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Fusion gene ID: 15810 |
FusionGeneSummary for HADH_HADH |
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Fusion gene information | Fusion gene name: HADH_HADH | Fusion gene ID: 15810 | Hgene | Tgene | Gene symbol | HADH | HADH | Gene ID | 3033 | 3033 |
Gene name | hydroxyacyl-CoA dehydrogenase | hydroxyacyl-CoA dehydrogenase | |
Synonyms | HAD|HADH1|HADHSC|HCDH|HHF4|MSCHAD|SCHAD | HAD|HADH1|HADHSC|HCDH|HHF4|MSCHAD|SCHAD | |
Cytomap | 4q25 | 4q25 | |
Type of gene | protein-coding | protein-coding | |
Description | hydroxyacyl-coenzyme A dehydrogenase, mitochondrialL-3-hydroxyacyl-Coenzyme A dehydrogenase, short chainmedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseshort-chain 3-hydroxyacyl-CoA dehydrogenasetestis secretory sperm-binding protein Li | hydroxyacyl-coenzyme A dehydrogenase, mitochondrialL-3-hydroxyacyl-Coenzyme A dehydrogenase, short chainmedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseshort-chain 3-hydroxyacyl-CoA dehydrogenasetestis secretory sperm-binding protein Li | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q16836 | Q16836 | |
Ensembl transtripts involved in fusion gene | ENST00000603302, ENST00000403312, ENST00000309522, ENST00000505878, ENST00000454409, ENST00000510728, | ENST00000603302, ENST00000403312, ENST00000309522, ENST00000505878, ENST00000454409, ENST00000510728, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 2 X 2 X 1=4 |
# samples | 7 | 2 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: HADH [Title/Abstract] AND HADH [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB164018 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000603302 | ENST00000603302 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000603302 | ENST00000403312 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000603302 | ENST00000309522 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000603302 | ENST00000505878 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000603302 | ENST00000454409 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-intron | ENST00000603302 | ENST00000510728 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
In-frame | ENST00000403312 | ENST00000603302 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
In-frame | ENST00000403312 | ENST00000403312 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
In-frame | ENST00000403312 | ENST00000309522 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
In-frame | ENST00000403312 | ENST00000505878 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
In-frame | ENST00000403312 | ENST00000454409 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5CDS-intron | ENST00000403312 | ENST00000510728 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000309522 | ENST00000603302 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000309522 | ENST00000403312 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000309522 | ENST00000309522 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000309522 | ENST00000505878 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-3CDS | ENST00000309522 | ENST00000454409 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
5UTR-intron | ENST00000309522 | ENST00000510728 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000505878 | ENST00000603302 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000505878 | ENST00000403312 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000505878 | ENST00000309522 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000505878 | ENST00000505878 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000505878 | ENST00000454409 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-intron | ENST00000505878 | ENST00000510728 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000454409 | ENST00000603302 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000454409 | ENST00000403312 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000454409 | ENST00000309522 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000454409 | ENST00000505878 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000454409 | ENST00000454409 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-intron | ENST00000454409 | ENST00000510728 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000510728 | ENST00000603302 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000510728 | ENST00000403312 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000510728 | ENST00000309522 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000510728 | ENST00000505878 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-3CDS | ENST00000510728 | ENST00000454409 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
intron-intron | ENST00000510728 | ENST00000510728 | HADH | chr4 | 108911008 | - | HADH | chr4 | 108935650 | + |
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FusionProtFeatures for HADH_HADH |
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Hgene | Tgene |
HADH | HADH |
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activitytoward 3-hydroxybutyryl-CoA. | Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activitytoward 3-hydroxybutyryl-CoA. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HADH_HADH |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HADH_HADH |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HADH_HADH |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HADH_HADH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HADH | C0028754 | Obesity | 1 | CTD_human |
Hgene | HADH | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | HADH | C1864948 | Hyperinsulinemic Hypoglycemia, Familial, 4 | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | HADH | C0028754 | Obesity | 1 | CTD_human |
Tgene | HADH | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | HADH | C1864948 | Hyperinsulinemic Hypoglycemia, Familial, 4 | 1 | CTD_human;ORPHANET;UNIPROT |