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Fusion gene ID: 15894 |
FusionGeneSummary for HCFC1_MRFAP1 |
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Fusion gene information | Fusion gene name: HCFC1_MRFAP1 | Fusion gene ID: 15894 | Hgene | Tgene | Gene symbol | HCFC1 | MRFAP1 | Gene ID | 3054 | 93621 |
Gene name | host cell factor C1 | Morf4 family associated protein 1 | |
Synonyms | CFF|HCF|HCF-1|HCF1|HFC1|MRX3|PPP1R89|VCAF | PAM14|PGR1 | |
Cytomap | Xq28 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | host cell factor 1VP16-accessory proteinprotein phosphatase 1, regulatory subunit 89 | MORF4 family-associated protein 1Mof4 family associated protein 1T-cell activation proteinprotein associated with MRG of 14 kDa | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P51610 | Q9Y605 | |
Ensembl transtripts involved in fusion gene | ENST00000310441, ENST00000369984, ENST00000354233, ENST00000461098, | ENST00000320912, ENST00000507420, ENST00000382581, | |
Fusion gene scores | * DoF score | 6 X 7 X 4=168 | 6 X 5 X 4=120 |
# samples | 7 | 6 | |
** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HCFC1 [Title/Abstract] AND MRFAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HCFC1 | GO:0006355 | regulation of transcription, DNA-templated | 12670868 |
Hgene | HCFC1 | GO:0010628 | positive regulation of gene expression | 21285374 |
Hgene | HCFC1 | GO:0043254 | regulation of protein complex assembly | 10675337 |
Hgene | HCFC1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
Hgene | HCFC1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
Hgene | HCFC1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
Hgene | HCFC1 | GO:0050821 | protein stabilization | 21285374 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-EB-A431-01A | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000310441 | ENST00000320912 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
intron-5UTR | ENST00000310441 | ENST00000507420 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
intron-5UTR | ENST00000310441 | ENST00000382581 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
5CDS-5UTR | ENST00000369984 | ENST00000320912 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
5CDS-5UTR | ENST00000369984 | ENST00000507420 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
5CDS-5UTR | ENST00000369984 | ENST00000382581 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
5CDS-5UTR | ENST00000354233 | ENST00000320912 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
5CDS-5UTR | ENST00000354233 | ENST00000507420 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
5CDS-5UTR | ENST00000354233 | ENST00000382581 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
intron-5UTR | ENST00000461098 | ENST00000320912 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
intron-5UTR | ENST00000461098 | ENST00000507420 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
intron-5UTR | ENST00000461098 | ENST00000382581 | HCFC1 | chrX | 153213014 | - | MRFAP1 | chr4 | 6642418 | + |
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FusionProtFeatures for HCFC1_MRFAP1 |
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Hgene | Tgene |
HCFC1 | MRFAP1 |
Involved in control of the cell cycle (PubMed:10629049,PubMed:10779346, PubMed:15190068, PubMed:16624878,PubMed:23629655). Also antagonizes transactivation by ZBTB17 andGABP2; represses ZBTB17 activation of the p15(INK4b) promoter andinhibits its ability to recruit p300 (PubMed:10675337,PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100,PubMed:14532282). Tethers the chromatin modifying Set1/Ash2histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histonedeacetylase (HDAC) complexes (involved in the activation andrepression of transcription, respectively) together(PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complexthat is required for the regulation of the transcriptionalactivity of RRM1 (PubMed:20200153). As part of the NSL complex itmay be involved in acetylation of nucleosomal histone H4 onseveral lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 toE2F1 responsive promoters promoting transcriptional activation andthereby facilitates G1 to S phase transition (PubMed:23629655).{ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337,ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100,ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282,ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878,ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153,ECO:0000269|PubMed:23629655}. (Microbial infection) In case of human herpes simplexvirus (HSV) infection, HCFC1 forms a multiprotein-DNA complex withthe viral transactivator protein VP16 and POU2F1 thereby enablingthe transcription of the viral immediate early genes.{ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HCFC1_MRFAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HCFC1_MRFAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HCFC1 | GABPA, KMT2A, HCFC2, MEN1, RBBP5, WDR5, ASH2L, SIN3A, EGR2, HDAC1, HDAC2, SUDS3, RBBP4, RBBP7, SETD1A, ASCL2, OGT, HSP90AA1, HSPA4, HSPA8, SP1, SIN3B, PDCD2, CREB3, CREBZF, PPP1CA, PPARGC1A, HCFC1R1, POU2F1, ZBTB17, BAP1, USP53, POLR2J, THAP3, THAP1, ASF1B, ZNF335, NFE2L1, THAP7, KAT8, USF1, E2F1, E2F3, E2F4, PHF8, WDR82, HDAC5, IRF1, IRF2, THAP11, YY1, SNRPB, SNRPN, ELAVL1, SIRT7, NR2C1, CUL3, CDK2, HCFC1, CLP1, EGFR, PPP1CB, DPY30, MAP3K7, NOTCH1, LMNA, EEF1D, RPA3, RPA2, RPA1, NUDCD3, FBXW11, CXXC1, NCOA6, EED, BTRC, THAP2, DDAH2, ALDOC, EEF2, PSMD7, TRIM28, NTRK1, DYNLT1, MPHOSPH8, FOXK1, FOXK2, FOXN2, ASXL1, ASXL2, KMT2E, KLF5, CDH1, CAMK2D, NFE2L3, FOXRED1, BRCA1 | MRFAP1 | MORF4L2, MORF4L1, RB1, MRGBP, PAM16, TK1, MAP1LC3B, C8orf33, HTT, SUV39H2, DCDC2, C14orf93, MRFAP1L1, GOLGA8G, C3orf62, GOLGA8F, ZDHHC17, MED4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HCFC1_MRFAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HCFC1_MRFAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HCFC1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | HCFC1 | C0796208 | MENTAL RETARDATION, X-LINKED 3 | 1 | ORPHANET;UNIPROT |