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Fusion gene ID: 158 |
FusionGeneSummary for ABCC4_CCDC169 |
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Fusion gene information | Fusion gene name: ABCC4_CCDC169 | Fusion gene ID: 158 | Hgene | Tgene | Gene symbol | ABCC4 | CCDC169 | Gene ID | 10257 | 728591 |
Gene name | ATP binding cassette subfamily C member 4 | coiled-coil domain containing 169 | |
Synonyms | MOAT-B|MOATB|MRP4 | C13orf38 | |
Cytomap | 13q32.1 | 13q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | multidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter | coiled-coil domain-containing protein 169RP11-251J8.1 | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | O15439 | A6NNP5 | |
Ensembl transtripts involved in fusion gene | ENST00000412704, ENST00000376887, ENST00000536256, ENST00000431522, ENST00000538287, ENST00000474158, | ENST00000503173, ENST00000239860, ENST00000491049, ENST00000379864, ENST00000510088, ENST00000379862, ENST00000239859, ENST00000477250, | |
Fusion gene scores | * DoF score | 6 X 6 X 7=252 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ABCC4 [Title/Abstract] AND CCDC169 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ABCC4 | GO:0032310 | prostaglandin secretion | 25173977 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-VP-A876-01A | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000412704 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000412704 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000412704 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000412704 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000412704 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000412704 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000412704 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000412704 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000376887 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000376887 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000376887 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000376887 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000376887 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000376887 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000376887 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000376887 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000536256 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000536256 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000536256 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000536256 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000536256 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000536256 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000536256 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000536256 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000431522 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000431522 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000431522 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
Frame-shift | ENST00000431522 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000431522 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000431522 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000431522 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
5CDS-intron | ENST00000431522 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-3CDS | ENST00000538287 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-3CDS | ENST00000538287 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-3CDS | ENST00000538287 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-3CDS | ENST00000538287 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-intron | ENST00000538287 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-intron | ENST00000538287 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-intron | ENST00000538287 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
3UTR-intron | ENST00000538287 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-3CDS | ENST00000474158 | ENST00000503173 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-3CDS | ENST00000474158 | ENST00000239860 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-3CDS | ENST00000474158 | ENST00000491049 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-3CDS | ENST00000474158 | ENST00000379864 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-intron | ENST00000474158 | ENST00000510088 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-intron | ENST00000474158 | ENST00000379862 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-intron | ENST00000474158 | ENST00000239859 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
intron-intron | ENST00000474158 | ENST00000477250 | ABCC4 | chr13 | 95838955 | - | CCDC169 | chr13 | 36801518 | - |
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FusionProtFeatures for ABCC4_CCDC169 |
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Hgene | Tgene |
ABCC4 | CCDC169 |
May be an organic anion pump relevant to cellulardetoxification. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ABCC4_CCDC169 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ABCC4_CCDC169 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ABCC4 | HAX1, ERBB2IP, SLC9A3R1, SLC9A3R2, PDZK1, SNTA1, CFTR, SNX27, LGALS3, LGALS8, LGALS9C, LPAR1, ATP2B2, SLC4A8, REEP5, TMEM128, TRIM25 | CCDC169 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ABCC4_CCDC169 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ABCC4_CCDC169 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ABCC4 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | ABCC4 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | ABCC4 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | ABCC4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | ABCC4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ABCC4 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | ABCC4 | C0236969 | Substance-Related Disorders | 1 | CTD_human |