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Fusion gene ID: 15780 |
FusionGeneSummary for H2AFZ_CD59 |
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Fusion gene information | Fusion gene name: H2AFZ_CD59 | Fusion gene ID: 15780 | Hgene | Tgene | Gene symbol | H2AFZ | CD59 | Gene ID | 3015 | 966 |
Gene name | H2A histone family member Z | CD59 molecule (CD59 blood group) | |
Synonyms | H2A.Z-1|H2A.z|H2A/z|H2AZ | 16.3A5|1F5|EJ16|EJ30|EL32|G344|HRF-20|HRF20|MAC-IP|MACIF|MEM43|MIC11|MIN1|MIN2|MIN3|MIRL|MSK21|p18-20 | |
Cytomap | 4q23 | 11p13 | |
Type of gene | protein-coding | protein-coding | |
Description | histone H2A.ZH2AZ histone | CD59 glycoprotein1F5 antigen20 kDa homologous restriction factorCD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)CD59 molecule, complement regulatory proteinLy-6-like proteinMEM43 antigenT cell-acti | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P0C0S5 | P13987 | |
Ensembl transtripts involved in fusion gene | ENST00000296417, ENST00000529158, | ENST00000534312, ENST00000395850, ENST00000533403, ENST00000351554, ENST00000415002, ENST00000445143, ENST00000426650, ENST00000437761, ENST00000527577, ENST00000528700, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 7 X 11 X 3=231 |
# samples | 4 | 17 | |
** MAII score | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(17/231*10)=-0.442358105278356 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: H2AFZ [Title/Abstract] AND CD59 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC050619 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - | ||
ChiTaRS3.1 | BM550843 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000296417 | ENST00000534312 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000296417 | ENST00000395850 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000296417 | ENST00000533403 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000296417 | ENST00000351554 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000296417 | ENST00000415002 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000296417 | ENST00000445143 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000296417 | ENST00000426650 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000296417 | ENST00000437761 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000296417 | ENST00000527577 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000296417 | ENST00000528700 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000529158 | ENST00000534312 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000529158 | ENST00000395850 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000529158 | ENST00000533403 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000529158 | ENST00000351554 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-3UTR | ENST00000529158 | ENST00000415002 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000529158 | ENST00000445143 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000529158 | ENST00000426650 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000529158 | ENST00000437761 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000529158 | ENST00000527577 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
intron-intron | ENST00000529158 | ENST00000528700 | H2AFZ | chr4 | 100870031 | - | CD59 | chr11 | 33730750 | - |
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FusionProtFeatures for H2AFZ_CD59 |
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Hgene | Tgene |
H2AFZ | CD59 |
Variant histone H2A which replaces conventional H2A in asubset of nucleosomes. Nucleosomes wrap and compact DNA intochromatin, limiting DNA accessibility to the cellular machinerieswhich require DNA as a template. Histones thereby play a centralrole in transcription regulation, DNA repair, DNA replication andchromosomal stability. DNA accessibility is regulated via acomplex set of post-translational modifications of histones, alsocalled histone code, and nucleosome remodeling. May be involved inthe formation of constitutive heterochromatin. May be required forchromosome segregation during cell division.{ECO:0000269|PubMed:15878876}. | Potent inhibitor of the complement membrane attackcomplex (MAC) action. Acts by binding to the C8 and/or C9complements of the assembling MAC, thereby preventingincorporation of the multiple copies of C9 required for completeformation of the osmolytic pore. This inhibitor appears to bespecies-specific. Involved in signal transduction for T-cellactivation complexed to a protein tyrosine kinase. The soluble form from urine retains its specificcomplement binding activity, but exhibits greatly reduced abilityto inhibit MAC assembly on cell membranes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for H2AFZ_CD59 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for H2AFZ_CD59 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for H2AFZ_CD59 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for H2AFZ_CD59 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CD59 | C2676767 | CD59 Deficiency | 1 | CTD_human;ORPHANET;UNIPROT |