FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15778

FusionGeneSummary for H2AFY_ZFHX4

check button Fusion gene summary
Fusion gene informationFusion gene name: H2AFY_ZFHX4
Fusion gene ID: 15778
HgeneTgene
Gene symbol

H2AFY

ZFHX4

Gene ID

9555

79776

Gene nameH2A histone family member Yzinc finger homeobox 4
SynonymsH2A.y|H2A/y|H2AF12M|MACROH2A1.1|mH2A1|macroH2A1.2ZFH4|ZHF4
Cytomap

5q31.1

8q21.13

Type of geneprotein-codingprotein-coding
Descriptioncore histone macro-H2A.1histone H2A.yhistone macroH2A1histone macroH2A1.1histone macroH2A1.2medulloblastoma antigen MU-MB-50.205zinc finger homeobox protein 4zinc-finger homeodomain protein 4
Modification date2018052320180523
UniProtAcc

O75367

Q86UP3

Ensembl transtripts involved in fusion geneENST00000511689, ENST00000512507, 
ENST00000304332, ENST00000312469, 
ENST00000423969, ENST00000510038, 
ENST00000521891, ENST00000517683, 
ENST00000050961, ENST00000455469, 
ENST00000518282, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 3=48
# samples 44
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: H2AFY [Title/Abstract] AND ZFHX4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneH2AFY

GO:0007549

dosage compensation

15053874

HgeneH2AFY

GO:0034184

positive regulation of maintenance of mitotic sister chromatid cohesion

26373281

HgeneH2AFY

GO:1904815

negative regulation of protein localization to chromosome, telomeric region

26373281


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB217196H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000511689ENST00000521891H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000511689ENST00000517683H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000511689ENST00000050961H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000511689ENST00000455469H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000511689ENST00000518282H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-3CDSENST00000512507ENST00000521891H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000512507ENST00000517683H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000512507ENST00000050961H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000512507ENST00000455469H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000512507ENST00000518282H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-3CDSENST00000304332ENST00000521891H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000304332ENST00000517683H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000304332ENST00000050961H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000304332ENST00000455469H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000304332ENST00000518282H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-3CDSENST00000312469ENST00000521891H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000312469ENST00000517683H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000312469ENST00000050961H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000312469ENST00000455469H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000312469ENST00000518282H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-3CDSENST00000423969ENST00000521891H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000423969ENST00000517683H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000423969ENST00000050961H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000423969ENST00000455469H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000423969ENST00000518282H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-3CDSENST00000510038ENST00000521891H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000510038ENST00000517683H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000510038ENST00000050961H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000510038ENST00000455469H2AFYchr5

134688713

-ZFHX4chr8

77764869

+
intron-intronENST00000510038ENST00000518282H2AFYchr5

134688713

-ZFHX4chr8

77764869

+

Top

FusionProtFeatures for H2AFY_ZFHX4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
H2AFY

O75367

ZFHX4

Q86UP3

Variant histone H2A which replaces conventional H2A in asubset of nucleosomes where it represses transcription(PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomeswrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. Involved in stable X chromosomeinactivation (PubMed:15897469). Inhibits the binding oftranscription factors, including NF-kappa-B, and interferes withthe activity of remodeling SWI/SNF complexes (PubMed:12718888,PubMed:16428466). Inhibits histone acetylation by EP300 andrecruits class I HDACs, which induces a hypoacetylated state ofchromatin (PubMed:16428466, PubMed:16107708).{ECO:0000269|PubMed:12718888, ECO:0000269|PubMed:15621527,ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16107708,ECO:0000269|PubMed:16428466}. Isoform 1: Binds ADP-ribose and O-acetyl-ADP-ribose, andmay be involved in ADP-ribose-mediated chromatin modulation(PubMed:15902274). Increases the expression of genes involved inredox metabolism, including SOD3 (PubMed:23022728).{ECO:0000269|PubMed:15902274, ECO:0000269|PubMed:23022728}. Isoform 2: Represses SOD3 gene expression.{ECO:0000269|PubMed:23022728}. May play a role in neural and muscle differentiation (Bysimilarity). May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for H2AFY_ZFHX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for H2AFY_ZFHX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for H2AFY_ZFHX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for H2AFY_ZFHX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource