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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15911

FusionGeneSummary for HCN3_MUC1

check button Fusion gene summary
Fusion gene informationFusion gene name: HCN3_MUC1
Fusion gene ID: 15911
HgeneTgene
Gene symbol

HCN3

MUC1

Gene ID

57657

4582

Gene namehyperpolarization activated cyclic nucleotide gated potassium channel 3mucin 1, cell surface associated
Synonyms-ADMCKD|ADMCKD1|CA 15-3|CD227|EMA|H23AG|KL-6|MAM6|MCD|MCKD|MCKD1|MUC-1|MUC-1/SEC|MUC-1/X|MUC1/ZD|PEM|PEMT|PUM
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
Descriptionpotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3mucin-1H23 antigenbreast carcinoma-associated antigen DF3cancer antigen 15-3carcinoma-associated mucinepisialinkrebs von den Lungen-6mucin 1, transmembranepeanut-reactive urinary mucinpolymorphic epithelial mucintumor associated epithelial mucin
Modification date2018052220180527
UniProtAcc

Q9P1Z3

P15941

Ensembl transtripts involved in fusion geneENST00000368358, ENST00000496230, 
ENST00000368395, ENST00000338684, 
ENST00000438413, ENST00000457295, 
ENST00000462215, ENST00000368392, 
ENST00000368393, ENST00000368390, 
ENST00000368396, ENST00000343256, 
ENST00000368398, ENST00000368389, 
ENST00000342482, ENST00000337604, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 5 X 2=40
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/40*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HCN3 [Title/Abstract] AND MUC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHCN3

GO:0071320

cellular response to cAMP

22748890

TgeneMUC1

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

15710329

TgeneMUC1

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

15710329

TgeneMUC1

GO:0010944

negative regulation of transcription by competitive promoter binding

15710329

TgeneMUC1

GO:0033629

negative regulation of cell adhesion mediated by integrin

7698991

TgeneMUC1

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

15710329

TgeneMUC1

GO:0043618

regulation of transcription from RNA polymerase II promoter in response to stress

15710329

TgeneMUC1

GO:0090240

positive regulation of histone H4 acetylation

15710329

TgeneMUC1

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

15710329


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI675977HCN3chr1

155259558

+MUC1chr1

155159684

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000368358ENST00000368395HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000338684HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000438413HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000457295HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000462215HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000368392HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000368393HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000368390HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000368396HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000343256HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000368398HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000368389HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000342482HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000368358ENST00000337604HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000368395HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000338684HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000438413HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000457295HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000462215HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000368392HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000368393HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000368390HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000368396HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000343256HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000368398HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000368389HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000342482HCN3chr1

155259558

+MUC1chr1

155159684

+
3UTR-intronENST00000496230ENST00000337604HCN3chr1

155259558

+MUC1chr1

155159684

+

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FusionProtFeatures for HCN3_MUC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HCN3

Q9P1Z3

MUC1

P15941

Hyperpolarization-activated potassium channel. May alsofacilitate the permeation of sodium ions.{ECO:0000269|PubMed:16043489}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HCN3_MUC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HCN3_MUC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HCN3_MUC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HCN3_MUC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMUC1C0007621Neoplastic Cell Transformation1CTD_human
TgeneMUC1C0025500Mesothelioma1CTD_human
TgeneMUC1C0026764Multiple Myeloma1CTD_human
TgeneMUC1C0031149Peritoneal Neoplasms1CTD_human
TgeneMUC1C0038356Stomach Neoplasms1CTD_human
TgeneMUC1C0345967Malignant mesothelioma1CTD_human
TgeneMUC1C1868139Medullary cystic kidney disease 11CTD_human