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Fusion gene ID: 15631 |
FusionGeneSummary for GTF2F2_SMAD9 |
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Fusion gene information | Fusion gene name: GTF2F2_SMAD9 | Fusion gene ID: 15631 | Hgene | Tgene | Gene symbol | GTF2F2 | SMAD9 | Gene ID | 2963 | 4093 |
Gene name | general transcription factor IIF subunit 2 | SMAD family member 9 | |
Synonyms | BTF4|RAP30|TF2F2|TFIIF | MADH6|MADH9|PPH2|SMAD8|SMAD8/9|SMAD8A|SMAD8B | |
Cytomap | 13q14.12-q14.13 | 13q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | general transcription factor IIF subunit 2ATP-dependent helicase GTF2F2TFIIF-betageneral transcription factor IIF 30 kDa subunitgeneral transcription factor IIF, polypeptide 2, 30kDatranscription initiation factor IIF subunit betatranscription initi | mothers against decapentaplegic homolog 9MAD homolog 9Mothers against decapentaplegic, drosophila, homolog of, 9SMAD, mothers against DPP homolog 9 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P13984 | O15198 | |
Ensembl transtripts involved in fusion gene | ENST00000340473, ENST00000494087, | ENST00000350148, ENST00000379826, ENST00000483941, ENST00000399275, | |
Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 2 X 2 X 2=8 |
# samples | 7 | 2 | |
** MAII score | log2(7/192*10)=-1.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GTF2F2 [Title/Abstract] AND SMAD9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA756136 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000340473 | ENST00000350148 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
5CDS-5UTR | ENST00000340473 | ENST00000379826 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
5CDS-5UTR | ENST00000340473 | ENST00000483941 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
5CDS-intron | ENST00000340473 | ENST00000399275 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
intron-5UTR | ENST00000494087 | ENST00000350148 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
intron-5UTR | ENST00000494087 | ENST00000379826 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
intron-5UTR | ENST00000494087 | ENST00000483941 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
intron-intron | ENST00000494087 | ENST00000399275 | GTF2F2 | chr13 | 45694856 | + | SMAD9 | chr13 | 37454014 | - |
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FusionProtFeatures for GTF2F2_SMAD9 |
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Hgene | Tgene |
GTF2F2 | SMAD9 |
TFIIF is a general transcription initiation factor thatbinds to RNA polymerase II and helps to recruit it to theinitiation complex in collaboration with TFIIB. It promotestranscription elongation. This subunit shows ATP-dependent DNA-helicase activity. {ECO:0000269|PubMed:2477704}. | Transcriptional modulator activated by BMP (bonemorphogenetic proteins) type 1 receptor kinase. SMAD9 is areceptor-regulated SMAD (R-SMAD). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GTF2F2_SMAD9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GTF2F2_SMAD9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GTF2F2 | GTF2B, HTATSF1, GTF2E1, TBP, AHR, ARNT, FOS, JUN, POLR2E, MSX2, ATF4, TCEA1, GTF2E2, AR, POLR2A, POLR2B, POLR2J, POLR2G, POLR2H, CTDP1, BAG6, MED29, SUPT5H, GPRC5A, POLR2C, GTF2F1, TAF10, TAF5, TAF4, HMGA1, LMNA, RPL27A, TCTEX1D2, HECW2, EFTUD2, SH3GL1, SHMT1, FAM177A1, UBR5, SRRT, SUPT4H1, NTRK1, KLF5, EWSR1, XPO1, POLR2F, CBLN4, TMEM184A | SMAD9 | SMAD4, SMAD9, TOB1, HMGA2, KAT2A, KAT2B, NOTCH1, UBA6, MTMR11, EIF3F, PIR, KMT2D, KDM6A, ZEB2, MCM3AP, MAN1A2, SF3B1, DKK1, AP2A1, CSH1, CSH2, FTL, CYP11A1, PSAP, SNRNP70, RFX1, MGAT1, YWHAQ, ARNT, GRN, PHKA2, QARS, PSMD8, ZNF83, AFF1, METAP1, TERF1, EIF3E, ACTB, DSTN, LMO4, SPTBN1, FLI1, DST, PPARD, PAPPA, PABPC4, TRIM29, TRIP12, PLEC, SMAD2, PPP2R5E, CAMSAP1, RNF123, CEP135, E4F1, CTR9, TTC37, CXXC5, EVC2, CHPF, PELP1, VPS8, TMEM57, ZNF557, ZSCAN4, EXPH5, ARID1B, ZNF592, ZNF587B, ABTB1, PNPLA2, DNAJA3, OTUB1, VCPIP1, SVEP1, ERVV-1, ASB2, RANBP9, SECISBP2, EIF3C, DNAJC7, PKP2, ARHGAP9, TBCD, TINAGL1, CLPB, SIL1, UNC45A, C10orf2, RMND5A, HEYL, MAN1C1, BAZ1A, UBQLN4, DIAPH3, MTMR10, RRBP1, ASH2L, LRP5, NAGK, UBQLN1, LEMD3, HEY1, KDM1A, PRMT6, SMAD3, PSG9, DSG4, VSIG8, SMAD7, ZNF143, SMAP2, RBMS1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GTF2F2_SMAD9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GTF2F2_SMAD9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SMAD9 | C3888002 | PULMONARY HYPERTENSION, PRIMARY, 2 | 1 | UNIPROT |