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Fusion gene ID: 15695 |
FusionGeneSummary for GUF1_ZNF354B |
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Fusion gene information | Fusion gene name: GUF1_ZNF354B | Fusion gene ID: 15695 | Hgene | Tgene | Gene symbol | GUF1 | ZNF354B | Gene ID | 60558 | 117608 |
Gene name | GUF1 homolog, GTPase | zinc finger protein 354B | |
Synonyms | EF-4|EF4|EIEE40 | KID2 | |
Cytomap | 4p12 | 5q35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | translation factor GUF1, mitochondrialGTP-binding protein GUF1 homologGTPase of unknown function 1elongation factor 4 homologribosomal back-translocase | zinc finger protein 354B | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q8N442 | Q96LW1 | |
Ensembl transtripts involved in fusion gene | ENST00000506793, ENST00000281543, | ENST00000322434, ENST00000522714, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GUF1 [Title/Abstract] AND ZNF354B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA227903 | GUF1 | chr4 | 44700627 | - | ZNF354B | chr5 | 178309781 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000506793 | ENST00000322434 | GUF1 | chr4 | 44700627 | - | ZNF354B | chr5 | 178309781 | - |
3UTR-intron | ENST00000506793 | ENST00000522714 | GUF1 | chr4 | 44700627 | - | ZNF354B | chr5 | 178309781 | - |
In-frame | ENST00000281543 | ENST00000322434 | GUF1 | chr4 | 44700627 | - | ZNF354B | chr5 | 178309781 | - |
5CDS-intron | ENST00000281543 | ENST00000522714 | GUF1 | chr4 | 44700627 | - | ZNF354B | chr5 | 178309781 | - |
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FusionProtFeatures for GUF1_ZNF354B |
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Hgene | Tgene |
GUF1 | ZNF354B |
Promotes mitochondrial protein synthesis. May act as afidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocatedribosomes. Binds to mitochondrial ribosomes in a GTP-dependentmanner. {ECO:0000255|HAMAP-Rule:MF_03137}. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GUF1_ZNF354B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_GUF1_ENST00000281543_chr4_44700627_-_ZNF354B_ENST00000322434_chr5_178309781_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_GUF1_ENST00000281543_chr4_44700627_-_ZNF354B_ENST00000322434_chr5_178309781_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_GUF1_ENST00000281543_chr4_44700627_-_ZNF354B_ENST00000322434_chr5_178309781_-_0nt |
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FusionGenePPI for GUF1_ZNF354B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GUF1_ZNF354B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GUF1_ZNF354B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |