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Fusion gene ID: 15924 |
FusionGeneSummary for HDAC1_EIF3I |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HDAC1_EIF3I | Fusion gene ID: 15924 | Hgene | Tgene | Gene symbol | HDAC1 | EIF3I | Gene ID | 3065 | 8668 |
| Gene name | histone deacetylase 1 | eukaryotic translation initiation factor 3 subunit I | |
| Synonyms | GON-10|HD1|RPD3|RPD3L1 | EIF3S2|PRO2242|TRIP-1|TRIP1|eIF3-beta|eIF3-p36 | |
| Cytomap | 1p35.2-p35.1 | 1p35.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone deacetylase 1reduced potassium dependency, yeast homolog-like 1 | eukaryotic translation initiation factor 3 subunit ITGF-beta receptor-interacting protein 1TGFbeta receptor-interacting protein 1eukaryotic translation initiation factor 3 subunit 2eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)euk | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q13547 | Q13347 | |
| Ensembl transtripts involved in fusion gene | ENST00000373548, ENST00000373541, ENST00000490081, | ENST00000373586, ENST00000471486, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 4 X 4 X 2=32 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HDAC1 [Title/Abstract] AND EIF3I [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HDAC1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18854353 |
| Hgene | HDAC1 | GO:0006476 | protein deacetylation | 17172643|23629966 |
| Hgene | HDAC1 | GO:0045893 | positive regulation of transcription, DNA-templated | 16762839 |
| Hgene | HDAC1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16762839 |
| Hgene | HDAC1 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 15919722 |
| Hgene | HDAC1 | GO:0070932 | histone H3 deacetylation | 12590135 |
| Hgene | HDAC1 | GO:0070933 | histone H4 deacetylation | 12590135 |
| Tgene | EIF3I | GO:0006413 | translational initiation | 17581632 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-A4J1-01A | HDAC1 | chr1 | 32768334 | + | EIF3I | chr1 | 32694100 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000373548 | ENST00000373586 | HDAC1 | chr1 | 32768334 | + | EIF3I | chr1 | 32694100 | + |
| 5CDS-3UTR | ENST00000373548 | ENST00000471486 | HDAC1 | chr1 | 32768334 | + | EIF3I | chr1 | 32694100 | + |
| 5UTR-3CDS | ENST00000373541 | ENST00000373586 | HDAC1 | chr1 | 32768334 | + | EIF3I | chr1 | 32694100 | + |
| 5UTR-3UTR | ENST00000373541 | ENST00000471486 | HDAC1 | chr1 | 32768334 | + | EIF3I | chr1 | 32694100 | + |
| intron-3CDS | ENST00000490081 | ENST00000373586 | HDAC1 | chr1 | 32768334 | + | EIF3I | chr1 | 32694100 | + |
| intron-3UTR | ENST00000490081 | ENST00000471486 | HDAC1 | chr1 | 32768334 | + | EIF3I | chr1 | 32694100 | + |
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FusionProtFeatures for HDAC1_EIF3I |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HDAC1 | EIF3I |
| Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Deacetylates SPproteins, SP1 and SP3, and regulates their function. Component ofthe BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calciumstimulation, HDAC1 is released from the complex and CREBBP isrecruited, which facilitates transcriptional activation.Deacetylates TSHZ3 and regulates its transcriptional repressoractivity. Deacetylates 'Lys-310' in RELA and thereby inhibits thetranscriptional activity of NF-kappa-B. Deacetylates NR1D2 andabrogates the effect of KAT5-mediated relieving of NR1D2transcription repression activity. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histonedeacetylase (HDAC) recruitment, a number of genes implicated inmultilineage blood cell development. Involved in CIART-mediatedtranscriptional repression of the circadian transcriptionalactivator: CLOCK-ARNTL/BMAL1 heterodimer. Required for thetranscriptional repression of circadian target genes, such asPER1, mediated by the large PER complex or CRY1 through histonedeacetylation. {ECO:0000269|PubMed:12837748,ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:17000776,ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965,ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227}. | Component of the eukaryotic translation initiationfactor 3 (eIF-3) complex, which is required for several steps inthe initiation of protein synthesis (PubMed:17581632,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008,ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EIF3I | chr1:32768334 | chr1:32694100 | ENST00000373586 | + | 5 | 11 | 180_217 | 176 | 326 | Repeat | Note=WD 5 |
| Tgene | >EIF3I | chr1:32768334 | chr1:32694100 | ENST00000373586 | + | 5 | 11 | 221_267 | 176 | 326 | Repeat | Note=WD 6 |
| Tgene | >EIF3I | chr1:32768334 | chr1:32694100 | ENST00000373586 | + | 5 | 11 | 275_316 | 176 | 326 | Repeat | Note=WD 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HDAC1 | chr1:32768334 | chr1:32694100 | ENST00000373548 | + | 2 | 14 | 9_321 | 54 | 483 | Region | Note=Histone deacetylase |
| Tgene | EIF3I | chr1:32768334 | chr1:32694100 | ENST00000373586 | + | 5 | 11 | 135_175 | 176 | 326 | Repeat | Note=WD 4 |
| Tgene | EIF3I | chr1:32768334 | chr1:32694100 | ENST00000373586 | + | 5 | 11 | 1_39 | 176 | 326 | Repeat | Note=WD 1 |
| Tgene | EIF3I | chr1:32768334 | chr1:32694100 | ENST00000373586 | + | 5 | 11 | 43_81 | 176 | 326 | Repeat | Note=WD 2 |
| Tgene | EIF3I | chr1:32768334 | chr1:32694100 | ENST00000373586 | + | 5 | 11 | 87_127 | 176 | 326 | Repeat | Note=WD 3 |
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FusionGeneSequence for HDAC1_EIF3I |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HDAC1_EIF3I |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HDAC1 | ZBTB16, MBD3L1, BUB1, BUB1B, BUB3, CDC20, CDH1, MAD1L1, KDM1A, HMG20B, RCOR1, PHF21A, HDAC2, RB1, CTBP1, TGIF1, DDX5, DDX17, DNMT3B, GATA1, PHB, CDYL, SIN3A, RBBP4, MTA1, MTA2, HDAC1, CHD4, RBBP7, CHD1, SP1, KMT2A, TXNIP, SAP30, SAP130, ARID4B, SUDS3, HCFC1, PTMA, EFCAB6, AR, YY1, GTF2I, MBD3, MBD2, TAB2, GATAD2B, HDAC9, HSPD1, HSPA4, TOP2B, TOP2A, RELA, NCOR2, ATR, PML, RFC1, BRCA1, MYOD1, NFKB1, MDM2, TP53, SMARCB1, SMARCA2, PCNA, DNMT1, RBL1, FKBP3, NFIX, PPARD, RBL2, E2F4, BCOR, MIER1, TGIF2, DAXX, CBFA2T3, SIN3B, HBP1, E2F1, IKZF1, CHD3, MECOM, KLF11, SMAD2, DNMT3L, BCL6, CABIN1, VHL, HIF1AN, HIF1A, DNMT3A, SATB1, HUS1, RAD9A, PHF12, ING1, RUNX1T1, SP3, SUV39H1, EED, EZH2, TPD52L1, TAL1, NR2F2, SPEN, TLE4, HR, HEY2, IFRD1, MXD1, DZIP3, UHRF1, PADI4, MECP2, SPI1, MBD4, WHSC1, ING2, ZMYND11, H2AFY, KDM5C, ETHE1, ZMYM2, REST, PRDM1, FRA10F, CDKN1A, GLI1, GLI2, KCTD11, APBB1, BNIP3, SFPQ, ZBTB7A, MKX, CHFR, TLE1, CDK5R1, SMARCA4, PPP1CC, DACH1, NUDT21, PAPOLA, HSF1, BANF1, ZFP36, MBTPS1, CEBPB, APPL1, BACH1, ADD1, POU2F1, CREM, JUN, SMAD7, HELLS, DACT1, NKX2-5, BRMS1, SERPINB5, HOXA11, FOSL1, SAP30L, EP300, PAX3, CREBBP, NR3C1, GATAD2A, RUNX2, RUVBL2, NKX3-1, RUNX1, NUP98, NUP54, GRIP1, PLAGL1, NFE4, MAPK8, MAPK9, MAPK10, INSM1, CEBPD, REPIN1, GCM1, RERE, RFX1, TRIM27, NFYC, SNAI1, SNAI2, SNAI3, NKX3-2, MEN1, ESR1, BCL3, LMO4, SYK, GFI1, CRYAB, ESCO2, CTNNB1, PARP1, E4F1, MTA3, CIITA, HES1, BCL6B, STAT5A, CREB1, LCOR, PITX2, TAF6, GLI3, SMARCE1, SMARCC2, HSD11B2, BCL11B, BCL11A, BAZ2A, TFCP2, HIST1H3A, MYT1, KDM4A, STAT3, NR0B2, CCND1, CEBPA, MBD3L2, NKX2-2, KLF5, CSNK2A1, PFDN5, HNRNPD, NR2E1, KLF4, KLF1, NFKBIA, SATB2, MNT, MYC, TBX3, MAFK, PRKACA, TBP, SMAD3, ARID4A, ELK1, HDAC7, TP73, UHRF2, ACTA1, PBX1, LEF1, SENP1, ATM, ENO1, PHB2, TAF1B, ZEB2, SKIL, ZFPM2, UBASH3B, PIAS4, NR1D2, BHLHE41, NONO, SOX6, ZNF395, SMAD1, SMAD5, SMAD4, SMEK1, ZNF148, NPM1, PRDM5, EMD, CCDC6, OVOL1, SAMSN1, GABPA, MORF4L1, MORF4L2, DMAP1, ATF3, PPARG, MEF2D, MEF2A, SMC4, CCT8, TCP1, VIM, TRIM21, ESCO1, PARK7, TSC22D3, CDK2AP1, TADA2A, BANP, NFYB, IRF5, DEC1, HIST2H2AA3, PPP6R3, PPP2R1B, PPP2R1A, HDAC5, KAT5, BRINP1, HIST1H4A, HIST3H3, THAP11, PRKG1, NFYA, DDIT3, SMARCAD1, SOX2, KDM5B, HDGF, FOXP3, WISP2, PRDM4, GPS2, UBTF, PCGF6, RNF2, HIST3H2BB, CDKN2A, NR2C1, NR2C2, POLD3, TRIM28, KDM4C, NFATC1, TFAP4, BAHD1, VPRBP, AIRE, BRMS1L, MAGEA1, JDP2, ZNF76, SMARCC1, SMARCA5, SMARCD1, NOTCH1, FN1, SS18, SSX2, DNTTIP1, GSE1, HMG20A, RCOR3, ELMSAN1, TRERF1, E2F3, TMEM54, EID3, STAT1, BHLHE40, ADNP, ADH5, ARID5B, BEND3, CSNK2B, TBL1XR1, GATAD1, EHMT2, BBX, KPNA1, KPNA3, KPNA4, KPNA6, IDH2, KDM5A, ACADM, MIER2, MIER3, PFDN2, VBP1, PFDN6, C11orf30, FAM60A, ZMYND8, PWWP2A, RREB1, RCOR2, ESD, TNRC18, TRMT61A, C16orf87, WDR5, ZBTB2, ZMYM3, ZNF217, ZNF512B, ZNF516, ZNF521, ZNF592, ZNF609, ZNF687, ZNF827, IKZF2, PRRG4, HEXIM1, UBE2I, ZGPAT, BRCC3, SF3A1, HNRNPR, LARP7, PAAF1, RABEP2, NACC2, RARA, FEZF2, HAUS2, PRDM6, NFE2L2, DDB1, CUL4B, APEX1, PHF6, LOXL2, SUZ12, SUMO2, SIRT6, MAP1LC3B, HIST1H2AA, HIST1H2BA, ZNF219, PHF20L1, C22orf31, DDB2, PHF1, CHD5, EP400, MAPK11, MAPK14, POLR3A, PIN1, TLE3, PPP1CA, RAP1A, NRIP1, RUNX3, HIST1H3E, ALDH1B1, CCT6A, E2F6, ERCC6, H3F3A, IPO5, AFF1, PEX10, PIK3CA, RING1, SRPR, TCF20, CCT3, TRPS1, CDC42BPA, NOLC1, PHF14, DNAJC6, PARP2, CCT7, CCT4, CCT2, ZNF273, RALBP1, TRAK1, CCT5, EXOSC7, PHLPP1, MGA, COG4, TIMM13, DESI1, SNX9, TRPM7, BCAS3, ZFP64, BAHCC1, GPAM, EHMT1, CCNL2, ASCC2, HSDL2, ANKRD13B, C2orf69, FOXK1, PGBD3, STRAP, KMT2E, NF2, USP37, FOXK2, MAGEB2, CCNB1, NFATC2, RNF138, USP19, RORC, CDK4, EGFR, L3MBTL2, CASP8AP2, SFMBT1, CCDC71, PHF21B, TFDP1, PWWP2B, ZNF608, CCT6B, ZNF800, CYBRD1, ZNF639, RYBP, C9orf41, WIZ, RFX3, XYLT2, RTCB, PTOV1, DDX1, TBC1D32, TAF6L, CDK20, FOXJ1, HSD17B10, RNF157, YAP1 | EIF3I | EIF3A, EIF1B, LYAR, EIF4G1, EIF3B, EIF3H, EIF3F, USP3, SRRM2, TADA2A, MYC, CD4, CLEC4G, RAD21, ARRB1, SIRT7, CUL3, CDK2, EIF3E, EIF3G, EIF3C, EIF3D, EIF3K, EIF3M, EIF3L, LIG4, PAXIP1, DDX3X, VCAM1, METTL18, ITGA4, PAN2, CD81, IGSF8, ICAM1, NPM1, EXOSC6, CDK18, TARDBP, HECW2, HUWE1, RNF2, HERC2, EPB41L1, PRRC2B, EIF3CL, EIF3J, TRIP12, DNAJA4, DCAF10, EIF2B5, CPNE8, EIF5, LMAN1, MYL9, NDUFB5, RPS13, SETD2, TRA2B, UBR5, YBX1, NUMA1, PDCD4, POLR1C, RAN, RPL37A, SLC3A2, SRRM1, SRSF6, SRSF7, SUB1, TMED2, SFN, NTRK1, TGFBR2, KIF11, MYO1C, RPL10, NES, L1TD1, GAN, GLI1, RC3H1, ZNF746, CERKL, EIF4A1, CYLD, DLD, HSD17B10, SOD1, G3BP1, CCND2, BRCA1, TES, BRD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HDAC1_EIF3I |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HDAC1 | Q13547 | DB01169 | Arsenic trioxide | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB01593 | Zinc | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB02546 | Vorinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB05015 | Belinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB06176 | Romidepsin | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB06603 | Panobinostat | Histone deacetylase 1 | small molecule | approved|investigational |
| Hgene | HDAC1 | Q13547 | DB08868 | Fingolimod | Histone deacetylase 1 | small molecule | approved|investigational |
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RelatedDiseases for HDAC1_EIF3I |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HDAC1 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | HDAC1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | HDAC1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | HDAC1 | C0018799 | Heart Diseases | 1 | CTD_human |
| Hgene | HDAC1 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human |
| Hgene | HDAC1 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | EIF3I | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human |
| Tgene | EIF3I | C0009375 | Colonic Neoplasms | 1 | CTD_human |
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