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Fusion gene ID: 15669 |
FusionGeneSummary for GTPBP1_TAF1D |
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Fusion gene information | Fusion gene name: GTPBP1_TAF1D | Fusion gene ID: 15669 | Hgene | Tgene | Gene symbol | GTPBP1 | TAF1D | Gene ID | 9567 | 79101 |
Gene name | GTP binding protein 1 | TATA-box binding protein associated factor, RNA polymerase I subunit D | |
Synonyms | GP-1|GP1|HSPC018 | JOSD3|RAFI41|TAF(I)41|TAFI41 | |
Cytomap | 22q13.1 | 11q21 | |
Type of gene | protein-coding | protein-coding | |
Description | GTP-binding protein 1G-protein 1 | TATA box-binding protein-associated factor RNA polymerase I subunit DJosephin domain containing 3RNA polymerase I-specific TBP-associated factor 41 kDaTATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDaTATA box-binding protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O00178 | Q9H5J8 | |
Ensembl transtripts involved in fusion gene | ENST00000216044, ENST00000460605, | ENST00000546088, ENST00000448108, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 6 X 6 X 4=144 |
# samples | 6 | 7 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GTPBP1 [Title/Abstract] AND TAF1D [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA648423 | GTPBP1 | chr22 | 39129501 | - | TAF1D | chr11 | 93474614 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000216044 | ENST00000546088 | GTPBP1 | chr22 | 39129501 | - | TAF1D | chr11 | 93474614 | - |
3UTR-5UTR | ENST00000216044 | ENST00000448108 | GTPBP1 | chr22 | 39129501 | - | TAF1D | chr11 | 93474614 | - |
intron-intron | ENST00000460605 | ENST00000546088 | GTPBP1 | chr22 | 39129501 | - | TAF1D | chr11 | 93474614 | - |
intron-5UTR | ENST00000460605 | ENST00000448108 | GTPBP1 | chr22 | 39129501 | - | TAF1D | chr11 | 93474614 | - |
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FusionProtFeatures for GTPBP1_TAF1D |
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Hgene | Tgene |
GTPBP1 | TAF1D |
Promotes degradation of target mRNA species. Plays arole in the regulation of circadian mRNA stability. Binds GTP andhas GTPase activity (By similarity). {ECO:0000250}. | Component of the transcription factor SL1/TIF-IBcomplex, which is involved in the assembly of the PIC(preinitiation complex) during RNA polymerase I-dependenttranscription. The rate of PIC formation probably is primarilydependent on the rate of association of SL1/TIF-IB with the rDNApromoter. SL1/TIF-IB is involved in stabilization of nucleolartranscription factor 1/UBTF on rDNA. Formation of SL1/TIF-IBexcludes the association of TBP with TFIID subunits.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GTPBP1_TAF1D |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GTPBP1_TAF1D |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GTPBP1_TAF1D |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GTPBP1_TAF1D |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TAF1D | C0037274 | Dermatologic disorders | 1 | CTD_human |
Tgene | TAF1D | C0311375 | Arsenic Poisoning | 1 | CTD_human |