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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15691

FusionGeneSummary for GUCY1A3_SIK3

check button Fusion gene summary
Fusion gene informationFusion gene name: GUCY1A3_SIK3
Fusion gene ID: 15691
HgeneTgene
Gene symbol

GUCY1A3

SIK3

Gene ID

23387

Gene nameSIK family kinase 3
SynonymsL19|QSK|SIK-3
Cytomap

11q23.3

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase SIK3salt-inducible kinase 3serine/threonine-protein kinase QSK
Modification date20180523
UniProtAcc

Q9Y2K2

Ensembl transtripts involved in fusion geneENST00000506455, ENST00000511108, 
ENST00000511507, ENST00000515602, 
ENST00000455639, ENST00000393832, 
ENST00000296518, ENST00000513574, 
ENST00000375300, ENST00000292055, 
ENST00000375288, ENST00000434315, 
ENST00000542607, ENST00000446921, 
ENST00000488337, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 3=108
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GUCY1A3 [Title/Abstract] AND SIK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIK3

GO:0006468

protein phosphorylation

14976552


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-BT-A20R-01AGUCY1A3chr4

156588571

+SIK3chr11

116827780

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000506455ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000506455ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000506455ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000506455ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000506455ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000506455ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-intronENST00000506455ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000511108ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000511108ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511108ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511108ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511108ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511108ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-intronENST00000511108ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000511507ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000511507ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511507ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511507ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511507ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000511507ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-intronENST00000511507ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
3UTR-3CDSENST00000515602ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
3UTR-3CDSENST00000515602ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
3UTR-5UTRENST00000515602ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
3UTR-5UTRENST00000515602ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
3UTR-5UTRENST00000515602ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
3UTR-5UTRENST00000515602ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
3UTR-intronENST00000515602ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000455639ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000455639ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000455639ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000455639ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000455639ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000455639ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-intronENST00000455639ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000393832ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000393832ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000393832ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000393832ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000393832ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000393832ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-intronENST00000393832ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000296518ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-3CDSENST00000296518ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000296518ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000296518ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000296518ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-5UTRENST00000296518ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
5UTR-intronENST00000296518ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
intron-3CDSENST00000513574ENST00000375300GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
intron-3CDSENST00000513574ENST00000292055GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
intron-5UTRENST00000513574ENST00000375288GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
intron-5UTRENST00000513574ENST00000434315GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
intron-5UTRENST00000513574ENST00000542607GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
intron-5UTRENST00000513574ENST00000446921GUCY1A3chr4

156588571

+SIK3chr11

116827780

-
intron-intronENST00000513574ENST00000488337GUCY1A3chr4

156588571

+SIK3chr11

116827780

-

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FusionProtFeatures for GUCY1A3_SIK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUCY1A3

SIK3

Q9Y2K2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GUCY1A3_SIK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GUCY1A3_SIK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GUCY1A3STUB1, MAPK8, IKBKG, COPS4, TP53, COPS5, CSNK2A1, GUCY1B3, ANKMY2SIK3PRKACA, PRKAA1, YWHAZ, ELAVL1, SMAD2, SMAD3, TAB2, MAP3K7, HDAC5, YWHAQ, YWHAE, YWHAB, YWHAH, SFN, TRAF1, TRIP6, PPP3CA, PPP3CC, SIK1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GUCY1A3_SIK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GUCY1A3_SIK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource