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Fusion gene ID: 1582 |
FusionGeneSummary for AMACR_NDUFAF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AMACR_NDUFAF2 | Fusion gene ID: 1582 | Hgene | Tgene | Gene symbol | AMACR | NDUFAF2 | Gene ID | 23600 | 91942 |
| Gene name | alpha-methylacyl-CoA racemase | NADH:ubiquinone oxidoreductase complex assembly factor 2 | |
| Synonyms | AMACRD|CBAS4|P504S|RACE|RM | B17.2L|MMTN|NDUFA12L|mimitin | |
| Cytomap | 5p13.2 | 5q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-methylacyl-CoA racemase2-methylacyl-CoA racemase | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UHK6 | Q8N183 | |
| Ensembl transtripts involved in fusion gene | ENST00000335606, ENST00000382072, ENST00000514195, ENST00000382085, ENST00000502637, ENST00000441713, ENST00000426255, ENST00000512079, ENST00000382068, | ENST00000296597, ENST00000511107, ENST00000512623, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 3=72 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AMACR [Title/Abstract] AND NDUFAF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AMACR | GO:0008206 | bile acid metabolic process | 10655068 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-8474-01A | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000335606 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000335606 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000335606 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| Frame-shift | ENST00000382072 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000382072 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000382072 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5UTR-3CDS | ENST00000514195 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5UTR-intron | ENST00000514195 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5UTR-3UTR | ENST00000514195 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| In-frame | ENST00000382085 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000382085 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000382085 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| In-frame | ENST00000502637 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000502637 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000502637 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| Frame-shift | ENST00000441713 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000441713 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000441713 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| In-frame | ENST00000426255 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000426255 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000426255 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| In-frame | ENST00000512079 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000512079 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000512079 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| Frame-shift | ENST00000382068 | ENST00000296597 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-intron | ENST00000382068 | ENST00000511107 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
| 5CDS-3UTR | ENST00000382068 | ENST00000512623 | AMACR | chr5 | 33998746 | - | NDUFAF2 | chr5 | 60368952 | + |
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FusionProtFeatures for AMACR_NDUFAF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AMACR | NDUFAF2 |
| Acts as a molecular chaperone for mitochondrial complexI assembly (PubMed:16200211). Complex I functions in the transferof electrons from NADH to the respiratory chain. The immediateelectron acceptor for the enzyme is believed to be ubiquinone(PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211,ECO:0000269|PubMed:27626371}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AMACR | chr5:33998746 | chr5:60368952 | ENST00000335606 | - | 4 | 5 | 380_382 | 246 | 383 | Motif | Note=Microbody targeting signal |
| Hgene | >AMACR | chr5:33998746 | chr5:60368952 | ENST00000382072 | - | 3 | 4 | 380_382 | 192 | 199 | Motif | Note=Microbody targeting signal |
| Hgene | >AMACR | chr5:33998746 | chr5:60368952 | ENST00000382085 | - | 4 | 6 | 380_382 | 246 | 395 | Motif | Note=Microbody targeting signal |
| Hgene | >AMACR | chr5:33998746 | chr5:60368952 | ENST00000441713 | - | 3 | 4 | 380_382 | 192 | 230 | Motif | Note=Microbody targeting signal |
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FusionGeneSequence for AMACR_NDUFAF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AMACR_ENST00000335606_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_374aa MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP >In-frame_AMACR_ENST00000382085_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_374aa MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP >In-frame_AMACR_ENST00000502637_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_359aa MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI DANMKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKT >In-frame_AMACR_ENST00000426255_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_374aa MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP >In-frame_AMACR_ENST00000512079_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_374aa MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AMACR_ENST00000335606_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1122nt ATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGT GTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCG CGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTG GGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCT GGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTG GCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATT GATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAG AACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTC TACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGAT ATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAA GAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAA ACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCA >In-frame_AMACR_ENST00000382085_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1122nt ATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGT GTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCG CGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTG GGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCT GGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTG GCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATT GATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAG AACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTC TACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGAT ATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAA GAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAA ACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCA >In-frame_AMACR_ENST00000502637_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1077nt ATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGT GTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCG CGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTG GGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCT GGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTG GCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATT GATGCAAATATGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACA GCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATT GTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACT CCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTC CTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAA >In-frame_AMACR_ENST00000426255_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1122nt ATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGT GTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCG CGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTG GGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCT GGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTG GCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATT GATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAG AACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTC TACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGAT ATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAA GAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAA ACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCA >In-frame_AMACR_ENST00000512079_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1122nt ATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGT GTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCG CGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTG GGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCT GGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTG GCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATT GATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAG AACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTC TACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGAT ATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAA GAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAA ACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AMACR_ENST00000335606_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1282nt GGCGCCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCA TGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTG TGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGC GGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGG GCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTG GCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGG CTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTG ATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGA ACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCT ACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATA TTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAG AAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAA CTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAG GATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTATTTTAAC >In-frame_AMACR_ENST00000382085_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1202nt GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA >In-frame_AMACR_ENST00000502637_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1233nt CCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGC ACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGT ACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGG AGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCC AGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCA CGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGA CTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGC AAATATGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGA TGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGA AGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACC TACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAG TAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACC CTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTA >In-frame_AMACR_ENST00000426255_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1258nt TTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGCACTGCAGGGCATCTCGGTCG TGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCT CCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTC TGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAA ATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTT TGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTA TGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAG CATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTT TCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAA CTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGA TTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATT TTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTG CTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCA >In-frame_AMACR_ENST00000512079_chr5_33998746_-_NDUFAF2_ENST00000296597_chr5_60368952_+_1202nt GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA |
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FusionGenePPI for AMACR_NDUFAF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AMACR | PEX5, FKBP5, HSP90AA5P, PSMG3, PSMG4 | NDUFAF2 | ACOT13, CDV3, RPS24, RPS26, PPIF, SUGP2, SON, ATXN3, CHST15, COQ9, C15orf48, NDUFA4, PTPMT1, COQ2, CBLN4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AMACR_NDUFAF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AMACR_NDUFAF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AMACR | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
| Hgene | AMACR | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Hgene | AMACR | C3280428 | Alpha-Methylacyl-CoA Racemase Deficiency | 2 | UNIPROT |
| Hgene | AMACR | C0001430 | Adenoma | 1 | CTD_human |
| Hgene | AMACR | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | AMACR | C0023895 | Liver diseases | 1 | CTD_human |
| Hgene | AMACR | C0027888 | Hereditary Motor and Sensory Neuropathies | 1 | CTD_human |
| Hgene | AMACR | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | AMACR | C1858328 | Bile acid synthesis defect, congenital, 4 | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | NDUFAF2 | C0752109 | Brain Diseases, Metabolic, Inborn | 1 | CTD_human |
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