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Fusion gene ID: 15819 |
FusionGeneSummary for HAND2_SLC30A9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HAND2_SLC30A9 | Fusion gene ID: 15819 | Hgene | Tgene | Gene symbol | HAND2 | SLC30A9 | Gene ID | 9464 | 10463 |
| Gene name | heart and neural crest derivatives expressed 2 | solute carrier family 30 member 9 | |
| Synonyms | DHAND2|Hed|Thing2|bHLHa26|dHand | BILAPES|C4orf1|GAC63|HUEL|ZNT9 | |
| Cytomap | 4q34.1 | 4p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heart- and neural crest derivatives-expressed protein 2basic helix-loop-helix transcription factor HAND2class A basic helix-loop-helix protein 26deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 | zinc transporter 9GRIP1-dependent nuclear receptor coactivatorexpressed in human embryonic lunghuman embryonic lung proteinsolute carrier family 30 (zinc transporter), member 9znT-9 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P61296 | Q6PML9 | |
| Ensembl transtripts involved in fusion gene | ENST00000359562, ENST00000505300, | ENST00000264451, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 5 X 3=45 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HAND2 [Title/Abstract] AND SLC30A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HAND2 | GO:0010613 | positive regulation of cardiac muscle hypertrophy | 24161931 |
| Hgene | HAND2 | GO:0034103 | regulation of tissue remodeling | 24161931 |
| Hgene | HAND2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15486975|16280598|24161931 |
| Hgene | HAND2 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 16280598 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PCPG | TCGA-SP-A6QI-01A | HAND2 | chr4 | 174449886 | - | SLC30A9 | chr4 | 42041003 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000359562 | ENST00000264451 | HAND2 | chr4 | 174449886 | - | SLC30A9 | chr4 | 42041003 | + |
| intron-3CDS | ENST00000505300 | ENST00000264451 | HAND2 | chr4 | 174449886 | - | SLC30A9 | chr4 | 42041003 | + |
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FusionProtFeatures for HAND2_SLC30A9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HAND2 | SLC30A9 |
| Essential for cardiac morphogenesis, particularly forthe formation of the right ventricle and of the aortic archarteries. Required for vascular development and regulation ofangiogenesis, possibly through a VEGF signaling pathway. Playsalso an important role in limb development, particularly in theestablishment of anterior-posterior polarization, acting as anupstream regulator of sonic hedgehog (SHH) induction in the limbbud. Is involved in the development of branchial arches, whichgive rise to unique structures in the head and neck. Binds DNA onE-box consensus sequence 5'-CANNTG-3' (By similarity).{ECO:0000250}. | Acts as a zinc transporter involved in intracellularzinc homeostasis (PubMed:28334855). Functions as a secondarycoactivator for nuclear receptors by cooperating with p160coactivators subtypes. Plays a role in transcriptional activationof Wnt-responsive genes (By similarity).{ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HAND2 | chr4:174449886 | chr4:42041003 | ENST00000359562 | - | 1 | 2 | 21_32 | 185 | 218 | Compositional bias | Note=Poly-Ala |
| Hgene | HAND2 | chr4:174449886 | chr4:42041003 | ENST00000359562 | - | 1 | 2 | 99_151 | 185 | 218 | Domain | bHLH |
| Tgene | >SLC30A9 | chr4:174449886 | chr4:42041003 | ENST00000264451 | + | 6 | 18 | 462_466 | 223 | 569 | Motif | Note=LXXLL motif |
| Tgene | >SLC30A9 | chr4:174449886 | chr4:42041003 | ENST00000264451 | + | 6 | 18 | 239_259 | 223 | 569 | Transmembrane | Helical |
| Tgene | >SLC30A9 | chr4:174449886 | chr4:42041003 | ENST00000264451 | + | 6 | 18 | 314_334 | 223 | 569 | Transmembrane | Helical |
| Tgene | >SLC30A9 | chr4:174449886 | chr4:42041003 | ENST00000264451 | + | 6 | 18 | 342_362 | 223 | 569 | Transmembrane | Helical |
| Tgene | >SLC30A9 | chr4:174449886 | chr4:42041003 | ENST00000264451 | + | 6 | 18 | 392_412 | 223 | 569 | Transmembrane | Helical |
| Tgene | >SLC30A9 | chr4:174449886 | chr4:42041003 | ENST00000264451 | + | 6 | 18 | 424_444 | 223 | 569 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HAND2_SLC30A9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HAND2_ENST00000359562_chr4_174449886_-_SLC30A9_ENST00000264451_chr4_42041003_+_531aa MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPP GLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEK RKKELPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYI SSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDT AAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKATDLGLGKV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HAND2_ENST00000359562_chr4_174449886_-_SLC30A9_ENST00000264451_chr4_42041003_+_1593nt ATGAGTCTGGTAGGTGGTTTTCCCCACCACCCGGTGGTGCACCACGAGGGCTACCCGTTTGCCGCCGCCGCCGCCGCAGCTGCCGCCGCC GCCGCCAGCCGCTGCAGCCATGAGGAGAACCCCTACTTCCATGGCTGGCTCATCGGCCACCCCGAGATGTCGCCCCCCGACTACAGCATG GCCCTGTCCTACAGCCCCGAGTATGCCAGCGGCGCCGCCGGCCTGGACCACTCCCATTACGGGGGGGTGCCGCCGGGCGCCGGGCCCCCG GGCCTGGGGGGGCCGCGCCCGGTGAAGCGCCGAGGCACCGCCAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCC GAACTGCGCGAGTGCATCCCCAACGTACCCGCCGACACCAAACTCTCCAAAATCAAGACCCTGCGCCTGGCCACCAGCTACATCGCCTAC CTCATGGACCTGCTGGCCAAGGACGACCAGAATGGCGAGGCGGAGGCCTTCAAGGCAGAGATCAAGAAGACCGACGTGAAAGAGGAGAAG AGGAAGAAGGAGCTGCCACGCTCCAGAACAGCATCAGTGTTTTTTAAGGGACCAGGAAAAGTGGTGATGGTTGCAATTTGCATCAATGGA TTAAACTGCTTCTTTAAATTTCTTGCCTGGATTTATACCGGTTCAGCAAGTATGTTCTCAGAAGCTATACACTCATTATCTGATACTTGT AATCAGGGTTTACTAGCATTGGGCATCAGTAAGTCTGTTCAAACACCAGATCCTTCTCATCCGTACGGATTTTCAAATATGCGCTATATT TCTTCGCTAATTAGTGGTGTTGGTATTTTCATGATGGGTGCAGGACTATCTTGGTACCATGGAGTCATGGGATTGCTTCATCCTCAACCA ATAGAATCCCTTCTATGGGCATATTGTATTTTAGCAGGATCATTAGTATCTGAAGGAGCAACACTTCTTGTTGCTGTAAATGAACTTCGT AGGAATGCTCGGGCTAAAGGAATGTCATTTTACAAGTATGTAATGGAAAGTCGTGATCCTAGTACAAATGTGATATTATTGGAGGATACT GCTGCAGTCTTGGGAGTTATAATAGCAGCCACTTGCATGGGCCTTACTTCTATAACAGGCAATCCACTGTATGACAGCCTAGGTTCTTTG GGTGTGGGCACCTTATTAGGCATGGTCTCAGCATTCCTCATCTACACTAACACAGAAGCACTCTTAGGGCGGTCCATCCAGCCAGAACAA GTACAACGGCTCACTGAACTCCTGGAGAATGACCCATCAGTAAGGGCAATTCATGATGTTAAAGCCACAGATCTGGGATTAGGTAAAGTA AGATTTAAGGCAGAAGTAGATTTTGATGGGCGAGTTGTTACAAGATCATATTTGGAAAAACAAGATTTTGACCAAATGTTACAAGAAATT CAAGAAGTGAAAACTCCTGAAGAACTAGAGACCTTTATGCTTAAACATGGAGAAAATATTATTGATACTTTAGGAGCTGAAGTAGATAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HAND2_ENST00000359562_chr4_174449886_-_SLC30A9_ENST00000264451_chr4_42041003_+_6864nt AGCTGTACATGGAGATCTTGCTGGGAAAATCCGCTTGCTCCCCTCACGTCGTCCAGCCCAGGAGAACCACCGCCGTCACCCCGGAGCTTC CTCGGCCACCGCGCAGAGCCCTCCGAGAGCCCGAGCCGCGGTCTTCGAGCTCCAAGGCTCATTCAGGGCCCCAGATCCTTGCCCCGAAAG GAGAGGATCTGAGAAAATGGATGCACTGAGACCTCTCTGAAAACCCTCCGAGAGAGCGCGAGAGGAGCGAGGACACGTTACTCGCAGCTA AAATCACATTTAAGGACCAAAACAACAACAACCAAAAATTTCATTAAAACAATAAGCGCCCAAGAACCCAGATCGGGCTGGTGGGGGGAG GGGAAGAGGCGGGAAGGGGAGGGTCGCACGGAGGTAGCTTTGCAGTGAGCAGTCGACCCCGCCGCCCCCCGGCACAGCTGGACCGGCTCC TCCAGCCGCGGCTCAGACTCGCCCCTGGATTCCGGGTTAGCTTCGGTGCCAGGACCGCGGCCCGGGCTTGGATTCCCGAGACTCCGCGTA CCAGCCTCGCGGGAGCCCCGGCACCTTTGTATGAGCACGAGAGGATTCTGCCTCCGCGCAGCAGCCCGGGAAGCAGGAGCCGAAGCGCGG GCCGTGGAGCAAGGCGGGAACCGGAGGCGGCGGCGGCGGCGGCCAGGGGCGCACGGTGCCAGGACCAGCTCGCCGCGCCCCATGGGGAGC CGGCGGCCGCAGCGCTGCTGAGGCGGGCCCGGCTGGCCAGGCGGGGGGACGGGGCCCGGGCTGCAGCAGCCCCCTCTGCGGCTGCCGGGC GGGCCCGGGCGCCCGGGGGCTGGGGGGTGGGGGGTGGGGGAGGACGCCGAGCGCTGAGGCAGGGGCCCGGGCCGAGGGCGCGGCGGGGCT GCGCGCACGCTGGGGCGCGTGGAGGGGCGCGGAGGGCGAAATGAGTCTGGTAGGTGGTTTTCCCCACCACCCGGTGGTGCACCACGAGGG CTACCCGTTTGCCGCCGCCGCCGCCGCAGCTGCCGCCGCCGCCGCCAGCCGCTGCAGCCATGAGGAGAACCCCTACTTCCATGGCTGGCT CATCGGCCACCCCGAGATGTCGCCCCCCGACTACAGCATGGCCCTGTCCTACAGCCCCGAGTATGCCAGCGGCGCCGCCGGCCTGGACCA CTCCCATTACGGGGGGGTGCCGCCGGGCGCCGGGCCCCCGGGCCTGGGGGGGCCGCGCCCGGTGAAGCGCCGAGGCACCGCCAACCGCAA GGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCCGAACTGCGCGAGTGCATCCCCAACGTACCCGCCGACACCAAACTCTCCAA AATCAAGACCCTGCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGGCCAAGGACGACCAGAATGGCGAGGCGGAGGCCTT CAAGGCAGAGATCAAGAAGACCGACGTGAAAGAGGAGAAGAGGAAGAAGGAGCTGCCACGCTCCAGAACAGCATCAGTGTTTTTTAAGGG ACCAGGAAAAGTGGTGATGGTTGCAATTTGCATCAATGGATTAAACTGCTTCTTTAAATTTCTTGCCTGGATTTATACCGGTTCAGCAAG TATGTTCTCAGAAGCTATACACTCATTATCTGATACTTGTAATCAGGGTTTACTAGCATTGGGCATCAGTAAGTCTGTTCAAACACCAGA TCCTTCTCATCCGTACGGATTTTCAAATATGCGCTATATTTCTTCGCTAATTAGTGGTGTTGGTATTTTCATGATGGGTGCAGGACTATC TTGGTACCATGGAGTCATGGGATTGCTTCATCCTCAACCAATAGAATCCCTTCTATGGGCATATTGTATTTTAGCAGGATCATTAGTATC TGAAGGAGCAACACTTCTTGTTGCTGTAAATGAACTTCGTAGGAATGCTCGGGCTAAAGGAATGTCATTTTACAAGTATGTAATGGAAAG TCGTGATCCTAGTACAAATGTGATATTATTGGAGGATACTGCTGCAGTCTTGGGAGTTATAATAGCAGCCACTTGCATGGGCCTTACTTC TATAACAGGCAATCCACTGTATGACAGCCTAGGTTCTTTGGGTGTGGGCACCTTATTAGGCATGGTCTCAGCATTCCTCATCTACACTAA CACAGAAGCACTCTTAGGGCGGTCCATCCAGCCAGAACAAGTACAACGGCTCACTGAACTCCTGGAGAATGACCCATCAGTAAGGGCAAT TCATGATGTTAAAGCCACAGATCTGGGATTAGGTAAAGTAAGATTTAAGGCAGAAGTAGATTTTGATGGGCGAGTTGTTACAAGATCATA TTTGGAAAAACAAGATTTTGACCAAATGTTACAAGAAATTCAAGAAGTGAAAACTCCTGAAGAACTAGAGACCTTTATGCTTAAACATGG AGAAAATATTATTGATACTTTAGGAGCTGAAGTAGATAGACTTGAGAAGGAACTGAAAAAACGAAATCCTGAAGTTCGACATGTAGATTT GGAGATACTGTGAGTTTGATGGAATGAATCACCTGGGTGGGGACCTTGGAAACAAGTTTGTCCGTCCACTCTACAAAGTTTCCTCCTCTC CTACACTGAAAGACTCAGTGCCATGCAGAAGCCTTTTTTTTAAGATGAAGGAAATATTTTATGTAAAGAGCAACTCAGCAGGACACAGAA CTAAAACTACTACTTACATCTAACAGACACACTACAAGTTGAATCAATTTGAAAATCATGTTTTTATGCTTCCATAGGGAACATTTTGGT TATTTAAATTGTTCATAATGTCCCATATTTCACCTGTTCAGTGTATACTGTACTTTGCAATCATCTTTCCTTTTTTCACATTGGTAAAAA TAAGTGGCATCCATAGGATCATGATTTTTAATTTGTTGCCTCTGAAGATTTCACTCCATCAAGATCTGCCAATCTTCAATATTCTGGCTA AATCTTGGTATGTGGTTTTTAAACAGTCACTCCGTTTCAAAGTCTGTCTTTCCTTATAGAATGTGGAAATTATTTCTCCATACCTTGTGA TTTTGACCTGAGTGCTAAGAGAATCACTCTCCTTACCTAGTTATCTACAAATGTTCATTCCAGAAATGTTTAGTTACTGAATTGAATGAA GACATCTCAGTACACTCTTTTAGGTCATAGTAGTTGCCATTTTGTAAAATTTCTTTTTTCTTCTTTGCTTTTTTCCCCTTATTTGGTTTA ATTTTTCTAATGTTAGGAGATATAGTCCTAGATATTTCCATGGGCCAGTGTGATGACTTTTTTTTAAATGAGGTTCAGTACCATAATGTT TATTTACTGGAAGATAATGCATTTATAAGCATTTTAAAATTCTGTAAAGTGGGTTAGAAATATTTATAATTTTACAGGCAGGACAGCATT TGACTTTTATTTAAAAGGCGGCACTACTTATGTAAATCTGAGCTGTGGGATATTTCTTGCTTTAAGAGAGAGACAGAATCTCTCACTGAA ACTCATGGTCATGATTTTGTATAATATAGTTCATACTGTGTCTGTGAGTTTCTTCAGTTACAAATGGGCATTTAGTATAGTTATATTGAC TATAACATGTAAGTAAATAGCTTTCTACTGACCCTAAGTTATCAAGGTGGAAAAAAAACATGCAATTCAGTAATTGAAAATGTGGTGAAA AGCTGCAGCTGTCATCATCAAAACAACTCATAACATACTTTAAAATGTTCAGGTAGCAGTGAGCATTGTTCATATGAGAATGGCGGCTGG GTGATCTCTTTGCTGAATTAATGAGTTCTTAACATGTGGACCCAACTGCCTGTGTGAGATCTGTGTCTTAAAACTTACTGGAATGGAAAT CTATGAATTATTGCAAATTGTAATGCTGGAAACAAAAAATAAATCCTTGGTTAAAGGGTTTGTAATGGTGATTTTTGACCCAGAAATCTC ATTTACTGGAAAATTGTGAGACTTTACGTTGGTGTATTTTTCTTTTTTTTTTTTTTACTATTACAGAGTATTTTGCATGCTGTACATTTT AAGTGAAATAACATTCCAGTTTTATTTTTAAGATAGAAAATTGTTATATATATATATAATTTGATACTCTATTCTTACAGTTTCAAATTC CTTATCCCTTCTTTACAAAAAAAACTTTTTTTTTACCTGTTATGATTTATTCTATACTTTTTTCTTCTTCCTTCCCCTTTCCCACTTGCC ATTTATTACTTCATGTCATTGCCATATGAGAAAGTACCAAATTATATCCAGTTTCCTCCTAGTGATATTACTCTGAAAAATTTCACAAAG CCAGACAAGAATAATTACTCATTTTTTTTCCCAAGACGACCCTCAAAGTTAATGTGCAGCAGGTATTCCAAATGGTAATTTTTTTTTTTT AGGATTCCCTAATAAAAAAAAAAAAAATTCTGATATTTCTTTTTAAATCTGATTTTGGTTGAGGTCATACCATTCTTAAATAATAATTGA AGGTTTATGTTGCCATCTTTTCTAATTCTGTTTTGCACTGATAAACTTACATAAAGTTTGTTTATGTAAAATAAGACATAAAGGAGTACA ACATATCAAGGAATTTGAGTATTTATGTGGAATCAGGAAATTTTTCTAGAGTCACTGAATTTTCAAATCAGAGAATTTGGGCTGGATATG GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATTGCTTGAGCTCAGGAGGTCAAGACCAGCCTGGGCAACACA GCGAGACCTCATCTCTACTAAAAAAAGTTAGCCGGGTGTGGTGGTGCTCACCTGTGTTAGTCCATTCTCACACTGCTATAAAGAAATACC TGAGACTGAGTAATCAAAAAAAGAGCTTTAATTGGCTCATGGTTCTGCAGACTGAACAGGAAACATAGCAGCTTCTGCTTCTGGGGAGGC CTCGGGAAACTTCATTCATGGCAGAATACGAAGGGGAAGCAGTCATAGCCAGAGGAAGAGCAAGAGGCGGGGATTGGGGGTAGGTGCCAC ACTCTTGTAAACAACCAGATCTCATGAGAACTCACTATACAGTACCAAGAGGGGAAGGTGCTAAAGTATTCATGAGAACTCCACCCCCGT GATCCAGTCATCTCCCACCAGGCCCTACCTCCAACATGGGATTACAATTCGACATGAGATTTGGTGGGGACAAAGATCCAAAGCATATCA GCATCTGTAGTCACAGCTACTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCCAGAGGTCGAGGCTGCAATGAGCTATGATCATGCCA CTCCAGCCTGAATGACAGAGTGAGATCCTGTCTCAAAAAGAGAATTTGGGTCTCTTTCTCCAAAAATAAGGCTATATTTAGTTTTTCAGG TTTCTTGTTATTTTACCAAATTAATGTTTCTTACTTTGTATCTACTTTGGCATATAGCATTTGAGTATTAAAGCATATAAATCATTTTTA AGGAAAATATTCTCTGCAGGAGAATAATTACAAAAATAATACTGGACAGAGGAGGGGCAGTCAAGGGTCCATGATTGATTCCTTCTTGCC CAAAACTAAAATCTAGGATTTATCAAAGGTGAGGTATACAGTGGTCCCTGACTTATAATGGTTGCACTTAAGAATTTTTATGATGGGTTT ATTGGCACATAACCCAATAATAAGTAAAAAGCATCTGTACCTACTTTTAGCTTTGGCTGAGAATGGATCTCTAATTCACTGTAAGTAGCA GTCCCCAAACTATATAAGGTGGCACAGTTTTCATCATGGCAGTGGGAGGATGAGGGGTGGAGTGTTTTTGTTTTTTTTGTTTTTTTTTGA GACAGAGTTTCGTTCTTGTTGCCCAGGCTGGAGTGCACTGGCACAATTGCAGCTCACCGCAACCTTCACCTCCCGATTCAAGTGATTCTC CTGCCTCCTGAGTAGCTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTGTATTTCTGGTTTAGACAAGGTTTCTCCATGTTGG TCAGGCTGGTCTTGAACTGCCGACCTCAGGTGATCCGCCCTCCTCGGCTTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCTCCGG TGATCTGTTTTTAAGTGGAGTATCCTGGGGGCCTATAGTATCCAACTCCAAAGAGGTAAGTTCCTGAACATACACTAAAGAACCTGTGAG ATAAGATCAGACGGAAAAATTTTCAAATTTTTTCAAAAGCAAAGGTAATCCCTGCATACATCCTCCTACACACACACACATAGTGCAAAG TGAATAACAAAATGTCATAAGGCTTGAGTTTTTGGTATATGGCTTTCAGTGTTACCTTATCTCATAATTTAGGTAATGATTTTTGCTAAA ATGATAACCATCTAAAGAGTGCCTAAGTTTTAAGTCTCGTAACTTTTTGAGGAAGAATGCTGGGAACTACAGAAAACTGCATAGGCATTT AGAATTTGTATTATCTTCTTAGACTGCATTTGTCAAGCTTTGGCAGCATTTCTTTTAAATGTGATGAACCCCAATTTGCCAAACTGTCAG AAGTCAGTGAAGCAAAGAATCGAAGGTAAAATGTTGATTCAAAGATTGTCTCCCCTAAATCCTTCATTTCTTTCTCTGAAATGGAACTTT GGAAGCCATTTATATAGATTAGTCTGACAGCCTTTATATTTGCATGTAAGTTTACTTGCATCCTTAGACTTGGCTTTATGCAAAAAGAAA ATTTTTATTCGTTATATTGTATTTCATCTGTCTGATTTCCCTGGCACATTAAGATGGTCCTGGTCCCTCAGGATACTTTTTCCCTTAATA |
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FusionGenePPI for HAND2_SLC30A9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HAND2 | CENPB, TCF3, PPP2R5D, COPS5, PRKCA, PRKACA, PHOX2A, GATA4, EP300, NPM1, HAND2, HOXD13, TCF4, DNMT3L | SLC30A9 | ELAVL1, DHX15, HLA-DQA1, SPDEF, COPS5, VSIG4, ERGIC3, HERC2, C6orf203, COX5A, VNN2, TBC1D15 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HAND2_SLC30A9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HAND2_SLC30A9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HAND2 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Hgene | HAND2 | C0039685 | Tetralogy of Fallot | 1 | CTD_human |
| Hgene | HAND2 | C0678807 | prenatal alcohol exposure | 1 | PSYGENET |
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