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Fusion gene ID: 15812 |
FusionGeneSummary for HADH_MEIS1 |
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Fusion gene information | Fusion gene name: HADH_MEIS1 | Fusion gene ID: 15812 | Hgene | Tgene | Gene symbol | HADH | MEIS1 | Gene ID | 3033 | 4211 |
Gene name | hydroxyacyl-CoA dehydrogenase | Meis homeobox 1 | |
Synonyms | HAD|HADH1|HADHSC|HCDH|HHF4|MSCHAD|SCHAD | - | |
Cytomap | 4q25 | 2p14 | |
Type of gene | protein-coding | protein-coding | |
Description | hydroxyacyl-coenzyme A dehydrogenase, mitochondrialL-3-hydroxyacyl-Coenzyme A dehydrogenase, short chainmedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseshort-chain 3-hydroxyacyl-CoA dehydrogenasetestis secretory sperm-binding protein Li | homeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q16836 | O00470 | |
Ensembl transtripts involved in fusion gene | ENST00000603302, ENST00000403312, ENST00000309522, ENST00000505878, ENST00000454409, ENST00000510728, | ENST00000560281, ENST00000407092, ENST00000272369, ENST00000488550, ENST00000398506, ENST00000444274, ENST00000495021, ENST00000409517, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 3 X 3 X 2=18 |
# samples | 7 | 3 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: HADH [Title/Abstract] AND MEIS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM504479 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000603302 | ENST00000560281 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000603302 | ENST00000407092 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000603302 | ENST00000272369 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000603302 | ENST00000488550 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000603302 | ENST00000398506 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000603302 | ENST00000444274 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000603302 | ENST00000495021 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000603302 | ENST00000409517 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000560281 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000407092 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000272369 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000488550 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000398506 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000444274 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000495021 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000403312 | ENST00000409517 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000560281 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000407092 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000272369 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000488550 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000398506 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000444274 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000495021 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000309522 | ENST00000409517 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000560281 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000407092 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000272369 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000488550 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000398506 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000444274 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000495021 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000505878 | ENST00000409517 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000560281 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000407092 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000272369 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000488550 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000398506 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000444274 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000495021 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
5CDS-intron | ENST00000454409 | ENST00000409517 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000560281 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000407092 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000272369 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000488550 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000398506 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000444274 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000495021 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
intron-intron | ENST00000510728 | ENST00000409517 | HADH | chr4 | 108935744 | + | MEIS1 | chr2 | 66784099 | + |
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FusionProtFeatures for HADH_MEIS1 |
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Hgene | Tgene |
HADH | MEIS1 |
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activitytoward 3-hydroxybutyryl-CoA. | Acts as a transcriptional regulator of PAX6. Acts as atranscriptional activator of PF4 in complex with PBX1 or PBX2.Required for hematopoiesis, megakaryocyte lineage development andvascular patterning. May function as a cofactor for HOXA7 andHOXA9 in the induction of myeloid leukemias.{ECO:0000269|PubMed:12609849}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HADH_MEIS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HADH_MEIS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HADH_MEIS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HADH_MEIS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HADH | C0028754 | Obesity | 1 | CTD_human |
Hgene | HADH | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | HADH | C1864948 | Hyperinsulinemic Hypoglycemia, Familial, 4 | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | MEIS1 | C0035258 | Restless Legs Syndrome | 1 | CTD_human |
Tgene | MEIS1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |