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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 15885

FusionGeneSummary for HBP1_PIK3CG

check button Fusion gene summary
Fusion gene informationFusion gene name: HBP1_PIK3CG
Fusion gene ID: 15885
HgeneTgene
Gene symbol

HBP1

PIK3CG

Gene ID

26959

5294

Gene nameHMG-box transcription factor 1phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms-PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K
Cytomap

7q22.3

7q22.3

Type of geneprotein-codingprotein-coding
DescriptionHMG box-containing protein 1high mobility group box transcription factor 1phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform1-phosphatidylinositol 3-kinasePI3-kinase subunit gammaphosphatidylinositol 3 kinase gamma, p110 gammaphosphatidylinositol 3-kinase catalytic 110-kD gammaphosphatidylinosit
Modification date2018051920180523
UniProtAcc

O60381

P48736

Ensembl transtripts involved in fusion geneENST00000468410, ENST00000222574, 
ENST00000485846, ENST00000461963, 
ENST00000440650, ENST00000496166, 
ENST00000359195, ENST00000466738, 
Fusion gene scores* DoF score7 X 6 X 5=2101 X 1 X 1=1
# samples 71
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: HBP1 [Title/Abstract] AND PIK3CG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePIK3CG

GO:0007186

G-protein coupled receptor signaling pathway

12507995

TgenePIK3CG

GO:0014065

phosphatidylinositol 3-kinase signaling

12507995

TgenePIK3CG

GO:0016310

phosphorylation

25327288

TgenePIK3CG

GO:0043406

positive regulation of MAP kinase activity

12507995

TgenePIK3CG

GO:0051897

positive regulation of protein kinase B signaling

12507995


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AC-A2BM-01AHBP1chr7

106826917

+PIK3CGchr7

106545554

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000468410ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000468410ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+
Frame-shiftENST00000468410ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
5CDS-intronENST00000468410ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000222574ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000222574ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+
Frame-shiftENST00000222574ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
5CDS-intronENST00000222574ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000485846ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000485846ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+
Frame-shiftENST00000485846ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
5CDS-intronENST00000485846ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+
3UTR-3CDSENST00000461963ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
3UTR-3CDSENST00000461963ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+
3UTR-3CDSENST00000461963ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
3UTR-intronENST00000461963ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+

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FusionProtFeatures for HBP1_PIK3CG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HBP1

O60381

PIK3CG

P48736

Transcriptional repressor that binds to the promoterregion of target genes. Plays a role in the regulation of the cellcycle and of the Wnt pathway. Binds preferentially to the sequence5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced byinteraction with RB1. Disrupts the interaction between DNA andTCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660,ECO:0000269|PubMed:11500377}. Phosphoinositide-3-kinase (PI3K) that phosphorylatesPtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generatephosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a keyrole by recruiting PH domain-containing proteins to the membrane,including AKT1 and PDPK1, activating signaling cascades involvedin cell growth, survival, proliferation, motility and morphology.Links G-protein coupled receptor activation to PIP3 production.Involved in immune, inflammatory and allergic responses. Modulatesleukocyte chemotaxis to inflammatory sites and in response tochemoattractant agents. May control leukocyte polarization andmigration by regulating the spatial accumulation of PIP3 and byregulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendriticcells. Together with PIK3CD is involved in natural killer (NK)cell development and migration towards the sites of inflammation.Participates in T-lymphocyte migration. Regulates T-lymphocyteproliferation and cytokine production. Together with PIK3CDparticipates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CDparticipates in neutrophil respiratory burst. Together with PIK3CDis involved in neutrophil chemotaxis and extravasation. Togetherwith PIK3CB promotes platelet aggregation and thrombosis.Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesivefunction in platelets downstream of P2Y12 through a lipid kinaseactivity-independent mechanism. May have also a lipid kinaseactivity-dependent function in platelet aggregation. Involved inendothelial progenitor cell migration. Negative regulator ofcardiac contractility. Modulates cardiac contractility byanchoring protein kinase A (PKA) and PDE3B activation, reducingcAMP levels. Regulates cardiac contractility also by promotingbeta-adrenergic receptor internalization by binding to GRK2 and bynon-muscle tropomyosin phosphorylation. Also has serine/threonineprotein kinase activity: both lipid and protein kinase activitiesare required for beta-adrenergic receptor endocytosis. May alsohave a scaffolding role in modulating cardiac contractility.Contributes to cardiac hypertrophy under pathological stress.Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 isassembled in a signaling complex in which the PI3K gamma complexis activated by RAPGEF3 and which is involved in angiogenesis.{ECO:0000269|PubMed:12163475, ECO:0000269|PubMed:15294162,ECO:0000269|PubMed:16094730, ECO:0000269|PubMed:21393242,ECO:0000269|PubMed:7624799}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511156_161217515Compositional biasNote=Poly-Ser
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511197_200217515Compositional biasNote=Poly-Asp
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511156_161217515Compositional biasNote=Poly-Ser
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511197_200217515Compositional biasNote=Poly-Asp
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612156_161217515Compositional biasNote=Poly-Ser
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612197_200217515Compositional biasNote=Poly-Asp

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511434_502217515DNA bindingHMG box
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511434_502217515DNA bindingHMG box
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612434_502217515DNA bindingHMG box
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511203_345217515DomainAXH
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511203_345217515DomainAXH
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612203_345217515DomainAXH
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+91119_2310101103Compositional biasNote=Poly-Arg
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+91119_2310101103Compositional biasNote=Poly-Arg
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+91119_2310101103Compositional biasNote=Poly-Arg
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+911217_30910101103DomainPI3K-RBD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+91134_14110101103DomainPI3K-ABD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+911357_52110101103DomainC2 PI3K-type
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+911541_72310101103DomainPIK helical
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+911828_107310101103DomainPI3K/PI4K
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+911217_30910101103DomainPI3K-RBD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+91134_14110101103DomainPI3K-ABD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+911357_52110101103DomainC2 PI3K-type
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+911541_72310101103DomainPIK helical
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+911828_107310101103DomainPI3K/PI4K
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+911217_30910101103DomainPI3K-RBD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+91134_14110101103DomainPI3K-ABD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+911357_52110101103DomainC2 PI3K-type
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+911541_72310101103DomainPIK helical
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+911828_107310101103DomainPI3K/PI4K
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+911829_83810101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+911864_87210101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195+911961_96910101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+911829_83810101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+911864_87210101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650+911961_96910101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+911829_83810101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+911864_87210101103Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166+911961_96910101103Nucleotide bindingATP


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FusionGeneSequence for HBP1_PIK3CG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HBP1_ENST00000468410_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_310aa
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHLCXGLSSPSSSHKPTDHPVLHDADDRNAPVNKQRRHXIYPGCPHSGEKXGG

>In-frame_HBP1_ENST00000468410_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_310aa
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHLCXGLSSPSSSHKPTDHPVLHDADDRNAPVNKQRRHXIYPGCPHSGEKXGG

>In-frame_HBP1_ENST00000222574_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_310aa
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHLCXGLSSPSSSHKPTDHPVLHDADDRNAPVNKQRRHXIYPGCPHSGEKXGG

>In-frame_HBP1_ENST00000222574_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_310aa
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHLCXGLSSPSSSHKPTDHPVLHDADDRNAPVNKQRRHXIYPGCPHSGEKXGG

>In-frame_HBP1_ENST00000485846_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_310aa
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHLCXGLSSPSSSHKPTDHPVLHDADDRNAPVNKQRRHXIYPGCPHSGEKXGG

>In-frame_HBP1_ENST00000485846_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_310aa
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHLCXGLSSPSSSHKPTDHPVLHDADDRNAPVNKQRRHXIYPGCPHSGEKXGG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HBP1_ENST00000468410_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_931nt
ATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGAC
TCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCT
GAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCT
TGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGT
CCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCA
CGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGG
GCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACT
GTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCAT
GATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGA
TGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGG

>In-frame_HBP1_ENST00000468410_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_931nt
ATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGAC
TCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCT
GAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCT
TGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGT
CCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCA
CGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGG
GCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACT
GTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCAT
GATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGA
TGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGG

>In-frame_HBP1_ENST00000222574_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_931nt
ATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGAC
TCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCT
GAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCT
TGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGT
CCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCA
CGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGG
GCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACT
GTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCAT
GATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGA
TGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGG

>In-frame_HBP1_ENST00000222574_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_931nt
ATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGAC
TCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCT
GAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCT
TGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGT
CCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCA
CGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGG
GCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACT
GTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCAT
GATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGA
TGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGG

>In-frame_HBP1_ENST00000485846_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_931nt
ATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGAC
TCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCT
GAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCT
TGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGT
CCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCA
CGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGG
GCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACT
GTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCAT
GATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGA
TGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGG

>In-frame_HBP1_ENST00000485846_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_931nt
ATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGAC
TCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCT
GAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCT
TGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGT
CCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCA
CGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGG
GCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACT
GTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCAT
GATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGA
TGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_HBP1_ENST00000468410_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_1447nt
AACCCCCAGGGGGTTGAGGGGAGGGGGAAGACGAAGCTTGAAAGACTTGGTAATGGCGACGGGTTTGTCAGAGCACCATAACATGGTGTG
GGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGA
GTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCA
GGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCA
AAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAG
TCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCC
ACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAG
TGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCA
CTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGA
TGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAA
AGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAAC
AAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAAC
TTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATG
TTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGA
ATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGA
ATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAGAAAAAGATGTAATC

>In-frame_HBP1_ENST00000468410_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_2758nt
AACCCCCAGGGGGTTGAGGGGAGGGGGAAGACGAAGCTTGAAAGACTTGGTAATGGCGACGGGTTTGTCAGAGCACCATAACATGGTGTG
GGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGA
GTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCA
GGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCA
AAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAG
TCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCC
ACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAG
TGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCA
CTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGA
TGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAA
AGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAAC
AAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAAC
TTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATG
TTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGA
ATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGA
ATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAGAAAAAGATGTAATC
GTTGTAACCTTTGTCTCATTCCTTAAATGATGCTTCCAAACATCTCCTTAGTGTCTGCAGGTGTTAGTGGTGTGCTAAAAGCAAGGAAAG
CGAGTTAGTCTTTTCAGTGTCTTTTGCAATTCAATTCTTTTGTCATGTATAACTGAGACACACAAACACAGCAGGAGAAATCTAAACCGT
TGTGCCTTGACCTTCCTCTGCTGGTCTTGTTCCAGGGTTATGAATATGAAAAAATAGAGATGAGACTTTTTGTGTCAACTCTGTCCACAA
GAGTGAGTTATCTAGTATGATTAGTATAGCTTTCTCCAGCATGGCAGCAGGAAGTAACTACAGGGCCTCTTTTATGCCTGACATTTCTTC
CCTTCCTTTTTCCCTGCCTCCCTTTTTCATCAATTGCGATGCTCCCACAACTCTTTACAGACTTGTGAAATCTTCAAGAACACCTTTACT
CTATAACTCAAAAATTAGTTGAAAAATAATTACTTCTCAAGGATTATTAGAATCTTAGGTACTTATTTGTAAAGATGTTTAGTGACTTTT
TTTTCAAGTATCTTATTAAAGGAGGCATTCTAGAAAATATGAATTAGTTTCCAAATGCCTTAATTTTAAACTTTGGCCTGAACAGTTTTT
TCTTTTTCTTAATGGAAGAAGATATTTAATATCTTAAAAATATTCCAAGTTAGGAAGAACACTACTTGCCTTATCCATTTCCCATTTAAA
GGACTTTTAAACTTTGACACATCCTTCAGATTTCCTGAAAATAATTGAAATATCTTACTTTAAAAATATTTTCATCTCTGAAATATCTCG
TTATTTATTGGAGGTATTGTTTAACCTTAGAGAGACCATTAAATTATTTATAAAATATTTTGTAATTACCTGTAGCTAATACATTACATA
GAAAAAAACTATGTTAACAGTGTCTCTGTTTAAGTATAATCAGATATAAATATATACTTAATTTTTTAATTTTAAAAATAGATACCTGTT
TGACTTTGAGGTAGTCCAGACCTTTTCTTTTTTTTTTTTTTTTTAATGTGTGCAAAAGCCCAAAGGTTCCTAAGCCTGGCTGCAAAGAAG
AATCAACAGGGACACTTTTTAAAAACACTCTTATCAGCCTGGGCAACACAGTGAGACTCCATCTCTTAAAAAAAAAATTAGCTGGGTATA
GTGGTATGTGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGGATTGCCTGAGCCCAGGAGGTGGAAACTGCAGAGAGTCATGAT

>In-frame_HBP1_ENST00000222574_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_1551nt
GGCGACGGGTTTGGTAAGTAGGAAAGTTTCGGTTGAGGAGTAAGAGCTGCCGCGGGAGCAGTAACCCGCGCGGGGGAGGCCGACGTCGGT
CGGAGAGGGGGTACGAGAGCTGCTGGTGGTGTTGTCGTGGCCGGAGCGGCCCGCGCCTGGGCTGCCGGCACTTCGCGGCAGTCAGAGCAC
CATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATG
AATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGAC
CTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGA
TCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCG
ACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCC
TATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACAC
GAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCT
TCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTT
CTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGA
GGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGT
TCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCAT
AGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCC
CTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTC
TGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCT
GGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAG

>In-frame_HBP1_ENST00000222574_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_2862nt
GGCGACGGGTTTGGTAAGTAGGAAAGTTTCGGTTGAGGAGTAAGAGCTGCCGCGGGAGCAGTAACCCGCGCGGGGGAGGCCGACGTCGGT
CGGAGAGGGGGTACGAGAGCTGCTGGTGGTGTTGTCGTGGCCGGAGCGGCCCGCGCCTGGGCTGCCGGCACTTCGCGGCAGTCAGAGCAC
CATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATG
AATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGAC
CTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGA
TCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCG
ACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCC
TATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACAC
GAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCT
TCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTT
CTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGA
GGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGT
TCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCAT
AGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCC
CTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTC
TGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCT
GGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAG
AAAAAGATGTAATCGTTGTAACCTTTGTCTCATTCCTTAAATGATGCTTCCAAACATCTCCTTAGTGTCTGCAGGTGTTAGTGGTGTGCT
AAAAGCAAGGAAAGCGAGTTAGTCTTTTCAGTGTCTTTTGCAATTCAATTCTTTTGTCATGTATAACTGAGACACACAAACACAGCAGGA
GAAATCTAAACCGTTGTGCCTTGACCTTCCTCTGCTGGTCTTGTTCCAGGGTTATGAATATGAAAAAATAGAGATGAGACTTTTTGTGTC
AACTCTGTCCACAAGAGTGAGTTATCTAGTATGATTAGTATAGCTTTCTCCAGCATGGCAGCAGGAAGTAACTACAGGGCCTCTTTTATG
CCTGACATTTCTTCCCTTCCTTTTTCCCTGCCTCCCTTTTTCATCAATTGCGATGCTCCCACAACTCTTTACAGACTTGTGAAATCTTCA
AGAACACCTTTACTCTATAACTCAAAAATTAGTTGAAAAATAATTACTTCTCAAGGATTATTAGAATCTTAGGTACTTATTTGTAAAGAT
GTTTAGTGACTTTTTTTTCAAGTATCTTATTAAAGGAGGCATTCTAGAAAATATGAATTAGTTTCCAAATGCCTTAATTTTAAACTTTGG
CCTGAACAGTTTTTTCTTTTTCTTAATGGAAGAAGATATTTAATATCTTAAAAATATTCCAAGTTAGGAAGAACACTACTTGCCTTATCC
ATTTCCCATTTAAAGGACTTTTAAACTTTGACACATCCTTCAGATTTCCTGAAAATAATTGAAATATCTTACTTTAAAAATATTTTCATC
TCTGAAATATCTCGTTATTTATTGGAGGTATTGTTTAACCTTAGAGAGACCATTAAATTATTTATAAAATATTTTGTAATTACCTGTAGC
TAATACATTACATAGAAAAAAACTATGTTAACAGTGTCTCTGTTTAAGTATAATCAGATATAAATATATACTTAATTTTTTAATTTTAAA
AATAGATACCTGTTTGACTTTGAGGTAGTCCAGACCTTTTCTTTTTTTTTTTTTTTTTAATGTGTGCAAAAGCCCAAAGGTTCCTAAGCC
TGGCTGCAAAGAAGAATCAACAGGGACACTTTTTAAAAACACTCTTATCAGCCTGGGCAACACAGTGAGACTCCATCTCTTAAAAAAAAA
ATTAGCTGGGTATAGTGGTATGTGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGGATTGCCTGAGCCCAGGAGGTGGAAACTG

>In-frame_HBP1_ENST00000485846_chr7_106826917_+_PIK3CG_ENST00000440650_chr7_106545554_+_2036nt
AAAAACAAGCCCGGAGTCCGGGCTGCGGTCACATGATGGGGGGAAGGGAGGGGAACGCGATGAATGGCGAAAGAGGGTGGGGGATGGACT
TGGCGTGAACCGGGAGGCACCGCTCTGTGTGACCCAAAGAGGAGGCTTGGCAGGCGATTCCAGTCTCCGCCTTTCAACCTATGCTGCCAC
CGCAGGCCGATTGAAACAAAACAAAACAAACCAGGCGAAGTGGACAGCCAGGTTTTTGTAGCTTTAAATGCTGCGTGCTGTCTAGGGTGT
TTCACTCTCCGCTGTGCACTCTACACTCGAGTTCATTCTTAGGGAGTTTTCAGCTACAGTCGTTTTTAGAAGGAGCACTGACAGCGAGGA
GTTTTGGGATGGTGGTTGATAACTAAGACAAAGTGCTGAAGAAATGATAGAAGTTGCAAAGAGACGTTAGTGTACTATACTTGGTGAATG
TTGGAAACTGCAGGACCTGCTGTAGGGAAGAAAAAAGTTCTAGCTGGAAAGAATGAGGAAACCAAAGAGCTCTGCAGAGGGAGGGGGAAG
ACAAGACAGACTGCAGCTGTGCTTCTGTGGACCCCAAGAACAGCACTGTTCATACACAGAGGATAGCTCTGAAGAGAGATACCTGTGTAG
TGCAGCTTCTAAATTTCATAATAAAGTCAGAGCACCATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAAC
TCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGAT
ATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGC
TGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATG
AGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTG
TACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTC
ATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAG
ATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCC
CTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAA
TATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGA
TGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCA
AAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTT
CAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTA
GGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCC
CTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAAT

>In-frame_HBP1_ENST00000485846_chr7_106826917_+_PIK3CG_ENST00000496166_chr7_106545554_+_3347nt
AAAAACAAGCCCGGAGTCCGGGCTGCGGTCACATGATGGGGGGAAGGGAGGGGAACGCGATGAATGGCGAAAGAGGGTGGGGGATGGACT
TGGCGTGAACCGGGAGGCACCGCTCTGTGTGACCCAAAGAGGAGGCTTGGCAGGCGATTCCAGTCTCCGCCTTTCAACCTATGCTGCCAC
CGCAGGCCGATTGAAACAAAACAAAACAAACCAGGCGAAGTGGACAGCCAGGTTTTTGTAGCTTTAAATGCTGCGTGCTGTCTAGGGTGT
TTCACTCTCCGCTGTGCACTCTACACTCGAGTTCATTCTTAGGGAGTTTTCAGCTACAGTCGTTTTTAGAAGGAGCACTGACAGCGAGGA
GTTTTGGGATGGTGGTTGATAACTAAGACAAAGTGCTGAAGAAATGATAGAAGTTGCAAAGAGACGTTAGTGTACTATACTTGGTGAATG
TTGGAAACTGCAGGACCTGCTGTAGGGAAGAAAAAAGTTCTAGCTGGAAAGAATGAGGAAACCAAAGAGCTCTGCAGAGGGAGGGGGAAG
ACAAGACAGACTGCAGCTGTGCTTCTGTGGACCCCAAGAACAGCACTGTTCATACACAGAGGATAGCTCTGAAGAGAGATACCTGTGTAG
TGCAGCTTCTAAATTTCATAATAAAGTCAGAGCACCATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAAC
TCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGAT
ATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGC
TGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATG
AGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTG
TACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTC
ATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAG
ATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCC
CTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAA
TATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGA
TGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCA
AAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTT
CAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTA
GGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCC
CTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAAT
TTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAGAAAAAGATGTAATCGTTGTAACCTTTGTCTCATTCCTTAAATGATGCTTCCAAAC
ATCTCCTTAGTGTCTGCAGGTGTTAGTGGTGTGCTAAAAGCAAGGAAAGCGAGTTAGTCTTTTCAGTGTCTTTTGCAATTCAATTCTTTT
GTCATGTATAACTGAGACACACAAACACAGCAGGAGAAATCTAAACCGTTGTGCCTTGACCTTCCTCTGCTGGTCTTGTTCCAGGGTTAT
GAATATGAAAAAATAGAGATGAGACTTTTTGTGTCAACTCTGTCCACAAGAGTGAGTTATCTAGTATGATTAGTATAGCTTTCTCCAGCA
TGGCAGCAGGAAGTAACTACAGGGCCTCTTTTATGCCTGACATTTCTTCCCTTCCTTTTTCCCTGCCTCCCTTTTTCATCAATTGCGATG
CTCCCACAACTCTTTACAGACTTGTGAAATCTTCAAGAACACCTTTACTCTATAACTCAAAAATTAGTTGAAAAATAATTACTTCTCAAG
GATTATTAGAATCTTAGGTACTTATTTGTAAAGATGTTTAGTGACTTTTTTTTCAAGTATCTTATTAAAGGAGGCATTCTAGAAAATATG
AATTAGTTTCCAAATGCCTTAATTTTAAACTTTGGCCTGAACAGTTTTTTCTTTTTCTTAATGGAAGAAGATATTTAATATCTTAAAAAT
ATTCCAAGTTAGGAAGAACACTACTTGCCTTATCCATTTCCCATTTAAAGGACTTTTAAACTTTGACACATCCTTCAGATTTCCTGAAAA
TAATTGAAATATCTTACTTTAAAAATATTTTCATCTCTGAAATATCTCGTTATTTATTGGAGGTATTGTTTAACCTTAGAGAGACCATTA
AATTATTTATAAAATATTTTGTAATTACCTGTAGCTAATACATTACATAGAAAAAAACTATGTTAACAGTGTCTCTGTTTAAGTATAATC
AGATATAAATATATACTTAATTTTTTAATTTTAAAAATAGATACCTGTTTGACTTTGAGGTAGTCCAGACCTTTTCTTTTTTTTTTTTTT
TTTAATGTGTGCAAAAGCCCAAAGGTTCCTAAGCCTGGCTGCAAAGAAGAATCAACAGGGACACTTTTTAAAAACACTCTTATCAGCCTG
GGCAACACAGTGAGACTCCATCTCTTAAAAAAAAAATTAGCTGGGTATAGTGGTATGTGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGG
CAGGAGGATTGCCTGAGCCCAGGAGGTGGAAACTGCAGAGAGTCATGATCATGTCCTTACACTCCAGCCTGGATAACAGAGCGAGACCCT


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FusionGenePPI for HBP1_PIK3CG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HBP1RB1, RBL2, SIN3A, HDAC1, ANKRD2, MYC, EP300, CREBBP, CD2AP, EWSR1, KIAA1279, ZNF212, SMAD1, TMEM37, FBXW11, RMND5A, TCF7L2, CASP8, ESR1, RB1CC1, PRKAR2BPIK3CGBCR, ERAS, PIK3CD, EPHA8, LYN, PIK3R5, NRAS, HRAS, KRAS, USP45, GABARAPL1, UTRN, PRMT7, PRKAA2, ZNF282, SET, SYK, BECN1, GNB1, GNG2, FPR1, KIT


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HBP1_PIK3CG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HBP1_PIK3CG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePIK3CGC0004352Autistic Disorder1CTD_human
TgenePIK3CGC0016059Fibrosis1CTD_human
TgenePIK3CGC0018800Cardiomegaly1CTD_human
TgenePIK3CGC0018801Heart failure1CTD_human
TgenePIK3CGC0025149Medulloblastoma1CTD_human
TgenePIK3CGC0079744Diffuse Large B-Cell Lymphoma1CTD_human