FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15912

FusionGeneSummary for HCP5_LY6G6C

check button Fusion gene summary
Fusion gene informationFusion gene name: HCP5_LY6G6C
Fusion gene ID: 15912
HgeneTgene
Gene symbol

HCP5

LY6G6C

Gene ID

10866

80740

Gene nameHLA complex P5lymphocyte antigen 6 family member G6C
Synonyms6S2650E|D6S2650E|P5-1C6orf24|G6c|NG24
Cytomap

6p21.33

6p21.33

Type of genencRNAprotein-coding
DescriptionHLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORFlymphocyte antigen 6 complex locus protein G6clymphocyte antigen 6 complex, locus G6Clymphocyte antigen-6 G6C
Modification date2018051920180523
UniProtAcc

O95867

Ensembl transtripts involved in fusion geneENST00000414046, ENST00000419355, 
ENST00000457127, ENST00000423496, 
ENST00000495859, ENST00000375819, 
ENST00000497123, ENST00000434915, 
ENST00000467714, ENST00000428498, 
ENST00000480025, ENST00000428121, 
ENST00000470946, ENST00000383413, 
ENST00000470881, ENST00000419939, 
ENST00000479794, ENST00000448386, 
Fusion gene scores* DoF score3 X 1 X 3=92 X 1 X 1=2
# samples 31
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/2*10)=2.32192809488736
Context

PubMed: HCP5 [Title/Abstract] AND LY6G6C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLY6G6C

GO:0051260

protein homooligomerization

17008713


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1474-01AHCP5chr6

31368540

+LY6G6Cchr6

31687087

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000414046ENST00000495859HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-5UTRENST00000414046ENST00000375819HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000497123HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000434915HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000467714HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000428498HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000480025HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000428121HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000470946HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000383413HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000470881HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000419939HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000479794HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
3UTR-intronENST00000414046ENST00000448386HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-5UTRENST00000419355ENST00000495859HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-5UTRENST00000419355ENST00000375819HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000497123HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000434915HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000467714HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000428498HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000480025HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000428121HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000470946HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000383413HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000470881HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000419939HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000479794HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000419355ENST00000448386HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-5UTRENST00000457127ENST00000495859HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-5UTRENST00000457127ENST00000375819HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000497123HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000434915HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000467714HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000428498HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000480025HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000428121HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000470946HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000383413HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000470881HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000419939HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000479794HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000457127ENST00000448386HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-5UTRENST00000423496ENST00000495859HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-5UTRENST00000423496ENST00000375819HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000497123HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000434915HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000467714HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000428498HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000480025HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000428121HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000470946HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000383413HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000470881HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000419939HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000479794HCP5chr6

31368540

+LY6G6Cchr6

31687087

-
intron-intronENST00000423496ENST00000448386HCP5chr6

31368540

+LY6G6Cchr6

31687087

-

Top

FusionProtFeatures for HCP5_LY6G6C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HCP5

LY6G6C

O95867

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HCP5_LY6G6C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HCP5_LY6G6C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HCP5APPLY6G6CZDHHC17, CCDC82


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HCP5_LY6G6C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HCP5_LY6G6C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource