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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1569

FusionGeneSummary for ALPK1_ELP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ALPK1_ELP2
Fusion gene ID: 1569
HgeneTgene
Gene symbol

ALPK1

ELP2

Gene ID

80216

55250

Gene namealpha kinase 1elongator acetyltransferase complex subunit 2
Synonyms8430410J10Rik|LAKMRT58|SHINC-2|STATIP1|StIP
Cytomap

4q25

18q12.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-protein kinase 1chromosome 4 kinaselymphocyte alpha-kinaselymphocyte alpha-protein kinaseelongator complex protein 2STAT3-interacting protein 1elongation protein 2 homologelongator protein 2signal transducer and activator of transcription 3 interacting protein 1
Modification date2018051920180523
UniProtAcc

Q96QP1

Q6IA86

Ensembl transtripts involved in fusion geneENST00000458497, ENST00000177648, 
ENST00000504176, ENST00000505912, 
ENST00000358232, ENST00000351393, 
ENST00000442325, ENST00000423854, 
ENST00000350494, ENST00000542824, 
ENST00000542050, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 2=18
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ALPK1 [Title/Abstract] AND ELP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ359089ALPK1chr4

113252491

+ELP2chr18

33739945

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000458497ENST00000358232ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000458497ENST00000351393ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000458497ENST00000442325ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000458497ENST00000423854ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000458497ENST00000350494ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000458497ENST00000542824ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-intronENST00000458497ENST00000542050ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000177648ENST00000358232ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000177648ENST00000351393ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000177648ENST00000442325ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000177648ENST00000423854ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000177648ENST00000350494ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000177648ENST00000542824ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-intronENST00000177648ENST00000542050ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000504176ENST00000358232ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000504176ENST00000351393ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000504176ENST00000442325ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000504176ENST00000423854ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000504176ENST00000350494ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000504176ENST00000542824ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-intronENST00000504176ENST00000542050ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000505912ENST00000358232ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000505912ENST00000351393ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000505912ENST00000442325ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000505912ENST00000423854ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000505912ENST00000350494ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-3CDSENST00000505912ENST00000542824ALPK1chr4

113252491

+ELP2chr18

33739945

-
intron-intronENST00000505912ENST00000542050ALPK1chr4

113252491

+ELP2chr18

33739945

-

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FusionProtFeatures for ALPK1_ELP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALPK1

Q96QP1

ELP2

Q6IA86

Kinase that recognizes phosphorylation sites in whichthe surrounding peptides have an alpha-helical conformation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ALPK1_ELP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ALPK1_ELP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ALPK1_ELP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ALPK1_ELP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneELP2C3714756Intellectual Disability1CTD_human