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Fusion gene ID: 15674 |
FusionGeneSummary for GTPBP2_USP49 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GTPBP2_USP49 | Fusion gene ID: 15674 | Hgene | Tgene | Gene symbol | GTPBP2 | USP49 | Gene ID | 54676 | 25862 |
| Gene name | GTP binding protein 2 | ubiquitin specific peptidase 49 | |
| Synonyms | - | - | |
| Cytomap | 6p21.1 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GTP-binding protein 2 | ubiquitin carboxyl-terminal hydrolase 49deubiquitinating enzyme 49ubiquitin specific protease 49ubiquitin thioesterase 49ubiquitin thiolesterase 49ubiquitin-specific-processing protease 49 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BX10 | Q70CQ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000476510, ENST00000307126, ENST00000307114, | ENST00000394253, ENST00000373010, ENST00000373006, ENST00000297229, ENST00000373009, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 4 X 2 X 4=32 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GTPBP2 [Title/Abstract] AND USP49 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | USP49 | GO:0016579 | protein deubiquitination | 14715245 |
| Tgene | USP49 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination | 23824326 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A2MR-06A | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000476510 | ENST00000394253 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| 5UTR-3CDS | ENST00000476510 | ENST00000373010 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| 5UTR-3CDS | ENST00000476510 | ENST00000373006 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| 5UTR-3CDS | ENST00000476510 | ENST00000297229 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| 5UTR-3CDS | ENST00000476510 | ENST00000373009 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| Frame-shift | ENST00000307126 | ENST00000394253 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| Frame-shift | ENST00000307126 | ENST00000373010 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| Frame-shift | ENST00000307126 | ENST00000373006 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| Frame-shift | ENST00000307126 | ENST00000297229 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| Frame-shift | ENST00000307126 | ENST00000373009 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| In-frame | ENST00000307114 | ENST00000394253 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| In-frame | ENST00000307114 | ENST00000373010 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| In-frame | ENST00000307114 | ENST00000373006 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| In-frame | ENST00000307114 | ENST00000297229 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
| In-frame | ENST00000307114 | ENST00000373009 | GTPBP2 | chr6 | 43593493 | - | USP49 | chr6 | 41766667 | - |
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FusionProtFeatures for GTPBP2_USP49 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GTPBP2 | USP49 |
| Specifically deubiquitinates histone H2B at 'Lys-120'(H2BK120Ub). H2BK120Ub is a specific tag for epigenetictranscriptional activation and acts as a regulator of mRNAsplicing. Deubiquitination is required for efficientcotranscriptional splicing of a large set of exons.{ECO:0000269|PubMed:23824326}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GTPBP2_USP49 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000394253_chr6_41766667_-_213aa MKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQVVWPXSSRE DWGPCRLXPGINHGTLLLQGHALLSXQRDLCLXSLRSGHASRERVWLRTLHSLLLQHRGRFLGPLQXLKAECMQCRGSVQNPGLHPFLHS >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373010_chr6_41766667_-_110aa MKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQVVWPXSSRE >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373006_chr6_41766667_-_165aa MKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQVVWPXSSRE >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000297229_chr6_41766667_-_165aa MKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQVVWPXSSRE >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373009_chr6_41766667_-_213aa MKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQVVWPXSSRE DWGPCRLXPGINHGTLLLQGHALLSXQRDLCLXSLRSGHASRERVWLRTLHSLLLQHRGRFLGPLQXLKAECMQCRGSVQNPGLHPFLHS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000394253_chr6_41766667_-_640nt ATGAAGTGGCGGCTCCAGGAGGGACGTGGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAG GAAATGCGAGCTTCGCTCAAGACCCTGCACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTAT GATAGCGACATGCCCCGGAAGATCACCGAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAA GATTGGGGTCCATGTCGTCTTTGACCAGGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTT TGCCTATGATCTCTCCGCAGTGGTCATGCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGG TTTTTGGGTCCACTGCAATGACTCAAAGCTGAATGTATGCAGTGTCGAGGAAGTGTGCAAAACCCAGGCCTACATCCTTTTTTACACTCA AAGAACAGTGCAGGGCAATGCAAGAATCTCAGAAACCCATCTCCAAGCTCAGGTGCAGTCCAGCAACAATGATGAAGGCAGACCACAGAC >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373010_chr6_41766667_-_331nt ATGAAGTGGCGGCTCCAGGAGGGACGTGGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAG GAAATGCGAGCTTCGCTCAAGACCCTGCACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTAT GATAGCGACATGCCCCGGAAGATCACCGAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAA >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373006_chr6_41766667_-_496nt ATGAAGTGGCGGCTCCAGGAGGGACGTGGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAG GAAATGCGAGCTTCGCTCAAGACCCTGCACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTAT GATAGCGACATGCCCCGGAAGATCACCGAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAA GATTGGGGTCCATGTCGTCTTTGACCAGGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTT TGCCTATGATCTCTCCGCAGTGGTCATGCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGG >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000297229_chr6_41766667_-_496nt ATGAAGTGGCGGCTCCAGGAGGGACGTGGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAG GAAATGCGAGCTTCGCTCAAGACCCTGCACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTAT GATAGCGACATGCCCCGGAAGATCACCGAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAA GATTGGGGTCCATGTCGTCTTTGACCAGGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTT TGCCTATGATCTCTCCGCAGTGGTCATGCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGG >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373009_chr6_41766667_-_640nt ATGAAGTGGCGGCTCCAGGAGGGACGTGGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAG GAAATGCGAGCTTCGCTCAAGACCCTGCACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTAT GATAGCGACATGCCCCGGAAGATCACCGAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAA GATTGGGGTCCATGTCGTCTTTGACCAGGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTT TGCCTATGATCTCTCCGCAGTGGTCATGCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGG TTTTTGGGTCCACTGCAATGACTCAAAGCTGAATGTATGCAGTGTCGAGGAAGTGTGCAAAACCCAGGCCTACATCCTTTTTTACACTCA AAGAACAGTGCAGGGCAATGCAAGAATCTCAGAAACCCATCTCCAAGCTCAGGTGCAGTCCAGCAACAATGATGAAGGCAGACCACAGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000394253_chr6_41766667_-_7430nt GTTTCCTAGACCAGTGACAAAGAAAGGTTTTAACAGCCTGGGCACAGAGGAGACATAGACTTCTGGGAAAAGCAGGCTGAAGATGGAAAC ATTGAATATAAATTGAAGCTGGTGAATCCATCCCAGTACCGCTTTGAGCACCTGGTGACACAAATGAAGTGGCGGCTCCAGGAGGGACGT GGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAGGAAATGCGAGCTTCGCTCAAGACCCTG CACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTATGATAGCGACATGCCCCGGAAGATCACC GAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCA GGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTTTGCCTATGATCTCTCCGCAGTGGTCAT GCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGGTTTTTGGGTCCACTGCAATGACTCAAA GCTGAATGTATGCAGTGTCGAGGAAGTGTGCAAAACCCAGGCCTACATCCTTTTTTACACTCAAAGAACAGTGCAGGGCAATGCAAGAAT CTCAGAAACCCATCTCCAAGCTCAGGTGCAGTCCAGCAACAATGATGAAGGCAGACCACAGACATTTTCCTGAATGGGAGGCATGTATCA AAGACTGGCTTTTGTGTATTGGTGTCCATACATCTTTCCTCTTATAGGAAATAAGGCTACTGCAGGAACAGATTACTAGGTTTGCCTTGC TGGGTCTAGAGTAGAAGGTGCCAGGTGATTCGTGTCCTGTCGTAAATTTTATAGTCTCTTTCTTTTGAATGAGTTTGGGAGTTCCCTCCT TTCCTAAAAACAAAAGAAGTAACTTCTATGAAGATCCTTTCATCAGTTGCTTCTGAATATAGAGGGATCTGGGTGGAGGAAAGCGGGGCG GGGGGGTAAATCAATCATATCCACACAGGAGAGCAGCCATGTTTTCTCTCCATGATGTGATTCCCCTGCTAATCAGGACCTCCTTGCAGC ACCAGAAGAACCCTCCGGATGTGAGCAGTCCTGGACAGAGCACGTGAGGAGGGGCCCTGGGCTAGCAGTTTGCTGGATGGGATTGGCTCC AAGATGGGAGATGAAGTCTAAAGGGTTTATTCCCACAAAGGAAGTAACCTTCAAGGGTTTAAAACAAACTTCCTTTTTTGGGGATAGCAG CTGAAGAGTGGAGTGAGATGCATGGAACAAATTTCCCCATGCAAAGTGGGATGGTTTTCATATGTCATACCCTCCCTACTTGCTGCTGTC ATATAATCATTCCATACTTCTGAGACTGGCATGAATACCCCTTCATTCTAAAGAAGGGGCAGGTCATATAAAGAAGCAATAGACTAGCAC ATGTTCCATGCTGAGCCAAAGGACACTCCTGGCTATCTCAGTTCTGTAGCAGATCCCTGGTTCAGGTCTAGGGCAAGCACATGGTTTGGT TTAAATTGATTCTTAGGTTTTCTCAGAACTCAATTGAGGGTGGGCAGAGATAGCTGATGCTCCAGGGCTTATTGAAGGCCTGTCACCCGT TCTCACTTCAGTGCGGCATGCAGCTTCTTAGCCTGCAGCTTCTTTCTTGCTCCTGGAGAGCTAGAACATTCATGTTCACAGGGTTTGGGA GCTTTTGGTTCTCTAGGGTATGTTAACTGCTTAGGAGTCCACCTCGTACATATCTGAAGAGTTGATTACCAATGGCCTTGACCTGTTTCC TCCCAAATCTGATAATCCCTACTGTTGCTTTACCCCCCATACTCAGTCCATCAGAGAAAAAAACAAGAGTGCCCCGTCCTTTCCCCCAGT GCTAGTAAAATACATCTTCCTTTTTAAATTGGGTCAGTTTCTAAACAGAATGAAATTGCCCAGATAAAAACCCTTGTCCCCATCAGGCAC CACTTCATTCTTAGTTCTTCACTTAGATTTGCTGGTGAAAGTGAATGCAAACCCTAACTTTTGTTGCTGTGGTCACTGCAGTGAGCCTCA CTCAACCTGTCACTATGAATGCTCATCTTTTGACTGAGTATATCATATTAATGTTTGAATTCAGGTAGAAGTACAGTTGTCACTTGAAGG GAGTAGATGTGGAAGGGCGTTCGGGGAGGAGTGGGAAGTGGGGAAAGCCAGGCTAAAGAATGAGGGTTATAGCTTTAGCAATGTTGATGA GCCACATTTCCCACACAGATCTGTAGCATTTGCTGTTGACCTCTTTTGAGATGAACTCTCCCATAGGCCCTGCCAGGCAGCACTGAGACA TGGAGGAAATTCAGACAAAAAATGGCTCACCCTGATAGGGAAGGAGTGACTATATTTTAAATTAAACTTGCTTTTTCCAACACTGTGAGG TTTCTGTAATATTTAGCTTTTATTTGGAAGCGATAGCGTATGGCATTTTTTATGCTGTTTGGTTTATATTGTCTACTGCAGGCTTCTTTG TATAAGCTTTGCCTGGGCTCACCCTCTCCTGGACACTGTTTTAAAGTGTCACCGCTGTCCATGCTGCCAGAGGCTCTGATGTGAAGCTGT ACTCTCAAGATCCACGTTTTTAAGTCGGCATGATTAGTAATGACTTTTTGTGGCAATAGAAAAGCCCATTAACTCAAAAAAACCAAGGAG AGTAAAAAGGAAAGGAAACTATGAATCGTGCCTCATCTTTCATTGAATCCTATATTTATTATTCTAGAAAAAAAGAACTTACAAGATAGA GAAGAACTAATAGAGCATCTACTTTACCCCTCAGGCTGTCCAGTGGGGATAATTATTAATAAACATTTAATGGAAAATTCAAAGATCTTC CAATTTAATTTTTAAAAATAGTTTTATACCAAATATTATAAGGATTTATTAAGCAGATTAAGGACTTTGTGAAATAAGTGCTTAACTTAG CTGAGCACGCATATATCAAAGTAATAAAAGAAACTAACATCAGAGTCTCCACTGAGCTACACATTTGTGAAAGGTGCCCACTGCAGTTAC AGACACCTCAGGTACCCAGAGGCGGCAGCACTGGACACTTAGGACGTTAGTATTTAAGGAGATTTTTATTAAAGAAGAGTTCCCTGCTGC ATAAGCCAATGGCTATTGTGAGGGAAATGTCCCTTTGCCTTTAATTTATTTACGTACTGGGTATAGATGAATGTCTCAGTTGCATCTGAA ATTGAATCATTCTAAAGAGAAGAAAATAAGAACCAGGTAAAAACTGACTAGATGCTGCCAAATCAAACCCAAGGTCTCCTAACCGAACCT TAATGGGCCTGCTTCTCTCCCAGGGCAAGTAGTTAAGAGTCTCATTCCAGGAACCCTTTGTAGTTAGTTGGCTGGCATGTTTACTTGCTG CTGTAGCCAGCCAAGATGAGTGCACCTAGGCCCTCAAAAAGGATTTTTTTTTACCTCAATCTAGCCTGACCCTCATATCTGTGGTTGCCT CTGAGACGAACATCCATGCTAGTATAAAAATAGTTAGGAATGCCCTTGGCAGAACTGAAGCTCTTATTAAATGGTGGACAGAGCTCTTGC CAGCTTTGATCCAGCCCCTCAGTCTCGGAGTTATGGGGCAGGGTTGGGGGGCAGTGCTACACTGTAAAGAATTTCCAGGCTGGGCGCGGT GGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGAGGGCGGATCACAAGGTCAAGAGATTGAGATCATCCTGGCCAACATGGTGA AACTCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAA TCGCTGGAACCCAGGAGGCAGAAGGGGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGCGACAGAGCGAGACTCTGTCTTAAAA AAAAAACAAAAACAAAAACAAAAAAAAAAAAAGAATTTCCAGATGTCTCTTAAAATGTCATGAATAAAATTGGAAACTGTAGAAGTGTTA ATGTGTCCTATGGACTCAATAGCAGAGTTTATTTTTGTTTTTAATGGCAAGGCTTCTAGAGTCAATGATTGTATGAGTTTGCTACTCTGG CTGTGCTTACAGCTTCATCCAAGTACAAGGGAAGAACCAATGAGGTGGATTGGCTGACAGTGGGGCATGCCCCAGCATAAGCCCTAGAGA GGTCGACAGTAGTGCAGAATGAAAACTTGGTCGGGGATGGCGGGTGGTGGGTGGGAGGAGGGTGGGCTGGCCGGGAGGGAGAAATGGAGT TTGTTCTACTTACTGATAAAGCTTTGTGAACTAATTTTATACAATTCATAAAATTTGGTGCCTTGTACTCAATTACGGTTTGCATGGAAT TGAAAAGATTAAGGGAAAGGATTTCTTCTTGTCATTTCAAGTGGCAAATGGGTCTGTGTAGTGTTTAAAGGACATCTGGTATCACAGACT TTTAAAAAGCATTTCATGTCTCTTGTGTGTGAATGCAAATTATTCTTACCAGCAAGTTCTGAAATTATGTTACAATGTCCAAATTCTTTG TATTTGTGACTGTTCATCAAATGGCTGCTTTTCAAGGCAGACTGTGTACTCCATTGTTTTTCACTTCCCTTGTCATGTTCCATACATTGA CTTGGGCCTTTTTAAATCAGGCTGGGGGGCTACCCCTTCTTAAATGAATACTATATCCCTATCTGAGGTTACCTCTTGTGAGTGGAAGGG TTGCTTTCCCAGGTGGTTGGGAGAGCACAAATGTTGAGAAAAGGCCTTTTAGTCTTTATCAAAACAATGACTAATGCTGGGCAACATATA GCAGAAGTCAAACAAAAATGATTCCTCCTGAAATGGTACCTTCATTGGTTCTGATGTTCTTTTGCAAAAAATGTCCGGAAGCAGTATAGA AAACCCCCTGTATGTGAACCTTAGATTGTAAGGCAAGCCAGTGCACTGTGTAATATGCAAAGGGAGTGGTGCAAAAGAGAAGGCACCCGT CCCAGCTCTCCATGCCCTTTCCCTGGCAGGCGCTGACTGAGATGGCGCTGAGTGAATGTGGAAGGTGCTAAGACCCAGTCTCTTCACTGC AGGGCTGTTTACAGCCAGTTTCTTTTACTCTGACCTTAAGGTTTCCACTGAGCTCATGAAACTTCAACATATGGTGTTTAAAAGTTTCCC ACTCAAATGCACACTTGAAAATTGGGTCCCTCAGCCTCATTACTGAACTAAATAAGTGAAGAAGTTGTATCTTTGGGGTAAAACTTTCCA GGGCCACTTAATTTTTTAACCAGTTAAGTACGCATCTTCCTGGTGGTTCAGACTTTTTAAGTCAGTGCTAAAGCTGAAAAGCGCCTTCTA AATATGACTGTGAGTTTAGTTTGTATCTTACATTTAGTAACTGTTCTGTTGGGCCAGGACTATGACTTTAATTACTATGTACTTATTCAT CCCACACTCTGCACTAAATACACCATAGCTACTATAGCATTGTGGCAGGCACTCATTTTTGTGGACTCATTCCATACTTCTGCTGGCATA TTTCGTTTAAAATCTAGCTAAAGATTTTCATAGTACTGTGTTAACTAGCCAGGGCTGAAAAGTGTGACAGGATATCAAATTGACTTTCCT TGGGGAAAATGTTGCTTTGGCAATAGTGAAGTCCAACTCCTTCATTTACAGAATTAGTGATTACTCATCAATTTTTGAAAGTTGTAGATT AAGTAGTTTTATTTACTAAATTCTTAACCACTTTGAAGATTTAAGCCAGTTGAAATGAAACATTGGCTGGATGCAGTTGGCTAGCACCTG TAATCCCAACACTTTGGGAGGCCAAGGTGGGAGGATTGCTTGAGGCCAGGAGCTCAAGACCAGCCTGGGAAACATAGATTTGAAATCTTT TCAAAAATGTATAAAAATTTAATAAATAAATAAATGAATCCTTACTCAACCATAATTATGGCTTTAAAACCCAACCAACAGTAAACACTT ACTTGAAGCCAAAACAGTAAATTTTGAATGAAATTTGAATTATGCTTTTGGAAGCTGCCATGTCTTAATTCTTGCTGGATTTTGATTTTC AATTTTGGAAGTTTTTATCAAAACTGTCCAGTCATGAGTATATCAGGTAGCAGCCTTTAAGGATCTAAGTTTCATTCCTATAAAGAACAG GAGGTGCTGGTATTTCTTGTCTTAGCAAGTGATCTGATGCAGGTCTAAATGGGGGTTAGCATCTATACTATGGCTTAAAAGTTTCCTCCT TGGTCACCATTTGGGAGGTGATGGCTTCAAAGCTAAGCTTTGCTCTCATGTGACCCTTCTTTATCTTAATACCCAATAAGATATAAACCT CTCAGAGTCAACCCAGTGTAGACTCAAAGGGTCTTAGCTTCATCTATCAGATAAGATCTATCTGATTTATACAAAGAATGGTGCTGTTTT TATATACATACTAAAAAAATCTAATTCTCAAACAATTTTCTTAATATTTATGCCAGCAAGGTCAGGAAAGACTATTTTGTCCTGTTTAAC TTTAGTAGTGAACAAACTGCTAGAGACATCTGTCATCCTTAACAGGCCACTGTGGTCCTTATATACTGACCCTCCTTTCCAATTAACGTC CTTTAATCCCATACTAGTTCCATAAGAGACTTGGCACATAAAAGCAGTATTTTTTTTAATGCCTAGTAAACTGGCCAGAAAAAAATATTG CCATGGTGGACCTGTTTCTATCCACCTCTTTCTATGGCTATATAAGTCTATACATGCCAGTTCCGTACATACTCCATTTCCAAAGAGCCC CCAAACCCTGGACAGTAGCACTACCATGAATTTTAGGGTCACAAAACATTTCCTTCTGAAGGAAGCAGCTGCCTCAGCAGTGTCACTTTA GTGACCACTGCCCAGGCTTACTTCACTTTGCCTCCCCCTACACATCACTGCCCTCTTTCTGCCACCAAACCTCACTATTCCAGCAATGAT GCCTCCCTGGTGTCTGGAAAACCCATCTGGTGCACTAAAATGCTATGCAACACCAAATGGCTTCTTCCCCTAATATTGCTCAACAATGTA AATTCTTCAAGAATAAACTTCATGCTAGGTTAACATCAATGTATGGTTACAGCTTCCTTTTTTTTTTTTCCCTTTTAAAATGAAGCAAAC CACCTCCATTAAAATCCATGTTTTGGGGCTTGTTTTTGTCTCTCAAGTGTGAAATATAAATCATGTTTTTATGATTTTTGTAAATCTTTT >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373010_chr6_41766667_-_677nt GTTTCCTAGACCAGTGACAAAGAAAGGTTTTAACAGCCTGGGCACAGAGGAGACATAGACTTCTGGGAAAAGCAGGCTGAAGATGGAAAC ATTGAATATAAATTGAAGCTGGTGAATCCATCCCAGTACCGCTTTGAGCACCTGGTGACACAAATGAAGTGGCGGCTCCAGGAGGGACGT GGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAGGAAATGCGAGCTTCGCTCAAGACCCTG CACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTATGATAGCGACATGCCCCGGAAGATCACC GAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCA GGTTTTTGGGTCCACTGCAATGACTCAAAGCTGAATGTATGCAGTGTCGAGGAAGTGTGCAAAACCCAGGCCTACATCCTTTTTTACACT CAAAGAACAGTGCAGGGCAATGCAAGAATCTCAGAAACCCATCTCCAAGCTCAGGTGCAGTCCAGCAACAATGATGAAGGCAGACCACAG >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373006_chr6_41766667_-_1681nt GTTTCCTAGACCAGTGACAAAGAAAGGTTTTAACAGCCTGGGCACAGAGGAGACATAGACTTCTGGGAAAAGCAGGCTGAAGATGGAAAC ATTGAATATAAATTGAAGCTGGTGAATCCATCCCAGTACCGCTTTGAGCACCTGGTGACACAAATGAAGTGGCGGCTCCAGGAGGGACGT GGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAGGAAATGCGAGCTTCGCTCAAGACCCTG CACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTATGATAGCGACATGCCCCGGAAGATCACC GAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCA GGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTTTGCCTATGATCTCTCCGCAGTGGTCAT GCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGGTGCGTGCGCTTTACTCTGTGGGGTGGG GGACACGGAAAGGGGTTGATTTGTCCACATTTTATTGTTTTCCTTTTATTTCCATCCCATGGATTACCTAGAGGGAAATTACATACATCA AAAATCCAGTGGAAAGAATTGTGAAAATTGGGTTGGGCGCCGTGGCTCACACCTGTAATCCTAGCGCTTTGGGAGGCCGCGGTGGGTGGA TCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTTAAACCCCGTCTCTACTAAAATAGTACAAAAATTAGCCGGGCGTGGT GGTGGGCACTGGTAATCCCAGGTACTCAAGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTA TGCCACTGCACTTCAGCCTGGGTGACAGAGCAAGACTCTTATCTCAAAAAAAATAAAAAGAATTATGAAAGTTGGATTCAAATTTTGGGT ATATTACTAAGTAACAACATATGGTTGTTCTAAGAATTAAAAGGAACTGACATGTAAAAGTGCTTAGAACAGGACCTAGGCCCTGTGCAA TGGCTCACACCTGTAATTCCAACACTTTGGGAGGCAGAGGCGGGAGGATTGCTTGAGGCCGAGGGTTCAAGACTAGCCTGGGCAACATAG CGAGACTGCATCTCTACAAAAAATTTAAAAATTATCCAGGTGTAATGGTGTGCACCTGTGATCCTAGCTACTTGGGAGGCTGAGGTGGGA GAATTGCTCAAGCCCAGGAGTTTGAAGTTGCAATGAGCTATGATTTCACCACTGCATTCTAGCCTGGGCAACAGAGTGAGATCCTGACTC AAATAAATAAATAAGAAGAGCAGTTGCCTACCACATAGTACTTATTCAGTCAGTGTTAGAGGATATTGTAGTATTATCAAAAGTATTGGT TATTGATAATATTACTGTTTTGTGGTAATGCTACTTCTGCACACCCCAGTTTCCTTCTTGGTTATGCAGAAACAGTAGAACCTGTGTAAC >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000297229_chr6_41766667_-_1680nt GTTTCCTAGACCAGTGACAAAGAAAGGTTTTAACAGCCTGGGCACAGAGGAGACATAGACTTCTGGGAAAAGCAGGCTGAAGATGGAAAC ATTGAATATAAATTGAAGCTGGTGAATCCATCCCAGTACCGCTTTGAGCACCTGGTGACACAAATGAAGTGGCGGCTCCAGGAGGGACGT GGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAGGAAATGCGAGCTTCGCTCAAGACCCTG CACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTATGATAGCGACATGCCCCGGAAGATCACC GAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCA GGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTTTGCCTATGATCTCTCCGCAGTGGTCAT GCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGGTGCGTGCGCTTTACTCTGTGGGGTGGG GGACACGGAAAGGGGTTGATTTGTCCACATTTTATTGTTTTCCTTTTATTTCCATCCCATGGATTACCTAGAGGGAAATTACATACATCA AAAATCCAGTGGAAAGAATTGTGAAAATTGGGTTGGGCGCCGTGGCTCACACCTGTAATCCTAGCGCTTTGGGAGGCCGCGGTGGGTGGA TCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTTAAACCCCGTCTCTACTAAAATAGTACAAAAATTAGCCGGGCGTGGT GGTGGGCACTGGTAATCCCAGGTACTCAAGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTA TGCCACTGCACTTCAGCCTGGGTGACAGAGCAAGACTCTTATCTCAAAAAAAATAAAAAGAATTATGAAAGTTGGATTCAAATTTTGGGT ATATTACTAAGTAACAACATATGGTTGTTCTAAGAATTAAAAGGAACTGACATGTAAAAGTGCTTAGAACAGGACCTAGGCCCTGTGCAA TGGCTCACACCTGTAATTCCAACACTTTGGGAGGCAGAGGCGGGAGGATTGCTTGAGGCCGAGGGTTCAAGACTAGCCTGGGCAACATAG CGAGACTGCATCTCTACAAAAAATTTAAAAATTATCCAGGTGTAATGGTGTGCACCTGTGATCCTAGCTACTTGGGAGGCTGAGGTGGGA GAATTGCTCAAGCCCAGGAGTTTGAAGTTGCAATGAGCTATGATTTCACCACTGCATTCTAGCCTGGGCAACAGAGTGAGATCCTGACTC AAATAAATAAATAAGAAGAGCAGTTGCCTACCACATAGTACTTATTCAGTCAGTGTTAGAGGATATTGTAGTATTATCAAAAGTATTGGT TATTGATAATATTACTGTTTTGTGGTAATGCTACTTCTGCACACCCCAGTTTCCTTCTTGGTTATGCAGAAACAGTAGAACCTGTGTAAC >In-frame_GTPBP2_ENST00000307114_chr6_43593493_-_USP49_ENST00000373009_chr6_41766667_-_793nt GTTTCCTAGACCAGTGACAAAGAAAGGTTTTAACAGCCTGGGCACAGAGGAGACATAGACTTCTGGGAAAAGCAGGCTGAAGATGGAAAC ATTGAATATAAATTGAAGCTGGTGAATCCATCCCAGTACCGCTTTGAGCACCTGGTGACACAAATGAAGTGGCGGCTCCAGGAGGGACGT GGTGAGGCCGTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAGGAAATGCGAGCTTCGCTCAAGACCCTG CACCGGATGGCAGAGAAGGTTGGGGCAGACATAACCGTTCTTCGAGAGCGAGAAGTGGATTATGATAGCGACATGCCCCGGAAGATCACC GAGGTGCTAGTACGAAAGGTCCCTGACAACCAACAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCA GGTATTAACCATGGAACCTTACTGCTGCAGGGACATGCTCTCCTCTCTTGACAAAGAGACCTTTGCCTATGATCTCTCCGCAGTGGTCAT GCATCACGGGAAAGGGTTTGGCTCAGGACACTACACAGCCTATTGCTACAACACAGAGGGAGGTTTTTGGGTCCACTGCAATGACTCAAA GCTGAATGTATGCAGTGTCGAGGAAGTGTGCAAAACCCAGGCCTACATCCTTTTTTACACTCAAAGAACAGTGCAGGGCAATGCAAGAAT |
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FusionGenePPI for GTPBP2_USP49 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GTPBP2 | IRF5, KDM1A, PRMT5, PRMT6, SUV39H1, DCP2, IFI30, HNRNPU, POLH, RPL10, RAB11A, GRAMD1B, RNASE3, UBE3D, PMEL, MUC20, CHRM3, PROSER2, IGFBP1, PLEKHO1, IQCF1 | USP49 | CETN1, CETN2, CETN3, COPA, F7, FKBP5, HADHA, MCM6, PDCD2, PPM1G, PPP5C, PRKACA, RPN1, SLC39A7, PPP6R2, HUWE1, LRPPRC, IPO7, STIP1, KRR1, PPP6R1, ANKRD28, DICER1, STAMBPL1, YARS2, UBR5, PPP6R3, IPO9, SHCBP1, NUP85, USP44, SHPRH, ANKRD52, TRIM35, RBCK1, HIST2H2BE, RUVBL1, PSMC5, TMEM173 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GTPBP2_USP49 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GTPBP2_USP49 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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