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Fusion gene ID: 15688 |
FusionGeneSummary for GUCY1A2_NLK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GUCY1A2_NLK | Fusion gene ID: 15688 | Hgene | Tgene | Gene symbol | GUCY1A2 | NLK | Gene ID | 2977 | 51701 |
| Gene name | guanylate cyclase 1 soluble subunit alpha 2 | nemo like kinase | |
| Synonyms | GC-SA2|GUC1A2 | - | |
| Cytomap | 11q22.3 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanylate cyclase soluble subunit alpha-2GCS-alpha-2guanylate cyclase 1, soluble, alpha 2 | serine/threonine-protein kinase NLK | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P33402 | Q9UBE8 | |
| Ensembl transtripts involved in fusion gene | ENST00000526355, ENST00000282249, ENST00000347596, | ENST00000407008, ENST00000583517, ENST00000582037, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 7 X 4=224 |
| # samples | 2 | 11 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(11/224*10)=-1.02599520853294 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GUCY1A2 [Title/Abstract] AND NLK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NLK | GO:0050821 | protein stabilization | 25512613 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-2F-A9KO-01A | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000526355 | ENST00000407008 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000526355 | ENST00000583517 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000526355 | ENST00000582037 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| In-frame | ENST00000282249 | ENST00000407008 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000282249 | ENST00000583517 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000282249 | ENST00000582037 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| In-frame | ENST00000347596 | ENST00000407008 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000347596 | ENST00000583517 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
| 5CDS-intron | ENST00000347596 | ENST00000582037 | GUCY1A2 | chr11 | 106647165 | - | NLK | chr17 | 26512205 | + |
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FusionProtFeatures for GUCY1A2_NLK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GUCY1A2 | NLK |
| Has guanylyl cyclase on binding to the beta-1 subunit. Isoform 2 acts as a negative regulator of guanylylcyclase activity as it forms non-functional heterodimers with thebeta subunits. | Serine/threonine-protein kinase that regulates a numberof transcription factors with key roles in cell fatedetermination. Positive effector of the non-canonical Wntsignaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 andHIPK2. Activation of this pathway causes binding to andphosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading tomethylation of PPARG target promoters at histone H3K9 andtranscriptional silencing. The resulting loss of PPARG target genetranscription inhibits adipogenesis and promotesosteoblastogenesis in mesenchymal stem cells (MSCs). Negativeregulator of the canonical Wnt/beta-catenin signaling pathway.Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting thedissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, aswell as the ubiquitination and subsequent proteolysis of LEF1.Together these effects inhibit the transcriptional activation ofcanonical Wnt/beta-catenin target genes. Negative regulator of theNotch signaling pathway. Binds to and phosphorylates NOTCH1,thereby preventing the formation of a transcriptionally activeternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negativeregulator of the MYB family of transcription factors.Phosphorylation of MYB leads to its subsequent proteolysis whilephosphorylation of MYBL1 and MYBL2 inhibits their interaction withthe coactivator CREBBP. Other transcription factors may also beinhibited by direct phosphorylation of CREBBP itself. Actsdownstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which isin turn required for activation of NLK by MAP3K7/TAK1. Upon IL1Bstimulus, cooperates with ATF5 to activate the transactivationactivity of C/EBP subfamily members. Phosphorylates ATF5 but alsostabilizes ATF5 protein levels in a kinase-independent manner(PubMed:25512613). {ECO:0000250|UniProtKB:O54949,ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582,ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15764709,ECO:0000269|PubMed:17952062, ECO:0000269|PubMed:20061393,ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444,ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GUCY1A2 | chr11:106647165 | chr17:26512205 | ENST00000282249 | - | 6 | 9 | 51_58 | 612 | 764 | Compositional bias | Note=Poly-Ala |
| Hgene | GUCY1A2 | chr11:106647165 | chr17:26512205 | ENST00000282249 | - | 6 | 9 | 51_76 | 612 | 764 | Compositional bias | Note=Ala-rich |
| Hgene | GUCY1A2 | chr11:106647165 | chr17:26512205 | ENST00000526355 | - | 6 | 8 | 51_58 | 612 | 733 | Compositional bias | Note=Poly-Ala |
| Hgene | GUCY1A2 | chr11:106647165 | chr17:26512205 | ENST00000526355 | - | 6 | 8 | 51_76 | 612 | 733 | Compositional bias | Note=Ala-rich |
| Tgene | >NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 428_527 | 383 | 528 | Region | Required for homodimerization and kinase activation and localization to the nucleus |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GUCY1A2 | chr11:106647165 | chr17:26512205 | ENST00000282249 | - | 6 | 9 | 521_648 | 612 | 764 | Domain | Guanylate cyclase |
| Hgene | >GUCY1A2 | chr11:106647165 | chr17:26512205 | ENST00000526355 | - | 6 | 8 | 521_648 | 612 | 733 | Domain | Guanylate cyclase |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 106_111 | 383 | 528 | Compositional bias | Note=Poly-Ala |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 115_119 | 383 | 528 | Compositional bias | Note=Poly-Ala |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 22_25 | 383 | 528 | Compositional bias | Note=Poly-Ala |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 27_34 | 383 | 528 | Compositional bias | Note=Poly-His |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 42_48 | 383 | 528 | Compositional bias | Note=Poly-His |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 71_83 | 383 | 528 | Compositional bias | Note=Poly-Ala |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 138_427 | 383 | 528 | Domain | Protein kinase |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 298_300 | 383 | 528 | Motif | Note=TQE |
| Tgene | NLK | chr11:106647165 | chr17:26512205 | ENST00000407008 | + | 6 | 11 | 144_152 | 383 | 528 | Nucleotide binding | ATP |
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FusionGeneSequence for GUCY1A2_NLK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GUCY1A2_ENST00000526355_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_757aa MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSL GESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQ VANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATR DVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQPSLPVLYTLSSQATHEAV HLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKG >In-frame_GUCY1A2_ENST00000282249_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_757aa MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSL GESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQ VANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATR DVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQPSLPVLYTLSSQATHEAV HLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKG >In-frame_GUCY1A2_ENST00000347596_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_778aa MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSL GESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQ VANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKSKHVTEGHLTQLSVAGFNSLEVMEVKGQMIHVPESNSILFLGSPCVDK LDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDD VTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGR PIQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GUCY1A2_ENST00000526355_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_2271nt ATGTCTCGAAGGAAGATTTCGTCCGAGTCCTTCAGCTCCCTGGGCTCCGACTACCTGGAGACCAGCCCGGAGGAGGAGGGGGAGTGCCCC CTGTCTAGGCTCTGCTGGAATGGCAGCCGGAGCCCGCCCGGGCCGCTGGAGCCCAGCCCGGCCGCAGCTGCCGCTGCCGCCGCCCCGGCC CCGACCCCGGCTGCTTCTGCCGCCGCCGCCGCTGCCACTGCCGGGGCCAGGAGGGTGCAGCGCCGGAGGCGGGTCAACCTGGACTCGCTG GGCGAGAGCATCAGCCGCCTGACGGCGCCCTCGCCTCAGACGATACAGCAGACTCTCAAGAGGACACTGCAGTATTATGAACATCAAGTT ATTGGTTACAGGGATGCAGAAAAGAATTTCCACAATATCTCTAACAGATGCTCCTATGCAGACCACTCCAACAAAGAAGAAATTGAAGAT GTCTCAGGAATTCTTCAGTGTACTGCTAATATACTCGGTTTGAAGTTTGAGGAAATTCAAAAAAGATTTGGTGAAGAGTTCTTTAATATA TGCTTTCATGAGAATGAGAGAGTCCTTCGAGCTGTAGGTGGCACTTTGCAGGACTTTTTTAACGGCTTTGATGCTTTGTTGGAACACATT AGAACTTCTTTTGGAAAACAGGCCACTCTGGAGTCACCATCTTTCCTATGCAAAGAGCTCCCTGAAGGTACTCTCATGCTCCACTACTTC CACCCTCACCATATTGTGGGGTTTGCAATGCTGGGGATGATTAAGGCTGCAGGAAAGAAGATCTATCGGCTGGATGTGGAAGTGGAACAG GTTGCAAATGAGAAGCTATGCTCTGATGTTTCAAACCCAGGCAATTGTAGCTGTCTTACTTTCCTTATCAAAGAATGTGAAAATACTAAT ATCATGAAGAACCTTCCACAGGGAACCTCCCAAGTTCCTGCGGACCTCAGAATTAGCATCAACACCTTCTGTAGAGCCTTCCCTTTCCAC TTGATGTTTGATCCCAGCATGTCAGTCCTTCAGTTGGGGGAAGGTCTAAGGAAGCAGCTTCGATGTGACACTCACAAAGTGCTCAAGTTT GAGGACTGCTTCGAGATTGTATCTCCAAAGGTTAATGCCACCTTTGAAAGGGTCCTGCTGCGACTGTCTACCCCGTTTGTGATTAGAACC AAGCCTGAGGCTTCTGGCTCTGAAAATAAAGACAAGGTGATGGAAGTCAAAGGACAAATGATCCATGTTCCAGAATCAAATTCCATTTTA TTTTTGGGCTCTCCATGTGTGGACAAGTTGGATGAACTCATGGGCCGAGGGCTACATCTCTCAGACATCCCTATCCATGATGCCACCCGA GATGTCATTTTGGTTGGTGAGCAGGCAAAGGCCCAAGATGGGTTGAAGAAAAGGATGGATAAATTAAAGGCAACTTTAGAAAGAACTCAC CAGGCCCTGGAAGAAGAGAAAAAGAAGACAGTGGATCTTCTATATTCTATTTTCCCTGGTGATGTAGCCCAGCAATTATGGCAAGGGCAG CAAGTACAGGCCAGAAAGTTTGATGATGTCACCATGCTCTTTTCAGACATTGTTGGCTTCACAGCCATATGTGCCCAGTGTACTCCCATG CAAGTAATCAGCATGCTGAATGAACTGTACACCAGATTTGACCACCAGTGTGGATTTTTGGATATTTATAAGGTGGAAACAATAGGTGAT GCCTACTGTGTTGCAGCAGGGCTCCACAGAAAAAGCCTCTGCCATGCTAAACCCATTGCTCTGATGGCCTTGAAGATGATGGAACTTTCA GAAGAGGTGCTGACACCTGATGGAAGACCGATTCAGCCATCTCTTCCTGTACTCTATACCCTGTCTAGCCAGGCTACACATGAAGCTGTT CATCTCCTTTGCAGGATGTTGGTCTTTGATCCATCCAAAAGAATATCCGCTAAGGATGCCTTAGCCCACCCCTACCTAGATGAAGGGCGA CTACGATATCACACATGTATGTGTAAATGTTGCTTTTCCACCTCCACTGGAAGAGTTTATACCAGTGACTTTGAGCCTGTCACCAATCCC AAATTTGATGACACTTTCGAGAAGAACCTCAGTTCTGTCCGACAGGTTAAAGAAATTATTCATCAGTTCATTTTGGAACAGCAGAAAGGA AACAGAGTGCCTCTCTGCATCAACCCTCAGTCTGCTGCTTTTAAGAGCTTTATTAGTTCCACTGTTGCTCAGCCATCTGAGATGCCCCCA >In-frame_GUCY1A2_ENST00000282249_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_2271nt ATGTCTCGAAGGAAGATTTCGTCCGAGTCCTTCAGCTCCCTGGGCTCCGACTACCTGGAGACCAGCCCGGAGGAGGAGGGGGAGTGCCCC CTGTCTAGGCTCTGCTGGAATGGCAGCCGGAGCCCGCCCGGGCCGCTGGAGCCCAGCCCGGCCGCAGCTGCCGCTGCCGCCGCCCCGGCC CCGACCCCGGCTGCTTCTGCCGCCGCCGCCGCTGCCACTGCCGGGGCCAGGAGGGTGCAGCGCCGGAGGCGGGTCAACCTGGACTCGCTG GGCGAGAGCATCAGCCGCCTGACGGCGCCCTCGCCTCAGACGATACAGCAGACTCTCAAGAGGACACTGCAGTATTATGAACATCAAGTT ATTGGTTACAGGGATGCAGAAAAGAATTTCCACAATATCTCTAACAGATGCTCCTATGCAGACCACTCCAACAAAGAAGAAATTGAAGAT GTCTCAGGAATTCTTCAGTGTACTGCTAATATACTCGGTTTGAAGTTTGAGGAAATTCAAAAAAGATTTGGTGAAGAGTTCTTTAATATA TGCTTTCATGAGAATGAGAGAGTCCTTCGAGCTGTAGGTGGCACTTTGCAGGACTTTTTTAACGGCTTTGATGCTTTGTTGGAACACATT AGAACTTCTTTTGGAAAACAGGCCACTCTGGAGTCACCATCTTTCCTATGCAAAGAGCTCCCTGAAGGTACTCTCATGCTCCACTACTTC CACCCTCACCATATTGTGGGGTTTGCAATGCTGGGGATGATTAAGGCTGCAGGAAAGAAGATCTATCGGCTGGATGTGGAAGTGGAACAG GTTGCAAATGAGAAGCTATGCTCTGATGTTTCAAACCCAGGCAATTGTAGCTGTCTTACTTTCCTTATCAAAGAATGTGAAAATACTAAT ATCATGAAGAACCTTCCACAGGGAACCTCCCAAGTTCCTGCGGACCTCAGAATTAGCATCAACACCTTCTGTAGAGCCTTCCCTTTCCAC TTGATGTTTGATCCCAGCATGTCAGTCCTTCAGTTGGGGGAAGGTCTAAGGAAGCAGCTTCGATGTGACACTCACAAAGTGCTCAAGTTT GAGGACTGCTTCGAGATTGTATCTCCAAAGGTTAATGCCACCTTTGAAAGGGTCCTGCTGCGACTGTCTACCCCGTTTGTGATTAGAACC AAGCCTGAGGCTTCTGGCTCTGAAAATAAAGACAAGGTGATGGAAGTCAAAGGACAAATGATCCATGTTCCAGAATCAAATTCCATTTTA TTTTTGGGCTCTCCATGTGTGGACAAGTTGGATGAACTCATGGGCCGAGGGCTACATCTCTCAGACATCCCTATCCATGATGCCACCCGA GATGTCATTTTGGTTGGTGAGCAGGCAAAGGCCCAAGATGGGTTGAAGAAAAGGATGGATAAATTAAAGGCAACTTTAGAAAGAACTCAC CAGGCCCTGGAAGAAGAGAAAAAGAAGACAGTGGATCTTCTATATTCTATTTTCCCTGGTGATGTAGCCCAGCAATTATGGCAAGGGCAG CAAGTACAGGCCAGAAAGTTTGATGATGTCACCATGCTCTTTTCAGACATTGTTGGCTTCACAGCCATATGTGCCCAGTGTACTCCCATG CAAGTAATCAGCATGCTGAATGAACTGTACACCAGATTTGACCACCAGTGTGGATTTTTGGATATTTATAAGGTGGAAACAATAGGTGAT GCCTACTGTGTTGCAGCAGGGCTCCACAGAAAAAGCCTCTGCCATGCTAAACCCATTGCTCTGATGGCCTTGAAGATGATGGAACTTTCA GAAGAGGTGCTGACACCTGATGGAAGACCGATTCAGCCATCTCTTCCTGTACTCTATACCCTGTCTAGCCAGGCTACACATGAAGCTGTT CATCTCCTTTGCAGGATGTTGGTCTTTGATCCATCCAAAAGAATATCCGCTAAGGATGCCTTAGCCCACCCCTACCTAGATGAAGGGCGA CTACGATATCACACATGTATGTGTAAATGTTGCTTTTCCACCTCCACTGGAAGAGTTTATACCAGTGACTTTGAGCCTGTCACCAATCCC AAATTTGATGACACTTTCGAGAAGAACCTCAGTTCTGTCCGACAGGTTAAAGAAATTATTCATCAGTTCATTTTGGAACAGCAGAAAGGA AACAGAGTGCCTCTCTGCATCAACCCTCAGTCTGCTGCTTTTAAGAGCTTTATTAGTTCCACTGTTGCTCAGCCATCTGAGATGCCCCCA >In-frame_GUCY1A2_ENST00000347596_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_2334nt ATGTCTCGAAGGAAGATTTCGTCCGAGTCCTTCAGCTCCCTGGGCTCCGACTACCTGGAGACCAGCCCGGAGGAGGAGGGGGAGTGCCCC CTGTCTAGGCTCTGCTGGAATGGCAGCCGGAGCCCGCCCGGGCCGCTGGAGCCCAGCCCGGCCGCAGCTGCCGCTGCCGCCGCCCCGGCC CCGACCCCGGCTGCTTCTGCCGCCGCCGCCGCTGCCACTGCCGGGGCCAGGAGGGTGCAGCGCCGGAGGCGGGTCAACCTGGACTCGCTG GGCGAGAGCATCAGCCGCCTGACGGCGCCCTCGCCTCAGACGATACAGCAGACTCTCAAGAGGACACTGCAGTATTATGAACATCAAGTT ATTGGTTACAGGGATGCAGAAAAGAATTTCCACAATATCTCTAACAGATGCTCCTATGCAGACCACTCCAACAAAGAAGAAATTGAAGAT GTCTCAGGAATTCTTCAGTGTACTGCTAATATACTCGGTTTGAAGTTTGAGGAAATTCAAAAAAGATTTGGTGAAGAGTTCTTTAATATA TGCTTTCATGAGAATGAGAGAGTCCTTCGAGCTGTAGGTGGCACTTTGCAGGACTTTTTTAACGGCTTTGATGCTTTGTTGGAACACATT AGAACTTCTTTTGGAAAACAGGCCACTCTGGAGTCACCATCTTTCCTATGCAAAGAGCTCCCTGAAGGTACTCTCATGCTCCACTACTTC CACCCTCACCATATTGTGGGGTTTGCAATGCTGGGGATGATTAAGGCTGCAGGAAAGAAGATCTATCGGCTGGATGTGGAAGTGGAACAG GTTGCAAATGAGAAGCTATGCTCTGATGTTTCAAACCCAGGCAATTGTAGCTGTCTTACTTTCCTTATCAAAGAATGTGAAAATACTAAT ATCATGAAGAACCTTCCACAGGGAACCTCCCAAGTTCCTGCGGACCTCAGAATTAGCATCAACACCTTCTGTAGAGCCTTCCCTTTCCAC TTGATGTTTGATCCCAGCATGTCAGTCCTTCAGTTGGGGGAAGGTCTAAGGAAGCAGCTTCGATGTGACACTCACAAAGTGCTCAAGTTT GAGGACTGCTTCGAGATTGTATCTCCAAAGGTTAATGCCACCTTTGAAAGGGTCCTGCTGCGACTGTCTACCCCGTTTGTGATTAGAACC AAGCCTGAGGCTTCTGGCTCTGAAAATAAAGACAAGAGCAAGCATGTCACCGAGGGGCATCTGACGCAGTTATCAGTGGCAGGATTCAAC AGTCTTGAGGTGATGGAAGTCAAAGGACAAATGATCCATGTTCCAGAATCAAATTCCATTTTATTTTTGGGCTCTCCATGTGTGGACAAG TTGGATGAACTCATGGGCCGAGGGCTACATCTCTCAGACATCCCTATCCATGATGCCACCCGAGATGTCATTTTGGTTGGTGAGCAGGCA AAGGCCCAAGATGGGTTGAAGAAAAGGATGGATAAATTAAAGGCAACTTTAGAAAGAACTCACCAGGCCCTGGAAGAAGAGAAAAAGAAG ACAGTGGATCTTCTATATTCTATTTTCCCTGGTGATGTAGCCCAGCAATTATGGCAAGGGCAGCAAGTACAGGCCAGAAAGTTTGATGAT GTCACCATGCTCTTTTCAGACATTGTTGGCTTCACAGCCATATGTGCCCAGTGTACTCCCATGCAAGTAATCAGCATGCTGAATGAACTG TACACCAGATTTGACCACCAGTGTGGATTTTTGGATATTTATAAGGTGGAAACAATAGGTGATGCCTACTGTGTTGCAGCAGGGCTCCAC AGAAAAAGCCTCTGCCATGCTAAACCCATTGCTCTGATGGCCTTGAAGATGATGGAACTTTCAGAAGAGGTGCTGACACCTGATGGAAGA CCGATTCAGCCATCTCTTCCTGTACTCTATACCCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTT GATCCATCCAAAAGAATATCCGCTAAGGATGCCTTAGCCCACCCCTACCTAGATGAAGGGCGACTACGATATCACACATGTATGTGTAAA TGTTGCTTTTCCACCTCCACTGGAAGAGTTTATACCAGTGACTTTGAGCCTGTCACCAATCCCAAATTTGATGACACTTTCGAGAAGAAC CTCAGTTCTGTCCGACAGGTTAAAGAAATTATTCATCAGTTCATTTTGGAACAGCAGAAAGGAAACAGAGTGCCTCTCTGCATCAACCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GUCY1A2_ENST00000526355_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_4485nt GAGGCGGGAGCAGAGAGGGAAAGGGGGCGAGATAGGCGCGCAGGCGGCAGAAGCCTCTGCCTCTGCCTCCCCTTCTGCTTGGGCCGCAGC CCTCCCCGCCCCGCCGACCGCGGTCACACACTCTCGGAGCCTCCCCGTGAGCGGGAGCGCGGCGCACGGCGATGCGCCGAGGCGGGCGCT GAGGCGGCGCCGCGCGAGCAGCAGCAGAGGCGGCGGCGGCCCCCAGCCCAGCCCGGCGCCGCCGCCGAGCCCGGGCCCCAAGGTGCGGCG GCGCCCCAAGTTCCCGCCATGAGCAGCCGGCTCGGGGGGCTCCGCGGCCCCGGGGACTCCCGCCCCGCCGGGCGCGACCGCAGCGCCCCG CGGCCCCGACGCGCTTAACGTTGTCGCTTGCCGGTCCCGCCACCGCCGCCTCCGCCGCCGCTCGCGTCCTCGCCGCCACCGCCTCGGCCG CTGCAGCTCCGCCGGCAGCATGTCTCGAAGGAAGATTTCGTCCGAGTCCTTCAGCTCCCTGGGCTCCGACTACCTGGAGACCAGCCCGGA GGAGGAGGGGGAGTGCCCCCTGTCTAGGCTCTGCTGGAATGGCAGCCGGAGCCCGCCCGGGCCGCTGGAGCCCAGCCCGGCCGCAGCTGC CGCTGCCGCCGCCCCGGCCCCGACCCCGGCTGCTTCTGCCGCCGCCGCCGCTGCCACTGCCGGGGCCAGGAGGGTGCAGCGCCGGAGGCG GGTCAACCTGGACTCGCTGGGCGAGAGCATCAGCCGCCTGACGGCGCCCTCGCCTCAGACGATACAGCAGACTCTCAAGAGGACACTGCA GTATTATGAACATCAAGTTATTGGTTACAGGGATGCAGAAAAGAATTTCCACAATATCTCTAACAGATGCTCCTATGCAGACCACTCCAA CAAAGAAGAAATTGAAGATGTCTCAGGAATTCTTCAGTGTACTGCTAATATACTCGGTTTGAAGTTTGAGGAAATTCAAAAAAGATTTGG TGAAGAGTTCTTTAATATATGCTTTCATGAGAATGAGAGAGTCCTTCGAGCTGTAGGTGGCACTTTGCAGGACTTTTTTAACGGCTTTGA TGCTTTGTTGGAACACATTAGAACTTCTTTTGGAAAACAGGCCACTCTGGAGTCACCATCTTTCCTATGCAAAGAGCTCCCTGAAGGTAC TCTCATGCTCCACTACTTCCACCCTCACCATATTGTGGGGTTTGCAATGCTGGGGATGATTAAGGCTGCAGGAAAGAAGATCTATCGGCT GGATGTGGAAGTGGAACAGGTTGCAAATGAGAAGCTATGCTCTGATGTTTCAAACCCAGGCAATTGTAGCTGTCTTACTTTCCTTATCAA AGAATGTGAAAATACTAATATCATGAAGAACCTTCCACAGGGAACCTCCCAAGTTCCTGCGGACCTCAGAATTAGCATCAACACCTTCTG TAGAGCCTTCCCTTTCCACTTGATGTTTGATCCCAGCATGTCAGTCCTTCAGTTGGGGGAAGGTCTAAGGAAGCAGCTTCGATGTGACAC TCACAAAGTGCTCAAGTTTGAGGACTGCTTCGAGATTGTATCTCCAAAGGTTAATGCCACCTTTGAAAGGGTCCTGCTGCGACTGTCTAC CCCGTTTGTGATTAGAACCAAGCCTGAGGCTTCTGGCTCTGAAAATAAAGACAAGGTGATGGAAGTCAAAGGACAAATGATCCATGTTCC AGAATCAAATTCCATTTTATTTTTGGGCTCTCCATGTGTGGACAAGTTGGATGAACTCATGGGCCGAGGGCTACATCTCTCAGACATCCC TATCCATGATGCCACCCGAGATGTCATTTTGGTTGGTGAGCAGGCAAAGGCCCAAGATGGGTTGAAGAAAAGGATGGATAAATTAAAGGC AACTTTAGAAAGAACTCACCAGGCCCTGGAAGAAGAGAAAAAGAAGACAGTGGATCTTCTATATTCTATTTTCCCTGGTGATGTAGCCCA GCAATTATGGCAAGGGCAGCAAGTACAGGCCAGAAAGTTTGATGATGTCACCATGCTCTTTTCAGACATTGTTGGCTTCACAGCCATATG TGCCCAGTGTACTCCCATGCAAGTAATCAGCATGCTGAATGAACTGTACACCAGATTTGACCACCAGTGTGGATTTTTGGATATTTATAA GGTGGAAACAATAGGTGATGCCTACTGTGTTGCAGCAGGGCTCCACAGAAAAAGCCTCTGCCATGCTAAACCCATTGCTCTGATGGCCTT GAAGATGATGGAACTTTCAGAAGAGGTGCTGACACCTGATGGAAGACCGATTCAGCCATCTCTTCCTGTACTCTATACCCTGTCTAGCCA GGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCATCCAAAAGAATATCCGCTAAGGATGCCTTAGCCCACCC CTACCTAGATGAAGGGCGACTACGATATCACACATGTATGTGTAAATGTTGCTTTTCCACCTCCACTGGAAGAGTTTATACCAGTGACTT TGAGCCTGTCACCAATCCCAAATTTGATGACACTTTCGAGAAGAACCTCAGTTCTGTCCGACAGGTTAAAGAAATTATTCATCAGTTCAT TTTGGAACAGCAGAAAGGAAACAGAGTGCCTCTCTGCATCAACCCTCAGTCTGCTGCTTTTAAGAGCTTTATTAGTTCCACTGTTGCTCA GCCATCTGAGATGCCCCCATCTCCTCTGGTGTGGGAGTGATGGTGGAAGATAATGTACTACTGAAGATGTAATGTAGCTTTCCACTGGAG TCTGGGATTTGCAATTCTGGAGGTTAATCATGCTTGTACTGTAATTTTACTAATGAAGTTTTAAATTAACAACCACTACTTGTATGATAT GAATAATATTTAGAAATGTTACTAGACTTTTAATCTTGTAAAGTGGTTGTGCTTTTAGAAGAAAAATATTTTACCCAGAGTTGCACATGT TTTATGAATTTAGTGCAGCTGTTATGGCTCACCTCAGAACAAAAGAGAATTGAACCAAATTTGGGAGTTTGGGGTTTTATGTTTTGTTTT TCTTTTCTAAAATGAAGTGAGATTGTTCACACACACACACACACACACACACACACACAAACACAAAGGACAGTCATACATTTTGATATT TGAGCCATTCCTAAAGATTTGGGGTTTTCTAAAACTAAAGAATCTAGGAACCTTGCCTGCGACCAATCATGGAGCCACGTGAGCTGATCG TGGCTGCACCTGGGGGGAGGGTAGGGAGGAGGGGCATGCCACCTAATGATCAAGCCCTATAATTAGCTTCTCATTAGAGCCGTGATGGTG ATGTGTGCTGTCTAAAATCCAATGTTGTGGGTAGAGAGAATGAGTTTGTGACTAGGAGAGACTAAACTTTTGTTTTCCTTACCCAGTATA AATATATATATATATATTTAATCTATTTTTATTAGAAGTTTTTCTGCTCTTTCTTACATAAAAGAACCCCAAGCATGCATCTTTCATGTG TGTAAATAATTCATTTCTGGGCTAATTTCAAAAGAATCCCAATATTGCTGTATAGAAAGAGAACTAGCTTGCACATTTTAGGTCTGTGAA ATTTTGTGAGACTTTTCCTGCACTGGACAGTAAAAAAATAATAAAAGACAAAAACAAATTTAAAAAAAAATTTAAGCCACAAAAAAAGGC ACATAGGGAATTATGTCAAATGTGTTTGTGTCCTTAGGCAAAGCTGTGGGAGTCTTGAAATGTCACAGTAGTAAATAACTTATTACTTTT TGACAAGTTCTTTTTTTCTGTTGGAACACTGAATTCTTCTGTGCATATGTACATATGAATACAAATCGAAGGCCTCTACCTCCTGGAGTT ATACAACTTGGCTTGTTTACCTCCACATGCTGATGATGACTATTTTTTTTTTTTGAGTTCAGTGTGGAGACTTGAAACTTGAATGTCCCT TCCAACTTTTATATTAAAAATAAAAAGACAAGAAAATTGAAGATCATTTTTCACCTGTACAAGGAATACTAATGGATCGTCTTAAAATTG GTCTAGGAAAAAACCTTGGTGTGTGTTATGGACAATTAACTGTTAAAGTTATTGTAAGTTATCTGTATTTAGCAGAGTATTTTCAACTTG AGTGATCTGAGCTGAATTTGAAGACTATTAATAAGTTATGTTTGGAAGTTTTAACTTCAATGAAGTAATTATTTGCTGTGAAAGAAACAA ACATTGAATTACTAAACAAAGATGGTGCAATATCTTTGTTTTTTTTTTATGAGGCTCCTGAGAATCAACCCAACTGAAGCATTTCAATTC ACTTGAATGAGAAACGTGTTTAGTATCAAAAGAGCCCAAGAAGACACTGGTGTGAAAGGTACAATCTCAGAGGTTGGTCAATTACCGTGG >In-frame_GUCY1A2_ENST00000282249_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_4406nt TGGGCCGCAGCCCTCCCCGCCCCGCCGACCGCGGTCACACACTCTCGGAGCCTCCCCGTGAGCGGGAGCGCGGCGCACGGCGATGCGCCG AGGCGGGCGCTGAGGCGGCGCCGCGCGAGCAGCAGCAGAGGCGGCGGCGGCCCCCAGCCCAGCCCGGCGCCGCCGCCGAGCCCGGGCCCC AAGGTGCGGCGGCGCCCCAAGTTCCCGCCATGAGCAGCCGGCTCGGGGGGCTCCGCGGCCCCGGGGACTCCCGCCCCGCCGGGCGCGACC GCAGCGCCCCGCGGCCCCGACGCGCTTAACGTTGTCGCTTGCCGGTCCCGCCACCGCCGCCTCCGCCGCCGCTCGCGTCCTCGCCGCCAC CGCCTCGGCCGCTGCAGCTCCGCCGGCAGCATGTCTCGAAGGAAGATTTCGTCCGAGTCCTTCAGCTCCCTGGGCTCCGACTACCTGGAG ACCAGCCCGGAGGAGGAGGGGGAGTGCCCCCTGTCTAGGCTCTGCTGGAATGGCAGCCGGAGCCCGCCCGGGCCGCTGGAGCCCAGCCCG GCCGCAGCTGCCGCTGCCGCCGCCCCGGCCCCGACCCCGGCTGCTTCTGCCGCCGCCGCCGCTGCCACTGCCGGGGCCAGGAGGGTGCAG CGCCGGAGGCGGGTCAACCTGGACTCGCTGGGCGAGAGCATCAGCCGCCTGACGGCGCCCTCGCCTCAGACGATACAGCAGACTCTCAAG AGGACACTGCAGTATTATGAACATCAAGTTATTGGTTACAGGGATGCAGAAAAGAATTTCCACAATATCTCTAACAGATGCTCCTATGCA GACCACTCCAACAAAGAAGAAATTGAAGATGTCTCAGGAATTCTTCAGTGTACTGCTAATATACTCGGTTTGAAGTTTGAGGAAATTCAA AAAAGATTTGGTGAAGAGTTCTTTAATATATGCTTTCATGAGAATGAGAGAGTCCTTCGAGCTGTAGGTGGCACTTTGCAGGACTTTTTT AACGGCTTTGATGCTTTGTTGGAACACATTAGAACTTCTTTTGGAAAACAGGCCACTCTGGAGTCACCATCTTTCCTATGCAAAGAGCTC CCTGAAGGTACTCTCATGCTCCACTACTTCCACCCTCACCATATTGTGGGGTTTGCAATGCTGGGGATGATTAAGGCTGCAGGAAAGAAG ATCTATCGGCTGGATGTGGAAGTGGAACAGGTTGCAAATGAGAAGCTATGCTCTGATGTTTCAAACCCAGGCAATTGTAGCTGTCTTACT TTCCTTATCAAAGAATGTGAAAATACTAATATCATGAAGAACCTTCCACAGGGAACCTCCCAAGTTCCTGCGGACCTCAGAATTAGCATC AACACCTTCTGTAGAGCCTTCCCTTTCCACTTGATGTTTGATCCCAGCATGTCAGTCCTTCAGTTGGGGGAAGGTCTAAGGAAGCAGCTT CGATGTGACACTCACAAAGTGCTCAAGTTTGAGGACTGCTTCGAGATTGTATCTCCAAAGGTTAATGCCACCTTTGAAAGGGTCCTGCTG CGACTGTCTACCCCGTTTGTGATTAGAACCAAGCCTGAGGCTTCTGGCTCTGAAAATAAAGACAAGGTGATGGAAGTCAAAGGACAAATG ATCCATGTTCCAGAATCAAATTCCATTTTATTTTTGGGCTCTCCATGTGTGGACAAGTTGGATGAACTCATGGGCCGAGGGCTACATCTC TCAGACATCCCTATCCATGATGCCACCCGAGATGTCATTTTGGTTGGTGAGCAGGCAAAGGCCCAAGATGGGTTGAAGAAAAGGATGGAT AAATTAAAGGCAACTTTAGAAAGAACTCACCAGGCCCTGGAAGAAGAGAAAAAGAAGACAGTGGATCTTCTATATTCTATTTTCCCTGGT GATGTAGCCCAGCAATTATGGCAAGGGCAGCAAGTACAGGCCAGAAAGTTTGATGATGTCACCATGCTCTTTTCAGACATTGTTGGCTTC ACAGCCATATGTGCCCAGTGTACTCCCATGCAAGTAATCAGCATGCTGAATGAACTGTACACCAGATTTGACCACCAGTGTGGATTTTTG GATATTTATAAGGTGGAAACAATAGGTGATGCCTACTGTGTTGCAGCAGGGCTCCACAGAAAAAGCCTCTGCCATGCTAAACCCATTGCT CTGATGGCCTTGAAGATGATGGAACTTTCAGAAGAGGTGCTGACACCTGATGGAAGACCGATTCAGCCATCTCTTCCTGTACTCTATACC CTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCATCCAAAAGAATATCCGCTAAGGATGCC TTAGCCCACCCCTACCTAGATGAAGGGCGACTACGATATCACACATGTATGTGTAAATGTTGCTTTTCCACCTCCACTGGAAGAGTTTAT ACCAGTGACTTTGAGCCTGTCACCAATCCCAAATTTGATGACACTTTCGAGAAGAACCTCAGTTCTGTCCGACAGGTTAAAGAAATTATT CATCAGTTCATTTTGGAACAGCAGAAAGGAAACAGAGTGCCTCTCTGCATCAACCCTCAGTCTGCTGCTTTTAAGAGCTTTATTAGTTCC ACTGTTGCTCAGCCATCTGAGATGCCCCCATCTCCTCTGGTGTGGGAGTGATGGTGGAAGATAATGTACTACTGAAGATGTAATGTAGCT TTCCACTGGAGTCTGGGATTTGCAATTCTGGAGGTTAATCATGCTTGTACTGTAATTTTACTAATGAAGTTTTAAATTAACAACCACTAC TTGTATGATATGAATAATATTTAGAAATGTTACTAGACTTTTAATCTTGTAAAGTGGTTGTGCTTTTAGAAGAAAAATATTTTACCCAGA GTTGCACATGTTTTATGAATTTAGTGCAGCTGTTATGGCTCACCTCAGAACAAAAGAGAATTGAACCAAATTTGGGAGTTTGGGGTTTTA TGTTTTGTTTTTCTTTTCTAAAATGAAGTGAGATTGTTCACACACACACACACACACACACACACACACAAACACAAAGGACAGTCATAC ATTTTGATATTTGAGCCATTCCTAAAGATTTGGGGTTTTCTAAAACTAAAGAATCTAGGAACCTTGCCTGCGACCAATCATGGAGCCACG TGAGCTGATCGTGGCTGCACCTGGGGGGAGGGTAGGGAGGAGGGGCATGCCACCTAATGATCAAGCCCTATAATTAGCTTCTCATTAGAG CCGTGATGGTGATGTGTGCTGTCTAAAATCCAATGTTGTGGGTAGAGAGAATGAGTTTGTGACTAGGAGAGACTAAACTTTTGTTTTCCT TACCCAGTATAAATATATATATATATATTTAATCTATTTTTATTAGAAGTTTTTCTGCTCTTTCTTACATAAAAGAACCCCAAGCATGCA TCTTTCATGTGTGTAAATAATTCATTTCTGGGCTAATTTCAAAAGAATCCCAATATTGCTGTATAGAAAGAGAACTAGCTTGCACATTTT AGGTCTGTGAAATTTTGTGAGACTTTTCCTGCACTGGACAGTAAAAAAATAATAAAAGACAAAAACAAATTTAAAAAAAAATTTAAGCCA CAAAAAAAGGCACATAGGGAATTATGTCAAATGTGTTTGTGTCCTTAGGCAAAGCTGTGGGAGTCTTGAAATGTCACAGTAGTAAATAAC TTATTACTTTTTGACAAGTTCTTTTTTTCTGTTGGAACACTGAATTCTTCTGTGCATATGTACATATGAATACAAATCGAAGGCCTCTAC CTCCTGGAGTTATACAACTTGGCTTGTTTACCTCCACATGCTGATGATGACTATTTTTTTTTTTTGAGTTCAGTGTGGAGACTTGAAACT TGAATGTCCCTTCCAACTTTTATATTAAAAATAAAAAGACAAGAAAATTGAAGATCATTTTTCACCTGTACAAGGAATACTAATGGATCG TCTTAAAATTGGTCTAGGAAAAAACCTTGGTGTGTGTTATGGACAATTAACTGTTAAAGTTATTGTAAGTTATCTGTATTTAGCAGAGTA TTTTCAACTTGAGTGATCTGAGCTGAATTTGAAGACTATTAATAAGTTATGTTTGGAAGTTTTAACTTCAATGAAGTAATTATTTGCTGT GAAAGAAACAAACATTGAATTACTAAACAAAGATGGTGCAATATCTTTGTTTTTTTTTTATGAGGCTCCTGAGAATCAACCCAACTGAAG CATTTCAATTCACTTGAATGAGAAACGTGTTTAGTATCAAAAGAGCCCAAGAAGACACTGGTGTGAAAGGTACAATCTCAGAGGTTGGTC >In-frame_GUCY1A2_ENST00000347596_chr11_106647165_-_NLK_ENST00000407008_chr17_26512205_+_4175nt CTTAACGTTGTCGCTTGCCGGTCCCGCCACCGCCGCCTCCGCCGCCGCTCGCGTCCTCGCCGCCACCGCCTCGGCCGCTGCAGCTCCGCC GGCAGCATGTCTCGAAGGAAGATTTCGTCCGAGTCCTTCAGCTCCCTGGGCTCCGACTACCTGGAGACCAGCCCGGAGGAGGAGGGGGAG TGCCCCCTGTCTAGGCTCTGCTGGAATGGCAGCCGGAGCCCGCCCGGGCCGCTGGAGCCCAGCCCGGCCGCAGCTGCCGCTGCCGCCGCC CCGGCCCCGACCCCGGCTGCTTCTGCCGCCGCCGCCGCTGCCACTGCCGGGGCCAGGAGGGTGCAGCGCCGGAGGCGGGTCAACCTGGAC TCGCTGGGCGAGAGCATCAGCCGCCTGACGGCGCCCTCGCCTCAGACGATACAGCAGACTCTCAAGAGGACACTGCAGTATTATGAACAT CAAGTTATTGGTTACAGGGATGCAGAAAAGAATTTCCACAATATCTCTAACAGATGCTCCTATGCAGACCACTCCAACAAAGAAGAAATT GAAGATGTCTCAGGAATTCTTCAGTGTACTGCTAATATACTCGGTTTGAAGTTTGAGGAAATTCAAAAAAGATTTGGTGAAGAGTTCTTT AATATATGCTTTCATGAGAATGAGAGAGTCCTTCGAGCTGTAGGTGGCACTTTGCAGGACTTTTTTAACGGCTTTGATGCTTTGTTGGAA CACATTAGAACTTCTTTTGGAAAACAGGCCACTCTGGAGTCACCATCTTTCCTATGCAAAGAGCTCCCTGAAGGTACTCTCATGCTCCAC TACTTCCACCCTCACCATATTGTGGGGTTTGCAATGCTGGGGATGATTAAGGCTGCAGGAAAGAAGATCTATCGGCTGGATGTGGAAGTG GAACAGGTTGCAAATGAGAAGCTATGCTCTGATGTTTCAAACCCAGGCAATTGTAGCTGTCTTACTTTCCTTATCAAAGAATGTGAAAAT ACTAATATCATGAAGAACCTTCCACAGGGAACCTCCCAAGTTCCTGCGGACCTCAGAATTAGCATCAACACCTTCTGTAGAGCCTTCCCT TTCCACTTGATGTTTGATCCCAGCATGTCAGTCCTTCAGTTGGGGGAAGGTCTAAGGAAGCAGCTTCGATGTGACACTCACAAAGTGCTC AAGTTTGAGGACTGCTTCGAGATTGTATCTCCAAAGGTTAATGCCACCTTTGAAAGGGTCCTGCTGCGACTGTCTACCCCGTTTGTGATT AGAACCAAGCCTGAGGCTTCTGGCTCTGAAAATAAAGACAAGAGCAAGCATGTCACCGAGGGGCATCTGACGCAGTTATCAGTGGCAGGA TTCAACAGTCTTGAGGTGATGGAAGTCAAAGGACAAATGATCCATGTTCCAGAATCAAATTCCATTTTATTTTTGGGCTCTCCATGTGTG GACAAGTTGGATGAACTCATGGGCCGAGGGCTACATCTCTCAGACATCCCTATCCATGATGCCACCCGAGATGTCATTTTGGTTGGTGAG CAGGCAAAGGCCCAAGATGGGTTGAAGAAAAGGATGGATAAATTAAAGGCAACTTTAGAAAGAACTCACCAGGCCCTGGAAGAAGAGAAA AAGAAGACAGTGGATCTTCTATATTCTATTTTCCCTGGTGATGTAGCCCAGCAATTATGGCAAGGGCAGCAAGTACAGGCCAGAAAGTTT GATGATGTCACCATGCTCTTTTCAGACATTGTTGGCTTCACAGCCATATGTGCCCAGTGTACTCCCATGCAAGTAATCAGCATGCTGAAT GAACTGTACACCAGATTTGACCACCAGTGTGGATTTTTGGATATTTATAAGGTGGAAACAATAGGTGATGCCTACTGTGTTGCAGCAGGG CTCCACAGAAAAAGCCTCTGCCATGCTAAACCCATTGCTCTGATGGCCTTGAAGATGATGGAACTTTCAGAAGAGGTGCTGACACCTGAT GGAAGACCGATTCAGCCATCTCTTCCTGTACTCTATACCCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTG GTCTTTGATCCATCCAAAAGAATATCCGCTAAGGATGCCTTAGCCCACCCCTACCTAGATGAAGGGCGACTACGATATCACACATGTATG TGTAAATGTTGCTTTTCCACCTCCACTGGAAGAGTTTATACCAGTGACTTTGAGCCTGTCACCAATCCCAAATTTGATGACACTTTCGAG AAGAACCTCAGTTCTGTCCGACAGGTTAAAGAAATTATTCATCAGTTCATTTTGGAACAGCAGAAAGGAAACAGAGTGCCTCTCTGCATC AACCCTCAGTCTGCTGCTTTTAAGAGCTTTATTAGTTCCACTGTTGCTCAGCCATCTGAGATGCCCCCATCTCCTCTGGTGTGGGAGTGA TGGTGGAAGATAATGTACTACTGAAGATGTAATGTAGCTTTCCACTGGAGTCTGGGATTTGCAATTCTGGAGGTTAATCATGCTTGTACT GTAATTTTACTAATGAAGTTTTAAATTAACAACCACTACTTGTATGATATGAATAATATTTAGAAATGTTACTAGACTTTTAATCTTGTA AAGTGGTTGTGCTTTTAGAAGAAAAATATTTTACCCAGAGTTGCACATGTTTTATGAATTTAGTGCAGCTGTTATGGCTCACCTCAGAAC AAAAGAGAATTGAACCAAATTTGGGAGTTTGGGGTTTTATGTTTTGTTTTTCTTTTCTAAAATGAAGTGAGATTGTTCACACACACACAC ACACACACACACACACACAAACACAAAGGACAGTCATACATTTTGATATTTGAGCCATTCCTAAAGATTTGGGGTTTTCTAAAACTAAAG AATCTAGGAACCTTGCCTGCGACCAATCATGGAGCCACGTGAGCTGATCGTGGCTGCACCTGGGGGGAGGGTAGGGAGGAGGGGCATGCC ACCTAATGATCAAGCCCTATAATTAGCTTCTCATTAGAGCCGTGATGGTGATGTGTGCTGTCTAAAATCCAATGTTGTGGGTAGAGAGAA TGAGTTTGTGACTAGGAGAGACTAAACTTTTGTTTTCCTTACCCAGTATAAATATATATATATATATTTAATCTATTTTTATTAGAAGTT TTTCTGCTCTTTCTTACATAAAAGAACCCCAAGCATGCATCTTTCATGTGTGTAAATAATTCATTTCTGGGCTAATTTCAAAAGAATCCC AATATTGCTGTATAGAAAGAGAACTAGCTTGCACATTTTAGGTCTGTGAAATTTTGTGAGACTTTTCCTGCACTGGACAGTAAAAAAATA ATAAAAGACAAAAACAAATTTAAAAAAAAATTTAAGCCACAAAAAAAGGCACATAGGGAATTATGTCAAATGTGTTTGTGTCCTTAGGCA AAGCTGTGGGAGTCTTGAAATGTCACAGTAGTAAATAACTTATTACTTTTTGACAAGTTCTTTTTTTCTGTTGGAACACTGAATTCTTCT GTGCATATGTACATATGAATACAAATCGAAGGCCTCTACCTCCTGGAGTTATACAACTTGGCTTGTTTACCTCCACATGCTGATGATGAC TATTTTTTTTTTTTGAGTTCAGTGTGGAGACTTGAAACTTGAATGTCCCTTCCAACTTTTATATTAAAAATAAAAAGACAAGAAAATTGA AGATCATTTTTCACCTGTACAAGGAATACTAATGGATCGTCTTAAAATTGGTCTAGGAAAAAACCTTGGTGTGTGTTATGGACAATTAAC TGTTAAAGTTATTGTAAGTTATCTGTATTTAGCAGAGTATTTTCAACTTGAGTGATCTGAGCTGAATTTGAAGACTATTAATAAGTTATG TTTGGAAGTTTTAACTTCAATGAAGTAATTATTTGCTGTGAAAGAAACAAACATTGAATTACTAAACAAAGATGGTGCAATATCTTTGTT TTTTTTTTATGAGGCTCCTGAGAATCAACCCAACTGAAGCATTTCAATTCACTTGAATGAGAAACGTGTTTAGTATCAAAAGAGCCCAAG AAGACACTGGTGTGAAAGGTACAATCTCAGAGGTTGGTCAATTACCGTGGCACACTTTCTGGTCACTTTGTACAATGTAGATTTGAAGTA |
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FusionGenePPI for GUCY1A2_NLK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GUCY1A2 | GUCY1B3, DLG1, DLG2, DLG3, DLG4, STUB1, HSPA4, HSP90AA1, ERBB2IP, SNTA1, LIN7A, SCRIB | NLK | LEF1, CTNNB1, TCF7L2, FBXW4, FBXW5, SKP2, CUL1, MYB, HIPK2, MYBL1, MYBL2, CREBBP, FOXO4, FOXO1, FOXO3, ASGR1, ELAVL1, USP4, ATXN1, TAB2, MAP3K7, NLK, SMAD4, RCHY1, SDR16C5, KPNB1, RANBP2, C2orf44, FAM222B, FAM222A, RNF219, TNKS1BP1, SKI, RANGAP1, TLE3, CEP97, PASK, CNOT2, CCP110, UBAP2L, TRPS1, CNOT11, BACH1, CNOT3, SHANK2, PKM, TP53, MDM2, GRN, KRTAP5-9, ZHX3, QRICH1, KRTAP4-2, KRTAP10-3, KRTAP5-6, STAT5A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GUCY1A2_NLK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GUCY1A2 | P33402 | DB00435 | Nitric Oxide | Guanylate cyclase soluble subunit alpha-2 | small molecule | approved |
| Hgene | GUCY1A2 | P33402 | DB01020 | Isosorbide Mononitrate | Guanylate cyclase soluble subunit alpha-2 | small molecule | approved |
| Hgene | GUCY1A2 | P33402 | DB08931 | Riociguat | Guanylate cyclase soluble subunit alpha-2 | small molecule | approved |
| Hgene | GUCY1A2 | P33402 | DB09241 | Methylene blue | Guanylate cyclase soluble subunit alpha-2 | small molecule | approved|investigational |
| Hgene | GUCY1A2 | P33402 | DB09282 | Molsidomine | Guanylate cyclase soluble subunit alpha-2 | small molecule | approved|investigational |
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RelatedDiseases for GUCY1A2_NLK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GUCY1A2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Hgene | GUCY1A2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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