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Fusion gene ID: 15781 |
FusionGeneSummary for H2AFZ_CSDE1 |
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Fusion gene information | Fusion gene name: H2AFZ_CSDE1 | Fusion gene ID: 15781 | Hgene | Tgene | Gene symbol | H2AFZ | CSDE1 | Gene ID | 3015 | 7812 |
Gene name | H2A histone family member Z | cold shock domain containing E1 | |
Synonyms | H2A.Z-1|H2A.z|H2A/z|H2AZ | D1S155E|UNR | |
Cytomap | 4q23 | 1p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | histone H2A.ZH2AZ histone | cold shock domain-containing protein E1N-ras upstream gene proteinNRAS-relatedcold shock domain containing E1, RNA bindingupstream of NRAS | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P0C0S5 | O75534 | |
Ensembl transtripts involved in fusion gene | ENST00000296417, ENST00000529158, | ENST00000339438, ENST00000438362, ENST00000358528, ENST00000261443, ENST00000530886, ENST00000369530, ENST00000483407, ENST00000534699, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 7 X 7 X 3=147 |
# samples | 4 | 8 | |
** MAII score | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: H2AFZ [Title/Abstract] AND CSDE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA903661 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000296417 | ENST00000339438 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-3CDS | ENST00000296417 | ENST00000438362 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-3CDS | ENST00000296417 | ENST00000358528 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-3CDS | ENST00000296417 | ENST00000261443 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000296417 | ENST00000530886 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000296417 | ENST00000369530 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000296417 | ENST00000483407 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000296417 | ENST00000534699 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-3CDS | ENST00000529158 | ENST00000339438 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-3CDS | ENST00000529158 | ENST00000438362 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-3CDS | ENST00000529158 | ENST00000358528 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-3CDS | ENST00000529158 | ENST00000261443 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000529158 | ENST00000530886 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000529158 | ENST00000369530 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000529158 | ENST00000483407 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
intron-intron | ENST00000529158 | ENST00000534699 | H2AFZ | chr4 | 100870059 | - | CSDE1 | chr1 | 115282348 | - |
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FusionProtFeatures for H2AFZ_CSDE1 |
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Hgene | Tgene |
H2AFZ | CSDE1 |
Variant histone H2A which replaces conventional H2A in asubset of nucleosomes. Nucleosomes wrap and compact DNA intochromatin, limiting DNA accessibility to the cellular machinerieswhich require DNA as a template. Histones thereby play a centralrole in transcription regulation, DNA repair, DNA replication andchromosomal stability. DNA accessibility is regulated via acomplex set of post-translational modifications of histones, alsocalled histone code, and nucleosome remodeling. May be involved inthe formation of constitutive heterochromatin. May be required forchromosome segregation during cell division.{ECO:0000269|PubMed:15878876}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for H2AFZ_CSDE1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for H2AFZ_CSDE1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for H2AFZ_CSDE1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for H2AFZ_CSDE1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |