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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 158

FusionGeneSummary for ABCC4_CCDC169

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC4_CCDC169
Fusion gene ID: 158
HgeneTgene
Gene symbol

ABCC4

CCDC169

Gene ID

10257

728591

Gene nameATP binding cassette subfamily C member 4coiled-coil domain containing 169
SynonymsMOAT-B|MOATB|MRP4C13orf38
Cytomap

13q32.1

13q13.3

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter coiled-coil domain-containing protein 169RP11-251J8.1
Modification date2018052320180329
UniProtAcc

O15439

A6NNP5

Ensembl transtripts involved in fusion geneENST00000412704, ENST00000376887, 
ENST00000536256, ENST00000431522, 
ENST00000538287, ENST00000474158, 
ENST00000503173, ENST00000239860, 
ENST00000491049, ENST00000379864, 
ENST00000510088, ENST00000379862, 
ENST00000239859, ENST00000477250, 
Fusion gene scores* DoF score6 X 6 X 7=2521 X 1 X 1=1
# samples 71
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ABCC4 [Title/Abstract] AND CCDC169 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC4

GO:0032310

prostaglandin secretion

25173977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-VP-A876-01AABCC4chr13

95838955

-CCDC169chr13

36801518

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000412704ENST00000503173ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000412704ENST00000239860ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000412704ENST00000491049ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000412704ENST00000379864ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000412704ENST00000510088ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000412704ENST00000379862ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000412704ENST00000239859ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000412704ENST00000477250ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000376887ENST00000503173ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000376887ENST00000239860ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000376887ENST00000491049ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000376887ENST00000379864ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000376887ENST00000510088ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000376887ENST00000379862ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000376887ENST00000239859ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000376887ENST00000477250ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000536256ENST00000503173ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000536256ENST00000239860ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000536256ENST00000491049ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000536256ENST00000379864ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000536256ENST00000510088ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000536256ENST00000379862ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000536256ENST00000239859ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000536256ENST00000477250ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000431522ENST00000503173ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000431522ENST00000239860ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000431522ENST00000491049ABCC4chr13

95838955

-CCDC169chr13

36801518

-
Frame-shiftENST00000431522ENST00000379864ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000431522ENST00000510088ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000431522ENST00000379862ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000431522ENST00000239859ABCC4chr13

95838955

-CCDC169chr13

36801518

-
5CDS-intronENST00000431522ENST00000477250ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-3CDSENST00000538287ENST00000503173ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-3CDSENST00000538287ENST00000239860ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-3CDSENST00000538287ENST00000491049ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-3CDSENST00000538287ENST00000379864ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-intronENST00000538287ENST00000510088ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-intronENST00000538287ENST00000379862ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-intronENST00000538287ENST00000239859ABCC4chr13

95838955

-CCDC169chr13

36801518

-
3UTR-intronENST00000538287ENST00000477250ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-3CDSENST00000474158ENST00000503173ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-3CDSENST00000474158ENST00000239860ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-3CDSENST00000474158ENST00000491049ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-3CDSENST00000474158ENST00000379864ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-intronENST00000474158ENST00000510088ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-intronENST00000474158ENST00000379862ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-intronENST00000474158ENST00000239859ABCC4chr13

95838955

-CCDC169chr13

36801518

-
intron-intronENST00000474158ENST00000477250ABCC4chr13

95838955

-CCDC169chr13

36801518

-

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FusionProtFeatures for ABCC4_CCDC169


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC4

O15439

CCDC169

A6NNP5

May be an organic anion pump relevant to cellulardetoxification.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABCC4_CCDC169


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABCC4_CCDC169


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABCC4HAX1, ERBB2IP, SLC9A3R1, SLC9A3R2, PDZK1, SNTA1, CFTR, SNX27, LGALS3, LGALS8, LGALS9C, LPAR1, ATP2B2, SLC4A8, REEP5, TMEM128, TRIM25CCDC169


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABCC4_CCDC169


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABCC4_CCDC169


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC4C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC4C0009404Colorectal Neoplasms1CTD_human
HgeneABCC4C0014175Endometriosis1CTD_human
HgeneABCC4C0027627Neoplasm Metastasis1CTD_human
HgeneABCC4C0033578Prostatic Neoplasms1CTD_human
HgeneABCC4C0041755Adverse reaction to drug1CTD_human
HgeneABCC4C0236969Substance-Related Disorders1CTD_human