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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15693

FusionGeneSummary for GUCY1B3_PTPRG

check button Fusion gene summary
Fusion gene informationFusion gene name: GUCY1B3_PTPRG
Fusion gene ID: 15693
HgeneTgene
Gene symbol

GUCY1B3

PTPRG

Gene ID

5793

Gene nameprotein tyrosine phosphatase, receptor type G
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPG
Cytomap

3p14.2

Type of geneprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-t
Modification date20180527
UniProtAcc

P23470

Ensembl transtripts involved in fusion geneENST00000505154, ENST00000502959, 
ENST00000505764, ENST00000507146, 
ENST00000264424, ENST00000503520, 
ENST00000513437, 
ENST00000295874, 
ENST00000474889, ENST00000495879, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 6 X 5=240
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GUCY1B3 [Title/Abstract] AND PTPRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KY-01AGUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000505154ENST00000295874GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
intron-3CDSENST00000505154ENST00000474889GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
intron-intronENST00000505154ENST00000495879GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
Frame-shitENST00000502959ENST00000295874GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
Frame-shitENST00000502959ENST00000474889GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5CDS-intronENST00000502959ENST00000495879GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-3CDSENST00000505764ENST00000295874GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-3CDSENST00000505764ENST00000474889GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-intronENST00000505764ENST00000495879GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-3CDSENST00000507146ENST00000295874GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-3CDSENST00000507146ENST00000474889GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-intronENST00000507146ENST00000495879GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
Frame-shitENST00000264424ENST00000295874GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
Frame-shitENST00000264424ENST00000474889GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5CDS-intronENST00000264424ENST00000495879GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
Frame-shitENST00000503520ENST00000295874GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
Frame-shitENST00000503520ENST00000474889GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5CDS-intronENST00000503520ENST00000495879GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-3CDSENST00000513437ENST00000295874GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-3CDSENST00000513437ENST00000474889GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+
5UTR-intronENST00000513437ENST00000495879GUCY1B3chr4

156681012

+PTPRGchr3

61975299

+

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FusionProtFeatures for GUCY1B3_PTPRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUCY1B3

PTPRG

P23470

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GUCY1B3_PTPRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GUCY1B3_PTPRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GUCY1B3NOS3, HSP90AA1, GUCY1A2, STUB1, APP, LIN7A, GUCY1A3, MXRA7, ANKMY2, UACA, NOX5, MTFR2, MYCBP2, BBS2, MUL1PTPRGDLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GUCY1B3_PTPRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GUCY1B3_PTPRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRGC0038356Stomach Neoplasms1CTD_human