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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15701

FusionGeneSummary for GUK1_KDM5C

check button Fusion gene summary
Fusion gene informationFusion gene name: GUK1_KDM5C
Fusion gene ID: 15701
HgeneTgene
Gene symbol

GUK1

KDM5C

Gene ID

2987

8242

Gene nameguanylate kinase 1lysine demethylase 5C
SynonymsGMKDXS1272E|JARID1C|MRX13|MRXJ|MRXSCJ|MRXSJ|SMCX|XE169
Cytomap

1q42.13

Xp11.22

Type of geneprotein-codingprotein-coding
Descriptionguanylate kinaseATP:GMP phosphotransferaseGMP kinaselysine-specific demethylase 5CJmjC domain-containing protein SMCXJumonji, AT rich interactive domain 1C (RBP2-like)Jumonji/ARID domain-containing protein 1CSmcx homolog, X chromosomeSmcy homolog, X-linkedhistone demethylase JARID1Clysine (K)-specif
Modification date2018052320180523
UniProtAcc

Q16774

P41229

Ensembl transtripts involved in fusion geneENST00000366730, ENST00000391865, 
ENST00000366726, ENST00000312726, 
ENST00000366728, ENST00000366723, 
ENST00000366722, ENST00000366721, 
ENST00000366718, ENST00000470040, 
ENST00000366716, 		ENST00000452825, 
ENST00000375401, ENST00000404049, 
ENST00000375379, ENST00000375383, 
ENST00000465402, 
Fusion gene scores* DoF score11 X 12 X 2=2643 X 3 X 1=9
# samples 133
** MAII scorelog2(13/264*10)=-1.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GUK1 [Title/Abstract] AND KDM5C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGUK1

GO:0006163

purine nucleotide metabolic process

8663313

TgeneKDM5C

GO:0034720

histone H3-K4 demethylation

17320160


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE939838GUK1chr1

228336098

+KDM5CchrX

53228198

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366730ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366730ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366730ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366730ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366730ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000366730ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000391865ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000391865ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000391865ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000391865ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000391865ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000391865ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366726ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366726ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366726ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366726ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366726ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000366726ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000312726ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000312726ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000312726ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000312726ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000312726ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000312726ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
intron-3CDSENST00000366728ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
intron-3CDSENST00000366728ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
intron-3CDSENST00000366728ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
intron-3CDSENST00000366728ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
intron-3CDSENST00000366728ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
intron-intronENST00000366728ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366723ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366723ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366723ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366723ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366723ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000366723ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366722ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366722ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366722ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366722ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
Frame-shiftENST00000366722ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000366722ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366721ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366721ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366721ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366721ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366721ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000366721ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366718ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366718ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366718ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366718ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366718ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000366718ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
3UTR-3CDSENST00000470040ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
3UTR-3CDSENST00000470040ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
3UTR-3CDSENST00000470040ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
3UTR-3CDSENST00000470040ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
3UTR-3CDSENST00000470040ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
3UTR-intronENST00000470040ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366716ENST00000452825GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366716ENST00000375401GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366716ENST00000404049GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366716ENST00000375379GUK1chr1

228336098

+KDM5CchrX

53228198

+
In-frameENST00000366716ENST00000375383GUK1chr1

228336098

+KDM5CchrX

53228198

+
5CDS-intronENST00000366716ENST00000465402GUK1chr1

228336098

+KDM5CchrX

53228198

+

Top

FusionProtFeatures for GUK1_KDM5C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUK1

Q16774

KDM5C

P41229

Essential for recycling GMP and indirectly, cGMP. Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code(PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylatestrimethylated and dimethylated but not monomethylated H3 'Lys-4'.Participates in transcriptional repression of neuronal genes byrecruiting histone deacetylases and REST at neuron-restrictivesilencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock componentPER2 (By similarity). {ECO:0000250|UniProtKB:P41230,ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161,ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689,ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379-02614_55-1781558DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379-026468_634-1781558DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379-02679_169-1781558DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383-02514_55-1781517DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383-025468_634-1781517DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383-02579_169-1781517DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401-02614_55-1781561DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401-026468_634-1781561DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401-02679_169-1781561DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049-02614_55-961560DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049-026468_634-961560DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049-02679_169-961560DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825-02414_55-1781380DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825-024468_634-1781380DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825-02479_169-1781380DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379-0261187_1248-1781558Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379-026326_372-1781558Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379-026707_759-1781558Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383-0251187_1248-1781517Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383-025326_372-1781517Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383-025707_759-1781517Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401-0261187_1248-1781561Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401-026326_372-1781561Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401-026707_759-1781561Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049-0261187_1248-961560Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049-026326_372-961560Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049-026707_759-961560Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825-0241187_1248-1781380Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825-024326_372-1781380Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825-024707_759-1781380Zinc fingerC5HC2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGUK1chr1:228336098chrX:53228198ENST00000312726+194_186-81198DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366716+174_186-20198DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366718+184_186-143198DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366726+184_186-32198DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366728+174_186-5242DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366730+184_186-67198DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000391865+184_186-25219DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000312726+1911_18-81198Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366716+1711_18-20198Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366718+1811_18-143198Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366726+1811_18-32198Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366728+1711_18-5242Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366730+1811_18-67198Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000391865+1811_18-25219Nucleotide bindingATP


Top

FusionGeneSequence for GUK1_KDM5C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0aa

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366730_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000391865_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366726_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000312726_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366721_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366718_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000452825_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375401_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000404049_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375379_chrX_53228198_+_0nt

>In-frame_GUK1_ENST00000366716_chr1_228336098_+_KDM5C_ENST00000375383_chrX_53228198_+_0nt


Top

FusionGenePPI for GUK1_KDM5C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GUK1_KDM5C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GUK1_KDM5C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKDM5CC1845243MENTAL RETARDATION, X-LINKED, SYNDROMIC, CLAES-JENSEN TYPE4CTD_human;ORPHANET;UNIPROT
TgeneKDM5CC0004352Autistic Disorder1CTD_human
TgeneKDM5CC0007134Renal Cell Carcinoma1CTD_human
TgeneKDM5CC3714756Intellectual Disability1CTD_human