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Fusion gene ID: 15694 |
FusionGeneSummary for GUCY2C_ART4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GUCY2C_ART4 | Fusion gene ID: 15694 | Hgene | Tgene | Gene symbol | GUCY2C | ART4 | Gene ID | 2984 | 420 |
| Gene name | guanylate cyclase 2C | ADP-ribosyltransferase 4 (Dombrock blood group) | |
| Synonyms | DIAR6|GC-C|GUC2C|MECIL|MUCIL|STAR | ARTC4|CD297|DO|DOK1 | |
| Cytomap | 12p12.3 | 12p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heat-stable enterotoxin receptorSTA receptorguanylyl cyclase Cintestinal guanylate cyclase | ecto-ADP-ribosyltransferase 4ADP-ribosyltransferase 4 (DO blood group)ADP-ribosyltransferase C2 and C3 toxin-like 4Dombrock blood group carrier moleculeNAD(+)--protein-arginine ADP-ribosyltransferase 4NAD(P)(+)--arginine ADP-ribosyltransferase 4mono | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P25092 | Q93070 | |
| Ensembl transtripts involved in fusion gene | ENST00000261170, | ENST00000228936, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GUCY2C [Title/Abstract] AND ART4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-8060-01A | GUCY2C | chr12 | 14781580 | - | ART4 | chr12 | 14982396 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261170 | ENST00000228936 | GUCY2C | chr12 | 14781580 | - | ART4 | chr12 | 14982396 | - |
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FusionProtFeatures for GUCY2C_ART4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GUCY2C | ART4 |
| Receptor for the E.coli heat-stable enterotoxin (E.colienterotoxin markedly stimulates the accumulation of cGMP inmammalian cells expressing GC-C). Also activated by the endogenouspeptides guanylin and uroguanylin. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GUCY2C | chr12:14781580 | chr12:14982396 | ENST00000261170 | - | 20 | 27 | 489_749 | 749 | 1074 | Domain | Protein kinase |
| Hgene | GUCY2C | chr12:14781580 | chr12:14982396 | ENST00000261170 | - | 20 | 27 | 24_430 | 749 | 1074 | Topological domain | Extracellular |
| Hgene | GUCY2C | chr12:14781580 | chr12:14982396 | ENST00000261170 | - | 20 | 27 | 431_454 | 749 | 1074 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GUCY2C | chr12:14781580 | chr12:14982396 | ENST00000261170 | - | 20 | 27 | 824_954 | 749 | 1074 | Domain | Guanylate cyclase |
| Hgene | >GUCY2C | chr12:14781580 | chr12:14982396 | ENST00000261170 | - | 20 | 27 | 455_1073 | 749 | 1074 | Topological domain | Cytoplasmic |
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FusionGeneSequence for GUCY2C_ART4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GUCY2C_ENST00000261170_chr12_14781580_-_ART4_ENST00000228936_chr12_14982396_-_780aa MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIH NSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDL PFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVI ILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTF EGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVA LLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQID YYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKI TDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GUCY2C_ENST00000261170_chr12_14781580_-_ART4_ENST00000228936_chr12_14982396_-_2341nt ATGAAGACGTTGCTGTTGGACTTGGCTTTGTGGTCACTGCTCTTCCAGCCCGGGTGGCTGTCCTTTAGTTCCCAGGTGAGTCAGAACTGC CACAATGGCAGCTATGAAATCAGCGTCCTGATGATGGGCAACTCAGCCTTTGCAGAGCCCCTGAAAAACTTGGAAGATGCGGTGAATGAG GGGCTGGAAATAGTGAGAGGACGTCTGCAAAATGCTGGCCTAAATGTGACTGTGAACGCTACTTTCATGTATTCGGATGGTCTGATTCAT AACTCAGGCGACTGCCGGAGTAGCACCTGTGAAGGCCTCGACCTACTCAGGAAAATTTCAAATGCACAACGGATGGGCTGTGTCCTCATA GGGCCCTCATGTACATACTCCACCTTCCAGATGTACCTTGACACAGAATTGAGCTACCCCATGATCTCAGCTGGAAGTTTTGGATTGTCA TGTGACTATAAAGAAACCTTAACCAGGCTGATGTCTCCAGCTAGAAAGTTGATGTACTTCTTGGTTAACTTTTGGAAAACCAACGATCTG CCCTTCAAAACTTATTCCTGGAGCACTTCGTATGTTTACAAGAATGGTACAGAAACTGAGGACTGTTTCTGGTACCTTAATGCTCTGGAG GCTAGCGTTTCCTATTTCTCCCACGAACTCGGCTTTAAGGTGGTGTTAAGACAAGATAAGGAGTTTCAGGATATCTTAATGGACCACAAC AGGAAAAGCAATGTGATTATTATGTGTGGTGGTCCAGAGTTCCTCTACAAGCTGAAGGGTGACCGAGCAGTGGCTGAAGACATTGTCATT ATTCTAGTGGATCTTTTCAATGACCAGTACTTTGAGGACAATGTCACAGCCCCTGACTATATGAAAAATGTCCTTGTTCTGACGCTGTCT CCTGGGAATTCCCTTCTAAATAGCTCTTTCTCCAGGAATCTATCACCAACAAAACGAGACTTTGCTCTTGCCTATTTGAATGGAATCCTG CTCTTTGGACATATGCTGAAGATATTTCTTGAAAATGGAGAAAATATTACCACCCCCAAATTTGCTCATGCTTTCAGGAATCTCACTTTT GAAGGGTATGACGGTCCAGTGACCTTGGATGACTGGGGGGATGTTGACAGTACCATGGTGCTTCTGTATACCTCTGTGGACACCAAGAAA TACAAGGTTCTTTTGACCTATGATACCCACGTAAATAAGACCTATCCTGTGGATATGAGCCCCACATTCACTTGGAAGAACTCTAAACTT CCTAATGATATTACAGGCCGGGGCCCTCAGATCCTGATGATTGCAGTCTTCACCCTCACTGGAGCTGTGGTGCTGCTCCTGCTCGTCGCT CTCCTGATGCTCAGAAAATATAGAAAAGATTATGAACTTCGTCAGAAAAAATGGTCCCACATTCCTCCTGAAAATATCTTTCCTCTGGAG ACCAATGAGACCAATCATGTTAGCCTCAAGATCGATGATGACAAAAGACGAGATACAATCCAGAGACTACGACAGTGCAAATACGACAAA AAGCGAGTGATTCTCAAAGATCTCAAGCACAATGATGGTAATTTCACTGAAAAACAGAAGATAGAATTGAACAAGTTGCTTCAGATTGAC TATTACAACCTGACCAAGTTCTACGGCACAGTGAAACTTGATACCATGATCTTCGGGGTGATAGAATACTGTGAGAGAGGATCCCTCCGG GAAGTTTTAAATGACACAATTTCCTACCCTGATGGCACATTCATGGATTGGGAGTTTAAGATCTCTGTCTTGTATGACATTGCTAAGGGA ATGTCATATCTGCACTCCAGTAAGACAGAAGTCCATGGTCGTCTGAAATCTACCAACTGCGTAGTGGACAGTAGAATGGTGGTGAAGATC ACTGATTTTGGCTGCAATTCCATTTTACCTCCAAAAAAGGACCTGTGGACAGCTCCAGAGCACCTCCGCCAAGCCAACATCTCTCAGAAA GGAGATGTGTACAGCTATGGGATCATCGCACAGGAGATCATCCTGCGGAAAGAAACCTTCTACACTTTGAGCTGTCGGGACCGGAATGAG AAGATTTTCAGAGTGGAAAATTCCAATGGAATGAAACCCTTCCGCCCAGATTTATTCTTGGAAACAGCAGAGGAAAAAGAGCTAGAAGTG TACCTACTTGTAAAAAACTGTTGGGAGGAAGATCCAGAAAAGAGACCAGATTTCAAAAAAATTGAGACTACACTTGCCAAGATATTTGGC TTCCAGCAAGAAATGCATCCCTGATCCTATAGCTATTGCATCTCTCTCCTTTTTGACCAGTGTCATCATCTTTTCCAAAAGCAGAGTATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GUCY2C_ENST00000261170_chr12_14781580_-_ART4_ENST00000228936_chr12_14982396_-_6280nt GACCAGAGAGAAGCGTGGGGAAGAGTGGGCTGAGGGACTCCACTAGAGGCTGTCCATCTGGATTCCCTGCCTCCCTAGGAGCCCAACAGA GCAAAGCAAGTGGGCACAAGGAGTATGGTTCTAACGTGATTGGGGTCATGAAGACGTTGCTGTTGGACTTGGCTTTGTGGTCACTGCTCT TCCAGCCCGGGTGGCTGTCCTTTAGTTCCCAGGTGAGTCAGAACTGCCACAATGGCAGCTATGAAATCAGCGTCCTGATGATGGGCAACT CAGCCTTTGCAGAGCCCCTGAAAAACTTGGAAGATGCGGTGAATGAGGGGCTGGAAATAGTGAGAGGACGTCTGCAAAATGCTGGCCTAA ATGTGACTGTGAACGCTACTTTCATGTATTCGGATGGTCTGATTCATAACTCAGGCGACTGCCGGAGTAGCACCTGTGAAGGCCTCGACC TACTCAGGAAAATTTCAAATGCACAACGGATGGGCTGTGTCCTCATAGGGCCCTCATGTACATACTCCACCTTCCAGATGTACCTTGACA CAGAATTGAGCTACCCCATGATCTCAGCTGGAAGTTTTGGATTGTCATGTGACTATAAAGAAACCTTAACCAGGCTGATGTCTCCAGCTA GAAAGTTGATGTACTTCTTGGTTAACTTTTGGAAAACCAACGATCTGCCCTTCAAAACTTATTCCTGGAGCACTTCGTATGTTTACAAGA ATGGTACAGAAACTGAGGACTGTTTCTGGTACCTTAATGCTCTGGAGGCTAGCGTTTCCTATTTCTCCCACGAACTCGGCTTTAAGGTGG TGTTAAGACAAGATAAGGAGTTTCAGGATATCTTAATGGACCACAACAGGAAAAGCAATGTGATTATTATGTGTGGTGGTCCAGAGTTCC TCTACAAGCTGAAGGGTGACCGAGCAGTGGCTGAAGACATTGTCATTATTCTAGTGGATCTTTTCAATGACCAGTACTTTGAGGACAATG TCACAGCCCCTGACTATATGAAAAATGTCCTTGTTCTGACGCTGTCTCCTGGGAATTCCCTTCTAAATAGCTCTTTCTCCAGGAATCTAT CACCAACAAAACGAGACTTTGCTCTTGCCTATTTGAATGGAATCCTGCTCTTTGGACATATGCTGAAGATATTTCTTGAAAATGGAGAAA ATATTACCACCCCCAAATTTGCTCATGCTTTCAGGAATCTCACTTTTGAAGGGTATGACGGTCCAGTGACCTTGGATGACTGGGGGGATG TTGACAGTACCATGGTGCTTCTGTATACCTCTGTGGACACCAAGAAATACAAGGTTCTTTTGACCTATGATACCCACGTAAATAAGACCT ATCCTGTGGATATGAGCCCCACATTCACTTGGAAGAACTCTAAACTTCCTAATGATATTACAGGCCGGGGCCCTCAGATCCTGATGATTG CAGTCTTCACCCTCACTGGAGCTGTGGTGCTGCTCCTGCTCGTCGCTCTCCTGATGCTCAGAAAATATAGAAAAGATTATGAACTTCGTC AGAAAAAATGGTCCCACATTCCTCCTGAAAATATCTTTCCTCTGGAGACCAATGAGACCAATCATGTTAGCCTCAAGATCGATGATGACA AAAGACGAGATACAATCCAGAGACTACGACAGTGCAAATACGACAAAAAGCGAGTGATTCTCAAAGATCTCAAGCACAATGATGGTAATT TCACTGAAAAACAGAAGATAGAATTGAACAAGTTGCTTCAGATTGACTATTACAACCTGACCAAGTTCTACGGCACAGTGAAACTTGATA CCATGATCTTCGGGGTGATAGAATACTGTGAGAGAGGATCCCTCCGGGAAGTTTTAAATGACACAATTTCCTACCCTGATGGCACATTCA TGGATTGGGAGTTTAAGATCTCTGTCTTGTATGACATTGCTAAGGGAATGTCATATCTGCACTCCAGTAAGACAGAAGTCCATGGTCGTC TGAAATCTACCAACTGCGTAGTGGACAGTAGAATGGTGGTGAAGATCACTGATTTTGGCTGCAATTCCATTTTACCTCCAAAAAAGGACC TGTGGACAGCTCCAGAGCACCTCCGCCAAGCCAACATCTCTCAGAAAGGAGATGTGTACAGCTATGGGATCATCGCACAGGAGATCATCC TGCGGAAAGAAACCTTCTACACTTTGAGCTGTCGGGACCGGAATGAGAAGATTTTCAGAGTGGAAAATTCCAATGGAATGAAACCCTTCC GCCCAGATTTATTCTTGGAAACAGCAGAGGAAAAAGAGCTAGAAGTGTACCTACTTGTAAAAAACTGTTGGGAGGAAGATCCAGAAAAGA GACCAGATTTCAAAAAAATTGAGACTACACTTGCCAAGATATTTGGCTTCCAGCAAGAAATGCATCCCTGATCCTATAGCTATTGCATCT CTCTCCTTTTTGACCAGTGTCATCATCTTTTCCAAAAGCAGAGTATAAAGAAATCTTGTGGCTCCTTTTATTTAAAAAAAATATTTAAAT AAAATCTTTTTTATTGGCCTTTTGGCTAGAAATGGACATTTATTTTCCAGGAAGGATGATCCCATCATACTTCTGCTGAAACCAGTGCAT GGCCTCCTCTTTGCTAATTCTCTTATGCCTTTCCTTGTACCCCTTTGCCTTATTTCAATCTGGGCACCCTAAGTACTCTTGGGGAAATCA CTCTGCCCAGCTAGCAACTGATGCAGAGCTGGCTCAGCCCACTGACTGTGATTGGCCTGTAACTCAGGCCTTAGCCAATCAGTATATTTC TTCTTCATGGACACAAAGATTCATGCTGGAATAGAAAATGATCCAATCAGAGCCTGTGAGATACAATCAGGGTACTTTTGTGGAATTGCA ATTGGAAATAGAATGGGAGCTTCTTTTCTGAATGGATATTAATGAAAGCAGGGTAGGAGCTTATAGCTGCCAGCAAAGATCCCGCCACCA GGAGAGGAGACCCCATCTCCTTGAGAAAGGATCTAACACAACAAAGGAAGAGCTGATAAGTGAAAAGAAACTGAGACCTGATGAGAATGT ATAAGCCTCTGGATCCAACTTTGCCTAAAGCTGAATACTACAAGATTTTTCATTACATAAATCAATAATTTATGTTTTTGCTTGCATAAT TTGAATTAGATTTTCTATGTCAAGCATCAAGCAGTTGAAGTTCCAACGAATACAAGCACTCTTCCTTATTTTTTTTAATTTAGTTATTCT AAATAGGAACAAATCAAAGAAGATTAAATTAGAAAGCAAAGGACAAATTCTTCACCAAACAGAAAAGCTTTGAACCCCAGAGATTAACCA AGGTGTGAATTTTCTTCAGAGATTTTTTATGAGCATTCAAGATTAAGCTAGTATGGCCTCAGATGAGAAGACACATGGAAACTTGAGAAA TAAAAGGGAAAGTTAATGAAAGATGTTAGTGAAATTTCATTCACCAGCAGTAATGGGTGTTCATGCATGTTCCTAAGACATTACAAAAGT TAAAATTTAAACTCATATGTTAATTCATAGAGAACTTGATGGCAAATTTAAGTCTTCATAGCAAATTTAAATATTAGGAAAACATGAGGG TATGTGTGAAGGTTAACAGAGAGTATGAGAGAAAAAAACACTGATTACAAACAAATATCAGCAATATAGCGAGGTCTCATTACATGTAAA CTAGTACATGCAAAGAAGTATAAATTGTTGAATTGTATAGCTGGAAATGTCCTCTAACGCTTCCCTCAGGTAGTAATTTAGGTAGCGACA TAAGGGATTATTTAACCCGATCACGATCACTGAAGACCCTGGTATCAGGCTAAATGGAGTAAAGATGAGGGCTAGCTCTATAATTTTGGA TTTTGAAAGTCCATGCTCCTTATCCCTTTTAAGATTTGGATAAGAAACAGCAAAACTGAAAATCGGTCCATCTATTTACTCTCCATAGGA CTTCCTGAATGGCCTGTGTCATGATCAAAGAAATGGAATGGGGAATAAGCTACATAAAATTACCTGGCAGGGAGTTCAGGCATCTCTGTA CTATCATTCTTTAAATTGGGATTTGAAACTAACAGGGCCAAATCACCTCTGTCACCTAGTTGCAGTAGCCTCTACAGTCAATAAAGGAAA GAATTTCTGCCAGGCATGGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCCGAGGAGGACGGATCACGAGGTCAGGAGTTCAAGAC CAGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTACAAATACAAAAATTAGCCAGGCATGGTGGCACGCACCTGTAATCCCAGCTACTT GGGAGGCTGAGGCAGGAAAATTGCCTAAACCCAGGAGGCGGAGGTAGTGCAGTGAGCCAAGTTCACACCACTGCACTCCAGCCTGGGCAA CAGAGTGAGACTCGATCTCAAAAAAAGAAAAAAAGAAAGAATTTCTACAAACAGACAATTTATGTGACTTGCATAGGATAGGGTCTTTGG CAGTTTGGTGGCTACCTAGTAGAGAGTCCTGGGGACATGGCTCTGGGAGCAAGCTTTTCCAGTGAGCATCGATGAGTCAGTAATGACATG CTATGTTGGTAAAAGCCACCCAACATCTTAAGTACATTTTTCCTGTGCCATATAAATGCATGTATTGAGCCATACTGTGTACAAAGCACT TTGGGGATTAAAAGTTAAGAACACTAGGCCAGATCTCTCATGAGTTTACAATCTCTTAGGAGAAATTAAGAACATAAAGCAAGCCACAAG TGAAATGCCAAAAAAAAAAAAGGCAAAAATCAAGTTTTCTGTTCATAACAATTCAAAAGAAAGATTTCTTCCAACTGAGGCAAGAAGAGA CACCCGGAAGGCTTTAAGTAAGAGGCTGCATTTGAACCAGCCGTTAGGGCTCTAGGCTGGGAGAAGGGGTGAGCAGAAGGAGAAAAAAAC AAGAAAGAGTATGTGCCAAGTGCGTAGTGCCCAAAACAAGGCCAAATATTAAATGCTTGGAGCTGAGAGAAAAATGTGATTCCTCTGGCC TATGGTTAGATAAAGCTTTCTATCAGAGATGATGTTTTACTTAGAGGAAAGCAGAAAATAGAAGCGAATACGGAATGATCGATGTATGTA CAGCATAAGGTCAGGGAGCAGATAGGTCTGGCAGAGAGTGAGGGGTAATGTGGGCTGGAGAGGAAATTGGAAGCCACTCAGTGAAGCTAA AAAGTCAGCCAAAAGCATTTGATTTCCATGAGAAGTCATAATTTTCTGAGTAAGACAATTCTCCTAAAGCGTTGACTCTCTAGGCACAAG CAGCAATAGCATCCTTTAAGAACTCATTAGAAATGTGAATTTTAGGGCCTGATCCCAGACTACAGACTACAGAAATTGAACAGTCTGTTT TAATAAGTCCTCTAGATGATTCTGCTATACACCAACATTTGAGAACACTGTGACTTACACAATTATGATCCTTAAGGGAATAGCCAAGTT TCTAAAAAAGATAACTTAGTTCTAACTCCTGCTGCTGTTTTACAGATCAAATCTCTGGAGACAGAAACTATTCTCTTAAAATTATGTAGA TTCATGAGTTTGGTTAAGGATAAATGTACATAGCTCACATCCCCTCAGTCTCTCCCTATAGTCCAAAGTTGTTGAGCAAGGAATCTGTAG AGTATTGATTTAAATTGATTAAGTTACATGTTTATGAAACTCTAAGAGACTAGTTTTAGAAATTTCACTGTAATTTCTGCTGGGATAAAT TTGTTAGCCTGGGATATCTTCCAAAGATAAGGCGGATGCTCAAATATGTGTAAATTCATGCAACTGTTAACAGAGACTGTGCTGTAAGGA GTACTTATGTCCTATAGTAATTTTATTAAACAAATACATGTATGTCTCCTTTTGATGTGTACAGAAATATACTGTTTAATCTGAAGAAGC TGATTGAAACAGGAAAAATTTAAAAAGTAAAAACACTCAACCCATGTAATACTTTATTTTTATAACAAGGTGTTCTCTTTAATACGCCTA TTAGATTATCCTGAAGTTCTCTATTTACTCTTACTTTAAAAAAAATCCAATGAAAGAAAATTTCAGTAAAGTTTGTTTTGCTAGAAGAAT CAGGATTCTTGTACTGAGTTGTCTAATAATATGAATCAAATTGATTTACACTGAATGAACTAGCTCTTGATTTGGTAAAATTCAACAAGC |
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FusionGenePPI for GUCY2C_ART4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GUCY2C | PDZD3 | ART4 | APP, UPF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GUCY2C_ART4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GUCY2C | P25092 | DB08890 | Linaclotide | Heat-stable enterotoxin receptor | small molecule | approved |
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RelatedDiseases for GUCY2C_ART4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GUCY2C | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | GUCY2C | C0011991 | Diarrhea | 1 | CTD_human;HPO |
| Hgene | GUCY2C | C2939175 | Meconium ileus | 1 | HPO;ORPHANET;UNIPROT |
| Hgene | GUCY2C | C3553270 | DIARRHEA 6 | 1 | ORPHANET;UNIPROT |
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