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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15781

FusionGeneSummary for H2AFZ_CSDE1

check button Fusion gene summary
Fusion gene informationFusion gene name: H2AFZ_CSDE1
Fusion gene ID: 15781
HgeneTgene
Gene symbol

H2AFZ

CSDE1

Gene ID

3015

7812

Gene nameH2A histone family member Zcold shock domain containing E1
SynonymsH2A.Z-1|H2A.z|H2A/z|H2AZD1S155E|UNR
Cytomap

4q23

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionhistone H2A.ZH2AZ histonecold shock domain-containing protein E1N-ras upstream gene proteinNRAS-relatedcold shock domain containing E1, RNA bindingupstream of NRAS
Modification date2018052320180519
UniProtAcc

P0C0S5

O75534

Ensembl transtripts involved in fusion geneENST00000296417, ENST00000529158, 
ENST00000339438, ENST00000438362, 
ENST00000358528, ENST00000261443, 
ENST00000530886, ENST00000369530, 
ENST00000483407, ENST00000534699, 
Fusion gene scores* DoF score3 X 3 X 1=97 X 7 X 3=147
# samples 48
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: H2AFZ [Title/Abstract] AND CSDE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA903661H2AFZchr4

100870059

-CSDE1chr1

115282348

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000296417ENST00000339438H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-3CDSENST00000296417ENST00000438362H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-3CDSENST00000296417ENST00000358528H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-3CDSENST00000296417ENST00000261443H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000296417ENST00000530886H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000296417ENST00000369530H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000296417ENST00000483407H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000296417ENST00000534699H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-3CDSENST00000529158ENST00000339438H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-3CDSENST00000529158ENST00000438362H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-3CDSENST00000529158ENST00000358528H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-3CDSENST00000529158ENST00000261443H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000529158ENST00000530886H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000529158ENST00000369530H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000529158ENST00000483407H2AFZchr4

100870059

-CSDE1chr1

115282348

-
intron-intronENST00000529158ENST00000534699H2AFZchr4

100870059

-CSDE1chr1

115282348

-

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FusionProtFeatures for H2AFZ_CSDE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
H2AFZ

P0C0S5

CSDE1

O75534

Variant histone H2A which replaces conventional H2A in asubset of nucleosomes. Nucleosomes wrap and compact DNA intochromatin, limiting DNA accessibility to the cellular machinerieswhich require DNA as a template. Histones thereby play a centralrole in transcription regulation, DNA repair, DNA replication andchromosomal stability. DNA accessibility is regulated via acomplex set of post-translational modifications of histones, alsocalled histone code, and nucleosome remodeling. May be involved inthe formation of constitutive heterochromatin. May be required forchromosome segregation during cell division.{ECO:0000269|PubMed:15878876}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for H2AFZ_CSDE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for H2AFZ_CSDE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for H2AFZ_CSDE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for H2AFZ_CSDE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource