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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15897

FusionGeneSummary for HCG18_MAP2K4

check button Fusion gene summary
Fusion gene informationFusion gene name: HCG18_MAP2K4
Fusion gene ID: 15897
HgeneTgene
Gene symbol

HCG18

MAP2K4

Gene ID

414777

6416

Gene nameHLA complex group 18mitogen-activated protein kinase kinase 4
Synonyms-JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1
Cytomap

6p22.1

17p12

Type of genencRNAprotein-coding
DescriptionHLA complex group 18 (non-protein coding)dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1
Modification date2018051720180523
UniProtAcc

P45985

Ensembl transtripts involved in fusion geneENST00000602550, ENST00000438412, 
ENST00000444126, ENST00000449544, 
ENST00000454129, ENST00000454269, 
ENST00000426882, ENST00000412685, 
ENST00000413358, ENST00000602290, 
ENST00000602498, ENST00000602591, 
ENST00000602698, ENST00000602861, 
ENST00000602319, ENST00000602516, 
ENST00000421520, ENST00000416289, 
ENST00000458584, ENST00000443909, 
ENST00000443079, ENST00000432895, 
ENST00000353533, ENST00000415385, 
ENST00000581941, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 5=150
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HCG18 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-0221-02AHCG18chr6

30294131

-MAP2K4chr17

12011107

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000602550ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602550ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602550ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000438412ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000438412ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3UTRENST00000438412ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000444126ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000444126ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000444126ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000449544ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000449544ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000449544ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454129ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454129ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000454129ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454269ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454269ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000454269ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000426882ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000426882ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3UTRENST00000426882ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000412685ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000412685ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3UTRENST00000412685ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000413358ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000413358ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000413358ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602290ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602290ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602290ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602498ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602498ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602498ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602591ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602591ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602591ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602698ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602698ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602698ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602861ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602861ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602861ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602319ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602319ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602319ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602516ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602516ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602516ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000421520ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000421520ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000421520ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000416289ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000416289ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000416289ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000458584ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000458584ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000458584ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443909ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443909ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000443909ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443079ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443079ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000443079ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000432895ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000432895ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000432895ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+

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FusionProtFeatures for HCG18_MAP2K4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HCG18

MAP2K4

P45985

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-JunN-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,is the one of the only known kinase to directly activate thestress-activated protein kinase/c-Jun N-terminal kinasesMAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 andMAP2K7/MKK7 both activate the JNKs by phosphorylation, but theydiffer in their preference for the phosphorylation site in theThr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation ofthe Tyr residue and MAP2K7/MKK7 for the Thr residue. Thephosphorylation of the Thr residue by MAP2K7/MKK7 seems to be theprerequisite for JNK activation at least in response toproinflammatory cytokines, while other stimuli activate bothMAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylateJNKs. MAP2K4 is required for maintaining peripheral lymphoidhomeostasis. The MKK/JNK signaling pathway is also involved inmitochondrial death signaling pathway, including the releasecytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7exclusively activates JNKs, MAP2K4/MKK4 additionally activates thep38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.{ECO:0000269|PubMed:7716521}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HCG18_MAP2K4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HCG18_MAP2K4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HCG18MAP2K4FLNC, SPAG9, MAPK8, MAP4K2, MAP2K7, MAP3K8, AKT1, MAPK8IP3, MAP3K11, MAP3K4, ARRB2, MAP3K2, MAP3K1, NPHS1, ITCH, MAPK9, BLNK, PML, MAPK10, MAP3K5, MAP2K6, MAP2K4, MAPK14, MAP3K3, LRRK2, APP, JUN, MAP3K7, ARRB1, MAPK1, GCH1, GEMIN5, RBBP8, EGFR, MAP3K10, NBR1, KTI12, VASP, FLNB, CDC5L, UBC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HCG18_MAP2K4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HCG18_MAP2K4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource