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Fusion gene ID: 15693 |
FusionGeneSummary for GUCY1B3_PTPRG |
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Fusion gene information | Fusion gene name: GUCY1B3_PTPRG | Fusion gene ID: 15693 | Hgene | Tgene | Gene symbol | GUCY1B3 | PTPRG | Gene ID | 5793 |
Gene name | protein tyrosine phosphatase, receptor type G | ||
Synonyms | HPTPG|PTPG|R-PTP-GAMMA|RPTPG | ||
Cytomap | 3p14.2 | ||
Type of gene | protein-coding | ||
Description | receptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-t | ||
Modification date | 20180527 | ||
UniProtAcc | P23470 | ||
Ensembl transtripts involved in fusion gene | ENST00000505154, ENST00000502959, ENST00000505764, ENST00000507146, ENST00000264424, ENST00000503520, ENST00000513437, | ENST00000295874, ENST00000474889, ENST00000495879, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 6 X 5=240 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GUCY1B3 [Title/Abstract] AND PTPRG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A1KY-01A | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000505154 | ENST00000295874 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
intron-3CDS | ENST00000505154 | ENST00000474889 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
intron-intron | ENST00000505154 | ENST00000495879 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
Frame-shift | ENST00000502959 | ENST00000295874 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
Frame-shift | ENST00000502959 | ENST00000474889 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5CDS-intron | ENST00000502959 | ENST00000495879 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-3CDS | ENST00000505764 | ENST00000295874 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-3CDS | ENST00000505764 | ENST00000474889 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-intron | ENST00000505764 | ENST00000495879 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-3CDS | ENST00000507146 | ENST00000295874 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-3CDS | ENST00000507146 | ENST00000474889 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-intron | ENST00000507146 | ENST00000495879 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
Frame-shift | ENST00000264424 | ENST00000295874 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
Frame-shift | ENST00000264424 | ENST00000474889 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5CDS-intron | ENST00000264424 | ENST00000495879 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
Frame-shift | ENST00000503520 | ENST00000295874 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
Frame-shift | ENST00000503520 | ENST00000474889 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5CDS-intron | ENST00000503520 | ENST00000495879 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-3CDS | ENST00000513437 | ENST00000295874 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-3CDS | ENST00000513437 | ENST00000474889 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
5UTR-intron | ENST00000513437 | ENST00000495879 | GUCY1B3 | chr4 | 156681012 | + | PTPRG | chr3 | 61975299 | + |
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FusionProtFeatures for GUCY1B3_PTPRG |
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Hgene | Tgene |
GUCY1B3 | PTPRG |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GUCY1B3_PTPRG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GUCY1B3_PTPRG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GUCY1B3 | NOS3, HSP90AA1, GUCY1A2, STUB1, APP, LIN7A, GUCY1A3, MXRA7, ANKMY2, UACA, NOX5, MTFR2, MYCBP2, BBS2, MUL1 | PTPRG | DLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GUCY1B3_PTPRG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GUCY1B3_PTPRG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PTPRG | C0038356 | Stomach Neoplasms | 1 | CTD_human |