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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15695

FusionGeneSummary for GUF1_ZNF354B

check button Fusion gene summary
Fusion gene informationFusion gene name: GUF1_ZNF354B
Fusion gene ID: 15695
HgeneTgene
Gene symbol

GUF1

ZNF354B

Gene ID

60558

117608

Gene nameGUF1 homolog, GTPasezinc finger protein 354B
SynonymsEF-4|EF4|EIEE40KID2
Cytomap

4p12

5q35.3

Type of geneprotein-codingprotein-coding
Descriptiontranslation factor GUF1, mitochondrialGTP-binding protein GUF1 homologGTPase of unknown function 1elongation factor 4 homologribosomal back-translocasezinc finger protein 354B
Modification date2018052220180522
UniProtAcc

Q8N442

Q96LW1

Ensembl transtripts involved in fusion geneENST00000506793, ENST00000281543, 
ENST00000322434, ENST00000522714, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: GUF1 [Title/Abstract] AND ZNF354B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA227903GUF1chr4

44700627

-ZNF354Bchr5

178309781

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000506793ENST00000322434GUF1chr4

44700627

-ZNF354Bchr5

178309781

-
3UTR-intronENST00000506793ENST00000522714GUF1chr4

44700627

-ZNF354Bchr5

178309781

-
In-frameENST00000281543ENST00000322434GUF1chr4

44700627

-ZNF354Bchr5

178309781

-
5CDS-intronENST00000281543ENST00000522714GUF1chr4

44700627

-ZNF354Bchr5

178309781

-

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FusionProtFeatures for GUF1_ZNF354B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUF1

Q8N442

ZNF354B

Q96LW1

Promotes mitochondrial protein synthesis. May act as afidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocatedribosomes. Binds to mitochondrial ribosomes in a GTP-dependentmanner. {ECO:0000255|HAMAP-Rule:MF_03137}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GUF1_ZNF354B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GUF1_ENST00000281543_chr4_44700627_-_ZNF354B_ENST00000322434_chr5_178309781_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GUF1_ENST00000281543_chr4_44700627_-_ZNF354B_ENST00000322434_chr5_178309781_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_GUF1_ENST00000281543_chr4_44700627_-_ZNF354B_ENST00000322434_chr5_178309781_-_0nt


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FusionGenePPI for GUF1_ZNF354B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GUF1_ZNF354B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GUF1_ZNF354B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource