|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 15726 |
FusionGeneSummary for GXYLT2_NEK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GXYLT2_NEK3 | Fusion gene ID: 15726 | Hgene | Tgene | Gene symbol | GXYLT2 | NEK3 | Gene ID | 727936 | 4752 |
| Gene name | glucoside xylosyltransferase 2 | NIMA related kinase 3 | |
| Synonyms | GLT8D4 | HSPK36 | |
| Cytomap | 3p13 | 13q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glucoside xylosyltransferase 2glycosyltransferase 8 domain containing 4glycosyltransferase 8 domain-containing protein 4 | serine/threonine-protein kinase Nek3HSPK 36NIMA (never in mitosis gene a)-related kinase 3glycogen synthase A kinasehydroxyalkyl-protein kinasenever in mitosis A-related kinase 3nimA-related protein kinase 3phosphorylase B kinase kinase | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | A0PJZ3 | P51956 | |
| Ensembl transtripts involved in fusion gene | ENST00000389617, | ENST00000378101, ENST00000339406, ENST00000452082, ENST00000400357, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GXYLT2 [Title/Abstract] AND NEK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GXYLT2 | GO:0016266 | O-glycan processing | 19940119 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EB-A44R-06A | GXYLT2 | chr3 | 72971486 | + | NEK3 | chr13 | 52719026 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000389617 | ENST00000378101 | GXYLT2 | chr3 | 72971486 | + | NEK3 | chr13 | 52719026 | - |
| In-frame | ENST00000389617 | ENST00000339406 | GXYLT2 | chr3 | 72971486 | + | NEK3 | chr13 | 52719026 | - |
| In-frame | ENST00000389617 | ENST00000452082 | GXYLT2 | chr3 | 72971486 | + | NEK3 | chr13 | 52719026 | - |
| In-frame | ENST00000389617 | ENST00000400357 | GXYLT2 | chr3 | 72971486 | + | NEK3 | chr13 | 52719026 | - |
Top |
FusionProtFeatures for GXYLT2_NEK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GXYLT2 | NEK3 |
| Glycosyltransferase which elongates the O-linked glucoseattached to EGF-like repeats in the extracellular domain of Notchproteins by catalyzing the addition of xylose.{ECO:0000269|PubMed:19940119}. | Protein kinase which influences neuronal morphogenesisand polarity through effects on microtubules. Regulatesmicrotubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancercells through mechanisms involving RAC1 activation andphosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286,ECO:0000269|PubMed:17297458}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GXYLT2 | chr3:72971486 | chr13:52719026 | ENST00000389617 | + | 3 | 7 | 68_98 | 200 | 444 | Compositional bias | Note=Arg-rich |
| Hgene | GXYLT2 | chr3:72971486 | chr13:52719026 | ENST00000389617 | + | 3 | 7 | 1_4 | 200 | 444 | Topological domain | Cytoplasmic |
| Hgene | GXYLT2 | chr3:72971486 | chr13:52719026 | ENST00000389617 | + | 3 | 7 | 5_25 | 200 | 444 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GXYLT2 | chr3:72971486 | chr13:52719026 | ENST00000389617 | + | 3 | 7 | 26_443 | 200 | 444 | Topological domain | Lumenal |
| Tgene | NEK3 | chr3:72971486 | chr13:52719026 | ENST00000400357 | - | 6 | 14 | 4_257 | 201 | 490 | Domain | Protein kinase |
| Tgene | NEK3 | chr3:72971486 | chr13:52719026 | ENST00000400357 | - | 6 | 14 | 10_18 | 201 | 490 | Nucleotide binding | ATP |
Top |
FusionGeneSequence for GXYLT2_NEK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000378101_chr13_52719026_-_506aa MKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGASPGVRRRRPPRPRPRAGRRGAARLEKL ARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEFDKQLRQWPDSYTKKFEHRIYPITFSVG NPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIM EYGEEVLEEIKNSKHNTPRKKANPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRR QWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGFLKGPLSEETE >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000339406_chr13_52719026_-_506aa MKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGASPGVRRRRPPRPRPRAGRRGAARLEKL ARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEFDKQLRQWPDSYTKKFEHRIYPITFSVG NPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIM EYGEEVLEEIKNSKHNTPRKKANPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRR QWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGFLKGPLSEETE >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000452082_chr13_52719026_-_489aa MKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGASPGVRRRRPPRPRPRAGRRGAARLEKL ARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEFDKQLRQWPDSYTKKFEHRIYPITFSVG NPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIM EYGEEVLEEIKNSKHNTPRKKQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENA SILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPE >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000400357_chr13_52719026_-_489aa MKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGASPGVRRRRPPRPRPRAGRRGAARLEKL ARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEFDKQLRQWPDSYTKKFEHRIYPITFSVG NPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIM EYGEEVLEEIKNSKHNTPRKKQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENA SILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000378101_chr13_52719026_-_1518nt ATGAAGCTCCGCAGCAAGGCGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCT GAGCCCCCAGCGCTGCCCGCGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTC CCCGGGGCCAGCCCGGGAGTTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTG GCGAGGAGGCCTGGAGAACCCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGG CTGGAGGAGACGCTGGTCATGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAG CCCGAGTTTGATAAGCAGTTACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGA AACCCTCAGGAGTGGAAGAAATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATC CTCAAAGTATGTCAAGGGTGCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAAT CCCTCACATCGCCCCTCGGCTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATG GAATATGGTGAGGAAGTATTAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAAGCAAACCCCAGCAGAATCAGGATAGCT TTGGGAAATGAAGCAAGCACAGTGCAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTT GAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGA CAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGA GGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAAT GCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAA GCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTT >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000339406_chr13_52719026_-_1518nt ATGAAGCTCCGCAGCAAGGCGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCT GAGCCCCCAGCGCTGCCCGCGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTC CCCGGGGCCAGCCCGGGAGTTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTG GCGAGGAGGCCTGGAGAACCCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGG CTGGAGGAGACGCTGGTCATGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAG CCCGAGTTTGATAAGCAGTTACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGA AACCCTCAGGAGTGGAAGAAATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATC CTCAAAGTATGTCAAGGGTGCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAAT CCCTCACATCGCCCCTCGGCTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATG GAATATGGTGAGGAAGTATTAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAAGCAAACCCCAGCAGAATCAGGATAGCT TTGGGAAATGAAGCAAGCACAGTGCAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTT GAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGA CAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGA GGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAAT GCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAA GCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTT >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000452082_chr13_52719026_-_1467nt ATGAAGCTCCGCAGCAAGGCGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCT GAGCCCCCAGCGCTGCCCGCGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTC CCCGGGGCCAGCCCGGGAGTTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTG GCGAGGAGGCCTGGAGAACCCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGG CTGGAGGAGACGCTGGTCATGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAG CCCGAGTTTGATAAGCAGTTACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGA AACCCTCAGGAGTGGAAGAAATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATC CTCAAAGTATGTCAAGGGTGCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAAT CCCTCACATCGCCCCTCGGCTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATG GAATATGGTGAGGAAGTATTAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAACAAGAGGAAGAACAAGATAGAAAGGGT AGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTC CATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCA TCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTC AAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCA GAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAG CGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACCCCGACTGGGTGTCAGAGCTGAAGAAGCGAGCT >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000400357_chr13_52719026_-_1467nt ATGAAGCTCCGCAGCAAGGCGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCT GAGCCCCCAGCGCTGCCCGCGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTC CCCGGGGCCAGCCCGGGAGTTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTG GCGAGGAGGCCTGGAGAACCCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGG CTGGAGGAGACGCTGGTCATGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAG CCCGAGTTTGATAAGCAGTTACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGA AACCCTCAGGAGTGGAAGAAATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATC CTCAAAGTATGTCAAGGGTGCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAAT CCCTCACATCGCCCCTCGGCTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATG GAATATGGTGAGGAAGTATTAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAACAAGAGGAAGAACAAGATAGAAAGGGT AGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTC CATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCA TCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTC AAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCA GAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAG CGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACCCCGACTGGGTGTCAGAGCTGAAGAAGCGAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000378101_chr13_52719026_-_2178nt GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAAGCAAACCCCAGCAGAATCAGGATAGCTTTGGGAAATGAAGCAAGCA CAGTGCAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAG TAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTAC CCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGT ACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTT TTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATG GAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACC CCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCGACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGA GGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGACGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAA CTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCTAGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTAT AGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGGGATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGA AATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATAATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTT ATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATGTGACTCTTTTTACATTTCCTAAAGGTTTGAGAATTAAAT >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000339406_chr13_52719026_-_2178nt GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAAGCAAACCCCAGCAGAATCAGGATAGCTTTGGGAAATGAAGCAAGCA CAGTGCAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAG TAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTAC CCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGT ACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTT TTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATG GAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACC CCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCGACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGA GGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGACGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAA CTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCTAGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTAT AGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGGGATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGA AATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATAATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTT ATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATGTGACTCTTTTTACATTTCCTAAAGGTTTGAGAATTAAAT >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000452082_chr13_52719026_-_2119nt GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAACAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAA GCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTT CACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTT TAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTT TGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCC CCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAG ATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACCCCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCG ACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGAGGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGA CGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAACTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCT AGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTATAGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGG GATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGAAATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATA ATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTTATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATG >In-frame_GXYLT2_ENST00000389617_chr3_72971486_+_NEK3_ENST00000400357_chr13_52719026_-_2119nt GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAACAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAA GCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTT CACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTT TAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTT TGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCC CCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAG ATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACCCCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCG ACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGAGGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGA CGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAACTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCT AGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTATAGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGG GATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGAAATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATA ATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTTATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATG |
Top |
FusionGenePPI for GXYLT2_NEK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GXYLT2 | FBL, SRPK2, MGAT4C, CD70, NEUROG3, HLA-DPA1, SCGB2A2, KCNC4, KLRG2, TRIM25 | NEK3 | HDAC6, NMNAT1, BPGM, CDCA8, VSIG4, CDK13, TNFSF8, CPNE2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | NEK3 | chr3:72971486 | chr13:52719026 | ENST00000400357 | - | 6 | 14 | 1_285 | 201 | 490 | VAV2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GXYLT2_NEK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GXYLT2_NEK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|