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Fusion gene ID: 15782 |
FusionGeneSummary for H2AFZ_RBPMS2 |
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Fusion gene information | Fusion gene name: H2AFZ_RBPMS2 | Fusion gene ID: 15782 | Hgene | Tgene | Gene symbol | H2AFZ | RBPMS2 | Gene ID | 3015 | 348093 |
Gene name | H2A histone family member Z | RNA binding protein, mRNA processing factor 2 | |
Synonyms | H2A.Z-1|H2A.z|H2A/z|H2AZ | - | |
Cytomap | 4q23 | 15q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | histone H2A.ZH2AZ histone | RNA-binding protein with multiple splicing 2RNA binding protein with multiple splicing 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P0C0S5 | Q6ZRY4 | |
Ensembl transtripts involved in fusion gene | ENST00000296417, ENST00000529158, | ENST00000560606, ENST00000300069, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 7 X 6 X 4=168 |
# samples | 4 | 8 | |
** MAII score | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: H2AFZ [Title/Abstract] AND RBPMS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN273387 | H2AFZ | chr4 | 100871147 | - | RBPMS2 | chr15 | 65067525 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000296417 | ENST00000560606 | H2AFZ | chr4 | 100871147 | - | RBPMS2 | chr15 | 65067525 | - |
intron-5UTR | ENST00000296417 | ENST00000300069 | H2AFZ | chr4 | 100871147 | - | RBPMS2 | chr15 | 65067525 | - |
intron-intron | ENST00000529158 | ENST00000560606 | H2AFZ | chr4 | 100871147 | - | RBPMS2 | chr15 | 65067525 | - |
intron-5UTR | ENST00000529158 | ENST00000300069 | H2AFZ | chr4 | 100871147 | - | RBPMS2 | chr15 | 65067525 | - |
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FusionProtFeatures for H2AFZ_RBPMS2 |
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Hgene | Tgene |
H2AFZ | RBPMS2 |
Variant histone H2A which replaces conventional H2A in asubset of nucleosomes. Nucleosomes wrap and compact DNA intochromatin, limiting DNA accessibility to the cellular machinerieswhich require DNA as a template. Histones thereby play a centralrole in transcription regulation, DNA repair, DNA replication andchromosomal stability. DNA accessibility is regulated via acomplex set of post-translational modifications of histones, alsocalled histone code, and nucleosome remodeling. May be involved inthe formation of constitutive heterochromatin. May be required forchromosome segregation during cell division.{ECO:0000269|PubMed:15878876}. | Contributes to the regulation of smooth muscle celldifferentiation and proliferation in the gastrointestinal system.Binds NOG mRNA. Mediates an increase of NOG mRNA levels, andthereby contributes to the negative regulation of the BMPsignaling pathway. This promotes reversible dedifferentiation ofsmooth muscle cells and promotes smooth muscle cell proliferation.{ECO:0000250|UniProtKB:Q9W6I1}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for H2AFZ_RBPMS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for H2AFZ_RBPMS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for H2AFZ_RBPMS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for H2AFZ_RBPMS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |