc | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB02546 | Vorinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB05015 | Belinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB06176 | Romidepsin | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB06603 | Panobinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB08868 | Fingolimod | Histone deacetylase 1 | small molecule | approved|investigational |
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RelatedDiseases for HDAC1_KPNA6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HDAC1 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | HDAC1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | HDAC1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | HDAC1 | C0018799 | Heart Diseases | 1 | CTD_human |
| Hgene | HDAC1 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human |
| Hgene | HDAC1 | C0525045 | Mood Disorders | 1 | PSYGENET |
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