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Fusion gene ID: 15897 |
FusionGeneSummary for HCG18_MAP2K4 |
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Fusion gene information | Fusion gene name: HCG18_MAP2K4 | Fusion gene ID: 15897 | Hgene | Tgene | Gene symbol | HCG18 | MAP2K4 | Gene ID | 414777 | 6416 |
Gene name | HLA complex group 18 | mitogen-activated protein kinase kinase 4 | |
Synonyms | - | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1 | |
Cytomap | 6p22.1 | 17p12 | |
Type of gene | ncRNA | protein-coding | |
Description | HLA complex group 18 (non-protein coding) | dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1 | |
Modification date | 20180517 | 20180523 | |
UniProtAcc | P45985 | ||
Ensembl transtripts involved in fusion gene | ENST00000602550, ENST00000438412, ENST00000444126, ENST00000449544, ENST00000454129, ENST00000454269, ENST00000426882, ENST00000412685, ENST00000413358, ENST00000602290, ENST00000602498, ENST00000602591, ENST00000602698, ENST00000602861, ENST00000602319, ENST00000602516, ENST00000421520, ENST00000416289, ENST00000458584, ENST00000443909, ENST00000443079, ENST00000432895, | ENST00000353533, ENST00000415385, ENST00000581941, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 5=150 |
# samples | 2 | 5 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/150*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HCG18 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-06-0221-02A | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000602550 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602550 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602550 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3CDS | ENST00000438412 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3CDS | ENST00000438412 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3UTR | ENST00000438412 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000444126 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000444126 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000444126 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000449544 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000449544 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000449544 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000454129 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000454129 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000454129 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000454269 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000454269 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000454269 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3CDS | ENST00000426882 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3CDS | ENST00000426882 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3UTR | ENST00000426882 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3CDS | ENST00000412685 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3CDS | ENST00000412685 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
5UTR-3UTR | ENST00000412685 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000413358 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000413358 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000413358 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602290 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602290 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602290 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602498 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602498 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602498 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602591 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602591 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602591 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602698 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602698 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602698 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602861 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602861 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602861 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602319 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602319 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602319 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602516 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000602516 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000602516 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000421520 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000421520 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000421520 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000416289 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000416289 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000416289 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000458584 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000458584 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000458584 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000443909 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000443909 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000443909 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000443079 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000443079 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000443079 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000432895 | ENST00000353533 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3CDS | ENST00000432895 | ENST00000415385 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
intron-3UTR | ENST00000432895 | ENST00000581941 | HCG18 | chr6 | 30294131 | - | MAP2K4 | chr17 | 12011107 | + |
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FusionProtFeatures for HCG18_MAP2K4 |
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Hgene | Tgene |
HCG18 | MAP2K4 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-JunN-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,is the one of the only known kinase to directly activate thestress-activated protein kinase/c-Jun N-terminal kinasesMAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 andMAP2K7/MKK7 both activate the JNKs by phosphorylation, but theydiffer in their preference for the phosphorylation site in theThr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation ofthe Tyr residue and MAP2K7/MKK7 for the Thr residue. Thephosphorylation of the Thr residue by MAP2K7/MKK7 seems to be theprerequisite for JNK activation at least in response toproinflammatory cytokines, while other stimuli activate bothMAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylateJNKs. MAP2K4 is required for maintaining peripheral lymphoidhomeostasis. The MKK/JNK signaling pathway is also involved inmitochondrial death signaling pathway, including the releasecytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7exclusively activates JNKs, MAP2K4/MKK4 additionally activates thep38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.{ECO:0000269|PubMed:7716521}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HCG18_MAP2K4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HCG18_MAP2K4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HCG18 | MAP2K4 | FLNC, SPAG9, MAPK8, MAP4K2, MAP2K7, MAP3K8, AKT1, MAPK8IP3, MAP3K11, MAP3K4, ARRB2, MAP3K2, MAP3K1, NPHS1, ITCH, MAPK9, BLNK, PML, MAPK10, MAP3K5, MAP2K6, MAP2K4, MAPK14, MAP3K3, LRRK2, APP, JUN, MAP3K7, ARRB1, MAPK1, GCH1, GEMIN5, RBBP8, EGFR, MAP3K10, NBR1, KTI12, VASP, FLNB, CDC5L, UBC, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HCG18_MAP2K4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HCG18_MAP2K4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |